Clinical Performance of Paraoxonase-1-Related Variables and Novel Markers of Inflammation in Coronavirus Disease-19. A Machine Learning ApproachArticle Published on 2021-06-212022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] alteration approach Biomarkers cause CCL2 chemokine chemokines circulating clinical clinical variable Comparisons COVID-19 COVID-19 negative death diagnosis of COVID-19 galectin-3 glycoprotein healthy individuals identify Inflammation inflammatory reaction innate immune system Interaction Ligand machine learning marker motif novel oxidative stress parameter parameters paraoxonase-1 Patient patients patients with COVID-19 performance PON1 positive positive patient Predictive pro-inflammatory mediator PROTECT recruited SARS-CoV-2 SARS-COV-2 infection serum synergy the disease variable was used [DOI] 10.3390/antiox10060991 PMC 바로가기 [Article Type] Article
PD-L1 Dysregulation in COVID-19 PatientsImmunology Published on 2021-06-072022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Adaptive immune response ARDS biological sample blood sample caused CD4+ T cells clinical study consequence COVID-19 COVID-19 pandemic COVID-19 pathogenesis COVID-19 patient cultures dysregulated dysregulated immune response dysregulation effective epithelial cell Evidence healthy donors healthy individuals hospitalized COVID-19 patient Host immune response identify Immune cell immune checkpoint molecules in vitro Infection inhibitors innate immune response Ligand manifestation Manifestations model system modulation Monocytes Neutrophils Patient PD-L1 Prognosis prognostic prognostic biomarker reached RNA expression SARS-CoV-2 Serum level subset T cell therapeutic approaches tissue tissue biopsy upregulation variety [DOI] 10.3389/fimmu.2021.695242 PMC 바로가기 [Article Type] Immunology
Transcriptional Changes in CD16+ Monocytes May Contribute to the Pathogenesis of COVID-19CD16+ 단핵구의 전사 변화가 COVID-19의 발병에 기여할 수 있음Immunology Published on 2021-05-242022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] analyzed Antigen presentation apoptotic caused CD16 CD16+ CD16+ monocyte CD16+ monocytes Cell cell activation cell movement change changes in characterized contribute contributing to COVID-19 COVID-19 case COVID-19 cases COVID-19 pandemic death dysregulated dysregulated immune response elevated expressed expression function functions gene signatures Genes healthy individual healthy individuals host response immune cells infiltration Inflammation Inflammatory Inflammatory response Inflammatory responses innate immune cell Innate immune cells interferon interferon response involved MHC class mild case mild cases mitochondrial Monocytes Non-classical monocytes Pathogenesis PBMC people with COVID-19 phenotype RNA sequencing data SARS-CoV-2 Severe case severe cases severity severity of COVID-19 Single Cell Single-cell transcriptomics the disease These cells tissue repair tissues transcriptional change Transcriptional changes transcriptomic upregulated upregulation Viral viral infections [DOI] 10.3389/fimmu.2021.665773 PMC 바로가기 [Article Type] Immunology
Transfer Learning to Detect COVID-19 Automatically from X-Ray Images Using Convolutional Neural NetworksResearch Article Published on 2021-05-152022-10-29 Journal: International Journal of Biomedical Imaging [Category] COVID-19, [키워드] Accuracy Algorithm Algorithms biological marker caused chest X-ray CNNs contagious COVID-19 COVID-19 diagnosis COVID-19 infection Critical CXR dataset death deep learning diagnosis of COVID-19 disease Effectiveness experiment Healthcare professional healthy individuals help high accuracy highest identify Image IMPROVE individual individuals with COVID-19 infections learning network Neural novel coronavirus disease offer pandemic Precision preventive measure required resources sensitivity significantly specificity the disease transfer Viral pneumonia with COVID-19 X-ray [DOI] 10.1155/2021/8828404 PMC 바로가기 [Article Type] Research Article
Circulating Type I Interferon Levels and COVID-19 Severity: A Systematic Review and Meta-Analysis순환하는 제1형 인터페론 수치와 COVID-19 심각도: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-05-122022-08-31 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 치료기술, [키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age antiviral response antiviral responses article association Biomarker can not caused clinical evolution clinical manifestation clinical manifestations clinical status Comparative complex coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Critical critical COVID-19 patients critical patients cytokine Cytokines database demonstrated determine disease severity elevated evaluated Evidence evidence of healthy individual healthy individuals IFN-α IFN-I IFN-α immunological alteration infections interferon interferon response interferons Level limit of detection marker means Meta-analysis Mild mild cases Mild disease no significant difference outcome outcomes Pathogenesis Patient patients performed peripheral plasma Plasma levels plasma protein random effect Reporting respiratory Result resulting review SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe cases Severe patient severity severity of COVID-19 Sex significant difference SMD standardized mean difference the MEDLINE Type Type I IFN type I interferon type I interferons was measured was performed Web of Science with mild disease [DOI] 10.3389/fimmu.2021.657363 PMC 바로가기 [Article Type] Meta-Analysis
Metabolite reanalysis revealed potential biomarkers for COVID-19: a potential link with immune response대사 산물 재분석은 COVID-19에 대한 잠재적인 바이오마커를 밝혔습니다: 면역 반응과의 잠재적 연결Research Article Published on 2021-05-112022-09-10 Journal: Future Microbiology [Category] SARS, 바이오마커, [키워드] Alanine applied betaine bioinformatics Biomarkers Classifier COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients glucuronate healthy healthy individuals immune response information metabolite metabolomic profiling metabolomics patients Potential biomarker potential biomarkers receiver operating characteristic reported sulfate taurochenodeoxycholic acid Treatment unique β-alanine [DOI] 10.2217/fmb-2021-0047 PMC 바로가기 [Article Type] Research Article
Interplay between SARS‐CoV‐2 and human long non‐coding RNAsShort Communication Published on 2021-05-092022-10-29 Journal: Journal of Cellular and Molecular Medicine [Category] COVID-19, MERS, SARS, [키워드] BALF binding Bronchoalveolar lavage fluid Cis regulation contributed COVID‐19 patient COVID‐19 Critical drug Efficiency exhibited Genome healthy individuals high affinity host response HOTAIRM1 infected cells Inflammation Interaction lncRNA long non‐coding RNA MALAT1 mononuclear cell NEAT1 overcome pandemic PBMC Peripheral blood PVT1 Regulatory RNA RNA sequencing data SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 genome Side effect trans regulation Transcriptome Vaccine viral infection [DOI] 10.1111/jcmm.16596 PMC 바로가기 [Article Type] Short Communication
High Levels of the Cleaved Form of Galectin-9 and Osteopontin in the Plasma Are Associated with Inflammatory Markers That Reflect the Severity of COVID-19 Pneumonia혈장 내 갈렉틴-9 및 오스테오폰틴의 높은 수준은 COVID-19 폐렴의 중증도를 반영하는 염증 마커와 관련이 있습니다Article Published on 2021-05-072022-09-10 Journal: International Journal of Molecular Sciences [Category] 바이오마커, 진단, [키워드] Analysis association Bacterial infection C-reactive protein can be used cleaved Coagulopathy coronavirus disease Coronavirus disease 2019 Correlation analysis COVID pneumonia COVID-19 COVID-19 patient CP group CP patient CP patients elevated ferritin followed by form full-length full-length galectin-9 full-length osteopontin Galectin-9 healthy individuals highest Infectious diseases Inflammation inflammatory biomarkers inflammatory markers interleukin Kidney function Laboratory Level Lung function marker mild clinical symptom mild clinical symptoms MONITOR number osteopontin Patient Plasma level Plasma levels plasma sample plasma samples Pneumonia Proteases Protein reduced ROC analysis severity significantly Spearman’s correlation suggested therapeutic effect therapeutic effects therapy Tocilizumab treated truncated galectin-9 undefined osteopontin [DOI] 10.3390/ijms22094978 PMC 바로가기 [Article Type] Article
High SARS-CoV-2 IgG/IGM seroprevalence in asymptomatic Congolese in Brazzaville, the Republic of Congo콩고 공화국 브라자빌의 무증상 콩고인에서 높은 SARS-CoV-2 IgG/IGM 혈청 유병률Article Published on 2021-05-012022-09-11 Journal: International Journal of Infectious Diseases [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adults analyzed anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody Asymptomatic blood sample Blood samples Chain Reaction collected conducted coronavirus coronavirus disease Coronavirus disease 2019 country Course COVID-19 COVID-19 infection COVID-19 infection status evaluate expected facilitate First wave force healthy individual healthy individuals healthy volunteer IgG IgG and IgM IgG or IgM antibodies IgM IgM antibodies Immunoglobulin Immunoglobulin G immunoglobulin M incidence introduced measure men negative RT-PCR oropharyngeal swab over participant polymerase chain polymerase chain reaction positive predict progression proportion Protective Rapid tests resource respiratory reverse transcription reverse transcription polymerase chain reaction risk RT-PCR RT-PCR assay SARS-CoV-2 seroconvert serological Serological tests Seroprevalence severe acute respiratory syndrome Coronavirus significantly higher subject subjects Swab tested the antibody The Republic of the Congo. women [DOI] 10.1016/j.ijid.2020.12.065 PMC 바로가기 [Article Type] Article
Expression, purification and immunological characterization of recombinant nucleocapsid protein fragment from SARS-CoV-2SARS-CoV-2의 재조합 뉴클레오캡시드 단백질 단편의 발현, 정제 및 면역학적 특성화Article Published on 2021-05-012022-09-11 Journal: Virology [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody approach biochemically characterized coronavirus COVID-19 COVID-19 convalescent patients derived protein Detection sensitivity Diagnosis E. coli ELISA expressed fragment of full-length healthy individuals IgG IgG and IgM IgM IgM antibodies immunoblot immunological immunologically Infection N protein nucleocapsid nucleocapsid protein positive Prokaryotic expression Protein purification purified recombinant Recombinant nucleocapsid protein respiratory RT-PCR SARS-CoV-2 SARS-COV-2 infection secondary structure sera Serological assay Serological testing severe acute respiratory syndrome Coronavirus specificity symptomatic patient virus was tested β-sheet [DOI] 10.1016/j.virol.2021.01.004 PMC 바로가기 [Article Type] Article