Common determinants of severe Covid-19 infection are explicable by SARS-CoV-2 secreted glycoprotein interaction with the CD33-related Siglecs, Siglec-3 and Siglec-5/14심각한 Covid-19 감염의 일반적인 결정 요인은 CD33 관련 Siglec, Siglec-3 및 Siglec-5/14와 SARS-CoV-2 분비 당단백질 상호작용으로 설명할 수 있습니다.Article Published on 2020-11-012022-09-11 Journal: Medical Hypotheses [Category] MERS, SARS, 바이오마커, 변종, 유전자 메커니즘, 치료제, [키워드] ACE-2 receptor activated allele Alzheimer's disease Anosmia Asian Bame binding black can not Cancer cancers CD33 Cell cells CNS common conjunction contribute COVID-19 infection cribriform plate Critical demography determinant deviation disease Europeans expansion explain expressed expression Genotype glycan glycoprotein greater group Host immune immune cells immune deviation immune function immune regulators induce Infection Inflammasome inhibitory Interaction Ligand mechanism microglia NLRP3 inflammasome North occur pathophysiological mechanism penetration Population porous progression promote receptor regulate residues risk SARS-CoV SARS-CoV-2 SARS-CoV-2 glycoprotein SARS-CoV-2 spike secreted Severe COVID-19 Infection SGP sialic acid suppressor cells susceptibility Variation Viral viral clearance viral persistence [DOI] 10.1016/j.mehy.2020.110168 PMC 바로가기 [Article Type] Article
Structural variations and expression profiles of the SARS-CoV-2 host invasion genes in lung cancer폐암에서 SARS-CoV-2 숙주 침입 유전자의 구조적 변이 및 발현 프로파일Article Published on 2020-11-012022-09-11 Journal: Journal of medical virology [Category] SARS, 변종, 유전자 메커니즘, 치료기술, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Amino acid analyses Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 Anomaly Basigin binding can be used Cancer CD147 cleaving coronavirus correlation Correlation analysis COVID-19 effective enzyme Evidence evidence of expression expression levels expression profile Features furin Gene Expression Gene expression analysis Genes Genetic genomic groups healthy control Host hypothese hypotheses in silico in silico analysis Invasion Laboratory lung lung adenocarcinoma lung cancer mechanism Mutation pathogenic Patient recent residue respiratory SARS-CoV-2 Serine severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly statistically survival survival analysis susceptibility target gene Target genes the RBD the SARS-CoV-2 therapy TMPRSS2 TMPRSS2 level today transmembrane serine protease transmembrane serine protease 2 Variation virus was determined was done [DOI] 10.1002/jmv.26107 PMC 바로가기 [Article Type] Article
Factors related to asymptomatic or severe COVID-19 infection무증상 또는 중증 COVID-19 감염과 관련된 요인Article Published on 2020-11-012022-09-11 Journal: Medical Hypotheses [Category] SARS, 변종, [키워드] 25-hydroxyvitamin D 25-Hydroxyvitamin D (25(OH)D) ACE2 androgen Asymptomatic balance Blood Blood Group complex contribute COVID-19 COVID-19 infection COVID-19 patient Estrogen examined Factor Factors histocompatibility Histocompatibility complex (MHC) class I Infection MHC Mutation nonsynonymous mutation Nonsynonymous mutations ORF3 pathogenicity Protein SARS-CoV-2 Severe COVID-19 Infection Stage susceptibility TMPRSS2 TMPRSS2 expression [DOI] 10.1016/j.mehy.2020.110296 PMC 바로가기 [Article Type] Article
Chemokine receptor gene polymorphisms and COVID-19: Could knowledge gained from HIV/AIDS be important?Review article Published on 2020-11-012022-10-05 Journal: Infection, genetics and evolution : journal of mol [Category] 유전자 메커니즘, [키워드] “cytokine storm” Applying CCR5 chemokine complications of COVID-19 COVID-19 COVID-19 patients Cytokine release syndrome Disease progression effort Factor genomic HIV infection HIV/AIDS Host host genetics Host immune response knowledge life-threatening pandemic Pathogenesis pathology Patient care polymorphism receptor reported severe COVID-19 severe COVID-19 disease susceptibility Treatment Treatment outcome with COVID-19 [DOI] 10.1016/j.meegid.2020.104512 [Article Type] Review article
SARS-CoV-2 and the safety margins of cell-based biological medicinal productsArticle Published on 2020-11-012023-07-12 Journal: Biologicals : journal of the International Associa [Category] SARS, [키워드] AAT Adventitious agent testing Biomedical products cell lines CHO HEK-293 HT-1080 permissiveness Safety SARS-CoV-2 susceptibility Vero. [DOI] 10.1016/j.biologicals.2020.08.010 PMC 바로가기
Age and Location in Severity of COVID-19 Pathology: Do Lactoferrin and Pneumococcal Vaccination Explain Low Infant Mortality and Regional Differences?Article Published on 2020-11-012023-07-12 Journal: Bioessays [Category] SARS, [키워드] Bacillus Calmette-Guérin Epidemiology pneumococcus polio SARS-CoV-2 susceptibility vaccination coverage [DOI] 10.1002/bies.202000076
The role of androgens in COVID-19COVID-19에서 안드로겐의 역할Review Published on 2020-11-012022-09-11 Journal: Diabetes & metabolic syndrome [Category] 치료제, [키워드] ACE-2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect allergy alopecia androgen androgenic alopecia androgens angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 article Asthma asthma medications cause causes Combination complications condition control group coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection effective Estrogen evaluate Evidence evidence of expressed expression Factors females functional Gender hair Hair loss health emergency higher risk hormone Hormones hospitalized patient hospitalized patients host cells hyperandrogenism immune system increased risk Infection lung tissue male male hormones medication multifactorial pandemic Patient patients with COVID-19 polycystic ovary Prevalence Prostate protease receptor Research respiratory Respiratory disease SARS-CoV-2 SARS-CoV-2 entry Serine serine 2 severe acute respiratory syndrome Coronavirus severe complication severe complications severe COVID-19 severity of symptom Sex hormones sexual suppresse susceptibility syndrome Testosterone TMPRSS2 transmembrane with COVID-19 women [DOI] 10.1016/j.dsx.2020.10.014 PMC 바로가기 [Article Type] Review
Epidemiological features and viral shedding in children with SARS-CoV-2 infectionSARS-CoV-2 감염 아동의 역학적 특징 및 바이러스 배출Multicenter Study Published on 2020-11-012022-09-11 Journal: Journal of medical virology [Category] SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 age Antiviral antiviral therapy Asymptomatic children China clearance close contact Clustering conducted Contact coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 Effect epidemiological Epidemiological characteristics epidemiological data evaluated Families feature fecal group Hospitalization Incubation period indication Infection Kaplan-Meier mean incubation period Mild symptom mild symptoms multicenter multicenter study not different not used pandemic Pediatric case Pediatric patient Pediatric patients Pneumonia positive quarantine respiratory retrospective reverse transcription PCR RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 RNA detection severe acute respiratory syndrome Coronavirus significantly lower subsequent susceptibility the SARS-CoV-2 treated Viral viral clearance viral excretion. viral shedding Zhejiang [DOI] 10.1002/jmv.26180 PMC 바로가기 [Article Type] Multicenter Study
Risk of severe COVID-19 disease with ACE inhibitors and angiotensin receptor blockers: cohort study including 8.3 million peopleSpecial Populations Published on 2020-10-312022-10-31 Journal: Heart (British Cardiac Society) [Category] COVID-19, MERS, SARS, [키워드] 95% CI ACE ACE inhibitor adjusted Admission African angiotensin receptor blocker ARB association black cardiac risk factors and prevention cohort study collected data confounders COVID-19 COVID-19 disease Cox proportional hazard diabetes diagnosed disease drug Effect England enzyme Epidemiology ethnic group finding geographical region group higher risk hypertension ICU ICU care increased risk inhibitor intensive care medication participant Patient primary care Primary outcome prospective cohort study raise receiving receptor reduced risk resulting risk risk of COVID-19 RT-PCR severe COVID-19 disease severity significant interaction significantly significantly increased sociodemographic factors susceptibility variables with COVID-19 [DOI] 10.1136/heartjnl-2020-317393 PMC 바로가기 [Article Type] Special Populations
ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBsArticle Published on 2020-10-282022-10-04 Journal: Nature Communications [Category] MERS, 유전자 메커니즘, [키워드] abundantly expressed ACE inhibitor ACE2 ACE2 expression ACE2 receptor ACE2 receptor protein ACEi acute respiratory disease airway airway epithelial cells angiotensin-converting enzyme 2 angiotensin-converting enzyme inhibitor ARB ARBs blocker blockers cellular tropism ciliary Clinical characteristics Comorbidities coronavirus SARS-CoV-2 COVID-19 demographics determine Evidence expression Host human donor initial medication Motile cilia nasal not affected pandemic pathogen pathogenesis of SARS-CoV-2 Patient receptor respiratory cilia respiratory tract Respiratory tract diseases SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral subcellular subcellular localization susceptibility the SARS-CoV-2 tissues Transmission transmission of SARS-CoV-2 understanding viral infection virulent [DOI] 10.1038/s41467-020-19145-6 PMC 바로가기 [Article Type] Article