Protective mucosal immunity against SARS-CoV-2 after heterologous systemic prime-mucosal boost immunization이종 전신 프라임-점막 부스트 면역화 후 SARS-CoV-2에 대한 보호 점막 면역Article Published on 2021-11-262022-09-10 Journal: Nature Communications [Category] MERS, SARS, 변종, 진단, [키워드] addition adenoviral vector adenoviral vector vaccine adenoviral vectors Adenovirus approach boost booster circulating Complete COVID-19 vaccine DNA DNA vaccines effective Heterologous IgA Immunity immunization induce intramuscular intranasal lead lung maintain memory T cell memory T cells mice mRNA mRNA vaccine mucosal Mucosal immunology neutralization Plasmid Preclinical research priming provoke response responses RNA vaccines SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine T cell T cell response T cells vaccination Vaccination strategy variants vectored vaccine virus variant virus variants while [DOI] 10.1038/s41467-021-27063-4 PMC 바로가기 [Article Type] Article
Susceptibility of livestock to SARS-CoV-2 infectionSARS-CoV-2 감염에 대한 가축의 감수성Comparative Study Published on 2021-11-222022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 진단, 치료기술, [키워드] alpaca cattle contribute evaluate goat horse Infection infection with SARS-CoV-2 Infectious virus intranasal livestock nasal neutralizing antibody titre neutralizing antibody titres pilot study rabbit SARS-CoV-2 SARS-CoV-2 epidemiology SARS-COV-2 infection sheep susceptibility unlikely Viral Viral RNA [DOI] 10.1080/22221751.2021.2003724 PMC 바로가기 [Article Type] Comparative Study
The Bacterial Mucosal Immunotherapy MV130 Protects Against SARS-CoV-2 Infection and Improves COVID-19 Vaccines Immunogenicity박테리아 점막 면역요법 MV130, SARS-CoV-2 감염으로부터 보호하고 COVID-19 백신 면역원성 개선Immunology Published on 2021-11-182022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] administration Against Bacteria Bacterial boost C57BL/6 CD8 cell activation Clinical efficacy COVID-19 COVID-19 vaccine heat-inactivated Heterologous IgA antibodies immunogenicity Immunotherapy IMPROVE Innate immunity innate response inoculated intramuscularly intranasal intranasally K18-hACE2 mice mice mucosal polybacterial mucosal immunotherapy Prophylactic Prophylaxis PROTECT Protein responses SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus shown susceptible the SARS-CoV-2 the vaccine vaccination Vaccine vaccine immunogenicity Vaccines viral infection viral infections viral respiratory infections [DOI] 10.3389/fimmu.2021.748103 PMC 바로가기 [Article Type] Immunology
Non-propagative human parainfluenza virus type 2 nasal vaccine robustly protects the upper and lower airways against SARS-CoV-2Article Published on 2021-11-172022-10-30 Journal: iScience [Category] COVID-19, [키워드] Abstract acute respiratory syndrome airway boost chimeric Complete coronavirus curtail ectopic expressing full-length hamster Health human parainfluenza virus IgA antibody IgG Immunity Immunoglobulin induce Infection Infection control in health technology intranasal lower airway lung mice mucosal nasal nasal turbinate Neutralizing PROTECT Protein RNA SARS-CoV-2 spike gene Spike protein the spike protein vaccination Vaccine vaccine candidate viral envelope viral surface Viral vector Virology virus transmission [DOI] 10.1016/j.isci.2021.103379 PMC 바로가기 [Article Type] Article
Intranasal Delivery of MVA Vector Vaccine Induces Effective Pulmonary Immunity Against SARS-CoV-2 in RodentsMVA 벡터 백신의 비강 내 전달은 설치류의 SARS-CoV-2에 대한 효과적인 폐 면역을 유도합니다Immunology Published on 2021-11-112022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, [키워드] Against anti-spike antibodies anti-spike antibody Antigen applied approach Booster vaccine bronchus-associated lymphoid tissue (BALT) CD4 CD8 component delivery effective followed by hamster hamsters identify IgA IgA antibodies IgA antibody immune responses Immunity immunization induce intramuscular intranasal Local lung Lung infection Lungs memory T memory T cell memory T cells mice modified vaccinia virus Ankara (MVA) Neutralizing Neutralizing antibodies pathology priming PROTECT protocol protocols pulmonary respiratory respiratory tract rodent SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 variant SARS-CoV-2-S serum severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein systemic immune response systemic immune responses T cell T cells tested Th1 Th2 titers of IgG treatment regimen vaccination Vaccine vaccine candidate vaccinia vector Viral viral infections virus Virus neutralization [DOI] 10.3389/fimmu.2021.772240 PMC 바로가기 [Article Type] Immunology
Enhanced protective immunity against SARS-CoV-2 elicited by a VSV vector expressing a chimeric spike protein키메라 스파이크 단백질을 발현하는 VSV 벡터에 의해 유발되는 SARS-CoV-2에 대한 보호 면역 강화Article Published on 2021-11-102022-09-12 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 administration Antigen cellular receptor Chimera chimeric coronavirus COVID-19 vaccines cross-neutralizing cross-reactivity dose elicit elicited enhanced expressing Genetic glycoprotein hACE2 Human human ACE2 humoral immune response immunization immunized immunized mice indicate intramuscular intranasal lesion Lungs macaque macaques mice Mouse models NAb nAb response NAbs neutralizing antibody protective immunity RBD receiving Receptor binding domain replacing rVSV-SARS-CoV-2 S protein Safe SARS-CoV SARS-CoV S SARS-CoV-2 SARS-CoV-2 RBD sera serum significantly significantly increased similarity single dose spike Spike protein spikes the S protein the SARS-CoV-2 titers transplantation Vaccines viruses VSV wild-type [DOI] 10.1038/s41392-021-00797-9 PMC 바로가기 [Article Type] Article
Identification of a therapeutic interfering particle—A single-dose SARS-CoV-2 antiviral intervention with a high barrier to resistanceArticle Published on 2021-11-102023-06-16 Journal: Cell [Category] MERS, SARS, [키워드] coronavirus defective interfering particles Evolution intranasal Lipid nanoparticle RNA SARS-CoV-2 therapeutic interfering particles variants Virus-like particle [DOI] 10.1016/j.cell.2021.11.004 PMC 바로가기 [Article Type] Article
Development of a Hamster Natural Transmission Model of SARS-CoV-2 InfectionArticle Published on 2021-11-092022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome animal model animals caused clinical output Clinical sign closely resemble common coronavirus disease Coronavirus-2 COVID-19 development disease Donor dose evaluate global pandemic hamster hamsters human infection Infection International Intervention intranasal intranasal route less Model moderate natural natural infection Pathogenesis physically Respiratory disease response resulting SARS-CoV-2 Severe case Transmission Transmission model utility Variation viral shedding virus virus strain weight loss [DOI] 10.3390/v13112251 PMC 바로가기 [Article Type] Article
577. COVI-VAC™, a Live Attenuated COVID-19 Vaccine, Provides Single Dose Protection Against Heterologous Challenge with SARS-CoV-2 Beta (B.1.351) in the Syrian Golden Hamster ModelPoster Abstracts Published on 2021-11-042022-10-29 Journal: Open Forum Infectious Diseases [Category] COVID-19, [키워드] affected Against age Amino acid Analysis animal B.1.351 Beta biodistribution board challenge change clinical trials conducted COVID-19 COVID-19 vaccine demonstrated Efficacy employee evaluated figure furin cleavage site hamster Heterologous heterologous challenge Histopathology in vivo Inc include intranasal intranasally key tissue Kushnir less maintain member Model Mutation neutralization neutralizing antibody non-human primate model Phase 1 PhD presenting prevented protection Protective qPCR raise reduced Result Robert SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant sequence serum Seven silent single dose spike-based vaccines Syrian Golden hamsters timepoint Vaccine variant variant of SARS-CoV-2 Viral antigen viral antigens viral evolution viral replication weighed weight weight loss wildtype [DOI] 10.1093/ofid/ofab466.775 PMC 바로가기 [Article Type] Poster Abstracts
Respiratory and Intramuscular Immunization With ChAdOx2-NPM1-NA Induces Distinct Immune Responses in H1N1pdm09 Pre-Exposed PigsOriginal Research Published on 2021-11-032023-06-08 Journal: Frontiers in Immunology [Category] Fulltext, 신종인플루엔자, [키워드] aerosol influenza A intramuscular intranasal pdmH1N1 pig pre-exposure Vaccine [DOI] 10.3389/fimmu.2021.763912 PMC 바로가기 [Article Type] Original Research