Longitudinal saliva omics responses to immune perturbation: a case study면역 교란에 대한 종적 타액 오믹스 반응: 사례 연구Article Published on 2021-01-122022-10-04 Journal: Scientific Reports [Category] 바이오마커, 폐렴구균 감염증, [키워드] activated Activation adaptive Bacterial baseline cytokine signaling Data integration Diagnostic markers diagnostics extracellular vesicle Fever Gene Expression healthy immune immune response immune system Immunity individual interferon Intervention longitudinal MHC antigen miRNA Molecular medicine mRNA Non-invasive over Paired analysis pathway pneumococcal polysaccharide vaccine populations proteome Regulation reported response RNA Saliva salivary statistically significant timepoints Transcriptome transcriptomics vaccination vaccination responses Variation were used [DOI] 10.1038/s41598-020-80605-6 PMC 바로가기 [Article Type] Article
Circulating Platelet-Derived Extracellular Vesicles Are a Hallmark of Sars-Cov-2 Infection순환하는 혈소판 유래 세포외 소포는 Sars-Cov-2 감염의 특징입니다Communication Published on 2021-01-072022-09-11 Journal: Cells [Category] MERS, 바이오마커, [키워드] acute respiratory distress acute respiratory distress syndrome ARDS AUC Biomarker Biomarkers Blood cause characteristic circulating biomarker circulating platelet Cohort combined cohort cough COVID-19 cut-off value diagnostic evaluate evaluated EVs extracellular vesicle Extracellular vesicles Fever flow cytometry healthy controls hospitalized patients independent Infection lead outcome Patient Platelets predict predictive power quantified receiver operating characteristic respiratory distress Respiratory distress syndrome ROC ROC analysis SARS-CoV-2 SARS-COV-2 infection sensitivity specificity syndrome These data [DOI] 10.3390/cells10010085 PMC 바로가기 [Article Type] Communication
Extracellular vesicles containing ACE2 efficiently prevent infection by SARS‐CoV‐2 Spike protein‐containing virusShort Communication Published on 2020-12-282022-10-29 Journal: Journal of Extracellular Vesicles [Category] COVID-19, MERS, SARS, [키워드] ACE2 binding EV therapy EVs extracellular vesicle Host Inclusion Infection lentivirus membrane fusion Prevent priming produced SARS‐CoV‐2 SARS‐CoV‐2 spike SARS‐CoV‐2 soluble ACE2 subsequent surface receptor the spike protein TMPRSS2 Vesicle virus [DOI] 10.1002/jev2.12050 PMC 바로가기 [Article Type] Short Communication
Might proton pump or sodium‐hydrogen exchanger inhibitors be of value to ameliorate SARs‐CoV‐2 pathophysiology?Review Article Published on 2020-12-252022-10-28 Journal: Physiological Reports [Category] COVID-19, [키워드] administration animal model approach benefit biogenesis bronchitis candidate cathepsin Cell cell entry cleavage complex compounds contributed CoV COVID‐19 COVID‐19 Cytokine release syndrome disease pathogenesis Disease progression disrupt disrupting drug Efficacy endocytic endosomal complexes required for transport endosomal pH entry pathway envelope exacerbate Exosome Exosomes extracellular vesicle Extracellular vesicles glycosylation Golgi Infection inhibit inhibiting inhibitor involved mechanism membrane mice Microvesicles multivesicular body occur Pathogenesis plasma membrane PPI promote Pulmonary edema pulmonary epithelial cell reported serine protease TMPRSS2 Spike protein suggested therapeutic Transport Vesicle viral endocytosis viroporin viruses [DOI] 10.14814/phy2.14649 PMC 바로가기 [Article Type] Review Article
Protein-Driven Mechanism of Multiorgan Damage in COVID-19Research article Published on 2020-12-012022-10-05 Journal: Medicine in Drug Discovery [Category] 신약개발, [키워드] activate biological networks candidate Combination COVID-19 damage damaged drug drug-drug interaction ellagic acid Endocrine Exosomes expressed Extracellular extracellular vesicle Extracellular vesicles eyes identify Lungs mathematical mechanism Multiorgan Multiorgan damage Musculoskeletal neurologic organ Perturbation predict Protein protein-protein interaction Proteins SARS-CoV-2 SARS-CoV-2 proteins severe COVID-19 patients Subdiffusion the lungs a treat [DOI] 10.1016/j.medidd.2020.100069 [Article Type] Research article
Detection of viral RNA fragments in human iPSC cardiomyocytes following treatment with extracellular vesicles from SARS-CoV-2 coding sequence overexpressing lung epithelial cells폐 상피 세포를 과발현하는 SARS-CoV-2 코딩 서열의 세포외 소포로 처리한 후 인간 iPSC 심근세포에서 바이러스 RNA 단편 검출Letter Published on 2020-11-302022-09-10 Journal: Stem Cell Research & Therapy [Category] SARS, 치료기술, [키워드] A549 ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Cardiomyocytes cardiovascular risk factors caused coding sequence coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 detectable detection direct viral infection epithelial cells Evidence evidence of EVs expression extracellular vesicle Extracellular vesicles global pandemic heart Human iPSCs lung epithelial cell Lung epithelial cells overexpressed overexpressing Patient pluripotent stem cell-derived cardiomyocytes receptor reported respiratory SARS-CoV-2 SARS-CoV-2 gene SARS-CoV-2 genes SARS-COV-2 infection SARS-CoV-2 RNA severe acute respiratory syndrome Coronavirus stem cells supplementary material Treatment upregulation Viral viral gene viral genes viral genome viral infection Viral RNA viral RNA fragment [DOI] 10.1186/s13287-020-02033-7 PMC 바로가기 [Article Type] Letter
Immune Regulation by Dendritic Cell Extracellular Vesicles in Cancer Immunotherapy and VaccinesReview Published on 2020-11-282022-10-31 Journal: Cancers [Category] COVID-19, [키워드] addition Affect anticancer approach Cancer cancer treatment candidate CD8 Cell cell type cells co-stimulatory molecule complexes cytosolic DCs dendritic cell dendritic cell (DC) EVs Express extracellular vesicle extracellular vesicles (EVs) highlight histocompatibility complex Immune cell immune function immune response immune responses immune-suppressive tumor microenvironment Immunotherapy impair Interaction Intercellular communication Ligand lipids malignant membrane myeloid cell natural killer nucleic acid offer oncogenic oncopathogens Pathogens Perspective platform promote Prophylactic Proteins raised regulate rejection responses resulting RNAs secreted secreting simple stimulate stimulatory subset T cells therapeutic therapeutic option translate Transport Tumor tumor cells tumor-derived EVs unique Vaccine Vaccines variety Vesicle [DOI] 10.3390/cancers12123558 PMC 바로가기 [Article Type] Review
COVID‐19 therapy with mesenchymal stromal cells (MSC) and convalescent plasma must consider exosome involvement: Do the exosomes in convalescent plasma antagonize the weak immune antibodies?중간엽 기질세포(MSC)와 회복기 혈장을 이용한 코로나19 치료는 엑소좀 침범을 고려해야 한다: 회복기 혈장의 엑소좀은 약한 면역 항체를 길항하는가?Review Published on 2020-11-142022-09-12 Journal: Journal of Extracellular Vesicles [Category] MERS, 진단, [키워드] acting activated Administered affected aggregate antagonistic antibody best biologic Biologic therapy Cell Cell therapy clinically convalescent plasma COVID‐19 COVID‐19 patients COVID‐19 COVID‐19 antibodies COVID‐19 convalescent exosomes cytokine Cytokine storm deficiencies disease Effect Effects Evidence Exosome Exosomes expected extracellular vesicle Extracellular vesicles immune immune resistance immune response in vivo Infection lung dysfunction mechanisms Mesenchymal stromal cells miRNA miRNAs modulating MSC MSCs Nanoparticles parental Patient plasma Pneumonia responsible resulting severe pneumonia shown stromal cell stromal cells T cell tendency the antibody therapeutic therapy transfer treat Vascular vascular insufficiency virus [DOI] 10.1002/jev2.12004 PMC 바로가기 [Article Type] Review
New Insights on the Mobility of Viral and Host Non-Coding RNAs Reveal Extracellular Vesicles as Intriguing Candidate Antiviral TargetsReview Published on 2020-10-242022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] antiviral therapies biological function candidate caused Contact coronavirus COVID-19 Critical disease disease pathogenesis ectasomes effective strategy Evidence Exosomes Extracellular extracellular vehicles extracellular vesicle facilitate functional generate highlight implication Infection insight Interaction lncRNA membrane-bound miRNA Mobility molecular multicellular organisms New non-coding RNA Novel coronavirus potential therapeutic target promote provide recent Research RNA SARS-CoV SARS-CoV-2 secreted Support target viral pathogenicity virus virus propagation [DOI] 10.3390/pathogens9110876 PMC 바로가기 [Article Type] Review
Extracellular Vesicles in the Pathogenesis of Viral Infections in HumansReview Published on 2020-10-212022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] alteration amplification antiviral immune responses Cell Cellular responses clinically complex coronavirus Enzymes EVs Exosomes extracellular vesicle extracellular vesicles (EVs) facilitate Herpes virus HIV Human Human immunodeficiency virus immune response in viral inhibiting Intercellular communication mechanisms membrane vesicle modulate modulation MOST neurotropic nucleic acids Pathogenesis pathogenicity pathology Proteins retrovirus signaling molecules Therapeutics viral infection viral pathogenicity viral spread viruses Zika Zika virus ZIKV [DOI] 10.3390/v12101200 PMC 바로가기 [Article Type] Review