A SARS-CoV-2 Reference Standard Quantified by Multiple Digital PCR Platforms for Quality Assessment of Molecular Tests분자 테스트의 품질 평가를 위해 여러 디지털 PCR 플랫폼으로 정량화된 SARS-CoV-2 참조 표준Article Published on 2021-01-192022-09-11 Journal: Analytical Chemistry [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approved assays assessment caused Complete Concentration Consensus coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Diagnosis diagnostic Digital digital PCR evaluate genomic in vitro inactivated infected individuals limit of detection median Multiple NATs Novel coronavirus novel coronavirus disease nucleic acid nucleic acid test nucleic acid tests outbreak PCR performed Plasmid plasmids provide Quality Quality control quantification quantified reference reference standard Reference standards Regulatory respiratory RNA SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spread Standard Surveillance Test titer treated Viral virus virus particle virus particles [DOI] 10.1021/acs.analchem.0c03996 PMC 바로가기 [Article Type] Article
Dynamics of Neutralizing Antibody Titers in the Months After Severe Acute Respiratory Syndrome Coronavirus 2 Infection중증 급성 호흡기 증후군 코로나 바이러스 2 감염 후 몇 개월 동안 항체 역가 중화의 역학Major Articles and Brief Reports Published on 2021-01-152022-09-12 Journal: The Journal of Infectious Diseases [Category] MERS, 진단, [키워드] accompanied acute respiratory syndrome acute respiratory syndrome coronavirus antibody Antibody dynamics antibody levels Antibody titer Antibody titers Asymptomatic average B cell B cells binding collected coronavirus coronavirus 2 COVID-19 declined determine develop disease domain Dynamics expected fold followed by Frame immune response immune responses Immunity individual Infection initial longitudinal samples Mild moderate-severe Month MOST Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers Other respiratory viruses prospective cohort quantified RBD Receptor-binding domain respiratory respiratory viruses SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spike protein symptom onset time frames titer total antibodies total antibody Viral viral infection viral spike protein [DOI] 10.1093/infdis/jiaa618 PMC 바로가기 [Article Type] Major Articles and Brief Reports
Discrepant Antigen-specific Antibody Responses Causing SARS-CoV-2 Persistence in a Patient Receiving B-cell-targeted Therapy with Rituximab리툭시맙으로 B 세포 표적 치료를 받는 환자에서 SARS-CoV-2 지속성을 유발하는 불일치 항원 특이적 항체 반응Case Reports Published on 2021-01-012022-09-11 Journal: Internal medicine (Tokyo, Japan) [Category] MERS, 진단, 치료기술, 치료법, 치료제, [키워드] antibody Antibody Response B-cell causing clearance comparable COVID-19 highlight humoral immune response humoral immune responses immune responses Kinetics Lymphoid tissue lymphoma magnitude MONITOR mucosa-associated lymphoid tissue Neutralizing Neutralizing activity Neutralizing antibody response persistent RNAemia Pneumonia recipient recipients remained response rituximab SARS-CoV-2 SARS-COV-2 infection serological suffered therapy titer treated unique Viral [DOI] 10.2169/internalmedicine.7884-21 PMC 바로가기 [Article Type] Case Reports
Comparison of Four SARS-CoV-2 Neutralization AssaysArticle Published on 2020-12-282022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] antibody binding antibody comparable competent correlated described effective ELISA focus forming assay In vitro assay induce Infection lentiviral Neutralization assay neutralization titers Neutralizing antibodies neutralizing antibody novel coronavirus SARS-CoV-2 Particle Patient produced pseudotype virus pseudotyped Replication robust S-protein SARS-CoV-2 SARS-CoV-2 neutralization SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike TCID titer vaccine candidate variety vesicular stomatitis virus virus [DOI] 10.3390/vaccines9010013 PMC 바로가기 [Article Type] Article
Manufacturing of convalescent plasma of COVID-19 patients: Aspects of quality코로나19 환자의 회복기 혈장 제조: 품질 측면Research Article Published on 2020-12-222022-09-12 Journal: PLoS ONE [Category] MERS, SARS, 진단, [키워드] antibody Antibody titer Antibody titers aspect binding antibodies binding antibody Blood confirmation convalescent plasma coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients domain Donor donors ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay feasible Final followed by IgG IL-8 LBP Level median Negative PCR pandemic patient safety PCR test performed Peripheral blood plasma Plasmapheresis Production RBD Real-time PCR Recovered COVID-19 patients resulting RT-PCR S-protein Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 specific antibodies screened selected severely ill COVID-19 patients subsequent the SARS-CoV-2 titer Treatment undergo [DOI] 10.1371/journal.pone.0243967 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 Spike Alterations Enhance Pseudoparticle Titers and Replication-Competent VSV-SARS-CoV-2 VirusArticle Published on 2020-12-182022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] acute respiratory syndrome alteration BSL2 can be used caused Cell cell tropism conditions coronavirus cytoplasmic tail death demonstrated determine expression fusion global pandemic IMPROVE Modification Mutation Particle Particles produced pseudotyped recombinant VSV removal residue retroviral SARS-CoV-2 spike spike glycoprotein the S protein titer variant vesicular stomatitis virus virus VSV while [DOI] 10.3390/v12121465 PMC 바로가기 [Article Type] Article
Simulation of the Clinical and Pathological Manifestations of Coronavirus Disease 2019 (COVID-19) in a Golden Syrian Hamster Model: Implications for Disease Pathogenesis and Transmissibility골든 시리아 햄스터 모델에서 코로나바이러스 질병 2019(COVID-19)의 임상 및 병리학적 징후 시뮬레이션: 질병 발병 및 전염성에 대한 의미Article Published on 2020-12-032022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] MERS, SARS, 진단, 치료법, [키워드] ACE2 Activation adaptive airway alveolar damage angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal Antibody titer Antibody titers Apoptosis atrophy binding Blood change chemokine clinical Clinical sign Clinical signs Contact convalescent serum coronavirus COVID-19 Diffuse alveolar damage docking expression hamster hamsters histopathological Histopathology immunoprophylaxis initial intestinal involvement with Koch's postulates Laboratory lung Lung pathology lung viral load lymphoid mammal manifestation molecular docking Mortality Mutation Neutralizing antibody titer nonsynonymous option organ Pathogenesis pathological pathology performed physiological proliferative rapid breathing Receptor-binding domain resulting SARS-CoV-2 Serum neutralizing antibody significant decrease Simulation Spike protein spleen suggested the receptor-binding domain tissue tissue repair titer Transmission Treatment vaccination Viral Viral load viral nucleocapsid protein virus virus titer viruses weight loss [DOI] 10.1093/cid/ciaa325 PMC 바로가기 [Article Type] Article
Analysis of Measles-Mumps-Rubella (MMR) Titers of Recovered COVID-19 Patients회복된 COVID-19 환자의 홍역-볼거리-풍진(MMR) 역가 분석Research Article Published on 2020-11-202022-09-12 Journal: mBio [Category] 진단, [키워드] age antibody arbitrary units association Asymptomatic children close contact contact with coronavirus coronavirus disease Coronavirus disease 2019 correlated correlation country COVID-19 COVID-19 severity COVID-19 vaccine COVID-19-related symptoms death rate death rates determine Hospitalized IgG titer illnesses immune immunization inverse correlation measles Mild symptom mild symptoms MMR MMR vaccine moderate moderate symptoms mump mumps oxygen pandemic positive recovered recovered COVID-19 patient Recovered COVID-19 patients required researcher responsible rubella SARS-CoV-2 second severe disease severity significantly subject Symptom titer titers two groups Vaccine Vaccines virus titer virus titers [DOI] 10.1128/mBio.02628-20 PMC 바로가기 [Article Type] Research Article
An 89-Year-Old Man with COVID-19-Associated Coagulopathy Presenting with a Prolonged Partial Thromboplastin Time, Lupus Anticoagulant, and a High Titer of Factor VIII Inhibitor연장된 부분 트롬보플라스틴 시간, 루푸스 항응고제 및 인자 VIII 억제제의 높은 역가를 나타내는 COVID-19 관련 응고병증을 가진 89세 남성Case Reports Published on 2020-10-302022-09-12 Journal: The American journal of case reports [Category] MERS, SARS, 진단, [키워드] abnormality activated acute respiratory syndrome Anticoagulant assumption bleeding caused Coagulopathy coronavirus coronavirus disease COVID-19 current D-dimer levels disease disease severity Disseminated intravascular coagulation Endothelial dysfunction factor VIII greater hematologic highlight hypertension immune dysregulation imperative inhibitor Lupus Man manifested occur Partial Patient patients with COVID-19 physician positive Prolonged Prostate cancer prothrombotic state receive respiratory compromise risk severe disease symptoms of COVID-19 the patient Thromboprophylaxis time titer type 2 diabetes weakness [DOI] 10.12659/AJCR.926728 PMC 바로가기 [Article Type] Case Reports
SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe diseaseLetter Published on 2020-09-252022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, SARS, [키워드] antibodies binding antibody Antibody neutralization determinant Immunity implication Isolation Live virus neutralization neutralizing monoclonal antibodies Non-severe Patient patients plasma plasma antibody response robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibody SARS-CoV-2 pseudovirus severe severe disease significantly higher Spike protein the viral nucleocapsid therapy titer [DOI] 10.1080/22221751.2020.1823890 PMC 바로가기 [Article Type] Letter