Repurposed drug

[키워드] ACE inhibitors ACE-2 ACEangiotensin-converting enzyme ACEIACE inhibitors Acute lung injury/Acute respiratory distress syndrome ADAlzheimer's disease ALI/ARDSAcute lung injury/Acute respiratory distress syndrome Alzheimer's disease Angangiotensin angiotensin Angiotensin II receptor type 1 Angiotensin II Receptor Type 2 Angiotensin receptor blockers Angiotensin-converting enzyme ARBsAngiotensin receptor blockers AT1RAngiotensin II receptor type 1 AT2RAngiotensin II receptor type 2 Aββ-amyloid benefit BKsBradykinins Bradykinin receptor Bradykinins BRBradykinin receptor caused chloroquine/hydroxychloroquine clinical study components Coronavirus disease 2019 COVID-19 COVID-19 pathogenesis COVID-19coronavirus disease 2019 CQ/HCQChloroquine/Hydroxychloroquine ECsEndothelial cells Effect effective effort endothelial cells endothelial Nitric oxide synthase Endothelin-1 eNOSendothelial Nitric oxide synthase ET-1Endothelin-1 Evidence fibrosis fMLPformyl Methionyl-meucyl-proline formyl Methionyl-meucyl-proline G protein-coupled Gastrin-releasing peptide GM-CSFGranulocyte-macrophage colony-stimulating factor GPCRG protein-coupled granulocyte-macrophage colony-stimulating factor GRPGastrin-releasing peptide Heme oxygenase-1 HO-1heme oxygenase-1 humans ILInterleukin interleukin MAPK/ERKMitogen-activated protein kinases/ Extracellular signal-regulated kinases Mas receptor MasRMas receptor MCP-1monocyte chemoattractant protein-1 MERSMiddle East Respiratory Syndrome Middle East respiratory syndrome Mitogen-activated protein kinases/ Extracellular signal-regulated kinases molecular mechanisms monocyte chemoattractant protein-1 NADPHNicotinamide adenine dinucleotide phosphate (reduced form) Natriuretic peptides NEPiNeprilysin inhibitors NEPNeprilysin neprilysin Neprilysin inhibitors NF-kBNuclear factor kappa B Nicotinamide adenine dinucleotide phosphate (reduced form) nitric oxide Non steroidal anti-inflammatory drugs NONitric Oxide NPsNatriuretic peptides Nrf2nuclear factor erythroid 2–related factor 2 NSAIDsNon steroidal anti-inflammatory drugs nuclear factor erythroid 2–related factor 2 nuclear factor kappa B pandemic disease pathophysiology pathway Peroxisome proliferator activator receptors Phospholipase C beta/inositol trisphosphate PLCb/IP3Phospholipase C beta/inositol trisphosphate PNECsPulmonary neuroendocrine cells PPARsPeroxisome proliferator activator receptors protective effect pulmonary inflammatory reaction pulmonary neuroendocrine cells RAS RASRenin angiotensin system reactive oxygen species receptors renin angiotensin system Repurposed drug researcher ROSreactive oxygen species SARS-CoV2 SARS-CoVsevere acute respiratory syndrome coronavirus Selective estrogen receptor modulators SERMsSelective estrogen receptor modulators severe acute respiratory syndrome Coronavirus severe pneumonia Streptozotocin STZStreptozotocin suggested targeting TGF-β1Transforming growth factor- β1 therapeutic intervention therapy TNFTumor Necrosis Factor Transforming growth factor- β1 treatment approaches tumor necrosis factor Vaccine vascular endothelial growth factor VEGFvascular endothelial growth factor β-amyloid
[DOI] 10.1016/j.bcp.2020.114057 [Article Type] Review article