IL-2 – Page 13 – Communicable Diseases Research

Early Differences in Cytokine Production by Severity of Coronavirus Disease 2019

Article

Published on 2021-04-012023-06-16
Journal: The Journal of Infectious Diseases [Category] MERS, SARS,

Repurposing approved drugs for cancer therapy

암 치료를 위해 승인된 약물의 용도 변경

Review

Published on 2021-03-252022-08-31
Journal: British medical bulletin [Category] 신약개발, 유전자 메커니즘,

[키워드] Abivertinib activities adverse event adverse events alterations anti-inflammatory compounds approved approved drug approved drugs Area Better can be used can not Cancer Cancer therapy chemotherapeutics Chemotherapy chromosome clinical trial clinical trials Covid-19 adjuvant treatments cytokine Cytokine storm Cytokines cytotoxicity diabete diabetes drug drug activity drug combinations drugs ENhance ER stress growth help IFN IL-2 IL-6 indication induce Inflammation inhibitor inhibitors interferon interferons interferons (IFN) interleukin interleukin-2 interleukin-2 (IL-2) interleukin-6 Kinase inhibitor kinase inhibitors knowledge limit literature mechanism metabolism metformin Mutation mutation rate Mutation rates Necrosis Patient proteolysis proteosome inhibitors receptor inhibitors reducing repurposing Side effect Side effects Symptom target gene thalidomide TNF treat Treatment Tumor tumor cell tumor cells tumor necrosis tumor necrosis factor tumor necrosis factor (TNF) tumorigenesis tumors tyrosine tyrosine kinase inhibitor unfolded protein response unfolded protein response (UPR). UPR
[DOI] 10.1093/bmb/ldaa045 PMC 바로가기 [Article Type] Review

Association and Interaction Between Serum Interleukin-6 Levels and Metabolic Dysfunction-Associated Fatty Liver Disease in Patients With Severe Coronavirus Disease 2019

Endocrinology

Published on 2021-03-082022-10-31
Journal: Frontiers in Endocrinology [Category] COVID-19, MERS, SARS,

SARS-CoV-2 Causes a Different Cytokine Response Compared to Other Cytokine Storm-Causing Respiratory Viruses in Severely Ill Patients

Immunology

Published on 2021-03-012022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] activate adaptive alleviate analyzed cause caused collected conserved contributing to coronavirus Coronavirus 2019 COVID-19 COVID-19 cases CRS cytokine cytokine level Cytokine release syndrome cytokine response Cytokine storm different disease downstream dysregulation evaluate exacerbated Factor H5N1 H7N9 help highlight identify IFN IL-10 IL-2 IL-4 IL-5 Ill Immune cell indicate induce Infection Inflammation Influenza influenza A interferon Intervention literature analysis MERS- and SARS-CoV MERS-CoV Mortality occur Other other coronavirus outbreak Patient patient data prevalent pro-inflammatory cytokines producing respiratory respiratory viruses response SARS-CoV SARS-CoV-2 SARS-CoV-2 pandemic subgroup of patients systematic review the SARS-CoV-2 unique viral pathogen virus viruses
[DOI] 10.3389/fimmu.2021.629193 PMC 바로가기 [Article Type] Immunology

T-Helper Cell Subset Response Is a Determining Factor in COVID-19 Progression

Observational Study

Published on 2021-02-262022-10-04
Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, 임상,

[키워드] accompanied activated acute COVID-19 acute phase analyzed association AUC Cell controls COVID-19 COVID-19 patient Cytokines death Department Determining Diagnosis died Disease progression elevated evaluated Factor flow cytometer Follow-up group groups hospital IL-10 IL-13 IL-15 IL-2 IL-6 immune response Immunity independent risk factor infections IP-10 lymphocyte Medicine organized outcome Patient percentage Phenotypes pro-inflammatory Prognosis Prospective Study recruited reduction response SARS-CoV2 senescent serum cytokine shown significant difference significantly higher T-helper Th2 Th2 cell Th2 response the disease the patient those who survived viral infection was obtained
[DOI] 10.3389/fcimb.2021.624483 PMC 바로가기 [Article Type] Observational Study

Comorbidities and inflammation associated with ovarian cancer and its influence on SARS-CoV-2 infection

난소암과 관련된 동반 질환 및 염증 및 SARS-CoV-2 감염에 대한 영향

Review

Published on 2021-02-252022-09-12
Journal: Journal of Ovarian Research [Category] MERS, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age aldosterone among others androgen angiotensin Cancer patients caused cellular Characteristics chemokine chemokines chronic inflammation colony-stimulating factor comorbid condition comorbid conditions Comorbidities Comorbidity condition contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 symptoms Cytokines death develop disease dysregulated early stage G-CSF gonadotropin granulocyte granulocyte colony-stimulating factor greater Hormones Hospitalization hospitalizations IL-10 IL-2 IL-6 Immunocompromised Increased Infection Inflammation Inflammatory cytokine Inflammatory cytokines interferon involved IP-10 M-CSF Macrophage macrophage colony-stimulating factor MCP-1 mechanism microenvironment molecular monocyte monocyte chemoattractant protein-1 Necrosis organs outcome ovarian cancer Pathogenesis Patient pro-inflammatory Protein public health RAAS Renin renin-angiotensin-aldosterone system risk risk factor SARS-CoV-2 SARS-COV-2 infection sera Severe case severe cases significantly subject TNF-α Tumor tumor necrosis tumor necrosis factor tumor necrosis factor α upregulation vulnerable population women
[DOI] 10.1186/s13048-021-00787-z PMC 바로가기 [Article Type] Review

The Rheumatology Drugs for COVID-19 Management: Which and When?

Review

Published on 2021-02-162022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

Localized and Systemic Immune Responses against SARS-CoV-2 Following Mucosal Immunization

Article

Published on 2021-02-062022-10-28
Journal: Vaccines [Category] COVID-19,

Human Dental Pulp Stem Cells Modulate Cytokine Production in vitro by Peripheral Blood Mononuclear Cells From Coronavirus Disease 2019 Patients

Cell and Developmental Biology

Published on 2021-02-052022-10-31
Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19,

[키워드] activated acute respiratory syndrome co-culture Concentration conditions Contact coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients cytokine dental dental pulp stem cells deregulated DPSC DPSCs form GM-CSF granulocyte healthy subject Human hyper-inflammation IFNγ IL-10 IL-12 IL-13 IL-17A IL-18 IL-1β IL-2 IL-21 IL-22 IL-23 IL-27 IL-4 IL-5 IL-6 IL-9 immune response immunomodulation in vitro interleukin investigated Macrophage mechanism mesenchymal stem cell Mesenchymal stem cells modulate modulation mononuclear cell MSC MSCs Multi-organ damage not affected Patient PBMC PBMCs peripheral Peripheral blood Pneumonia Production promote Pulp Real-time PCR Result SARS-CoV-2 STEM stem cell subset supernatant tissue regeneration TNFα
[DOI] 10.3389/fcell.2020.609204 PMC 바로가기 [Article Type] Cell and Developmental Biology

Calming the Storm: Natural Immunosuppressants as Adjuvants to Target the Cytokine Storm in COVID-19

Pharmacology

Published on 2021-01-272022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] absence adjuvant alleviate Antiviral antiviral agent approach ARDS can be used caused chemokine chemokines Combination compounds Consequences COVID-19 COVID-19 pandemic CXCL8 cytokine Cytokine storm disease drug effective G-CSF GM-CSF Health HGF IL-10 IL-12 IL-13 IL-17 IL-1β IL-2 IL-4 IL-6 IL-7 IL-9 immune response Immunomodulatory agents Immunopathogenesis Immunosuppressant individual Infection inhibit inhibitory effect involved IP10 JAK/STAT Luteolin MCP1 morbidity and mortality natural NF-κB pathway Patient piperine plant-derived immunosuppressants Prevent pro-inflammatory cytokine resveratrol SARS-COV-2 infection Sepsis serious complication storm subsequent synergistic target targeting the cytokine storm the SARS-CoV-2 TNFα treat treating COVID-19 Treatment Vaccine while
[DOI] 10.3389/fphar.2020.583777 PMC 바로가기 [Article Type] Pharmacology