healthy individual – Page 11 – Communicable Diseases Research

Potential Misdiagnosis between COVID-19 and Dengue Infection Using Rapid Serological Test

Article

Published on 2021-06-072022-10-30
Journal: Infectious Disease Reports [Category] COVID-19,

Regulatory KIR + RA + T cells accumulate with age and are highly activated during viral respiratory disease

Original Paper

Published on 2021-05-272022-10-28
Journal: Aging Cell [Category] COVID-19, MERS, SARS,

[키워드] accumulate accumulated activated Activation addition Affect age aging Blood CD45RA CD8 CD8⁺ T cells characterized coronavirus COVID‐19 disease explain expresse expressed expression feature healthy individual identify Immune suppression immunological increase Infection Infectious disease Influenza influenza A Influenza virus killer‐cell immunoglobulin‐like receptors KIR marker Older older population phenotypical proliferation Regulation Regulatory regulatory T cells respiratory symptoms respiratory viral respiratory viral infection subset susceptibility T cell T cells T‐cell T‐cell response T‐cell responses T‐cell activation unique viral respiratory viral respiratory disease
[DOI] 10.1111/acel.13372 PMC 바로가기 [Article Type] Original Paper

Blood DNA methylation and COVID-19 outcomes

Research

Published on 2021-05-252022-10-31
Journal: Clinical Epigenetics [Category] COVID-19, SARS,

[키워드] acute respiratory distress syndrome (ARDS) Analysis Autoimmune disorders Blood blood sample circulating collected contribute controls COVID-19 COVID-19 patient COVID-19 progression COVID-19 severity CpG disease DNA DNA methylation expression of gene Gene Expression genome-wide analysis healthy healthy individual Hospitalized Human immune response leukocyte methylated Methylation Mortality not differ Ontology outcome outcome measure outcomes pandemic Patient patients performed platform Predictive promoter region Prospective Region regulate reported Result supplementary material the SARS-CoV-2 These data viral infection
[DOI] 10.1186/s13148-021-01102-9 PMC 바로가기 [Article Type] Research

Transcriptional Changes in CD16+ Monocytes May Contribute to the Pathogenesis of COVID-19

CD16+ 단핵구의 전사 변화가 COVID-19의 발병에 기여할 수 있음

Immunology

Published on 2021-05-242022-09-11
Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘,

[키워드] analyzed Antigen presentation apoptotic caused CD16 CD16+ CD16+ monocyte CD16+ monocytes Cell cell activation cell movement change changes in characterized contribute contributing to COVID-19 COVID-19 case COVID-19 cases COVID-19 pandemic death dysregulated dysregulated immune response elevated expressed expression function functions gene signatures Genes healthy individual healthy individuals host response immune cells infiltration Inflammation Inflammatory Inflammatory response Inflammatory responses innate immune cell Innate immune cells interferon interferon response involved MHC class mild case mild cases mitochondrial Monocytes Non-classical monocytes Pathogenesis PBMC people with COVID-19 phenotype RNA sequencing data SARS-CoV-2 Severe case severe cases severity severity of COVID-19 Single Cell Single-cell transcriptomics the disease These cells tissue repair tissues transcriptional change Transcriptional changes transcriptomic upregulated upregulation Viral viral infections
[DOI] 10.3389/fimmu.2021.665773 PMC 바로가기 [Article Type] Immunology

Circulating Type I Interferon Levels and COVID-19 Severity: A Systematic Review and Meta-Analysis

순환하는 제1형 인터페론 수치와 COVID-19 심각도: 체계적인 검토 및 메타 분석

Meta-Analysis

Published on 2021-05-122022-08-31
Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 치료기술,

[키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age antiviral response antiviral responses article association Biomarker can not caused clinical evolution clinical manifestation clinical manifestations clinical status Comparative complex coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Critical critical COVID-19 patients critical patients cytokine Cytokines database demonstrated determine disease severity elevated evaluated Evidence evidence of healthy individual healthy individuals IFN-α IFN-I IFN-α immunological alteration infections interferon interferon response interferons Level limit of detection marker means Meta-analysis Mild mild cases Mild disease no significant difference outcome outcomes Pathogenesis Patient patients performed peripheral plasma Plasma levels plasma protein random effect Reporting respiratory Result resulting review SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe cases Severe patient severity severity of COVID-19 Sex significant difference SMD standardized mean difference the MEDLINE Type Type I IFN type I interferon type I interferons was measured was performed Web of Science with mild disease
[DOI] 10.3389/fimmu.2021.657363 PMC 바로가기 [Article Type] Meta-Analysis

Automated, multiparametric monitoring of respiratory biomarkers and vital signs in clinical and home settings for COVID-19 patients

COVID-19 환자를 위한 임상 및 가정 환경에서 호흡기 바이오마커 및 바이탈 사인에 대한 자동화된 다중 매개변수 모니터링

Clinical Trial

Published on 2021-05-112022-09-10
Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 바이오마커, 임상, 진단,

[키워드] (heart rate ambient approach automated Biomarker Biomarkers biometrics can be used can not capture Care Continuous continuous monitoring Conventional Convolutional neural networks correlation correlations cough coughing Course COVID-19 COVID-19 infection COVID-19 infections COVID-19 pandemic COVID-19 patient COVID-19 patients Data analysis demographic groups Digital health disease disease spread Diseases effort events feature Frequency Health care health care workers Health status healthy control healthy controls healthy individual heart rate high fidelity high risk hospital Immunity individual Infection Infectious diseases infectiousness intensity limitations methodology monitoring system overcome parameter Patient physiological populations Probability quantitative measurement respiratory respiratory activity Respiratory disease respiratory rate response sick Significance Soft Spread temperature Therapeutics translational Trial Variation vital sign vital signs wearable electronics
[DOI] 10.1073/pnas.2026610118 PMC 바로가기 [Article Type] Clinical Trial

Metabolic biomarker profiling for identification of susceptibility to severe pneumonia and COVID-19 in the general population

일반 인구에서 중증 폐렴 및 COVID-19에 대한 감수성을 식별하기 위한 대사 바이오마커 프로파일링

Research Article

Published on 2021-05-042022-09-10
Journal: eLife [Category] 바이오마커,

[키워드] Alter amino acids association best Biomarker Biomarkers Blood blood sample Blood samples blood sampling cardiometabolic disease cardiometabolic diseases change chronic inflammation circulating collected complement condition Course COVID-19 COVID-19 pandemic determine develop diabete diabetes diagnosed died disease onset Diseases elevated eLife event fatty acids General population health condition healthy individual help high risk higher risk highest hospitalised Human Hypothesis identify Immunity impair include individual Infection infections Infectious disease Infectious diseases inhibited investigated life-threatening lipids liver liver diseases low-grade inflammation lowest measure metabolic molecular molecules NMR nuclear nuclear magnetic resonance Odds ratio Older age other infectious diseases performed Pneumonia Predictive Predictive value Proteins provided risk Risk factors severe COVID-19 severe pneumonia susceptibility the disease UK biobank United Kingdom
[DOI] 10.7554/eLife.63033 PMC 바로가기 [Article Type] Research Article

Comparative analysis of antibodies to SARS-CoV-2 between asymptomatic and convalescent patients

Article

Published on 2021-05-012022-10-30
Journal: iScience [Category] COVID-19,

[키워드] Abstract ACE2 binding analyzed Anti-RBD IgG anti-S antibody antibody cross-reactivity Antibody Response Asymptomatic asymptomatic individual Asymptomatic individuals Comparative analysis convalescent patient coronavirus correlation COVID-19 COVID-19 patient cross-reactivity develop effective Health healthy individual highest IgG IgG antibody immune response Immunological response immunology Increased individual Infection control in health technology pandemic positive post vaccination protective immunity Protein RBD Responder responses responses against robust SARS-CoV-2 SARS-CoV-2 antibody response SARS-COV-2 infection SARS-CoV-2 patient SARS-CoV-2 symptomatic patient SARS-CoV-2 viral screened Southeastern United State spike tested Treatment Vaccines Virology were assessed without symptom without symptoms
[DOI] 10.1016/j.isci.2021.102489 PMC 바로가기 [Article Type] Article

High SARS-CoV-2 IgG/IGM seroprevalence in asymptomatic Congolese in Brazzaville, the Republic of Congo

콩고 공화국 브라자빌의 무증상 콩고인에서 높은 SARS-CoV-2 IgG/IGM 혈청 유병률

Article

Published on 2021-05-012022-09-11
Journal: International Journal of Infectious Diseases [Category] MERS, SARS, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adults analyzed anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody Asymptomatic blood sample Blood samples Chain Reaction collected conducted coronavirus coronavirus disease Coronavirus disease 2019 country Course COVID-19 COVID-19 infection COVID-19 infection status evaluate expected facilitate First wave force healthy individual healthy individuals healthy volunteer IgG IgG and IgM IgG or IgM antibodies IgM IgM antibodies Immunoglobulin Immunoglobulin G immunoglobulin M incidence introduced measure men negative RT-PCR oropharyngeal swab over participant polymerase chain polymerase chain reaction positive predict progression proportion Protective Rapid tests resource respiratory reverse transcription reverse transcription polymerase chain reaction risk RT-PCR RT-PCR assay SARS-CoV-2 seroconvert serological Serological tests Seroprevalence severe acute respiratory syndrome Coronavirus significantly higher subject subjects Swab tested the antibody The Republic of the Congo. women
[DOI] 10.1016/j.ijid.2020.12.065 PMC 바로가기 [Article Type] Article

Acquired decrease of the C3b/C4b receptor (CR1, CD35) and increased C4d deposits on erythrocytes from ICU COVID-19 patients

ICU COVID-19 환자의 C3b/C4b 수용체(CR1, CD35) 획득 감소 및 적혈구의 C4d 침착 증가

Article

Published on 2021-05-012022-09-11
Journal: Immunobiology [Category] SARS, 유전자 메커니즘, 진단, 치료기술,

[키워드] Acquired Activation Activation factor assisted ventilation C3 C4 C4d capillary CD35 cell debris clearance Clinical severity coated complement Complement activation Course COVID-19 COVID-19 patient COVID-19 patients CR1 cumulative damage decrease disease endothelial erythrocyte erythrocytes Erythrocytes. France handling healthy individual healthy individuals highlight ICU immune complex immune pathophysiology individuals Inflammation innate immune response marker measurement mechanism observation organ Organ transplant parameter Participation pathophysiology Patient patients Protein receptor regulate Regulatory rejection reported SARS-CoV-2 SLE student t-test therapy transplant rejection Ventilation Virus spike were assessed
[DOI] 10.1016/j.imbio.2021.152093 PMC 바로가기 [Article Type] Article