Temporal development and neutralising potential of antibodies against SARS-CoV-2 in hospitalised COVID-19 patients: An observational cohort study입원한 COVID-19 환자에서 SARS-CoV-2에 대한 항체의 일시적 발달 및 중화 가능성: 관찰 코호트 연구Observational Study Published on 2021-01-262022-09-10 Journal: PLoS ONE [Category] 임상, 진단, 치료기술, 치료법, [키워드] ACE-2 antibody Antibody Response Antibody responses attachment protein best binding clinical presentation Cohort COVID-19 description diagnostic diagnostic testing domain event explain Frame help hospitalised hospitalised COVID-19 patient hospitalised COVID-19 patients house human host Humoral response humoral responses IgG antibodies IgG antibody IgG response IgG responses Infection inhibiting binding neutralising nucleocapsid protein Observational cohort study onset of symptoms outcome Patient predictor produced Protective Protein RBD reached receptor respiratory respiratory infection S protein SARS-CoV-2 Seroconversion seroconverting Serological assay serological assays symptom onset Temporal the S protein These data Time frame unit Viral viral respiratory infection Virus neutralisation were used [DOI] 10.1371/journal.pone.0245382 PMC 바로가기 [Article Type] Observational Study
The Utility of Specific Antibodies Against SARS-CoV-2 in Laboratory DiagnosisMicrobiology Published on 2021-01-132022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acute respiratory syndrome Against caused Characteristics characterized clinical utility Combination Coronavirus-2 COVID-19 diagnostic Dynamic change Efficiency epidemiological global pandemic IgA antibody IgG IMPROVE less limitation neutralizing antibody nucleic acid nucleic acid test SARS-CoV-2 Serological assay serological assays serological test Serological testing Specific specific antibodies specific IgM suggested suspected patients the antibody response Transmissibility unique virus [DOI] 10.3389/fmicb.2020.603058 PMC 바로가기 [Article Type] Microbiology
Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease-2019 (COVID-19)코로나바이러스 질병-2019(COVID-19) 입원 환자의 감염성 바이러스 배출 기간 및 주요 결정인자Article Published on 2021-01-112022-09-10 Journal: Nature Communications [Category] MERS, 진단, 치료기술, 치료법, [키워드] 95% confidence interval Analysis coronavirus COVID-19 COVID-19 patient COVID-19 patients Culture determinant determinants disease disease control drop Duration Hospitalized hospitalized patient identify Infection prevention Infectious virus IQR Isolation log median multivariate multivariate analyses non-infectious observé Odds ratio onset of symptom onset of symptoms Patient precautions Prevention and control Quantitative question respiratory respiratory tract respiratory tract sample respiratory tract samples RNA RNA copies SARS-CoV-2 Serological assay serological assays Serum neutralizing antibody titre Translational research Viral viral infection Viral load viral loads viral RNA load virus virus cultures with COVID-19 [DOI] 10.1038/s41467-020-20568-4 PMC 바로가기 [Article Type] Article
Performance Characteristics of the Vidas SARS-CoV-2 IgM and IgG Serological AssaysVidas SARS-CoV-2 IgM 및 IgG 혈청학적 분석의 성능 특성Immunoassays Published on 2021-01-082022-09-10 Journal: Journal of Clinical Microbiology [Category] Coronavirus, SARS, 진단, 치료기술, [키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 assays automated caused clinical clinical sensitivity clinical specificity coefficients Combined coronavirus COVID-19 COVID-19 pandemic cross-reactivity declined Diagnosis Emergency use authorization epidemiological epidemiological surveillance healthy donor Hospitalized IgG IgG responses IgM and IgG IgM/IgG immunoserology Infection pandemic Patient patients performance positive Precision reached remained respiratory respiratory virus response reverse transcriptase reverse transcriptase PCR RT-PCR SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 IgM SARS-CoV-2 infections SARS-CoV-2 patients SARS-CoV-2 PCR SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody sensitivity sera Seroconversion Serological assay serological assays serological test Serological testing Serological tests significantly higher specific IgM specificity Spread Surveillance symptom onset test results Variation Vidas virus infection was determined [DOI] 10.1128/JCM.02292-20 PMC 바로가기 [Article Type] Immunoassays
Humoral Responses and Serological Assays in SARS-CoV-2 InfectionsSARS-CoV-2 감염의 체액 반응 및 혈청학적 분석Review Published on 2020-12-182022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] abundance acute respiratory disease antibody benefit Betacoronavirus Community coronavirus coronavirus 2 COVID-19 Critical cross-reactivity death detect develop Efficiency effort epidemiological expression levels Genetic variant genetic variants healthcare highlight humoral immune response humoral immune responses Humoral immunity Humoral response immune responses Immunity immunological implementation implication individuals knowledge limitation measure neutralization new strain novel Betacoronavirus original antigenic sin pandemic virus public health measure public health measures Reinfection respiratory Respiratory disease response resulting risk robust SARS-CoV-2 SARS-COV-2 infection seasonal coronaviruses serological Serological assay serological assays Serological testing serology stability Transmission dynamics vaccination Vaccine development virus Wuhan Wuhan, China [DOI] 10.3389/fimmu.2020.610688 PMC 바로가기 [Article Type] Review
Ultra-Sensitive Serial Profiling of SARS-CoV-2 Antigens and Antibodies in Plasma to Understand Disease Progression in COVID-19 Patients with Severe Disease중증 질환이 있는 COVID-19 환자의 질병 진행을 이해하기 위한 혈장 내 SARS-CoV-2 항원 및 항체의 초민감 직렬 프로파일링Article Published on 2020-12-012022-09-11 Journal: Clinical Chemistry [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus analyzed anti-SARS-CoV-2 Antigen Biomarker Blood changes in clearance clinical outcomes Clustering Combined Concentration coronavirus coronavirus disease COVID-19 COVID-19 case COVID-19 negative COVID-19 positive patients detect detectable Disease progression Hierarchical hierarchical clustering ICU admission identify Infection intubation longitudinal plasma samples molecule MONITOR N antigen nasopharyngeal nucleocapsid antigen nucleocapsid antigens Patient patients patients with COVID-19 PCR plasma plasma sample positive positive result Profiling quantified reported respiratory Respiratory failure RT-PCR test S1 subunit SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 S1 SARS-CoV-2 spike SARS-CoV-2 viral Seroconversion serological serological assays serology tests severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe disease Simoa single molecule arrays statistically significant test results These data Viral Viral antigen viral antigens [DOI] 10.1093/clinchem/hvaa213 PMC 바로가기 [Article Type] Article
Validation of a commercially available SARS-CoV-2 serological immunoassayArticle Published on 2020-10-012023-07-11 Journal: Clinical microbiology and infection : the official [Category] SARS, [키워드] COVID-19 ELISA pseudovirus neutralisation assay Recombinant immunofluorescence assay SARS-CoV-2 serological assays Serological testing strategy. [DOI] 10.1016/j.cmi.2020.06.024 PMC 바로가기
Serological Assays Estimate Highly Variable SARS-CoV-2 Neutralizing Antibody Activity in Recovered COVID-19 Patients혈청학적 분석, 회복된 COVID-19 환자에서 매우 가변적인 SARS-CoV-2 중화 항체 활성 추정Immunoassays Published on 2020-09-112022-09-10 Journal: Journal of Clinical Microbiology [Category] SARS, 진단, 치료기술, [키워드] 2019 Abbott Abbott SARS-CoV-2 IgG Accuracy activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-SARS-CoV-2 antibody antiviral activity center choice collected convalescent plasma convalescent plasma samples coronavirus coronavirus disease correlated COVID-19 Critical determine Donor ELISA ELISAs enrolled enzyme enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays estimate gold gold standard house IgG Immunity immunoglobin Infection Interpretation levels of antibodies levels of antibody methodology NAb NAb activity NAb assay NAb assays NAbs neutralization Neutralizing antibodies neutralizing antibody New York offer pandemic Particles patient sera Population population immunity predict Program proportion Pseudotyped virus recovered reopening respiratory SARS-CoV-2 SARS-CoV-2 detection Sensitivity and specificity serologic tests Serological assay serological assays serological measurement serological measurements serological test Serological tests serology Seroprevalence severe acute respiratory syndrome Coronavirus therapeutic therapeutic trials total Ig Trial unique vaccination variable Variation Viral viral infection [DOI] 10.1128/JCM.02005-20 PMC 바로가기 [Article Type] Immunoassays
Characterisation of SARS-CoV-2 Lentiviral Pseudotypes and Correlation between Pseudotype-Based Neutralisation Assays and Live Virus-Based Micro Neutralisation AssaysArticle Published on 2020-09-102022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] approach biosafety characterising classical complement detect evaluate Human monoclonal antibody human sera human serum humans Immunity Italian lentiviral lentiviral pseudotypes Live virus microneutralisation neutralisation neutralisation assay Neutralising activity outbreak pandemic pseudotype SARS-CoV-2 SARS-CoV-2 spike protein sera serological serological assays serological assessment Spike protein Spread the SARS-CoV-2 this system virus was tested wild type wild type virus wild-type strain [DOI] 10.3390/v12091011 PMC 바로가기 [Article Type] Article
A comparison of four serological assays for detecting anti–SARS-CoV-2 antibodies in human serum samples from different populationsResearch Article Published on 2020-09-022022-10-29 Journal: Science Translational Medicine [Category] COVID-19, MERS, SARS, [키워드] addition antibody antibody assay antibody profiling Antibody Response Antibody titer Antigen Asymptomatic Cell COVID-19 difference domain ectodomain ELISA assay evaluate expressed flow cytometry full-length healthy blood donors healthy individual Hospitalized hospitalized patient human serum immunoprecipitation individual infected with SARS-CoV-2 LIPS Luciferase immunoprecipitation system Mild mild symptoms neutralization activity Neutralizing activity occurred pandemic performed pilot study Population Prevalence Previous studies profiles Protein pseudotype virus S1 domain SARS-CoV-2 SARS-CoV-2 antigen SARS-COV-2 infection SARS-CoV-2 seroprevalence sensitivity Seroconversion Serological assay serological assays Seropositivity serum sample Severe case severity subpopulation symptom onset symptomatic symptomatic case symptomatic individual the disease the S protein the SARS-CoV-2 trimeric spike Virus neutralization with COVID-19 [DOI] 10.1126/scitranslmed.abc3103 PMC 바로가기 [Article Type] Research Article