The Yin and Yang of ACE/ACE2 Pathways: The Rationale for the Use of Renin-Angiotensin System Inhibitors in COVID-19 PatientsReview Published on 2020-07-162022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] ACE ACE2 Administered Arm Asthma cardiac dysfunction Combination COVID-19 COVID-19 patient Critical downstream eosinophil hypertension Hypothesis hypoxia IL-10 in vivo inhibit inhibitor Lung fibrosis Mas receptor mechanisms pathway Patient positive positive feedback loop Prevent RAS rationale renin-angiotensin system SARS-CoV-2 severe acute respiratory syndrome coronavirus-2 Stage sustained System target the disease triggered upregulated [DOI] 10.3390/cells9071704 PMC 바로가기 [Article Type] Review
Renin-Angiotensin-Aldosterone System Blockers Are Not Associated With Coronavirus Disease 2019 (COVID-19) Hospitalization: Study of 1,439 UK Biobank CasesCardiovascular Medicine Published on 2020-07-142022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] ACEi/ARB adjusted adverse outcome age angiotensin Angiotensin converting enzyme inhibitors Angiotensin receptor blockers ARBs Asian association associations Bame black blocker BMI body mass index cardiometabolic cardiometabolic disease Cohort comparison coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 negative diabetes Enzyme inhibitor Ethnicity Factor greater hospital Hospitalization hypertension increased risk individual Male sex medications moderate morbidity Myocardial infarction obesity Other participant positive positive result Regression model severe symptom Sex smoking specificity System tested UK biobank were used with COVID-19 [DOI] 10.3389/fcvm.2020.00138 PMC 바로가기 [Article Type] Cardiovascular Medicine
TWIRLS , a knowledge‐mining technology, suggests a possible mechanism for the pathological changes in the human host after coronavirus infection via ACE2Research Article Published on 2020-07-132022-10-31 Journal: Drug development research [Category] COVID-19, [키워드] ACE2 acute lung injury Analysis analyzed Angiotensin II approach ARB article automatically binding blockers Blood build caused changes in coronavirus Coronavirus infection COVID‐19 patient cytokine Cytokine storm effective Efficiency enzyme Epidemic functional had more help homeostasis Host hosts human host hypertension independent Infection information involved knowledge leukemia Literature mining Liver cancer Lower mechanism pathological change Perspective problems processed public health emergency receptor Regulation Regulatory renin‐angiotensin system researcher subject Symptom System topic inference treat triggering virus [DOI] 10.1002/ddr.21717 PMC 바로가기 [Article Type] Research Article
Early Experiences With COVID-19 Testing in TransplantationRegistry Report Published on 2020-07-112022-10-28 Journal: Transplantation Direct [Category] COVID-19, [키워드] acute respiratory syndrome Alliance Candidates coronavirus coronavirus disease COVID-19 Critical Deceased diagnostic diagnostic test Donor donors Effect End-stage renal disease experience HCW HCWs healthcare worker Johns Hopkin kidney kidney transplant liver Mortality organization pandemic Patient positive prevalence of COVID-19 recipients registry screened screening test System tested Testing Transplant transplantation [DOI] 10.1097/TXD.0000000000001024 PMC 바로가기 [Article Type] Registry Report
COVID-19, Renin-Angiotensin System and Endothelial DysfunctionReview Published on 2020-07-092022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory distress Adhesion Molecule ARDS caused CD209L Cell cell types complications COVID-19 Critical Cytokine storm Endothelial cell endothelial cell injury Endothelial dysfunction endothelial injury enzyme exacerbate expressed generate global public health hallmark homeostasis host cells hypertension immune response induce Infection Injury interact involved L-SIGN molecular basis molecular mechanism Mortality novel coronavirus disease obesity offer outbreak pathophysiology pathway physiological primary mechanism RAS Regulation related viruses renin-angiotensin system respiratory epithelium SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 virus Signaling spike glycoprotein stimulate syndrome System therapeutic strategy thought understanding Vascular damage Vascular endothelium [DOI] 10.3390/cells9071652 PMC 바로가기 [Article Type] Review
Development and Clinical Evaluation of a Web-Based Upper Limb Home Rehabilitation System Using a Smartwatch and Machine Learning Model for Chronic Stroke Survivors: Prospective Comparative Study스마트워치와 머신러닝 모델을 이용한 만성 뇌졸중 생존자를 위한 웹 기반 상지 재활 시스템 개발 및 임상 평가: 전향적 비교 연구Original Paper Published on 2020-07-092022-08-13 Journal: JMIR mHealth and uHealth [Category] 임상, [키워드] accelerometer Accuracy activity Algorithm artificial intelligence assessment Beck Care chronic chronic stroke clinical clinical evaluation clinical outcomes Clinical research clinical study Comparative conducted control group Convolutional neural network COVID-19 pandemic data set data sets determine develop development drop Efficacy enrolled evaluate extremity facilitate feasibility flexion Follow-up Frequency function functional group Gyroscope Health care health care systems home home care home-based rehabilitation IMPROVE internal rotation inventory joint machine learning ML model Model motor Motor Function objective participant Participation Patient performed physical Physical therapy Prospective range of motion recent recognize Registration rehabilitation rehabilitation exercises Research Result ROM service shoulder joint shown Smartphone smartwatch statistical analysis stroke survivor Survivors System Test the mean therapy Treatment two group two groups upper Upper extremity user was used wearable device wearable technology Wolf [DOI] 10.2196/17216 PMC 바로가기 [Article Type] Original Paper
Viral Evasion of the Complement System and Its Importance for Vaccines and TherapeuticsImmunology Published on 2020-07-092022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] adaptive Adaptive immune response Antiviral effect antivirals chemotaxis complement complement system COVID-19 pandemic dengue virus disease disease symptoms dysregulation Effective vaccines Effects ENhance evade exacerbate Extracellular Factor functions Genetic host response Immunity immunology Importance induce Inflammatory responses Innate immunity Interaction mechanism microorganisms neutralization Nipah virus occur outcome Pathogenesis Pathogens pathway PROTECT Regulation Research respond Stage System Therapeutics this system Vaccines viral infection viral infections viral infectivity Virology virus viruses West Nile Virus [DOI] 10.3389/fimmu.2020.01450 PMC 바로가기 [Article Type] Immunology
Scientia Potentia Est: How the Italian World of Oncology Changes in the COVID-19 PandemicOriginal Reports Published on 2020-07-072022-10-31 Journal: JCO Global Oncology [Category] COVID-19, SARS, [키워드] Analysis Care change changes in clinical activity coronavirus disease COVID-19 COVID-19 pandemic demonstrated emergency response female Health health worker heterogeneous hospital Italian Italy majority management oncologist oncology pandemic participant participated Patient Patient care professional professionals Protective Psychological distress question required System the SARS-CoV-2 the WHO [DOI] 10.1200/GO.20.00209 PMC 바로가기 [Article Type] Original Reports
ACE2 as a Therapeutic Target for COVID-19; Its Role in Infectious Processes and Regulation by Modulators of the RAAS SystemReview Published on 2020-07-032022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] ACE2 ACE2 expression Activation acute respiratory syndrome Ang II angiotensin converting enzyme angiotensin II converting enzyme inhibitors angiotensin II type 1 receptor blockers animal model bind catalytic activity cellular circumvent cleavage complex interplay concern coronavirus deleterious effect Diseases Effect expected facilitate favor host cell receptor Infection Inflammatory response knowledge Meta-analysis mitigate modulator organs plasma Pneumonia Preserving pro-inflammatory status RAAS raised renin-angiotensin-aldosterone system responsible role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected patient susceptibility System target tissue tissue expression various tissues [DOI] 10.3390/jcm9072096 PMC 바로가기 [Article Type] Review
The U.S. Health Care System on the Eve of the Covid-19 Epidemic: A Summary of Recent Evidence on Its Impaired PerformanceII. The limitations of the Medical Care Industry's Response to COVID-19: the Case of the U.S. Published on 2020-06-302022-10-30 Journal: International journal of health services : plannin [Category] Coronavirus, MERS, SARS, [키워드] American Care caused COVID-19 COVID-19 pandemic Eve Health Health care Health inequalities highlight hospital Impaired increasingly inefficient neoliberalism outcome pandemic Patient performance physical plummet Racial recent Surgical Procedure System the United State United States yawning [DOI] 10.1177/0020731420937631 PMC 바로가기 [Article Type] II. The limitations of the Medical Care Industry's Response to COVID-19: the Case of the U.S.