Virus Caused Imbalance of Type I IFN Responses and Inflammation in COVID-19Immunology Published on 2021-04-122022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Activation acute respiratory syndrome antiviral response caused coronavirus coronavirus disease COVID-19 eliminating excessive inflammation explain Health host innate immunity IFN Imbalance Immunity Inflammation Innate innate immune system Innate immunity mechanisms potential therapeutic target public health response SARS-CoV-2 Type Type I IFN type I interferon type I interferons viral infection virus viruses vital role [DOI] 10.3389/fimmu.2021.633769 PMC 바로가기 [Article Type] Immunology
Therapeutic Targeting of the Complement System: From Rare Diseases to Pandemics보완 시스템의 치료적 표적화: 희귀 질병에서 유행병까지Article Published on 2021-04-012022-09-12 Journal: Pharmacological reviews [Category] MERS, SARS, 진단, [키워드] activate approved Atypical candidate chronic disease Clinical treatment clinical trials common disease complement contribute COVID-19 COVID-19 disease death Defense disease disease pathogenesis Diseases disorders dysfunction dysregulated Evidence example Hemostasis homeostasis Host include Inflammation innate immune system invading pathogens ischemia-reperfusion injury killing microbes modulation molecular pattern multifunctional Myocardial infarction neurologic organ Organ failure pandemic coronavirus paroxysmal nocturnal hemoglobinuria pathogen-associated molecular patterns patient group pharmacological strategy pharmacological treatment plasma PROTECT rare disease robust Sepsis severe coronavirus disease stroke syndrome systemic inflammatory targeting the antibody Therapies therapy Thromboinflammation tissue damage tissue regeneration tissue repair trauma treat treated Treatment [DOI] 10.1124/pharmrev.120.000072 PMC 바로가기 [Article Type] Article
Dulaglutide Alone and in Combination with Empagliflozin Attenuate Inflammatory Pathways and Microbiome Dysbiosis in a Non-Diabetic Mouse Model of NASHArticle Published on 2021-03-302023-08-29 Journal: Biomedicines [Category] E형 간염, [키워드] adaptive immune system GLP-1 agonist innate immune system Liver disease metabolic syndrome non-alcoholic steatohepatitis SGLT-2 inhibitor type 2 diabetes [DOI] 10.3390/biomedicines9040353 PMC 바로가기 [Article Type] Article
Underlying Vulnerabilities to the Cytokine Storm and Adverse COVID-19 Outcomes in the Aging Immune SystemArticle Published on 2021-03-252023-06-16 Journal: The Journals of Gerontology Series A: Biological S [Category] MERS, [키워드] adaptive immune system aging COVID-19 Cytokine storm innate immune system [DOI] 10.1093/gerona/glaa209 PMC 바로가기
Community Use of Face Masks against the Spread of COVID-19Commentary Published on 2021-03-192022-10-30 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] addition Asymptomatic benefit body temperature clearance Community condition conditions COVID-19 Critical Defense detrimental droplet early stage Evidence face Face mask Face masks favor health protection Human immune system infected individual inhibiting innate immune system Mask nasal Nasal cavity nasal mucosa physical barrier physiological physiological temperature pre-symptomatic Prevent PROTECT reduced SARS-CoV-2 Spread stability Support susceptibility temperature Transmissibility transmission of SARS-CoV-2 upper airway upper airways viral infection viral replication Viral transmission virion viruses warm [DOI] 10.3390/ijerph18063214 PMC 바로가기 [Article Type] Commentary
Host Defence RNases as Antiviral Agents against Enveloped Single Stranded RNA Viruses외피 단일 가닥 RNA 바이러스에 대한 항바이러스제로서의 숙주 방어 RNaseReview Published on 2021-03-042022-09-10 Journal: Virulence [Category] SARS, 치료법, [키워드] agent antiviral activity antiviral drugs apoptosis pathways approved coronavirus coronavirus disease COVID-19 Defense develop drug drug candidate Drug development effective Enveloped single-stranded RNA Viruses evade focus Host host defense immune immune modulation immune regulation include information innate immune system Innate immunity outbreak pandemic Pathogens Pathways Perspective Prevent Recognition reported RNA RNase RNases Safe single-stranded ssRNA Stress treat unique Viral viral genome viral infection viral infections viral pathogens virus virus-host interplay viruses [DOI] 10.1080/21505594.2021.1871823 PMC 바로가기 [Article Type] Review
A pharmacological framework for integrating treating the host, drug repurposing and the damage response framework in COVID-19COVID-19에서 숙주 치료, 약물 용도 변경 및 손상 대응 프레임워크를 통합하기 위한 약리학적 프레임워크Review Published on 2021-03-012022-08-31 Journal: British Journal of Clinical Pharmacology [Category] 신약개발, 치료제, [키워드] absence Analysis angiotensin antiviral drugs antiviral therapeutics approach approaches clinical pharmacology clinician conserved COVID-19 damage response framework defined disease dose dose and safety dysregulated effective Elimination framework Government homology Host increasingly infective agent information innate immune innate immune system integration locus mapped novel antiviral drug novel antiviral drugs Observational data outcome Pandemics Pathogenesis pathophysiological pathway patients pharmacological Renin renin angiotensin system renin-angiotensin system repurposing Research reveal severe disease Spectrum target homology the disease therapeutic therapeutic repurposing Therapeutics therapy treating the host. Treatment Vaccine Vaccines Viral virus viruses void [DOI] 10.1111/bcp.14551 PMC 바로가기 [Article Type] Review
Investigation of immune cells on elimination of pulmonary-Infected COVID-19 and important role of innate immunity, phagocytes폐감염 COVID-19 제거에 대한 면역세포의 연구와 선천면역, 식세포의 중요한 역할Review Published on 2021-03-012022-09-12 Journal: Reviews in Medical Virology [Category] 진단, [키워드] Activation acute phase Adaptive immune response Adults alleviate antibody B cell cause CD4+ T cell CD4+ T cells children contribute COVID-19 COVID-19 infection Factor IgM and IgG Immune cell immune system Infection innate immune system Innate immunity investigation Mild much higher observation Patient patients phagocyte producing PROTECT required vaccination vaccine for COVID-19 white [DOI] 10.1002/rmv.2158 PMC 바로가기 [Article Type] Review
Low compositions of human toll-like receptor 7/8-stimulating RNA motifs in the MERS-CoV, SARS-CoV and SARS-CoV-2 genomes imply a substantial ability to evade human innate immunityBioinformatics Published on 2021-02-242022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] bats comparison computational method coronavirus coronavirus genomes Coronaviruses Defense evade evaluate exhibited Genome genomic genomic RNA hosts Immunostimulating RNA motifs innate immune response innate immune system Innate immunity Logistic regression mammalian MERS-CoV motif pathway positive prediction receptor Result RNA RNAs SARS-CoV SARS-CoV-2 SARS-CoV-2 genome single-stranded RNA virus Single-stranded RNA viruses Surveillance the interferon TLR Toll-like receptor Toll-like receptor 7/8 trimer was used [DOI] 10.7717/peerj.11008 PMC 바로가기 [Article Type] Bioinformatics
The Outcome of Critically Ill COVID-19 Patients Is Linked to Thromboinflammation Dominated by the Kallikrein/Kinin System중환자 COVID-19 환자의 결과는 칼리크레인/키닌 시스템이 지배하는 혈소판 염증과 관련이 있습니다Observational Study Published on 2021-02-222022-09-11 Journal: Frontiers in Immunology [Category] MERS, 바이오마커, 임상, 진단, [키워드] activated Activation Analysis Angiogenesis ARDS association biochemical parameter Biomarkers Blood C3a C4d cascade Clinical outcome Coagulation Coagulation system complement complement system components Contact COVID-19 COVID-19 patient Critically ill critically ill COVID-19 patients Critically ill patient critically ill patients D-dimer death debris demonstrated driving drug eliminating Evidence fibrinolysis system ICU Ill Illness severity Inflammation inhibitor innate immune system involved kallikrein/kinin system kidneys lung Lung injury microorganism molecular weight organ damage outcome Pathogenesis pathogenesis of COVID-19 Patient patients with COVID-19 prekallikrein Prognosis Prognostic marker Prospective Study recognizing reflected SC5b-9 severe COVID-19 Strong survival System TAT the patient Thromboinflammation thrombosis Treatment Uppsala University Vascular with COVID-19 [DOI] 10.3389/fimmu.2021.627579 PMC 바로가기 [Article Type] Observational Study