Discovery of a Generalization Gap of Convolutional Neural Networks on COVID-19 X-Rays ClassificationBiomedical Engineering Published on 2021-05-132022-10-30 Journal: Ieee Access [Category] COVID-19, [키워드] Accuracy Adults AUC build chest X-ray Chest X-ray images classification clinically confounder Coronavirus (COVID-19) COVID-19 data set deep learning detect eliminated example experimental evidence feature Features Gap generalization high accuracy IMPROVE indicate lung network Neural Pediatric case Pneumonia raw data scored shown Still X-ray [DOI] 10.1109/ACCESS.2021.3079716 PMC 바로가기 [Article Type] Biomedical Engineering
Machine Learning Based Clinical Decision Support System for Early COVID-19 Mortality PredictionPublic Health Published on 2021-05-122022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] accelerate Accuracy acute respiratory disease age Analysis Biomarker Biomarkers Blood blood test caused clinical Combination coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 mortality CT-scans decision determine FIVE form Healthcare system Healthcare systems help high accuracy high mortality rate High-sensitivity C-reactive protein identify Infection key factor lactate dehydrogenase LDH Logistic regression Lymphocytes machine learning medical treatment ML model Mortality Neutrophils outcome pandemic patient treatment practicality predict prediction Predictive Prognosis random risk SARS-CoV-2 SVM System the disease virus was performed WHO World Health Organization [DOI] 10.3389/fpubh.2021.626697 PMC 바로가기 [Article Type] Public Health
COVID-Classifier: an automated machine learning model to assist in the diagnosis of COVID-19 infection in chest X-ray imagesCOVID-Classifier: 흉부 X선 영상에서 COVID-19 감염 진단을 지원하는 자동화된 기계 학습 모델Article Published on 2021-05-102022-09-01 Journal: Scientific Reports [Category] SARS, 진단, 치료기술, [키워드] assist automated build can be used caused Chest X-ray image Classifier conjunction COVID-19 COVID-19 case COVID-19 cases COVID-19 patient COVID-19 patients CXR dataset diagnosis of COVID-19 differential diagnosis feature form generate high accuracy hospital resource hospital resources Infection Mathematics and computing Medical research non-COVID-19 case non-COVID-19 cases non-COVID-19 patient Non-COVID-19 patients Pneumonia radiologist Radiologists reduction sensitivity similarity [DOI] 10.1038/s41598-021-88807-2 PMC 바로가기 [Article Type] Article
Interleukin-6, procalcitonin and neutrophil-to-lymphocyte ratio: Potential immune-inflammatory parameters to identify severe and fatal forms of COVID-19인터루킨-6, 프로칼시토닌 및 호중구 대 림프구 비율: COVID-19의 심각하고 치명적인 형태를 식별하기 위한 잠재적인 면역 염증 매개변수Article Published on 2021-05-012022-09-11 Journal: Cytokine [Category] Coronavirus, SARS, 바이오마커, [키워드] acute respiratory distress acute respiratory distress syndrome Analysis ARDS AUROC Biomarker Blood blood cell blood count blood levels C-reactive protein calculated chemiluminescence complete blood count Corticosteroid corticosteroid treatment COVID-19 COVID-19 pathogenesis COVID-19 patients CRP cut-off value Cutoff cytokine Cytokine storm death demonstrated determine e parameters evaluate Evidence ferritin form groups high accuracy hyper-inflammatory immune response identify IL-6 IL2 receptor IL6 Inflammatory biomarker inflammatory biomarkers Inflammatory marker inflammatory markers interleukin interleukin 6 involved kinetic analysis lymphocyte median Mortality multi-organ failure neutrophil neutrophil count Neutrophil-to-lymphocyte ratio NLR parameter Patient PCT Peripheral blood positively correlated Potential predict Predictive procalcitonin prognostic Prognostic marker Prognostic value progression receptor respiratory distress risk ROC Curve severe forms of COVID-19 severity significantly higher steroid steroid therapy Support syndrome therapy threshold threshold value viral-induced was performed WBC were measured White blood cell white blood cell count [DOI] 10.1016/j.cyto.2021.155428 PMC 바로가기 [Article Type] Article
In Vitro Inhibitory Analysis of Rationally Designed siRNAs against MERS-CoV Replication in Huh7 CellsArticle Published on 2021-04-292022-10-30 Journal: Molecules [Category] COVID-19, MERS, [키워드] antiviral efficacy antiviral therapy approach Camel can be used cell line cell lines Combination confirmed case country cytotoxicity death designing develop disease-causing effective evaluate evaluated filtration high accuracy Hospitalized Huh7 HUH7 cells Huh7cells in silico prediction in vitro in vitro study in vivo information Jeddah MERS-CoV ORF1ab gene Patient predict prevalent Replication RNAfold Safe Saudi Arabia secondary structure selected siRNA siRNAs specificity spread to Transmission viral replication virus viruses was performed was used [DOI] 10.3390/molecules26092610 PMC 바로가기 [Article Type] Article
Establishment of a reverse genetics system for SARS-CoV-2 using circular polymerase extension reaction순환중합효소연장반응을 이용한 SARS-CoV-2 역유전학 시스템 구축Article Published on 2021-04-202022-09-11 Journal: Cell Reports [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis assembly bacterium base pairs causative agent cells clone construction coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CPER DNA fragment extension functional generate genetics Genome high accuracy infectious clone lack multiple mutation multiple mutations Mutagenesis mutant virus mutant viruses Mutation PCR polymerase recombinant reporter reporter viruses rescued resulting reverse genetics SARS-CoV-2 SARS-CoV-2 cDNA SARS-CoV-2 infectious clones severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 susceptible transfection virus [DOI] 10.1016/j.celrep.2021.109014 PMC 바로가기 [Article Type] Article
Markers of Polyfunctional SARS-CoV-2 Antibodies in Convalescent Plasma회복기 혈장 내 다작용성 SARS-CoV-2 항체 마커Research Article Published on 2021-04-202022-09-10 Journal: mBio [Category] MERS, SARS, 변종, 진단, [키워드] Activation activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ADCC addition analyzed antibody Antibody Response antibody-dependent cellular cytotoxicity Antiviral antiviral activity Antiviral effect Better binding blood donor Blood donors Cell Characteristics complement Complement activation contribute convalescent convalescent individual convalescent plasma convalescent plasma samples coronavirus coronavirus disease Coronavirus disease 2019 correlation COVID-19 Diversity Donor Efficacy eligible evaluate evaluated exhibited expand Features fraction function functional functional antibody response functions high accuracy Humoral response humoral responses IgA IgG individuals Intervention Mutation neutralization neutralizing capacity offer phagocytosis plasma plasma sample plasma samples reduced respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus therapy treatment for COVID-19 validation cohort variant Viral viral neutralization [DOI] 10.1128/mBio.00765-21 PMC 바로가기 [Article Type] Research Article
The Impact of Temperature on the Risk of COVID-19: A Multinational StudyArticle Published on 2021-04-122022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] 95% CI acute respiratory syndrome adjusted affecting age ambient analyzed average coronavirus country Coverage death determinant disease Diseases elder Epidemic Factor Factors Health help high accuracy highlight Impact incidence rate International international tourism Measures mortality risk outbreak Population random randomly divided risk risk factor ROC SARS-CoV-2 statistical model temperature the SARS-CoV-2 Universal health coverage [DOI] 10.3390/ijerph18084052 PMC 바로가기 [Article Type] Article
Bioinformatic prediction of immunodominant regions in spike protein for early diagnosis of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Bioinformatics Published on 2021-04-082022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] acute respiratory syndrome Amino acid antibody Antibody detection Antigen antigen detection Antigen-capture antigenicity approach Bioinformatic bioinformatics Bioinformatics analysis caused coronavirus COVID-19 Critical detection system early diagnosis epitope expected generate glycosylation site high accuracy hydrophilicity immunodominant immunodominant epitopes Immunodominant fragments mice Mutation nucleic acid Pandemics peptide Region Result S1 subunit SARS-CoV-2 SARS-CoV-2 detection selected sequence specificity spike Spike protein stimulate strong immune response the S1 subunit virus particle [DOI] 10.7717/peerj.11232 PMC 바로가기 [Article Type] Bioinformatics
RGD-Binding Integrins Revisited: How Recently Discovered Functions and Novel Synthetic Ligands (Re-)Shape an Ever-Evolving FieldReview Published on 2021-04-042022-10-31 Journal: Cancers [Category] COVID-19, [키워드] αvβ3 αvβ6 accumulated Angiogenesis approach approaches binding Cancer cancer progression Cell cells Clinical studies clinical trials compounds diagnostic disease dose elevated Exosomes expression fibrosis field function functions high accuracy integrin integrin targeted therapy Integrins investigated knowledge Ligand ligands Metastasis molecular molecular imaging motif non-cancerous novel nuclear optical other diseases patient selection pharmacological progression receptors respiratory RGD-binding integrins SARS-CoV-2 SARS-COV-2 infection selective Sepsis Signal transduction simple subtype Subtypes synthetic synthetic integrin ligands target therapeutic target therapeutic targets therapy translation translational Treatment protocol treatment strategy Trial vascular normalization therapy viral infections [DOI] 10.3390/cancers13071711 PMC 바로가기 [Article Type] Review