Serological profiles of pan-coronavirus-specific responses in COVID-19 patients using a multiplexed electro-chemiluminescence-based testing platform다중 전기 화학 발광 기반 테스트 플랫폼을 사용한 COVID-19 환자에서 Pan-Coronavirus 특이 적 반응의 혈청 학적 프로파일Research Article Published on 2021-06-032022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 치료법, [키워드] antibody Antibody Response antibody response against Antibody responses carried collected Contact tracing COVID-19 COVID-19 patient COVID-19 sample COVID-19 samples CoVs cross-reactive cross-reactivity diagnosed with COVID-19 Diagnosis diagnostic domain epitope epitope specificity full-length spike protein group healthcare HKU1 hospital human coronavirus human CoV human CoVs IgG response IgG responses IgM and IgG IgM response IgM responses MERS MERS-CoV Multiplex assay N-terminal domain Non-COVID-19 nucleocapsid protein OC43 occur plasma sample plasma samples platform Prevalence profile Protein reactivity Receptor-binding domain reported response responses robust SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 nucleocapsid SARS-CoV-2 spike protein seasonal coronavirus serological assessment South South Korea specificity Spike protein Spike proteins subject Symptom the SARS-CoV-2 the spike protein unique [DOI] 10.1371/journal.pone.0252628 PMC 바로가기 [Article Type] Research Article
Limited specificity of commercially available SARS-CoV-2 IgG ELISAs in serum samples of African origin아프리카 기원의 혈청 샘플에서 상업적으로 이용 가능한 SARS-CoV-2 IgG ELISA의 제한된 특이성Article Published on 2021-06-012022-09-11 Journal: Tropical medicine & international health : TM & IH [Category] MERS, SARS, 진단, 치료법, [키워드] Africa African analysed Antigen binding collected common cold common cold CoV common cold CoVs country COVID-19 COVID-19 pandemic CoVs diagnostics Donor elicited ELISA ELISAs Endemic enzyme enzyme-linked immunosorbent assay Euroimmun Europe Germany house IgG IgG antibodies IgG antibody immune response immune responses Immunoglobulin Immunoglobulin G Infection inhibit Interference Limited mandatory much lower Nigeria novel Novel coronavirus nucleocapsid OC43 parasites pathogen Pathogens Population positive protocol reduced SARS-CoV-2 SARS-CoV-2 IgG sera Seroepidemiologic studies serological test Serological tests serum serum sample serum/plasma significantly South America Specific Specificities specificity virus Virus neutralisation viruses [DOI] 10.1111/tmi.13569 PMC 바로가기 [Article Type] Article
Targeting SARS-CoV-2 viral proteases as a therapeutic strategy to treat COVID-19COVID-19를 치료하기 위한 치료 전략으로 SARS-CoV-2 바이러스 프로테아제 표적화Review Published on 2021-05-012022-09-11 Journal: Journal of medical virology [Category] SARS, 치료제, [키워드] 3 chymotrypsin-like cysteine protease 3CL pro acute respiratory syndrome Amino acid caused chymotrypsin coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus main protease COVID-19 COVID-19 infection CoVs cysteine cysteine protease death Epidemic Infection information MERS Middle East Middle East respiratory syndrome outbreak Papain papain-like cysteine protease. Papain-like protease protease Protein SARS Coronavirus SARS infection SARS-CoV SARS-CoV-2 SARS-CoV-2 viral Severe acute respiratory syndrome similarity Spread Support syndrome targeting the United State Therapeutic molecule therapeutic molecules therapeutic strategy treat treatment strategy United States Viral proteins virus [DOI] 10.1002/jmv.26814 PMC 바로가기 [Article Type] Review
Pan-coronavirus fusion inhibitors possess potent inhibitory activity against HIV-1, HIV-2, and simian immunodeficiency virusResearch Article Published on 2021-04-292022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, SARS, [키워드] activities activity Analysis antiviral activity broad-spectrum antivirals cholesterol Combined coronavirus COVID-19 CoVs Critical exhibited fusion inhibitor HIV-1 HIV-2 human coronavirus Infection information inhibited inhibitor inhibitors inhibitory activity isolates lipopeptide mechanism membrane fusion molecular docking mutant outbreak peptide provide reported SARS-CoV-2 sequence significantly simian immunodeficiency virus SIV [DOI] 10.1080/22221751.2021.1917309 PMC 바로가기 [Article Type] Research Article
Current updates on adaptive immune response by B cell and T cell stimulation and therapeutic strategies for novel coronavirus disease 2019 (COVID-19) treatmentReview Article Published on 2021-04-272022-10-04 Journal: Heliyon [Category] 신약개발, 치료법, 치료제, [키워드] Adaptive immune response adaptive immune system assumed B cell confirmed case CoV COVID-19 COVID-19 patients COVID-19 severity CoVs current death demonstrated drugs General population highlighting human-to-human transmission immune response Immunity improvement information measure MONITOR novel coronavirus disease Occurrence Pathogenesis pre-existing immunity Precaution prevalence of COVID-19 reduce Research SARS-CoV-2 T cell therapeutic therapeutic strategy Therapeutic treatment Transmission Treatment Vaccine Vaccine development [DOI] 10.1016/j.heliyon.2021.e06894 PMC 바로가기 [Article Type] Review Article
The taxonomy, host range and pathogenicity of coronaviruses and other viruses in the Nidovirales orderReview Published on 2021-04-232022-10-28 Journal: Animal Diseases [Category] COVID-19, [키워드] Analysis benefit caused coronavirus CoV COVID-19 pandemic CoVs cross Diseases Epidemic Epidemics Evolution feature Genetic variation genetics genomic highly pathogenic Host host range hosts infect information mammals Nidovirale Nidovirales nidovirus nidoviruses pathogenic pathogenicity Phylogenetic relationship promote public health Research S protein the Coronaviridae Transmission variety Viral detection viral disease viral genome Virological virus viruses [DOI] 10.1186/s44149-021-00005-9 PMC 바로가기 [Article Type] Review
Severe acute respiratory syndrome (SARS) related coronavirus in batsReview Published on 2021-04-232022-10-28 Journal: Animal Diseases [Category] COVID-19, [키워드] 2019 coronavirus disease acute respiratory syndrome bat caused coronavirus coronavirus disease CoV COVID-19 CoVs cross-species Cross-species transmission disease genetic diversity genomic geographical distribution hosts Human humans infect knowledge MERS Middle East occurred outbreak Outbreaks Pathogenesis SARS-CoV-1 SARS-CoV-2 SARS-related coronavirus SARS-related CoV similarity spillover syndrome transmitted virus viruses [DOI] 10.1186/s44149-021-00004-w PMC 바로가기 [Article Type] Review
Recombinant Human Thymosin Beta-4 Protects against Mouse Coronavirus InfectionResearch Article Published on 2021-04-212022-10-31 Journal: Mediators of Inflammation [Category] COVID-19, MERS, [키워드] acetylated Actin activity acute respiratory syndrome Angiogenesis Anti-inflammatory antioxidant BALB/c conducted coronavirus Coronavirus infection COVID-19 CoVs disease evaluate experiment expressed function Host Human human CoV human tissues humans immune response infect inhibiting linear liver MERS MERS-CoV MHV MHV-A59 mice Middle East mouse mouse CoV mouse hepatitis virus N-terminus pathogenic coronavirus peptide promoter protective effect recombinant regulate required RNA genome SARS-CoV SARS-CoV-2 significantly increased survival rate syndrome treat Treatment viral pathogenesis virus replication wound healing [DOI] 10.1155/2021/9979032 PMC 바로가기 [Article Type] Research Article
The SARS‐unique domain (SUD) of SARS‐CoV and SARS‐CoV‐2 interacts with human Paip1 to enhance viral RNA translationArticle Published on 2021-04-202022-10-31 Journal: The EMBO Journal [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Analysis assays association binding cells complex coronavirus CoVs determinant domain ENhance eukaryotic translation initiation factors fluorescent functional Host host protein interact Interaction macrodomain mechanism Microbiology, Virology & Host Pathogen Interaction outbreak Protein protein 3 Protein Biosynthesis & Quality Control protein synthesis protein translation provide public health reveal SARS‐CoV‐2 scattering size‐exclusion chromatography structural biology translation Viral RNA virus‐host interactions [DOI] 10.15252/embj.2019102277 PMC 바로가기 [Article Type] Article
Pharmacological Modulators of Autophagy as a Potential Strategy for the Treatment of COVID-19Review Published on 2021-04-152022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] angiotensin-converting enzyme inhibitor antiviral properties autophagy autophagy machinery Camostat mesylate can be used Chloroquine clinically Compound coronavirus CoV COVID-19 CoVs drug Effect effort endolysosomal system Glucocorticoids growth highlight host cell host cells Hydroxychloroquine identify in vitro in vivo infected with SARS-CoV-2 Infection inhibit lysosomotropic agents modulate modulator Mortality Patient Pharmacology Potential Prevent promote Protease inhibitor Protein proteolytic cleavage Rapamycin reducing Research risk SARS-COV-2 infection signaling pathways Stage Strategy treat umifenovir viral entry viral infection [DOI] 10.3390/ijms22084067 PMC 바로가기 [Article Type] Review