translational – Page 10 – Communicable Diseases Research

Big Data for Biomedical Education with a Focus on the COVID-19 Era: An Integrative Review of the Literature

Review

Published on 2021-08-262022-10-29
Journal: International Journal of Environmental Research an [Category] Coronavirus, MERS, SARS,

Towards the sustainable discovery and development of new antibiotics

Reviews

Published on 2021-08-192022-10-05
Journal: The Pan African Medical Journal [Category] 유전자 메커니즘,

[키워드] Antibiotics antimicrobial bacterial pathogen benefit caused develop displaying IMPROVE Infection life-threatening limitation multidrug-resistant New overcome public health Research Small molecules Spread translational treat
[DOI] 10.1038/s41570-021-00313-1 [Article Type] Reviews

SPIKE-1: A Randomised Phase II/III trial in a community setting, assessing use of camostat in reducing the clinical progression of COVID-19 by blocking SARS-CoV-2 Spike protein-initiated membrane fusion

SPIKE-1: SARS-CoV-2 스파이크 단백질 개시 막 융합을 차단하여 COVID-19의 임상 진행을 줄이는 데 camostat의 사용을 평가하는 커뮤니티 환경에서의 무작위 2상/3상 시험

Letter

Published on 2021-08-192022-09-10
Journal: Trials [Category] MERS, SARS, 임상,

[키워드] 1:1 acute respiratory syndrome coronavirus apyrexia available data baseline best Biomarkers Blinding camostat clearance Clinical improvement clinical trial Community conducted control arm coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 symptom COVID-19 symptoms COVID-2019 Day defined Deterioration determined by diagnostics disease dissemination duration of illness Efficacy element eligibility criteria Eligible patients EudraCT evaluate Evidence evidence of Formal four times daily functional Guidance Health Organization health protection high risk hospital Hospital admission Hospital admissions Host include Infection initial Interactive Web Response System interim analysis Ireland IWRS Laboratory testing maximum membrane fusion moderate Mortality multicentre nasal negative swab number objective open open label Open-label Ordinal Scale outcome outcome measure overall mortality oxygen oxygen-free day Oxygenation participant Patient patient population patients with SARS-CoV-2 performed phase PK data Prevent primary care progression protection protocol provided Public Public Health Agency Public Health England qPCR questionnaire randomisation randomised randomised controlled trial receive recruit recruited recruitment reduce reducing refinement requiring supplemental oxygen Research respiratory risk RT-PCR Saliva Sample size Sample size calculations SARS-CoV-2 SARS-COV-2 infection secondary Secondary objective Secondary objectives secondary outcome measures serum antibody Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus 2 severity spike status supplemental oxygen supplementary material supplementary oxygen supportive care Swab symptom severity tablets temperature the patient TMPRSS2 translational Translational research Treatment treatment arm Trial trial protocol Trial registration typical symptom typical symptoms upper respiratory Ventilation ventilator ventilator-free day Ventilator-free days Viral Viral load viral shedding website World Health Organization
[DOI] 10.1186/s13063-021-05461-9 PMC 바로가기 [Article Type] Letter

Vivo-Morpholino-Based Antiviral for SARS-CoV-2: Implications for Novel Therapies in the Treatment of Acute COVID-19 Disease

Article

Published on 2021-08-152022-10-28
Journal: Biomedicines [Category] COVID-19,

[키워드] 384-well plate Antiviral Cell culture complex conducted coronavirus Coronavirus infection COVID-19 COVID-19 hospitalization COVID-19 infection CPE cytotoxicity deaths dendrimers disease effective evaluate humans Hydroxychloroquine immune clearance in vitro individual infected patient Infection inhibit limit morpholinos MRCV-19 novel overlap Phase I pp1a Prevent pulmonary disease reduce reducing reduction Remdesivir Replication SARS-CoV-2 SARS-CoV-2 replication shown Support target the SARS-CoV-2 Toxicity translation translation initiation translational Vaccine viral burden Viral transmission
[DOI] 10.3390/biomedicines9081018 PMC 바로가기 [Article Type] Article

Weighted Gene Co-Expression Network Analysis Combined with Machine Learning Validation to Identify Key Modules and Hub Genes Associated with SARS-CoV-2 Infection

Article

Published on 2021-08-132022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

[키워드] A549 acute respiratory syndrome Algorithm Analysis applied biological process Biomarkers Bronchial epithelium bronchial epithelium cells candidate drugs categories caused Cell cell line cells clinical trial co-expression network Combined conducted coronavirus correlated COVID-19 COVID-19 infection COVID-19 patient Defense disease drug drug target effective enrichment analysis evaluate Explainable artificial intelligence gene co-expression network gene signature HEPHL1 human lung epithelium IL-17 in vitro in vivo Infection KEGG pathway lung alveolar machine learning module network NHBE pandemic pathogenesis of COVID-19 pathogenicity pathway PGLYRP4 prognostic Regulation SARS-CoV-2 signaling pathway significantly therapeutic approaches therapeutic targets transcriptional change transcriptional profiling translational treat Treatment type I interferon Vaccine validation viral infection virus WGCNA
[DOI] 10.3390/jcm10163567 PMC 바로가기 [Article Type] Article

Significance of High-Containment Biological Laboratories Performing Work During the COVID-19 Pandemic: Biosafety Level-3 and -4 Labs

Bioengineering and Biotechnology

Published on 2021-08-132022-10-31
Journal: Frontiers in Bioengineering and Biotechnology [Category] COVID-19,

[키워드] activity Aerosols applied Biological biosafety biosecurity BSL BSL-2 BSL-3 BSL-3 laboratory BSL-4 Case history Community costly COVID-19 Culture diagnostic equipment Establishing group high containment biological laboratory include Laboratory Local Measures National organizations Performing required Research resource SARS-CoV-2 scenario Significance translational transmissible variants virus while work zoonosis
[DOI] 10.3389/fbioe.2021.720315 PMC 바로가기 [Article Type] Bioengineering and Biotechnology

The degree of frailty as a translational measure of health in aging

Reviews

Published on 2021-08-122022-10-05
Journal: Nature Aging [Category] 바이오마커, 비임상, 유전자 메커니즘,

[키워드] Adults age Care cellular and molecular clinical manifestations clinical trial condition disease explain expressed expressing expression favor frailty Health help increased risk less modify Older organ outcomes risk social determinants subcellular the disease tissue translational
[DOI] 10.1038/s43587-021-00099-3 [Article Type] Reviews

Mass spectrometry-based proteomics in basic and translational research of SARS-CoV-2 coronavirus and its emerging mutants

Review

Published on 2021-08-122022-11-01
Journal: Clinical Proteomics [Category] COVID-19,

[키워드] acute respiratory syndrome anti-viral antibody assays Betacoronavirus clinical study Combination continuous monitoring coronavirus coronavirus disease COVID-19 cross-reactivity diagnostic Diseases Emerging mutations evaluate facilitate functional identify Immunity immunoassays immunoprecipitation information knowledge mass mass spectrometry molecular diagnostics mutant mutations pandemic Pandemics Perspective Population post-translational modifications Protein protein–protein interactions proteomic proteomics quantification rapid response Research RNA sequencing RT-PCR SARS-CoV-2 SARS-CoV-2 coronavirus sensitivity Serology diagnostics serology test specificity targeted proteomics translational Viral protein Viral RNA viruses while
[DOI] 10.1186/s12014-021-09325-x PMC 바로가기 [Article Type] Review

Clinical and Histopathologic Features of a Feline SARS-CoV-2 Infection Model Are Analogous to Acute COVID-19 in Humans

Article

Published on 2021-08-052022-10-28
Journal: Viruses [Category] COVID-19, MERS, SARS,

Adenoviral vector vaccine platforms in the SARS-CoV-2 pandemic

Review Article

Published on 2021-08-052022-10-04
Journal: NPJ Vaccines [Category] 비임상,