Natural experiment concept to accelerate the Re-purposing of existing therapeutics for Covid-19Research article Published on 2020-11-012022-10-05 Journal: Global Epidemiology [Category] 신약개발, [키워드] accelerate approach attributes candidate Clinical treatment clinical trials collected computational modeling diagnostic Disease progression distribution drug drugs Effect Epidemic epidemiological experiment group Infection Intensive limitation Mild molecular morbidity natural experiment normalized Novel coronavirus pandemic positive Prophylactic question resource SARS-COV-2 infection selected serologic antibody Surveillance test negative the patient therapeutic time-consuming Treatment [DOI] 10.1016/j.gloepi.2020.100026 [Article Type] Research article
Application value of artificial liver support system in the treatment of cytokine storm in patients with COVID-19Article Published on 2020-10-312022-10-04 Journal: International immunopharmacology [Category] SARS, 치료법, [키워드] abnormality addition alanine aminotransferase ALT Analysis analyzed application Artificial liver support system Aspartate aminotransferase AST B lymphocyte C-reactive protein carried CD3 CD4 CD8 T cell Cell Clinical effect Clinical treatment college Computed tomography contributed coronavirus disease COVID-19 COVID-19 patients cytokine cytokine level Cytokine storm decrease IFN-γ IL-10 IL-2 IL-4 IL-6 Inflammation lesions liver lymphocyte Medicine natural killer neutrophil no significant difference objective observé Patient patients with COVID-19 plasma exchange procalcitonin promote proportion pulmonary lesion pulmonary lesions recruited reduce reduced Result severe COVID-19 patient significantly Support the patient TNF-α treated Treatment university was used White blood cell Zhejiang [DOI] 10.1016/j.intimp.2020.107120 PMC 바로가기 [Article Type] Article
In Vitro Antiviral Activity of Doxycycline against SARS-CoV-2Article Published on 2020-10-312022-10-30 Journal: Molecules [Category] COVID-19, SARS, [키워드] activities activity acute respiratory syndrome America Anti-inflammatory anti-inflammatory effect antimalarial Antiviral antiviral activity antiviral drug Antiviral effect approach approved drug Asia Clinical treatment clinically Co-infection Concentration containment measures coronavirus coronavirus disease COVID-19 doxycycline Drug discovery effective Europe evaluate experimental model expression high-risk patient identifying in vitro in vitro activity in vitro study initiated intravenous median moderate patients Prevent pro-inflammatory cytokine Prophylaxis Replication required SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 strain Severe COVID-19 Infection Spread Therapies translate Treatment Trial Vero E6 cell virus entry Wuhan, China [DOI] 10.3390/molecules25215064 PMC 바로가기 [Article Type] Article
The influence of hypoglycemia and hyperglycemia on the adverse outcome of COVID-19 combined with diabetes mellitus A protocol for systematic review and meta-analysis4300 Published on 2020-10-302022-10-30 Journal: Medicine [Category] COVID-19, MERS, SARS, [키워드] adverse outcome Affect Analysis analyzed blood glucose CBM China Chinese chronic inflammation Clinical treatment CNKI Comorbidities conducted Controlled COVID-19 COVID-19 patient database diabete Diabetes Mellitus Epidemic evaluate evaluated Evidence hyperglycemia hypoglycemia independent Infection Inflammatory mediators Infrastructure literature Meta-analysis Mortality Multiple organ damage NOS outcome oxidative stress patients with COVID-19 patients with diabete peer-reviewed Prognosis protocol review Risk of bias Science sensitivity subgroup analysis systematic review systematic review and meta-analysis technology Treatment Trial VIP with COVID-19 [DOI] 10.1097/MD.0000000000022587 PMC 바로가기 [Article Type] 4300
A model based on CT radiomic features for predicting RT-PCR becoming negative in coronavirus disease 2019 (COVID-19) patientsResearch Article Published on 2020-10-202022-10-28 Journal: BMC Medical Imaging [Category] COVID-19, Fulltext, MERS, SARS, [키워드] abnormality addition Algorithm Analysis AUC automatically Characteristics Chest computed tomography Chest CT image China clinical Clinical characteristics Clinical data Clinical treatment cohorts collected Computed tomography coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 patient COVID-19 patients criterion datasets deep learning Diagnosis diagnostic evaluated feature Features global pandemic groups Hospital stay Logistic regression median mild COVID-19 patient multivariate logistic regression negativity nine no significant difference Patient predict Quantitative Radiomics repeated Result ROC Curve RT-PCR RT-PCR test selected Spearman symptom onset treatment guideline [DOI] 10.1186/s12880-020-00521-z PMC 바로가기 [Article Type] Research Article
The therapeutic efficacy of Huashi Baidu Formula combined with antiviral drugs in the treatment of COVID-19 A protocol for systematic review and meta-analysis3800 Published on 2020-10-162022-10-30 Journal: Medicine [Category] Coronavirus, MERS, SARS, [키워드] analyzed antiviral drug antiviral drugs article Baidu CBM China Chinese citation Clinical diagnosis Clinical treatment CNKI Cochrane Library Combination Corona coronary pneumonia COVID-19 Efficacy and safety evaluate Formula global public health Guidance Huashi Baidu Formula Infrastructure lack Meta-analysis protocol recorded Research respiratory infectious disease Science screened Severe patient Stata systematic review therapeutic efficacy Treatment VIP [DOI] 10.1097/MD.0000000000022715 PMC 바로가기 [Article Type] 3800
“Fei Yan No. 1” as a Combined Treatment for COVID-19: An Efficacy and Potential Mechanistic StudyPharmacology Published on 2020-10-082022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acute respiratory syndrome Analyzer Antiviral Apoptosis Bioavailability biological processes caused China Chinese Clinical efficacy Clinical treatment combination therapy Combined combined treatment component components Compound conducted control group coronavirus coronavirus disease COVID-19 COVID-19 patient criteria Cytoscape database determine Fei Yan NO1 Gene ontology identify immune response indicated Inflammation KEGG KEGG pathway Kyoto network network pharmacology offered oral outbreak parameter pathway enrichment Pathways Patient Potential PPI proportion protein-protein interaction public health regulated Regulation Renmin Hospital representing Retrospective study RT-PCR SARS-CoV-2 SARS-CoV-2 nucleic acid selected significantly higher Symptom target targets TCM TCMSP TCMSP database therapeutic Topology treat Treatment treatment for COVID-19 were used [DOI] 10.3389/fphar.2020.581277 PMC 바로가기 [Article Type] Pharmacology
Coronavirus in human diseases: Mechanisms and advances in clinical treatmentReview Published on 2020-10-012022-10-30 Journal: MedComm [Category] COVID-19, [키워드] 3CLpro accessory protein acute respiratory syndrome Antiviral agents antiviral drug association Cell Clinical treatment clinical treatments coronavirus COVID‐19 COVID‐19 CoVs current disease effective Helicase highlight Human human coronaviruses human diseases infections mechanism MERS Middle East Mild pathogen PLPro Protein provide RdRP RNA virus S protein SARS SARS‐CoV‐2 signaling pathway strain syndrome target therapeutic option Therapeutic strategies Treatment treatment strategy upper respiratory viral life cycle virus [DOI] 10.1002/mco2.26 PMC 바로가기 [Article Type] Review
The Important Role of Volatile Components From a Traditional Chinese Medicine Dayuan-Yin Against the COVID-19 PandemicPharmacology Published on 2020-09-252022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Administered administration Against aromatic aromatic Chinese herbs Chinese Clinical treatment component confirmed case coronavirus COVID-19 COVID-19 patients Dayuan-Yin drugs Efficacy epidemic diseases expected Follow-up Health Local mechanism of action Medicine National National Health Commission Novel coronavirus observation plague plan Prevent produced Research role SARS virus selected Symptoms the patient Traditional Traditional Chinese medicine Treatment unique variety volatile components was selected [DOI] 10.3389/fphar.2020.583651 PMC 바로가기 [Article Type] Pharmacology
Effectiveness and safety of acupuncture for anxiety disorder of coronavirus disease 2019 A protocol of systematic review and meta-analysis3800 Published on 2020-09-182022-10-30 Journal: Medicine [Category] Coronavirus, SARS, [키워드] acupuncture Anxiety Anxiety Disorder CBM China Chinese Clinical treatment CNKI Cochrane Library contribute coronavirus disease COVID-19 database disorder Effectiveness Evidence Fang information Infrastructure journal Meta-analysis patients of COVID-19 peer-reviewed protocol Randomized controlled trial searched systematic review Treatment VIP [DOI] 10.1097/MD.0000000000022177 PMC 바로가기 [Article Type] 3800