Impaired Cytotoxic Response in PBMCs From Patients With COVID-19 Admitted to the ICU: Biomarkers to Predict Disease SeverityICU에 입원한 COVID-19 환자의 PBMC에서 손상된 세포독성 반응: 질병 중증도를 예측하는 바이오마커Immunology Published on 2021-05-262022-09-11 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 진단, [키워드] Admission advance Algorithm analyzed association Biomarkers blood sample Blood samples cause CD4 CD8 lymphocytes + CD8+ T cell CD8+ T cells Cell cell population Cellular immune response center COVID-19 COVID-19 severity Critical cytotoxic cytotoxic cell cytotoxic response decrease develop effort elicit feature forest form hospitalized patients ICU IL-2 immune immune response immunological parameter Impaired infected cell infected cells Inflammatory response Invasive mechanical ventilation marker MHC class I MHC class I molecules NK and NKT cells NKT Novel coronavirus novel coronavirus SARS-CoV-2 pandemic parameter Patient PBMC plasma predict pseudotyped SARS-CoV-2 Random forest recruited reduce viral replication reduced response SARS-CoV-2 SARS-COV-2 infection Spain subpopulation susceptible T cell T cells target cell target cells Th1 the disease to define translated Tregs Viral viral replication [DOI] 10.3389/fimmu.2021.665329 PMC 바로가기 [Article Type] Immunology
Immunosuppression as a Hallmark of Critical COVID-19: Prospective StudyArticle Published on 2021-05-232022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] adaptive Admission analyzed B cells Cell cells Clinical deterioration Clinical outcome comprehensive analysis Course COVID-19 COVID-19 patient COVID-19 patients Critical Critically ill Cytokines dysregulation hospital Hospitalization ICU IL-2 IL-2/INFγ ratio Immunosuppression immunosuppressive impaired function INFγ Infection leukocyte lymphocyte subpopulation Lymphocyte subsets naïve NK cell NK cells non-ICU outcome outcomes Patient patients with COVID-19 performed Peripheral blood predict Prospective reductions in regulatory T cells required response SARS-CoV-2 SARS-COV-2 infection secreted subpopulations subsequent T cell T cells TCR γ/δ cells TCRα/β the disease the SARS-CoV-2 TNFα Treg cell Treg cells [DOI] 10.3390/cells10061293 PMC 바로가기 [Article Type] Article
Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes환기된 COVID-19 환자의 심각한 T 세포 과민반응은 장기간의 바이러스 지속성 및 나쁜 결과와 상관관계가 있습니다Article Published on 2021-05-212022-09-12 Journal: Nature Communications [Category] SARS, 바이오마커, 진단, 치료기술, 치료법, [키워드] basophils benefit blood sample caused Cell clinical recovery components coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cytokine secretion dendritic cells downstream Effect extrinsic Factor female hospitalized COVID-19 patient hospitalized COVID-19 patients hyperinflammation identify IL-2 Immunosuppressive medication independent independent of male marker monocyte Monocytes neutrophil Neutrophils outcome overcome Patient patients plasma plasmacytoid dendritic cells Pneumonia polyclonal poor prognosis predict prolonged virus persistence reduced Respiratory distress syndrome respond SARS-CoV-2 SARS-CoV2 infection shown T cell T cell activation T cell response Ventilated ventilated patients viral infection viral persistence Whole blood [DOI] 10.1038/s41467-021-23334-2 PMC 바로가기 [Article Type] Article
Type 1 Diabetes Mellitus in the SARS-CoV-2 Pandemic: Oxidative Stress as a Major Pathophysiological Mechanism Linked to Adverse Clinical OutcomesReview Published on 2021-05-092022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] “cytokine storm” ACE2 Activation acute respiratory syndrome adaptive Adverse Alpha association binding characterized chronic inflammation clinical clinical study cohorts Combination contribute coronavirus coronavirus disease COVID-19 COVID-19 pathogenesis cytokine demonstrated determine diabete Diabetes Mellitus Diabetic disease severity elevated endothelial Endothelial cell Endothelial dysfunction enzyme extreme Glucose hyperglycemia IL-1β IL-2 IL-6 Immunity Impaired impairment Infection Inflammation life-threatening COVID-19 disease Major morbidity and mortality multi-organ failure Necrosis outcome outcomes oxidative stress pancreatic Pathogenesis pathway Patient PKC pro-inflammatory cytokines Protein recent receptor required risk factor SARS-CoV-2 the SARS-CoV-2 TNF-α turn Type Type 1 diabetes mellitus vaccination [DOI] 10.3390/antiox10050752 PMC 바로가기 [Article Type] Review
Comparative immunogenicity analysis of intradermal versus intramuscular administration of SARS-CoV-2 RBD epitope peptide-based immunogen In vivoSARS-CoV-2 RBD 에피토프 펩타이드 기반 면역원의 In vivo 대 근육 내 투여 비교 면역원성 분석Article Published on 2021-05-012022-09-12 Journal: Microbes and infection [Category] 진단, [키워드] Administered administration Antibody Response approach BALB/c mice Candidates caused cellular cellular response characteristic Comparative condition COVID-19 disease effective epitope feature Health Human humans humoral Humoral and cellular responses IFN-γ IL-2 immunization immunogenicity analysis indicate Intradermal Intradermal immunization intramuscular limit magnitude pandemic peptide peptide-based Prevent provide RBD RBD peptide reproductive SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RBD SARS-CoV-2 vaccine SARS-CoV-2 virus spectrum of disease the SARS-CoV-2 virus Transmissibility triggered vaccination Vaccine vaccine administration virus [DOI] 10.1016/j.micinf.2021.104843 PMC 바로가기 [Article Type] Article
Identification of selected genes associated with the SARS-CoV-2: a therapeutic approach and disease severityReview Published on 2021-04-232022-10-28 Journal: Bulletin of the National Research Centre [Category] COVID-19, [키워드] ACE2 ARDS Beta blood pressure Brain can be used China complex condition coronavirus Cytokines develop disease severity early diagnosis endosomal pathway Fever Genes highlight host cell identification IL-2 immune system individual Inflammation interleukin involved MERS-CoV Neurological symptom non-structural protein pandemic of COVID-19 positive-sense single-stranded RNA Potential biomarker problem reducing respiratory problems SARS-CoV SARS-CoV-2 selected severe complication syndrome the Coronaviridae the SARS-CoV-2 Therapeutic approach TNF VEGF Viral pneumonia viral RNA synthesis virus was recorded WHO with COVID-19 worldwide pandemic Wuhan [DOI] 10.1186/s42269-021-00540-y PMC 바로가기 [Article Type] Review
Correlation between ground-glass opacity on pulmonary CT and the levels of inflammatory cytokines in patients with moderate-to-severe COVID-19 pneumonia중등도에서 중증의 COVID-19 폐렴 환자에서 폐 CT의 유리 유리 혼탁도와 염증성 사이토카인 수치 간의 상관관계Research Paper Published on 2021-04-162022-09-10 Journal: International Journal of Medical Sciences [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] age Analysis analyzed characteristic Clinical characteristics Comparative analysis correlation correlations COVID-19 COVID-19 patients defined Department elevated examined females GGO GGOs greater Ground-glass opacities ground-glass opacity IFN-γ IL-2 IL-4 independent risk factor indicated INF-γ Infectious diseases Inflammatory cytokine Inflammatory cytokines laboratory data lung Lungs males mechanism Moderate-to-severe moderate-to-severe COVID-19 moderate-to-severe COVID-19 patient moderate-to-severe COVID-19 patients moderate-to-severe COVID-19 pneumonia Multivariate analysis Patient presenting pulmonary CT pulmonary lesion pulmonary lesions receiver operating characteristic report Retrospective study Risk factors ROC ROC analysis SARS-CoV-2 sensitivity specificity two group two groups Union Hospital Wuhan [DOI] 10.7150/ijms.56683 PMC 바로가기 [Article Type] Research Paper
Interplay of Opposing Effects of the WNT/β-Catenin Pathway and PPARγ and Implications for SARS-CoV2 TreatmentImmunology Published on 2021-04-132022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] ACE2 ACE2 expression acute respiratory syndrome agonist angiotensin-converting enzyme 2 ARDS canonical caused coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Cytokine storm decrease Diseases distress Effect Evidence expression IL-1β IL-2 IL-6 immunomodulatory drug Inflammation Inflammatory interact lung NF-κB pathway novel coronavirus SARS-CoV-2 organ pandemic pathway PPARγ PPARγ profile proportions reached recent resulting SARS-CoV2 SARS-CoV2 infection shown syndrome the cytokine storm TNF-α Treatment upregulation WNT/β-catenin pathway [DOI] 10.3389/fimmu.2021.666693 PMC 바로가기 [Article Type] Immunology
The role of CD4 + FoxP3 + regulatory T cells in the immunopathogenesis of COVID-19: implications for treatmentCOVID-19의 면역 병인 발생에서 CD4 + FoxP3 + 조절 T 세포의 역할: 치료에 대한 의미Review Published on 2021-04-102022-08-31 Journal: International Journal of Biological Sciences [Category] MERS, SARS, 바이오마커, [키워드] “cytokine storm” acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus adalimumab addressed Antiviral ARDS attenuation Azithromycin CD4 CD4+FoxP3+ regulatory T cells Chloroquine Coagulopathy coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine Cytokine release syndrome Cytokine storm Defense deficiencies deficiency Dexamethasone early stage FOXP3 Hydroxychloroquine IL-2 immune Immune homeostasis immune response immune responses Immunopathogenesis immunopathology implication Infection Inflammatory responses introduced involved late stage low dose maintenance mechanisms organ damage organ injury Patient Perspective problem problems Regulatory Regulatory T cell regulatory T cells respiratory respiratory distress Respiratory distress syndrome sarilumab SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Severe case severe cases syndrome T cell T cells tetrandrine therapeutic agent therapeutic agents Therapies Tocilizumab transfer Treatment Treg Treg cell Treg cells Tregs Vitamin D [DOI] 10.7150/ijbs.59534 PMC 바로가기 [Article Type] Review
Plasma biomarker profiling of PIMS-TS, COVID-19 and SARS-CoV2 seropositive children – a cross-sectional observational study from southern India.PIMS-TS, COVID-19 및 SARS-CoV2 혈청양성 아동의 혈장 바이오마커 프로파일링 - 인도 남부의 횡단면 관찰 연구.Observational Study Published on 2021-04-022022-08-31 Journal: EBioMedicine [Category] MERS, 바이오마커, 유전자 메커니즘, 임상, [키워드] acute COVID-19 Analysis Biomarker Care CCL11 CCL19 CCL2 CCL20 CCL5 chemokine chemokines Chennai children Children's Hospital clinical phenotype clinical phenotypes conditions controls correlated country COVID-19 COVID-19 infection cross-sectional CRP CXCL10 cytokine Cytokine storm Cytokines elevated finding GM-CSF granzyme granzyme B growth factor Growth factors hospital Hyperinflammatory IFNα IFNβ IFNγ IL-1 IL-10 IL-15 IL-17A IL-1α IL-2 IL-33 IL-6 immune India Infection Inflammatory lymphocyte Lymphocyte count management MIS-C multiplex negative correlation paediatric inflammatory multisystem syndrome Pathogenesis performed PIMS PIMS-TS plasma biomarker positive correlation presenting pro-inflammatory cytokines SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 seropositive significantly sodium sodium levels syndrome TNFα trajectory unique VEGF [DOI] 10.1016/j.ebiom.2021.103317 PMC 바로가기 [Article Type] Observational Study