ICU Patients – Page 13 – Communicable Diseases Research

Community-acquired and hospital-acquired respiratory tract infection and bloodstream infection in patients hospitalized with COVID-19 pneumonia

Research

Published on 2021-01-182022-10-30
Journal: Journal of Intensive Care [Category] COVID-19,

Hemostatic System (Fibrinogen Level, D-Dimer, and FDP) in Severe and Non-Severe Patients With COVID-19: A Systematic Review and Meta-Analysis

중증 및 비 중증 COVID-19 환자의 지혈 시스템(피브리노겐 수준, D-이량체 및 FDP): 체계적인 검토 및 메타 분석

Meta-Analysis

Published on 2021-01-012022-09-11
Journal: Clinical and applied thrombosis/hemostasis : offic [Category] 바이오마커,

[키워드] Abnormalities abnormality articles CMA2 Coagulation coagulation parameter Coagulation parameters contribute COVID-19 COVID-19 patients Critically ill D-dimer determine diagnostic Egger FDP fibrinogen fibrinogen level Fibrinogen levels funnel plot groups Hemostatic ICU patient ICU Patients Level Meta-analysis non-ICU non-ICU patients non-severe patient non-severe patients parameter patients with COVID-19 performed predict Research review SARS-CoV-2 severe COVID-19 Severe patient severe patients Severity of disease significantly significantly higher System thrombosis Trigger triggers with COVID-19
[DOI] 10.1177/10760296211010973 PMC 바로가기 [Article Type] Meta-Analysis

Imaging trend and disease course in admitted COVID-19 patients

COVID-19 입원 환자의 영상 동향 및 질병 경과

Article

Published on 2021-01-012022-09-11
Journal: Saudi medical journal [Category] 치료기술,

[키워드] affecting association Atelectasis bronchiectasis calculated carried cavitation Chest Chest radiograph Chi-square chi-square test co-morbidities co-morbidity Comorbidities Comorbidity Complication complications Computed tomography Consensus consolidation consolidations coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 patient CT scan CT scans CXR death Department determine Dhahran disease course elderly elderly patients Embolism evaluated Fatality rate followed by GGO ground-glass opacity Hospital stay ICU ICU Patients imaging intensive care intensive care unit King Laboratory less Lymphadenopathy majority male males morbidities nodularity outcome outcomes Patient patients pleural effusion Radiographic radiologist radiology radiology department reticulation Retrospective study shifting Symptoms ward was used were recorded worsening
[DOI] 10.15537/smj.2021.1.25642 PMC 바로가기 [Article Type] Article

Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID-19

혈장의 바이러스 RNA 부하는 COVID-19의 심각한 질병 및 조절되지 않는 숙주 반응과 관련이 있습니다

Research

Published on 2020-12-142022-09-11
Journal: Critical Care [Category] MERS, 바이오마커, 진단, 치료제,

[키워드] Activation Analysis angiopoietin association Biomarker Biomarkers Blood CCL2 characterized chemokine chemokines Coagulation correlated correlation coefficients correlations Course COVID-19 Critical Critical illness critical patient critical patients Critically ill Critically ill patient critically ill patients CRP CXCL10 cytokine D-dimer digital PCR disease dysregulated dysregulated response dysregulation Endothelial dysfunction evaluated ferritin Frequency GM-CSF GPT highest Hospitalized host response host responses ICAM-1 ICU ICU Patients IL-10 IL-15 IL-6 INR LDH lymphopenia monocytopenia Multivariate analysis multivariate logistic regression myeloperoxidase N1 and N2 neutrophil neutrophil response Neutrophils NK cell NK cells non-critically ill patients non-survivor Non-survivors Outpatient outpatients Pathogenesis Patient patients with COVID-19 PD-L1 plasma quantification recruited Region respiratory respiratory sample Respiratory samples Result RNA RNAemia SARS-CoV-2 SARS-CoV-2 RNA Sepsis severe COVID-19 severity Spearman Stool systemic inflammatory response the SARS-CoV-2 tissue damage Urine VCAM-1 Viral viral replication Viral RNA viral RNA detection viral RNA load virus ward was performed
[DOI] 10.1186/s13054-020-03398-0 PMC 바로가기 [Article Type] Research

Longitudinal proteomic profiling reveals increased early inflammation and sustained apoptosis proteins in severe COVID-19

종단 단백질 프로파일링은 심각한 COVID-19에서 증가된 초기 염증 및 지속적인 세포자멸사 단백질을 보여줍니다

Article

Published on 2020-11-252022-09-01
Journal: Scientific Reports [Category] SARS, 바이오마커, 유전자 메커니즘, 진단,

[키워드] addition age antibodies Apoptosis apoptotic pathway Blood CASP8 CCL2 CCL7 CCL8 chemokines cohorts COVID-19 COVID-19 disease CXCL10 CXCL11 Cytokines defined develop disease severity Factor HGF hospitalized COVID-19 patient hospitalized COVID-19 patients Host hypertension ICU ICU admission ICU Patients IFNγ IL-10 IL-6 Inflammation inflammation markers Inflammatory inflammatory condition Inflammatory marker inflammatory markers intensive care intensive care unit life-threatening COVID-19 disease longitudinal marker Molecular medicine monocyte neutralization capacity non-ICU Patient plasma protein plasma proteins Protein proteomic reveal risk Risk factors SARS-COV-2 infection SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody selective severe COVID-19 specific antibodies Stratification sustained TGFB1 TNFSF14 Treatment upregulation viral infection while
[DOI] 10.1038/s41598-020-77525-w PMC 바로가기 [Article Type] Article

Neutralizing antibody against SARS-CoV-2 spike in COVID-19 patients, health care workers, and convalescent plasma donors

COVID-19 환자, 의료 종사자 및 회복기 혈장 기증자의 SARS-CoV-2 급증에 대한 중화 항체

Technical Advance

Published on 2020-11-192022-09-12
Journal: JCI Insight [Category] SARS, 진단,

[키워드] antibody Antibody testing Cellular immune response cohorts convalescent plasma COVID-19 COVID-19 pathogenesis COVID-19 patients COVID-19 symptoms Donor donors Efficacy evaluate followed by glycoprotein HCWs Health care Health care worker health care workers highest highlight HIV-1 hospitalized patients human antibody response ICU ICU Patients individual individuals intensive care intensive care unit intron lentiviral lentivirus Neutralization assay neutralizing antibody Neutralizing antibody titer neutralizing antibody titers Patient phenotypic phenotypic variation pseudotype pseudotyped Rapid reporter SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 spike SARS-CoV-2 strain secreted serological survey Serological surveys serum the SARS-CoV-2 Treatment Variation Virus neutralization was used
[DOI] 10.1172/jci.insight.143213 PMC 바로가기 [Article Type] Technical Advance

Early indicators of intensive care unit bed requirement during the COVID-19 epidemic: A retrospective study in Ile-de-France region, France

Research Article

Published on 2020-11-182022-10-28
Journal: PLoS ONE [Category] COVID-19, MERS,

Prognostic Assessment of COVID-19 in the Intensive Care Unit by Machine Learning Methods: Model Development and Validation

Original Paper

Published on 2020-11-112022-10-30
Journal: Journal of Medical Internet Research [Category] COVID-19,

[키워드] actual risk addition Additive administer albumin Algorithm Algorithms Analysis assessment AUC calculator can be used characteristic Conventional Correlation analysis COVID-19 COVID-19 prognosis creatinine cross database death death prediction model development eosinophil explanation Factor Factor analysis Gradient high mortality rate Hill ICU ICU patient ICU Patients intensive care intensive care unit Interpretation lactate dehydrogenase LIME Logistic regression lymphocyte machine learning machine learning algorithm machine learning model Model Mortality neutrophil objective outcome patients with COVID-19 performed potential risk predict predicted Prognosis prognosis of patient Prothrombin time randomly divided recorded reliability Result risk risk factor risk of death selected SHAP Significance stability total bilirubin training data translated Treatment validation was measured were used with COVID-19
[DOI] 10.2196/23128 PMC 바로가기 [Article Type] Original Paper

Clinical course and treatment efficacy of COVID-19 near Hubei Province, China: A multicentre, retrospective study

중국 후베이성 인근 코로나19의 임상 경과 및 치료 효능: 다기관, 후향적 연구

Multicenter Study

Published on 2020-11-012022-09-11
Journal: Transboundary and emerging diseases [Category] SARS, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus analysed Anti-viral anti-viral agent anti-viral efficacy Anti-viral therapy benefit China clinical Clinical course clinical courses clinical outcomes Combination concerning coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) country Course COVID-19 COVID-19 patient current died effective Efficacy enrolled Epidemiology expand fatality Fever Henan Province hospital ICU ICU patient ICU Patients Infection intensive care intensive care unit knowledge males management median median age multicentre Newborn non-ICU non-ICU patient non-ICU patients Non-survivors occurred outbreak outcome Pneumonia pregnant Premature reported required respiratory Retrospective study SARS-CoV-2 SARS-CoV-2 clearance SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Shaanxi Province subgroups of patients the epidemic the median the SARS-CoV-2 Treatment Vaccine Viral viral shedding was performed
[DOI] 10.1111/tbed.13674 PMC 바로가기 [Article Type] Multicenter Study

Safety and efficacy of antiviral combination therapy in symptomatic patients of Covid-19 infection – a randomised controlled trial (SEV-COVID Trial): A structured summary of a study protocol for a randomized controlled trial

Letter

Published on 2020-10-202022-10-29
Journal: Trials [Category] COVID-19, MERS, SARS,

[키워드] 1:1 2019-nCoV allergic Antipyretic Antiretroviral therapy Antiviral Arm as required assigned Breastfeeding Care categories cause clinical combination therapy compassionate use cough country COVID-19 COVID-19 infection criteria death defined described discharged disease dissemination drug Efficacy element eligibility criteria enrolled enrolment Etiquette exclusion criteria exploratory female Fever Frequency H1N1 hand hygiene Hydration Hydroxychloroquine ICU Patients inclusion criteria India Infection infection with SARS-CoV-2 investigator Laboratory Loading dose Lopinavir/ritonavir Lopinavir/Ritonavir combination mechanical ventilation medication Mortality non-ICU non-invasive ventilation Non-severe case Normalisation number nutrition objective off-label organ oxygen saturation paO2/fiO2 participant Participants Patient pharmacotherapy Placebo positive Precaution progression protocol QT prolongation randomisation randomised randomised controlled trial randomization Randomized controlled trial Randomly receipt recruitment regimen Registration registry replaced required Research respiratory rate ribavirin RT-PCR Safety Sample size SARS-CoV-2 RT-PCR screened secondary secure Serious Adverse Event Severe COVID-19 Infection Severe patient severity specimen Standard standard treatment status stratified study period Study protocol supplemental oxygen Support Suppressant surgical sustained symptomatic patient Tablet tested the patient therapeutic intervention therapy time time to defervescence treated Treatment treatment arm treatment group Trial upper respiratory tract Vasopressor Ventilation ventilator wear website
[DOI] 10.1186/s13063-020-04774-5 PMC 바로가기 [Article Type] Letter