Antibody responses to SARS-CoV-2 in patients with differing severities of coronavirus disease 20192019년 코로나바이러스 질병의 중증도가 다른 환자의 SARS-CoV-2에 대한 항체 반응Research Article Published on 2020-10-092022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] 95% CI analyzed Antibody Response Antigen association clinical manifestations collected coronavirus disease COVID-19 Cutoff ELISA enrolled enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Euroimmun female greater healthy control IgA IgG IgG antibodies IgG antibody infections male Mild moderate onset of symptom onset of symptoms optical optical density other respiratory infections participant Patient patient group patients positive result respiratory respiratory infections Result SARS-CoV-2 SARS-CoV-2 infections sensitivity serological response serological test severe group severity Severity of disease Severity of infection Sex significantly higher Symptom the antibody response the patient the SARS-CoV-2 vaccination was performed [DOI] 10.1371/journal.pone.0240502 PMC 바로가기 [Article Type] Research Article
The potential association between common comorbidities and severity and mortality of coronavirus disease 2019: A pooled analysis2019년 코로나바이러스 질병의 일반적인 동반질환과 중증도 및 사망률 간의 잠재적 연관성: 통합 분석Clinical Investigations Published on 2020-10-072022-09-10 Journal: Clinical Cardiology [Category] MERS, 유전자 메커니즘, [키워드] 95% CI 95% confidence interval Acute cardiac injury Analysis association Cancer cardiac injury cardiovascular disease cardiovascular diseases Chronic kidney disease Cochrane Library Comorbidities Comorbidity conducted coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 diabete diabetes higher risk hypertension increased risk Injury Kidney disease meta‐analysis MONITOR Mortality nonsurvivor nonsurvivors Odds ratio organ Patient poor prognosis Prevalence Probability Prognosis pulmonary disease Result severe group severity survivor Web were used [DOI] 10.1002/clc.23465 PMC 바로가기 [Article Type] Clinical Investigations
Prognostic Factors for COVID-19 Pneumonia Progression to Severe Symptoms Based on Earlier Clinical Features: A Retrospective AnalysisMedicine Published on 2020-10-052022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Admission Analysis AUC C-reactive protein change characteristic clinical Clinical characteristics clinical manifestation Clinical outcome collected Combination Comorbidity COVID-19 COVID-19 patient CRP develop disease elevated evaluated Factor group healthcare increased respiratory rate indicated Laboratory laboratory feature Laboratory test lactate dehydrogenase LDH management Mild mitigate multivariate logistic regression Occurrence patients predict predicted Predictive Prognostic factor Prognostic value respiratory rate retrospective risk factor ROC SARS-CoV-2 sensitivity serum Severe COVID-19 pneumonia severe group Severe patient severe pneumonia significantly significantly increased specificity subsequent underlying diseases Viral RNA [DOI] 10.3389/fmed.2020.557453 PMC 바로가기 [Article Type] Medicine
Nomogram to identify severe coronavirus disease 2019 (COVID-19) based on initial clinical and CT characteristics: a multi-center studyResearch Article Published on 2020-10-022022-10-28 Journal: BMC Medical Imaging [Category] COVID-19, Fulltext, MERS, [키워드] 95% CI analyzed AUC benefit Characteristics clinical impact Cohort COVID-19 develop early stage evaluated help high accuracy identify independent risk factor initial interquartile range lung Mild mild case nomogram Patient patients with COVID-19 Pneumonia randomly divided Result risk risk factor selected sensitivity Severe case severe coronavirus disease severe COVID-19 severe group Severe patient severity significantly higher specificity tomography validation cohort validation cohorts with COVID-19 X-ray computed [DOI] 10.1186/s12880-020-00513-z PMC 바로가기 [Article Type] Research Article
Serum KL-6 concentrations as a novel biomarker of severe COVID-19중증 COVID-19의 새로운 바이오마커로서의 혈청 KL-6 농도Article Published on 2020-10-012022-08-31 Journal: Journal of medical virology [Category] MERS, SARS, 바이오마커, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Alveolar Type II Analysis analyzed best Biomarker Clinical management Concentration coronavirus coronavirus 2 coronavirus disease COVID-19 COVID-19 patient cut-off value Cytopathic effect damaged enrolled evaluate groups help identify Increased KL-6 lung damage lymphocyte males median age natural killer NK cell Patient peripheral pneumocyte Pneumocytes produced Prognosis prognostic biomarker Prognostic value receiver operating characteristic respiratory respiratory impairment serum serum concentrations Serum level serum levels Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 severe COVID-19 patients severe group Severe patient severe patients severe pulmonary involvement severity significantly higher subset type I type I and II pneumocytes with COVID-19 [DOI] 10.1002/jmv.26087 PMC 바로가기 [Article Type] Article
Immune dysfunction following COVID-19, especially in severe patientsArticle Published on 2020-09-282022-10-04 Journal: Scientific Reports [Category] SARS, 치료제, [키워드] Analysis B cell blood cell count CD4 CD8 cell count characteristic clinical feature coagulation function collected Complete coronavirus disease COVID-19 COVID-19 patient Critical CT scan D-dimer Disease progression disease severity Diseases dysfunction dysregulated immune response healthy identify immunology include Inflammatory cytokines Logistic regression analysis lymphocyte Medical research Microbiology mild patients multivariate neutrophil count Neutrophil-to-lymphocyte ratio NK cell NLR outcomes parameter participant patients Predictive progressed progression Pulmonary infection recruited risk factor Risk factors ROC SARS-CoV-2-infected patient severe cases severe group Severe patient shown Surveillance T cell T lymphocyte White blood cell [DOI] 10.1038/s41598-020-72718-9 PMC 바로가기 [Article Type] Article
Characteristics, laboratories, and prognosis of severe COVID-19 in the Tokyo metropolitan area: A retrospective case seriesResearch Article Published on 2020-09-242022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] Admission albumin analyzed body mass index C-reactive protein case sery COVID-19 case COVID-19 pandemic COVID-19 patient death died discharged ECMO elevated Epidemiology expressed fibrinogen group Hospital stay hyperlipidemia ICU Japan Japanese lactate dehydrogenase less lymphopenia mechanical ventilation median medical record Mild mild case multiple organ failure nonparametric test Oxygenation pathophysiology Patient procalcitonin Prognosis required retrospective risk factor Severe case severe COVID-19 Severe COVID-19 pneumonia severe group Sex short-term survival survival rate survived Tokyo transaminases two group university hospital [DOI] 10.1371/journal.pone.0239644 PMC 바로가기 [Article Type] Research Article
Temporal changes of CT findings between non-severe and severe cases of COVID-19 pneumonia: a multi-center, retrospective, longitudinal StudyResearch Paper Published on 2020-09-212022-10-29 Journal: International Journal of Medical Sciences [Category] COVID-19, MERS, SARS, [키워드] abnormality age analyzed both groups change changes China consolidation COVID-19 CT abnormalities CT finding CT score decrease discharge disease Disease progression distribution dominant enrolled faster feature female GGO ground-glass opacity groups involved longitudinal analysis lung abnormalities lung lesion male manifestation median Non-severe non-severe group parameter Patient patients with COVID-19 peaked peaking Pneumonia proportion Radiologists retrospective severe Severe case severe group Temporal Treatment with COVID-19 zone [DOI] 10.7150/ijms.51159 PMC 바로가기 [Article Type] Research Paper
Efficacy of Early Combination Therapy With Lianhuaqingwen and Arbidol in Moderate and Severe COVID-19 Patients: A Retrospective Cohort StudyPharmacology Published on 2020-09-182022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] accelerate acute respiratory syndrome adverse events Arbidol benefit Chest CT China city Combination combination therapy conducted coronavirus coronavirus disease COVID-19 COVID-19 patient drug enrolled global pandemic Hospital stay IMPROVE Inpatient LianhuaQingwen material moderate Moderate COVID-19 monotherapy negativity nucleic acid objective outbreak patients with moderate prognosis of patient reducing Result retrospective cohort study Ruijin SARS-CoV-2 severe COVID-19 patient severe group Shanghai significantly therapeutic drug time to conversion Tongji Hospital treat treated two group Wuhan Wuhan, China [DOI] 10.3389/fphar.2020.560209 PMC 바로가기 [Article Type] Pharmacology
Re-analysis of Single Cell Transcriptome Reveals That the NR3C1-CXCL8-Neutrophil Axis Determines the Severity of COVID-19Immunology Published on 2020-08-282022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] airway apoptotic axis BAL Bronchoalveolar lavage fluid Cell chemokine COVID-19 COVID-19 patient CXCL8 differential expression disease severity DNA damage drastic epithelial epithelial cells expressed gene expression feature glucocorticoid immunological Inflammation lung myeloid neutrophil Neutrophil extracellular traps neutrophil infiltration Neutrophils pandemic Patient Proinflammatory cytokine receptor recruited regulated SARS-CoV-2 SARS-COV-2 infection scRNA-seq scRNA-seq data severe COVID-19 symptom severe group Severe patient severe symptom suggested [DOI] 10.3389/fimmu.2020.02145 PMC 바로가기 [Article Type] Immunology