Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor NetworksArticle Published on 2021-01-072023-07-13 Journal: Cell [Category] SARS, [키워드] coronavirus COVID-19 CRISPR genetic screens HCoV-229E HCoV-NL63 HCoV-OC43 host factors. SARS-CoV-2 Tmem41b [DOI] 10.1016/j.cell.2020.12.006 PMC 바로가기
Intrafamilial Exposure to SARS-CoV-2 Associated with Cellular Immune Response without Seroconversion, France혈청전환 없는 세포 면역 반응과 관련된 SARS-CoV-2에 대한 가족 내 노출, 프랑스Research Published on 2021-01-012022-09-12 Journal: Emerging Infectious Diseases [Category] MERS, SARS, 진단, [키워드] 229E acute respiratory syndrome antibodies antibody Contact Control coronavirus coronavirus disease coronavirus symptoms COVID-19 COVID-19 symptom Evidence exposure to France HCoV-229E HCoV-OC43 healthy controls household exposure IgA IgG IgM induce interferon intrafamilial contacts investigated median Mild OC43 Patient positive remained reported response RT-PCR SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2–specific antibody Seroconversion serologic testing seronegative severe acute respiratory syndrome coronavirus 2 symptom onset T-cell Response viral-specific T-cell response virus-specific T-cell response [DOI] 10.3201/eid2701.203611 PMC 바로가기 [Article Type] Research
High prevalence of pre-existing serological cross-reactivity against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in sub-Saharan Africa사하라 사막 이남 아프리카에서 중증 급성 호흡기 증후군 코로나바이러스-2(SARS-CoV-2)에 대한 기존 혈청학적 교차 반응의 높은 유병률Article Published on 2021-01-012022-09-11 Journal: International Journal of Infectious Diseases [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Asia collected Coronavirus-2 correlated COVID-19 COVID-19 pandemic cross-protection cross-reactive cross-reactive antibodies cross-reactive antibody cross-reactivity death disease Europe evaluated exposure to HCoV HCoV-229E HCoV-NL63 HCoVs Human human coronavirus Hypothesis immunofluorescence assay in some incidence Infection morbidity and mortality MOST nucleocapsid protein Nucleocapsid proteins occurred other coronavirus other coronaviruses pandemic Pathogenesis plasma sample plasma samples pre-pandemic plasma sample Pre-pandemic plasma samples Prevalence prevalent Protein Recognition remained respiratory SARS-CoV-2 SARS-COV-2 infection serological serology Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Significant significantly higher Spike proteins SSA sub-Saharan Africa tested the SARS-CoV-2 the spike protein USA [DOI] 10.1016/j.ijid.2020.10.104 PMC 바로가기 [Article Type] Article
HCoV- and SARS-CoV-2 Cross-Reactive T Cells in CVID PatientsImmunology Published on 2020-12-232022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] Anti-viral Antibody Response CD4+ cell CD4+ T cell CD4+ T cells CD8+ cell Cell characterized common variable immunodeficiency disorder (CVID) Coronavirus disease 2019 (COVID-19) correlation COVID-19 cross-reactive cross-reactivity CVID detectable Endemic evaluate evaluated Evidence Frequency had no HCoV-229E healthy control healthy individuals human endemic coronavirus 229E (HCoV-229E) human endemic coronavirus OC-43 (HCoV-OC43) IFNγ IL-2 Immunity less marker multifunctional nucleocapsid pathogen Patient patients patients with CVID peptide pools primary immunodeficiency (PID) profiles Protective Proteins provide raised reactive reactivity reported risk SARS-CoV-2 SARS-COV-2 infection Seven severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) severity T cell T cell response T cell responses TNFα virus [DOI] 10.3389/fimmu.2020.607918 PMC 바로가기 [Article Type] Immunology
Improved plaque assay for human coronaviruses 229E and OC43Biotechnology Published on 2020-12-212022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] 229E Agarose antivirals approach Biosafety Level 3 BSL-2 BSL-3 can be used Cell cells comparable conditions Contact coronavirus Coronavirus infection COVID-19 COVID-19 pandemic effective facilitate faster growth HCoV 229E HCoV-229E Host immune response human coronavirus human coronaviruses 229E immunostaining Improved less Lung epithelial cells OC43 Plaque assay produced Research researcher SARS-CoV-2 sensitivity Stress temperature Tolerance turn [DOI] 10.7717/peerj.10639 PMC 바로가기 [Article Type] Biotechnology
Inhibition of SARS-CoV-2 by Highly Potent Broad-Spectrum Anti-Coronaviral Tylophorine-Based DerivativesPharmacology Published on 2020-12-142022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] anti-viral activity antiviral properties assays Compound coronavirus Coronaviruses COVID-19 derivative end point examined FIPV gastroenteritis greater HCoV-229E HCoV-OC43 host cell factors human coronavirus OC43 human coronaviruses inhibit SARS-CoV-2 inhibited inhibition inhibitor inhibitors log magnitude ouabain potent Replication SARS-CoV-2 steroid tested therapeutic Treatment tylophorine Viral RNA virus [DOI] 10.3389/fphar.2020.606097 PMC 바로가기 [Article Type] Pharmacology
Seasonality and immunity to laboratory-confirmed seasonal coronaviruses (HCoV-NL63, HCoV-OC43, and HCoV-229E): results from the Flu Watch cohort studyResearch Article Published on 2020-12-102022-10-28 Journal: Wellcome Open Research [Category] COVID-19, [키워드] 95% CI 95%CI Analysis assumption caused Cohort cohort study collected coronavirus Coronavirus infection dependent on develop England Epidemiology Evidence First wave H1N1 influenza HCoV-229E HCoV-NL63 HCoV-OC43 highest homologous identify Immunity individual Infection infections intensity laboratory-confirmed novel coronavirus SARS-CoV-2 pandemic participant PCR-confirmed prospective cohort study public health Reinfection Respiratory illness SARS-CoV-2 seasonal coronavirus seasonality second wave Swab tested Transmission [DOI] 10.12688/wellcomeopenres.15812.2 PMC 바로가기 [Article Type] Research Article
Healthy donor T cell responses to common cold coronaviruses and SARS-CoV-2감기 코로나바이러스와 SARS-CoV-2에 대한 건강한 기증자 T 세포 반응Clinical Trial Published on 2020-12-012022-09-11 Journal: The Journal of Clinical Investigation [Category] SARS, 임상, 치료기술, 치료법, 치료제, [키워드] 229E acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immunity Cell characterized circulating common cold common cold coronavirus common cold Coronaviruses coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Culture determine Donor donors ELISPOT ELISpot assay enzyme enzyme-linked immunospot exposure to had no HCoV HCoV-229E HCoV-NL63 HCoV-OC43 healthy donor Immunity immunology in vitro Infectious disease influence memory T memory T cell NL63 Novel coronavirus nucleocapsid protein Nucleocapsid proteins OC43 outcomes peptide peptide pool peptide pools peptides Recognition recognize reported response SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein seronegative severe acute respiratory syndrome Coronavirus Spike protein Spike proteins suggested T cell T cell response T cell responses T cells the spike protein virus [DOI] 10.1172/JCI143120 PMC 바로가기 [Article Type] Clinical Trial
Human coronavirus spike protein-host receptor recognitionReview Published on 2020-10-312023-06-14 Journal: Progress in Biophysics and Molecular Biology [Category] MERS, SARS, [키워드] Amino peptidase N angiotensin-converting enzyme 2 Dipeptidyl peptidase 4 HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 human coronavirus MERS-CoV Receptor binding domain SARS-CoV SARS-CoV-2 sialic acid Spike protein [DOI] 10.1016/j.pbiomolbio.2020.10.006 PMC 바로가기 [Article Type] Review
Targeting Macrophages as a Therapeutic Option in Coronavirus Disease 2019Pharmacology Published on 2020-10-292022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] addressed antiviral immune response antiviral response antiviral responses approach breadth Cell characterized clinical trial complications coronavirus coronavirus disease Coronaviruses COVID-19 Critical Cytokine storm detrimental effect environmental cues evaluated fibrosis functions HCoV-229E hypercoagulability Inflammatory responses initial interactions interferon signaling Lineage Macrophage macrophage phenotype MERS-CoV Numerous option pathogen clearance patients phenotype plasticity provided pulmonary fibrosis recruitment SARS-CoV SARS-CoV-2 targeting Therapeutic approach tissue repair variety viral infection while [DOI] 10.3389/fphar.2020.577571 PMC 바로가기 [Article Type] Pharmacology