vaccine response – Page 10 – Communicable Diseases Research

Spike-directed vaccination elicits robust spike-specific T-cell response, including to mutant strains

스파이크 유도 백신은 돌연변이 균주를 포함하여 강력한 스파이크 특이적 T 세포 반응을 이끌어냅니다.

Article

Published on 2022-01-012022-09-11
Journal: Cytotherapy [Category] SARS, 변종, 진단,

Comparison of SARS-CoV-2 Antibody Response 4 Weeks After Homologous vs Heterologous Third Vaccine Dose in Kidney Transplant Recipients A Randomized Clinical Trial

신장 이식 수용자에서 상 동성 대 이종 제 3 백신 용량 4 주 후 SARS-COV-2 항체 반응의 비교 무작위 임상 시험

Randomized Controlled Trial

Published on 2021-12-202022-08-13
Journal: JAMA Internal Medicine [Category] Fulltext, MERS, 임상, 진단,

[키워드] 1:1 95% CI addition age Analysis antibody Antibody Response antibody response rate association BNT162b2 Characteristics clinical clinical trial comparable conducted develop dose doubling Effectiveness end point EudraCT evaluated finding Frequency groups Heterologous homologous immune response immunogenicity Immunosuppression Importance induce injection injection site interferon interferon-γ kidney transplant kidney transplant recipient kidney transplant recipients local pain Logistic regression measure mRNA mRNA vaccine mRNA-1273 mRNA-based Neutralizing antibodies neutralizing antibody no statistically significant difference objective Odds ratio participant Patient performed plasma Point positive response Preliminary data randomized clinical trial reactogenicity recipient Registration Relevance response response rate Result Safe SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 spike protein SARS-CoV-2 vaccination SARS-CoV-2 vaccine secondary Seroconversion seroconverted patient seroconverted patients setting significantly single center Spike protein statistically significant difference study population systemic symptom systemic symptoms T-cell Response the SARS-CoV-2 the vaccine the vaccines Transplant vaccination Vaccination strategy Vaccine vaccine dose vaccine response Vaccines vector Vector-based vaccine Viral Viral vector vaccines virus Week women
[DOI] 10.1001/jamainternmed.2021.7372 PMC 바로가기 [Article Type] Randomized Controlled Trial

Host factors and vaccine efficacy: Implications for COVID‐19 vaccines

Review

Published on 2021-12-072022-11-01
Journal: Journal of medical virology [Category] COVID-19, COVID19(2023년), SARS,

Association of COVID-19 Vaccination With SARS-CoV-2 Infection in Patients With Cancer A US Nationwide Veterans Affairs Study

암 환자의 SARS-CoV-2 감염과 COVID-19 예방 접종의 연관성 미국 전역 재향 군인 연구

Multicenter Study

Published on 2021-12-022022-09-10
Journal: JAMA Oncology [Category] COVID19(2023년), MERS, SARS, 치료기술,

[키워드] 1:1 95% CI Affair age association Cancer cancer type Care Chemotherapy Cohort cohort study Control controls COVID-19 COVID-19 vaccination death defined determine dose effective Effectiveness eligibility criteria eligible Endocrine Endocrine Therapy Ethnicity exposure finding first vaccination Follow-up for inclusion Health Health care Health care system hematologic Immunosuppressed Importance increased risk individuals Infection infection rate measure median multicenter objective outcomes participant Patient patients Patients with cancer Point positive result Primary outcome receipt receiving Relevance Result risk risk ratio risk reduction rurality SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 vaccination SARS-CoV-2 vaccine second dose serologic testing setting severe COVID-19 solid tumor solid tumors subgroup systemic therapy the vaccine therapy Treatment tumors vaccinated individual vaccinated individuals vaccination Vaccine vaccine dose vaccine response veteran white
[DOI] 10.1001/jamaoncol.2021.5771 PMC 바로가기 [Article Type] Multicenter Study

COVID-19 mRNA Based Vaccine Immune-Response Assessment in Nursing Home Residents for Public Health Decision

Article

Published on 2021-12-022022-10-28
Journal: Vaccines [Category] COVID-19,

SARS CoV-2 vaccine AND rituximab, timing might be a key for a better vaccine response

SARS CoV-2 백신 및 리툭시맙, 시기가 더 나은 백신 반응의 열쇠일 수 있음

Article

Published on 2021-12-012022-09-12
Journal: Joint bone spine [Category] SARS, 진단,

[키워드] Abstract COVID rituximab SARS CoV-2 Vaccine vaccine response
[DOI] 10.1016/j.jbspin.2021.105258 PMC 바로가기 [Article Type] Article

Inadequate Vaccine Responses in Children With Multiple Sclerosis

Original Research

Published on 2021-12-012024-09-02
Journal: Frontiers in Pediatrics [Category] 대상포진,

[키워드] Immunology and infectious diseases multiple sclerosis pediatric Vaccine vaccine response
[DOI] 10.3389/fped.2021.790159 PMC 바로가기 [Article Type] Original Research

Humoral protection to SARS-CoV2 declines faster in patients on TNF alpha blocking therapies

SARS-CoV2에 대한 체액 보호는 TNF 알파 차단 요법을 받는 환자에서 더 빨리 감소합니다

Article

Published on 2021-12-012022-09-11
Journal: RMD Open [Category] 변종, 진단,

[키워드] Anti-spike anti-Spike IgG anti-TNF Antigen appearance Arthritis blockade booster booster vaccination booster vaccinations CD4+ T cell CD4+ T-cell chronic inflammatory disease chronic inflammatory diseases clinically Cohort controls COVID-19 Critical Decline declined Efficacy faster Frequency greater groups healthy controls healthy individual humoral immune response Humoral response humoral responses IgA level IgA levels IgG immune responses Inflammatory diseases lack mRNA vaccination Necrosis neutralization Neutralizing antibodies no differences pandemic Patient patients persistence receiving regimens response SARS-CoV2 second vaccination significantly T cell therapy TNF TNF alpha Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor inhibitors vaccination vaccine response vaccine responses variants while
[DOI] 10.1136/rmdopen-2021-002008 PMC 바로가기 [Article Type] Article

Vaccination against SARS-CoV-2 in Patients with Inflammatory Bowel Diseases: Where Do We Stand?

Review

Published on 2021-11-112022-10-29
Journal: International Review of Cell and Molecular Biology [Category] COVID-19,

[키워드] acute respiratory distress acute respiratory syndrome approach ARDS circulation Complication coronavirus disease Coronavirus-2 Course COVID-19 Crohn’s disease Crohn’s disease effective Effectiveness expected gastrointestinal tract greater IBD Immunocompromised immunological immunosuppressive therapies immunosuppressive therapy Infection Inflammation Inflammatory bowel disease knowledge management medication pandemic pathogen Pathogens Patient patients provide reducing risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination severe disease course shown subject syndrome Therapeutic approach ulcerative colitis underlying condition vaccination Vaccine vaccine response
[DOI] 10.3390/life11111220 PMC 바로가기 [Article Type] Review

24. Longitudinal Assessment of Immune Responses to COVID-19 Vaccines in Solid Organ Transplant Recipients

Oral Abstracts

Published on 2021-11-042022-10-29
Journal: Open Forum Infectious Diseases [Category] COVID-19,

[키워드] 95% CI anti-N IgG anti-RBD anti-S anti-S IgG Anti-S1 antibody assessment baseline black BNT162b2 board cellular response Characteristics Clinical efficacy Cohort collected consultant controls coronavirus disease COVAX COVID COVID-19 COVID-19 vaccine Cutoff DAVID demographics detect domain dose Efficacy enrolled evaluate figure first dose greater healthy healthy control humoral IgG antibodies IgG titer longitudinal magnitude median member mRNA COVID-19 vaccine mRNA vaccine mRNA-1273 natural infection participant Pfizer Phase 3 trials plasma positive positive response prospective cohort study Quanterix Corporation RBD receive recipient recipients reducing Research respond response Result risk SARS-CoV-2 second dose serological response significantly significantly lower Simoa Solid solid organ transplant SOT spike sub-cohort subset T-cell Response table the healthy the SARS-CoV-2 threshold time timepoint timepoints titer Transplant understanding Vaccine vaccine response were excluded were used with COVID-19
[DOI] 10.1093/ofid/ofab466.024 PMC 바로가기 [Article Type] Oral Abstracts