hACE2 – Page 12 – Communicable Diseases Research

Microglia Do Not Restrict SARS-CoV-2 Replication following Infection of the Central Nervous System of K18-Human ACE2 Transgenic Mice

소교세포는 K18-인간 ACE2 형질전환 마우스의 중추신경계 감염 후 SARS-CoV-2 복제를 제한하지 않습니다

Pathogenesis and Immunity

Published on 2021-12-222022-09-10
Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단,

Modeling SARS-CoV-2 Infection in Mice Using Lentiviral hACE2 Vectors Infers Two Modes of Immune Responses to SARS-CoV-2 Infection

Lentiviral hACE2 벡터를 사용한 쥐의 SARS-CoV-2 감염 모델링은 SARS-CoV-2 감염에 대한 두 가지 면역 반응 모드를 추론합니다

Article

Published on 2021-12-212022-09-12
Journal: Viruses [Category] SARS, 진단,

[키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus Analysis angiotensin antiviral drugs applied caused contribute coronavirus COVID-19 effectors element enzyme expression Gene expression analysis generate global pandemic hACE2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 human cell human cells IFNAR1 immune immune response immune responses immunogenic in vivo infected cell Infection interferon interferon receptor knock-out lack Lentiviral vector lentiviral vectors lentivirus lung Lung disease mice Mild mode modeling mouse model pathology productive viral replication receptor response SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 particle SARS-CoV-2 particles SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Signaling stimulate Strains supported susceptible transgenic mice triggered Type I IFN Vaccine development vector virus wild-type
[DOI] 10.3390/v14010011 PMC 바로가기 [Article Type] Article

Insights into the Binding of Receptor-Binding Domain (RBD) of SARS-CoV-2 Wild Type and B.1.620 Variant with hACE2 Using Molecular Docking and Simulation Approaches

Article

Published on 2021-12-102022-10-28
Journal: Biology [Category] COVID-19,

Computational Saturation Mutagenesis of SARS-CoV-1 Spike Glycoprotein: Stability, Binding Affinity, and Comparison With SARS-CoV-2

Molecular Biosciences

Published on 2021-12-092022-10-31
Journal: Frontiers in Molecular Biosciences [Category] COVID-19,

[키워드] addition affinity Amino acid Analysis Antiviral binding binding affinity computational saturation mutagenesis decrease destabilized Effect enzyme example functions generate hACE2 host cell surface identify Interaction isolate Missense mutation Mutagenesis mutate Mutation mutations N-linked glycosylation predicted protein stability RBD receptor residue respiratory syndrome coronavirus RNA genome S glycoprotein S glycoproteins S protein SARS-CoV-1 SARS-CoV-2 saturation sequence similarity spike spike glycoprotein spike missense mutations stability the binding affinity the receptor-binding domain the S protein therapeutic Vaccine viral mutation weakened would increase
[DOI] 10.3389/fmolb.2021.784303 PMC 바로가기 [Article Type] Molecular Biosciences

Intranasal HD-Ad vaccine protects the upper and lower respiratory tracts of hACE2 mice against SARS-CoV-2

Research

Published on 2021-12-082022-11-01
Journal: Cell & Bioscience [Category] COVID-19,

Lyophilized, thermostable Spike or RBD immunogenic liposomes induce protective immunity against SARS-CoV-2 in mice

Research Article

Published on 2021-12-012022-10-28
Journal: Science Advances [Category] COVID-19,

Postmortem Stability of SARS-CoV-2 in Mouse Lung Tissue

Research Letter

Published on 2021-12-012022-10-31
Journal: Emerging Infectious Diseases [Category] COVID-19, SARS,

E484K mutation in SARS-CoV-2 RBD enhances binding affinity with hACE2 but reduces interactions with neutralizing antibodies and nanobodies: Binding free energy calculation studies

SARS-CoV-2 RBD의 E484K 돌연변이는 hACE2와의 결합 친화도를 향상시키지만 중화 항체 및 나노바디와의 상호작용을 감소시킵니다. 결합 자유 에너지 계산 연구

Article

Published on 2021-12-012022-09-11
Journal: Journal of molecular graphics & modelling [Category] SARS, 변종, 유전자 메커니즘, 진단,

[키워드] addition All-atom molecular dynamics simulation angiotensin Angiotensin-converting enzyme antibody binding binding affinities binding affinity Burial cause caused compensating conformational contribute COVID-19 COVID-19 disease death decrease drug design E484K E484K mutation Effect effective effective vaccine Effective vaccines Effectiveness electrostatic interaction ENhance enzyme group hACE2 Human human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 hydrogen Hydrogen bond hydrogen bonds immune response Impact IMPROVE Infection information Interaction investigated leads molecular molecular dynamics Molecular mechanics molecular mechanism mutant mutate Mutation mutations nanobodies nanobody Neutralizing Neutralizing antibodies neutralizing antibody pandemic polar RBD receptor Receptor binding receptor hACE2 Receptor-binding domain Recognition reduce reduced residue SARS-CoV-2 SARS-CoV-2 RBD selected significantly surface area the binding affinity the receptor-binding domain Transmissibility Vaccine development variant variants
[DOI] 10.1016/j.jmgm.2021.108035 PMC 바로가기 [Article Type] Article

Chemical Composition of the Red Sea Green Algae Ulva lactuca : Isolation and In Silico Studies of New Anti-COVID-19 Ceramides

Article

Published on 2021-11-292022-10-30
Journal: Metabolites [Category] COVID-19,

[키워드] Ulva lactuca activities addition Algae Anticoagulant antioxidant Antiviral antiviral activity biological activity caused ceramide Ceramides Chemical claimed Community compounds Coronavirus disease 2019 COVID-19 derivatives effective electrospray ionization Encephalitis enzyme fatty acids green hACE2 High-resolution human cell human host identify immunomodulatory in silico Approach include inhibiting investigated M pro M^Pro mass spectroscopy metabolic profiling metabolite New pandemic protease protein complex Red reported Research responsible Safe SARS-CoV-2 the disease the SARS-CoV-2 the SARS-CoV-2 virus Transcription Treatment Ulva viral replication virus
[DOI] 10.3390/metabo11120816 PMC 바로가기 [Article Type] Article

The alpha/B.1.1.7 SARS-CoV-2 variant exhibits significantly higher affinity for ACE-2 and requires lower inoculation doses to cause disease in K18-hACE2 mice

alpha/B.1.1.7 SARS-CoV-2 변이체는 ACE-2에 대해 훨씬 더 높은 친화성을 나타내며 K18-hACE2 마우스에서 질병을 유발하기 위해 더 낮은 접종 용량이 필요합니다

Research Article

Published on 2021-11-252022-09-10
Journal: eLife [Category] MERS, SARS, 변종, 진단,

[키워드] a minor ACE-2 affinity Alpha angiotensin angiotensin-converting enzyme-2 anti-RBD Antibody neutralization asparagine B.1.1.7 B.1.1.7 variant convalescent individual convalescent individuals COVID-19 case disease Disease progression domination dose driven by elevated enzyme Epidemiology European exhibit faster functional hACE2 Human human Angiotensin-converting enzyme immunology incidence Infection K18-hACE2 mice low dose mice minor monoclonal antibodies mouse mouse model N501Y other variant other variants RBD Receptor-binding domain residue responsible SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 variant sera severity significantly higher Strains the receptor-binding domain transgenic transmission rate transmitted tyrosine United Kingdom variant Winter
[DOI] 10.7554/eLife.70002 PMC 바로가기 [Article Type] Research Article