severe cases – Page 12 – Communicable Diseases Research

Clinical characteristics of COVID-19 in Osaka, Japan: Comparison of the first-third waves with the fourth wave

Observational Study

Published on 2021-11-012022-10-04
Journal: Respiratory investigation [Category] SARS, 바이오마커, 임상,

COVID-19: risk factors for severe cases of the Delta variant

Covid-19 : 델타 변형의 심각한 사례에 대한 위험 요소

Comparative Study

Published on 2021-10-312022-09-10
Journal: Aging (Albany NY) [Category] MERS, SARS, 변종,

Multicellular spatial model of RNA virus replication and interferon responses reveals factors controlling plaque growth dynamics

Research Article

Published on 2021-10-252022-10-28
Journal: PLoS Computational Biology [Category] COVID-19,

[키워드] acute respiratory syndrome Analysis antiviral response Cell Cell culture coefficients condition coronavirus COVID-19 cultures cytokine cytokine signaling Cytokine storm diffusion drug candidates early stage epithelial evaluated evidenced excessive inflammation exhibit experiment Factor flu form growth H1N1 influenza H3N2 help highlight immune immune response immunopathology IMPROVE in some in vitro include induce Infection inflammatory condition Inflammatory response Influenza inhibit innate immune response interferon interferon response interferon signaling interferons involved JAK/STAT pathway lesion linear local concentration lung lung cell Lung epithelial cells Lung infection Lungs manifestation mechanism molecular multicellular Occurrence pandemic Pandemics parameter pathway performed plaque plaques protective effect public health radial growth Replication respiratory Respiratory disease respiratory infection responsible reveal RNA virus RNA viruses SARS-CoV-2 severe cases severe inflammation severity Signaling signaling molecule Spanish the disease tissue Treatment Trigger type I interferons understanding Variation viral growth Viral load viral replication virus virus-infected cell
[DOI] 10.1371/journal.pcbi.1008874 PMC 바로가기 [Article Type] Research Article

Soluble Urokinase Receptor as a Promising Marker for Early Prediction of Outcome in COVID-19 Hospitalized Patients

Article

Published on 2021-10-242022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

[키워드] acute respiratory distress Admission Algorithm ARDS Biomarker Biomarkers caused Clinical severity complement system Coronavirus disease 2019 Course COVID-19 COVID-19 patients COVID-19 symptomatic patient Critically ill patient death Disease progression evaluated facilitate global pandemic health care systems healthy controls hospital resources Hospitalized ICU intensive care management marker Mild Mild symptom moderate molecular multiple organ failure outcome Patient prediction receptor risk risk stratification in the emergency room SARS-CoV-2 SARS-COV-2 infection Sepsis serum severe cases severe disease severely ill patients spread to suPAR syndrome thrombotic complication urokinase with COVID-19 with mild disease
[DOI] 10.3390/jcm10214914 PMC 바로가기 [Article Type] Article

Emerging Severe Acute Respiratory Syndrome Coronavirus 2 Mutation Hotspots Associated With Clinical Outcomes and Transmission

Microbiology

Published on 2021-10-182022-10-31
Journal: Frontiers in Microbiology [Category] COVID-19,

[키워드] acute respiratory syndrome ADAR analyzed APOBEC association Asymptomatic Beta clinical Clinical outcome Complete coronavirus coronavirus 2 coronavirus disease correlated COVID-19 Critical D614G enzyme Epidemic expression Frame Frequency Gamma GISAID database hotspot mechanism Mild mild case Mutation mutation hotspots mutations occur occurred ORF1ab outcome pandemic predict Prevalence Q57H RdRP respiratory RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 sequence severe cases severe disease shown single-nucleotide SNV strain Strains symptomatic the SARS-CoV-2 the SARS-CoV-2 genome Treatment understanding variant
[DOI] 10.3389/fmicb.2021.753823 PMC 바로가기 [Article Type] Microbiology

COVID-19 Is a Multi-Organ Aggressor: Epigenetic and Clinical Marks

COVID-19는 다기관 공격자입니다: 후성 유전적 및 임상적 징후

Review

Published on 2021-10-082022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alterations chromatin clinical clinical manifestation clinical phenotype clinical phenotypes Clinical significance coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic Cytokine storm DNA methylation driven by environmental factors Epigenetic epigenetics event Genetic highlight histone host genome Infection involved management MARK mechanisms multi-organ occur pro-inflammatory cytokines progression respiratory respond resulting SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe cases severe COVID-19 survival therapeutic TMPRSS2 understanding Viral viral replication virus viruses with COVID-19
[DOI] 10.3389/fimmu.2021.752380 PMC 바로가기 [Article Type] Review

Clinical Presentation of a COVID-19 Delta Variant Patient: Case Report and Literature Review

Internal Medicine

Published on 2021-10-082022-10-31
Journal: Cureus [Category] COVID-19,

[키워드] acute respiratory distress Admission Antibiotics ARDS bilateral pneumonia cause clinical clinical outcomes coronavirus cough Course COVID pneumonia COVID-19 Critical care Delta delta variant Diagnosis diarrhea difficulty breathing Genetic variation had no high risk hospital hypoxic respiratory failure ICU admission ICU admissions Immune escape intensive care Intubated lab literature management mechanical ventilation mechanically ventilated Mutation over pandemic past medical history patchy Patient Pneumonia presentation Prevent Re-infection Remdesivir report reported review SARS-CoV-2 severe cases Shortness of breath spike glycoprotein sputum Steroids syndrome the patient Tocilizumab transfer treated vaccination Ventilation with COVID-19 worsened
[DOI] 10.7759/cureus.18603 PMC 바로가기 [Article Type] Internal Medicine

COVID-19 in pregnancy: placental pathological patterns and effect on perinatal outcome in five cases

Case Report

Published on 2021-10-032022-11-01
Journal: Diagnostic Pathology [Category] COVID-19, MERS, SARS,

[키워드] acute respiratory disease Analysis Case report caused Computed tomography consolidation coronavirus Coronavirus disease 2019 COVID-19 discharged disease distal distress evaluate Evidence examined FIVE Foetal vascular underperfusion gestation Ground-glass opacities histological immunoreactivity Inflammatory late stage lesion lesions lobular Maternal vascular underperfusion Mild nasopharyngeal Newborn novel coronavirus SARS-CoV-2 outcome pandemic Particle performed placental placental tissue Pneumonia Pregnancy pregnant women risk SARS-CoV-2 SARS-CoV-2 transmission severe cases Structure subsegmental syndrome the disease thrombotic Two patient Ultrastructural analysis Vascular with COVID-19 women
[DOI] 10.1186/s13000-021-01148-6 PMC 바로가기 [Article Type] Case Report

Clinical, obstetrical and anaesthesia outcomes in pregnant women during the first COVID-19 surge in France: A prospective multicentre observational cohort study

Observational Study

Published on 2021-10-012022-10-05
Journal: Anaesthesia, critical care & pain medicine [Category] SARS, 임상,

[키워드] Admission age anaesthesia Caesarean section clinical Cohort cohort study conducted COVID-19 Critical care Factor First wave form France Haemoglobin hospitalisation ICU ICU admission rate intensive care invasive Labour morbidity multicentre nasal oxygen non-invasive ventilation Observational cohort study Obstetric occurred outcome oxygen saturation oxygen supplementation oxygen support Patient Positive test Postpartum Pregnancy pregnant women preterm delivery Prevalence proportion receiving Respiratory Support resulting retrospective risk factor RT-PCR testing SARS-CoV-2 severe cases SOFAresp therapy Ventilation was performed with COVID-19 women
[DOI] 10.1016/j.accpm.2021.100937 PMC 바로가기 [Article Type] Observational Study

Clinical experience on umbilical cord mesenchymal stem cell treatment in 210 severe and critical COVID-19 cases in Turkey

Clinical Trial

Published on 2021-10-012022-10-05
Journal: Stem cell reviews and reports [Category] SARS, 임상,

[키워드] 95% CI added administration age Biorender.com Cell clinical clinical experience Clinical outcome COVID-19 COVID-19 case COVID-19 patient COVID-19 patients Critical Critically ill Cytokine storm discharged downregulate Effect elevated evaluated group groups ICU immunomodulatory effects IMPROVE Intubated intubated patient intubation Linear regression analysis MSC MSCs organ Oxygenation parameter pathophysiology Patient patients patients hospitalized phase randomised risk Safe SARS-CoV-2 severe cases severe COVID-19 severe COVID-19 patient severe COVID-19 patients statistically significant stem cell Stem cell therapy. survival the cytokine storm therapeutic Therapeutic benefit Therapeutic treatment therapy tissue treated Treatment Turkey UC-MSC UC-MSCs umbilical
[DOI] 10.1007/s12015-021-10214-x PMC 바로가기 [Article Type] Clinical Trial