pro-inflammatory cytokine – Page 12 – Communicable Diseases Research

Changes in Glycolytic Pathway in SARS-COV 2 Infection and Their Importance in Understanding the Severity of COVID-19

Chemistry

Published on 2021-09-102022-10-31
Journal: Frontiers in Chemistry [Category] COVID-19,

Use of Tocilizumab May Avoid the Need of Invasive Ventilation

Internal Medicine

Published on 2021-09-082022-10-31
Journal: Cureus [Category] COVID-19,

Differential plasmacytoid dendritic cell phenotype and type I Interferon response in asymptomatic and severe COVID-19 infection

차등 혈장 세포질 수지상 세포 표현형 및 무증상 및 심한 COVID-19 감염에서 I 형 인터페론 반응

Research Article

Published on 2021-09-022022-08-13
Journal: PLoS Pathogens [Category] Biochemistry, SARS, 유전자 메커니즘,

[키워드] absence accompanied adaptive immune responses Anti-viral anti-viral IFN anti-viral response antiviral responses Asymptomatic asymptomatic SARS-CoV-2 infected subjects Cell cells cellular characterized chemokine chemokines circulating contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pathogenesis COVID-19 patient Critically ill Critically ill patient critically ill patients cytokine Cytokine storm Cytokines death Defense dendritic cell dendritic cells disease severity early phase elevated ENhance epithelial cells event Evidence Ex vivo expression fine-tune Frequency hospitalized patient hospitalized patients Host host defense Host-directed therapies host-directed therapy human peripheral blood mononuclear cell IFN IFN-stimulated gene Immune cell immune cells immune responses Immunity IMPROVE in vitro induce Infection Inflammatory cytokine Inflammatory cytokines inflammatory phenotype inhibiting viral replication Innate innate immune response Innate immunity Interaction interferon interferons investigated low frequency Lung epithelial cells mechanism mononuclear cell multi-organ failure neuropilin observation Pathogenesis PBMC PD-L1 marker pDC/type I IFN axis Peripheral blood pharmacological strategy phenotype plasmacytoid dendritic cell plasmacytoid dendritic cells pro-inflammatory cytokine pro-inflammatory cytokines producing productive viral replication progression protective role regulate Regulation released responsible resulting SARS-CoV-2 SARS-CoV-2 infected subject SARS-COV-2 infection SARS-CoV-2 pandemic secreted secretion serum severe COVID-19 Severe COVID-19 Infection severe COVID-19 patients stratified the cytokine storm the interferon tissue damage TLR7/8 type I type I and III IFNs type I and III interferons Type I IFN type I IFN producing cells Viral viral replication Viral resistance virus viruses
[DOI] 10.1371/journal.ppat.1009878 PMC 바로가기 [Article Type] Research Article

A CASE REPORT: RESPIRATORY MANIFESTATIONS OF COVID-19 STARTING WITH A GASTROINTESTINAL COMPLAINT: A COINCIDENCE OR A CORRELATION?

Article

Published on 2021-09-012022-10-27
Journal: African Journal of Infectious Diseases [Category] COVID-19,

TLR3 and TLR7 RNA Sensor Activation during SARS-CoV-2 Infection

Article

Published on 2021-08-262022-10-29
Journal: Microorganisms [Category] COVID-19,

[키워드] activate Activation adaptive component coronavirus disease COVID-19 early stage ELISA etiological agent evaluated IFN IFN-α IFN-β IFN-γ IL-1α IL-1β IL-4 IL-6 Immunity immunofluorescence Infection Innate immunity Interaction interferons investigated involved IRF3 lung multicellular NFκB pandemic pathogen-associated molecular pattern pathway Pathways Post-infection pro-inflammatory cytokine pro-inflammatory cytokines producing PRRs quantitative real-time PCR receptor respiratory syndrome coronavirus RNA RNA sensors SARS-CoV-2 SARS-COV-2 infection secretion sensor the disease the SARS-CoV-2 TLR TLR3 TLR7 transcription factors
[DOI] 10.3390/microorganisms9091820 PMC 바로가기 [Article Type] Article

Protective Effects of Astodrimer Sodium 1% Nasal Spray Formulation against SARS-CoV-2 Nasal Challenge in K18-hACE2 Mice

K18-HACE2 마우스에서 SARS-COV-2 코 챌린지에 대한 아스 토드리머 나트륨 1% 코 스프레이 제제의 보호 효과

Article

Published on 2021-08-202022-08-31
Journal: Viruses [Category] MERS, SARS, 치료기술, 치료제,

[키워드] administration animal animal model animals anti-SARS-CoV-2 Antiviral astodrimer blocked Brain challenge chemokine COVID-19 Cytokines Day dendrimer detectable Effect Efficacy Formulation hACE2 IL-1 IL-1α IL-1β IL-6 Incubation infected intranasally Infection Infectious virus intranasally K18-hACE2 K18-hACE2 mice lack liver lung MCP-1 nasal Nasal cavity Nasal spray neutralisation pathogen PBS Post-infection pro-inflammatory cytokine pro-inflammatory cytokines product PROTECT reduced reducing reduction reduction in SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication secretion serum severity of COVID-19 significantly sodium SPL7013 spray Strategy TGFβ These data TNFα Trachea treated Treatment undetectable Viraemia Viral viral genome viral replication viral shedding virus virus replication virus transmission was used were infected
[DOI] 10.3390/v13081656 PMC 바로가기 [Article Type] Article

HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19

Article

Published on 2021-08-182022-10-29
Journal: Signal Transduction and Targeted Therapy [Category] COVID-19, MERS, SARS,

[키워드] aggravate Analysis clinical coronavirus 2 COVID-19 COVID-19 patients COVID-19 prognosis Critical cytokine Cytokine storm dysregulated elderly patients elicited expression facilitate HIF-1α HIF-1α signaling high mortality Host identify immune response induce infected cells Infection Infectious diseases Inflammatory response Inflammatory responses Innate immunity mechanism metabolism mitochondrial ORF3a pathway Patient pro-inflammatory cytokine pro-inflammatory response pro-inflammatory responses promote respiratory RNA sequencing SARS-CoV-2 SARS-COV-2 infection turn understanding viral infection virus infection viruses
[DOI] 10.1038/s41392-021-00726-w PMC 바로가기 [Article Type] Article

COVID-19 and Obesity: Role of Ectopic Visceral and Epicardial Adipose Tissues in Myocardial Injury

Endocrinology

Published on 2021-08-162022-10-31
Journal: Frontiers in Endocrinology [Category] COVID-19, MERS, SARS,

[키워드] “cytokine storm” ACE2 Activation acute respiratory distress acute respiratory syndrome adipocyte adipose Adipose tissue Admission amplification angiotensin-converting enzyme 2 cardiac injury Cardiovascular events cascade caused Chronic low-grade inflammation coronavirus coronavirus disease COVID-19 COVID-19 patient cytokine ectopic ectopic fat Epicardial adipose tissue expression fat global pandemic host cells immune dysregulation immune response Immunity increased risk individual Infection Inflammation inflammatory mediator Injury intensive care involved macrophage activation syndrome mechanical ventilation mechanism myocarditis Myocardium obesity outcome outcomes overexpression pneumopathy poor prognosis predict pro-inflammatory cytokine pro-inflammatory cytokines Prognosis progression prolonged viral shedding receptors risk factor role SARS-CoV-2 subsequent syndrome the WHO Therapeutic strategies tissue Vascular Viral reservoir viral spread visceral
[DOI] 10.3389/fendo.2021.726967 PMC 바로가기 [Article Type] Endocrinology

The cytokines HGF and CXCL13 predict the severity and the mortality in COVID-19 patients

사이토카인 HGF와 CXCL13은 코로나19 환자의 중증도와 사망률을 예측한다

Article

Published on 2021-08-092022-09-10
Journal: Nature Communications [Category] MERS, SARS, 바이오마커, 유전자 메커니즘,

[키워드] Admission anti-inflammatory properties anti-inflammatory property association B cell response best cellular chemokine Cohort cohorts Combination coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CXCL13 cytokine Cytokines death fibrosis Follow-up French hepatocyte growth factor HGF Host immune response ICU ICU admission identify immunological inflammatory pathways intensive care intensive care unit investigated Ligand likelihood Lung fibrosis lung tissue marker maturation mechanism Mortality motif Negative predictive value non-ICU non-ICU patients Occurrence over Patient patients pleiotropic positive power predict Predictive predictive values Prevent pro-inflammatory pro-inflammatory cytokine pro-inflammatory cytokines pulmonary fibrosis reflect SARS-CoV-2 severe coronavirus disease severity significantly university up-regulation viral infection
[DOI] 10.1038/s41467-021-25191-5 PMC 바로가기 [Article Type] Article

White button mushroom interrupts tissue AR-mediated TMPRSS2 expression and attenuates pro-inflammatory cytokines in C57BL/6 mice

Article

Published on 2021-08-022022-10-29
Journal: NPJ Science of Food [Category] COVID-19,