Initial Insights Into the Genetic Epidemiology of SARS-CoV-2 Isolates From Kerala Suggest Local Spread From Limited IntroductionsGenetics Published on 2021-03-172022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] A2a clade Affect affecting amplicon-based sequencing Analysis China Coronavirus disease 2019 country COVID-19 COVID-19 case COVIDSeq COVIDSeq protocol Efficacy Epidemiology FIVE functional variant Genetic Genetic epidemiology haplotype analysis India individuals insight isolate Kerala knowledge Limited Local mapped outbreak Patient primer binding site rapid increase RT-PCR S gene SARS-CoV-2 sequenced single-nucleotide Spread variant variants virus [DOI] 10.3389/fgene.2021.630542 PMC 바로가기 [Article Type] Genetics
First confirmed detection of SARS-COV-2 in untreated municipal and aircraft wastewater in Dubai, UAE: The use of wastewater based epidemiology as an early warning tool to monitor the prevalence of COVID-19UAE 두바이의 미처리 도시 및 항공기 폐수에서 SARS-COV-2의 첫 번째 확인 확인: COVID-19의 확산을 모니터링하기 위한 조기 경고 도구로 폐수 기반 역학 사용Article Published on 2021-03-152022-09-11 Journal: The Science of the total environment [Category] SARS, 치료기술, 치료제, [키워드] aircraft Aircraft sewage airport Arab country assist coronavirus 2 country COVID-19 determine Dubai Epidemiology Infectious disease Infectious diseases measure mind MONITOR N gene nasal swabs Occurrence ORF1 ORF1ab outbreak pandemic patients positive positive result Prevalence prevalence of COVID-19 provide raised respiratory resulting RT-PCR kit S gene SARS-CoV-2 SARS-CoV-2 gene SARS-CoV-2 genes Severe acute respiratory syndrome Spread spread to Stool stool samples stools Symptoms target tested the WHO viral shedding virus Wastewater-based epidemiology Wuhan Wuhan, China [DOI] 10.1016/j.scitotenv.2020.143350 PMC 바로가기 [Article Type] Article
Long-term monitoring of SARS-CoV-2 RNA in wastewater of the Frankfurt metropolitan area in Southern GermanyArticle Published on 2021-03-082022-10-04 Journal: Scientific Reports [Category] SARS, 진단, [키워드] Analysis approach average averaged collected Community Concentration Course COVID-19 COVID-19 case determine Environmental impact Epidemiology European Frankfurt Germany hotspot identify incidence increase in Infection Local MONITOR N gene ORF1ab gene performed public health ranged RNA RT-qPCR S gene SARS-COV-2 infection SARS-CoV-2 RNA temporal dynamics the SARS-CoV-2 Treatment [DOI] 10.1038/s41598-021-84914-2 PMC 바로가기 [Article Type] Article
Genetic Characteristics and Phylogeny of 969-bp S Gene Sequence of SARS-CoV-2 from Hawai‘i Reveals the Worldwide Emerging P681H MutationArticle Published on 2021-03-012023-07-01 Journal: Hawai'i journal of health & social welfare [Category] SARS, [키워드] genomic characterization Hawai‘i strains Phylogenetic tree proline S gene Single nucleotide polymorphism Spike protein variant PMC 바로가기 [Article Type] Article
Dynamics of binding ability prediction between spike protein and human ACE2 reveals the adaptive strategy of SARS-CoV-2 in humans스파이크 단백질과 인간 ACE2 간의 결합 능력 예측의 역학은 인간에서 SARS-CoV-2의 적응 전략을 보여줍니다Article Published on 2021-02-042022-09-10 Journal: Scientific Reports [Category] MERS, 바이오마커, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Amino acid Analysis analyzed binding ability binding affinity collected Computational biology and bioinformatics conserved coronavirus country COVID-19 pandemic Dynamics Ethnic groups genome sequence hACE2 Host hosts Human human ACE2 Interaction Mutation natural reservoir Novel coronavirus Phylogenetic analysis Phylogeny plasticity RBD Receptor-binding domain recombination event reconstructed Region respiratory reveal S gene SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spike protein spike protein RBD stability the receptor-binding domain the spike protein Transmission variant variants viral infection [DOI] 10.1038/s41598-021-82938-2 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Genomes From Oklahoma, United StatesGenetics Published on 2021-02-032022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] acute respiratory syndrome Analysis clinical sample conformational flexibility coronavirus D614G determine different time point FIVE Genome genomes sequenced genomic geographical locations globe indicate influence initial linker Modification Mutation mutations N gene nCoV-19 nucleocapsid protein Oklahoma ORF1ab ORF7b ORF8 pandemic pathogenicity reported S gene SARS-CoV-2 SARS-CoV-2 virus sequenced Sequencing similarity the spike protein United State [DOI] 10.3389/fgene.2020.612571 PMC 바로가기 [Article Type] Genetics
School in Italy: a safe place for children and adolescents이탈리아의 학교: 어린이와 청소년을 위한 안전한 곳Research Published on 2021-02-022022-09-10 Journal: Italian Journal of Pediatrics [Category] MERS, 치료기술, 치료제, [키워드] amplifier analyzed children collected complexes coronavirus coronavirus SARS-CoV-2 COVID detection diffusion E gene Efficacy evaluate Evidence implementation measure N gene oral positive Prevention measures RdRP Real-time PCR Result Rome S gene Safe SARS-CoV-2 SARS-CoV-2 pandemic School Schools secretion specimen Spread subject target Target genes transmission of SARS-CoV-2 virus viruses was performed [DOI] 10.1186/s13052-021-00978-w PMC 바로가기 [Article Type] Research
SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated in vitro during propagation in TMPRSS2-deficient cellsS1/S2 절단 부위에 돌연변이가 있는 SARS-CoV-2 변이체는 TMPRSS2 결핍 세포에서 증식하는 동안 시험관 내에서 생성됩니다Research Article Published on 2021-01-212022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, COVID-19, [키워드] alteration antivirals bind Cell cell lines cell tropism cleavage cleavage site cleaved Coronaviruses Critical de novo demonstrated direct fusion dominant entry pathway exhibited experiments facilitate generate Host host cell host cell receptor host protease in vitro inefficient infect motif mutant mutants Mutation performed plaque plaques polybasic Protein proteolytic cleavage researcher respiratory S gene S protein S1/S2 cleavage site SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 propagation SARS-CoV-2 S gene SARS-CoV-2 variant SARS-CoV-2 variants screened Serine Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 shown target cells the cell the S protein TMPRSS2 transmembrane serine protease Transmissibility type strain undergo Vaccine variant Vero Cell Vero cells Viral viral entry virus virus strains virus variants viruses wild-type strain [DOI] 10.1371/journal.ppat.1009233 PMC 바로가기 [Article Type] Research Article
The evolutionary dynamics of endemic human coronavirusesRapid Communication Published on 2021-01-202022-10-28 Journal: Virus Evolution [Category] COVID-19, [키워드] accumulated acute respiratory syndrome adaptive Affect amino acid change analyzed antigenic antigenic variant average Bayesian Bayesian framework Cell changes in coronavirus Coronavirus-2 dataset Endemic endemic human coronavirus Evidence Evolution evolutionary dynamics Evolutionary rate expected gene regions Genes genetic variability glycoprotein H3N2 HCoV-229E HCoV-OC43 highest Host HPD human coronavirus human coronaviruses human pathogen IAV influenza A virus influenza vaccines less likelihood maximum mutations neutralizing antibody responses Non-synonymous mutation occurred pandemic Phylogeny Positive selection protective immunity RBD Receptor binding domain representing reservoir RNA virus S gene SARS-CoV-2 SARS-CoV-2 evolution similarities similarity stability Substitution supported target the RBD Vaccine viral entry virus [DOI] 10.1093/ve/veab020 PMC 바로가기 [Article Type] Rapid Communication
Findings of Hepatic Severe Acute Respiratory Syndrome Coronavirus-2 Infection간중증급성호흡기증후군 코로나바이러스-2 감염 소견Article Published on 2021-01-012022-09-12 Journal: Cellular and molecular gastroenterology and hepato [Category] SARS, 진단, [키워드] absence acute respiratory syndrome analyzed Apoptosis apoptotic bodies cell injury cellular change Clinical course coronavirus disease Coronavirus-2 COVID-19 cytopathic Endotheliitis finding formalin-fixed paraffin-embedded hepatic Hepatitis histologic histology hybridized In situ hybridization increasingly Inflammatory Injury intrahepatic light microscopy liver Liver Biopsy Liver injury liver tissue Liver transplantation majority Microscopy Non-hepatotropic Virus occur other organs Patient patients probe processed rejection respiratory S gene SARS-CoV-2 severe COVID-19 severity [DOI] 10.1016/j.jcmgh.2020.09.015 PMC 바로가기 [Article Type] Article