innate immune system – Page 13 – Communicable Diseases Research

Sex differences in COVID-19: candidate pathways, genetics of ACE2, and sex hormones

COVID-19의 성별 차이: 후보 경로, ACE2의 유전학 및 성 호르몬

Review

Published on 2021-01-012022-09-11
Journal: American journal of physiology. Heart and circulat [Category] SARS, 유전자 메커니즘,

Deaminase-Independent Mode of Antiretroviral Action in Human and Mouse APOBEC3 Proteins

Review

Published on 2020-12-122022-10-29
Journal: Microorganisms [Category] COVID-19,

Lactoferrin and Its Derived Peptides: An Alternative for Combating Virulence Mechanisms Developed by Pathogens

Review

Published on 2020-12-082022-10-30
Journal: Molecules [Category] COVID-19,

[키워드] acidic conditions addition Anti-inflammatory antibiotic antimicrobial antiviral drugs Bacteria binding Cancer cationic caused cell proliferation cell receptor colostrum develop Developed digestive disease Effect evaluate facilitate Factor fungi glycoprotein Granule growth Host immune immunoregulatory effects IMPROVE infect Infection inhibit innate immune system Interaction Invasion Ion lactoferricins lactoferrin leukocytes mammal mechanism membrane microbial mitochondrial multidrug-resistant multifunctional N-terminus parental pathogen pathogenic pathogenic bacteria pathogenicity mechanisms Pathogens peptide polymorphonuclear Prevent produced promote protease Protozoa provide Regulated cell death reported reproductive shown stimulate synergistic synthetic target toxins Treatment viral entry Viral particles virulence virulence factors virus
[DOI] 10.3390/molecules25245763 PMC 바로가기 [Article Type] Review

Novel Molecular Evidence Related to COVID-19 in Patients with Diabetes Mellitus

Review

Published on 2020-12-072022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

[키워드] ACE2 acute respiratory syndrome affected aggravate angiotensin-converting enzyme 2 anti-inflammatory effect Asymptomatic COVID-19 Autoimmune benefit binding caused Cell cleavage clinical trial coronavirus Coronavirus disease 2019 COVID-19 COVID-19 progression cytosolic Diabetes Mellitus Dipeptidyl peptidase-4 Effectiveness Evidence exhibit facilitate furin global pandemic glycemic control glycosylation Hospitalization human Angiotensin-converting enzyme hyperglycemia immune response induce inhibitor Injury innate immune system Innate immunity Lactate lower mortality medication metabolites Mild novel outcomes pancreatic Patient patients with diabete pro-inflammatory cytokine protective effect Randomized receptor reduction in renin–angiotensin–aldosterone system S protein SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome coronavirus 2 susceptibility targets Th1 Th2 immunity the S protein TMPRSS2 transmembrane serine protease Treatment Trigger uncontrolled vicious cycle viral entry viral genome viral S protein
[DOI] 10.3390/jcm9123962 PMC 바로가기 [Article Type] Review

Antagonism of Type I Interferon by Severe Acute Respiratory Syndrome Coronavirus 2

중증급성호흡기증후군 코로나바이러스 2에 의한 I형 인터페론의 길항작용

Review

Published on 2020-12-012022-09-11
Journal: Journal of interferon & cytokine research : the of [Category] SARS, 변종, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antagonism Antiviral caused coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 early stage eliminating evade facilitate Host Host immune response IFN-I immune immune evasion Infection innate immune response innate immune system interferon knowledge molecular mechanism molecular mechanisms pandemic Pathogenesis Prevent provided respiratory responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins severe acute respiratory syndrome Coronavirus Signaling Transmission Type type I interferon Vaccine Viral viral replication virus
[DOI] 10.1089/jir.2020.0214 PMC 바로가기 [Article Type] Review

Interferon‐stimulated gene products as regulators of central carbon metabolism

Viewpoint

Published on 2020-12-012022-10-31
Journal: The Febs Journal [Category] Coronavirus, MERS, SARS,

Immunological imprint of COVID‐19 on human peripheral blood leukocyte populations

인간 말초 혈액 백혈구 개체군에 대한 COVID-19의 면역학적 각인

Original Article

Published on 2020-11-222022-09-01
Journal: Allergy [Category] SARS, 진단, 치료법,

[키워드] activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive addition antibody antibody levels B cells CD25 CD3 CD31 CD38 CD4 CD45 CD45RA CD8 Cell cells cellular Cellular immune response cellular immune responses central memory clinical immunology Cohort convalescent patient Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID‐19 COVID‐19 patient COVID‐19 patients determined by disease domain effector memory elevated ELISA expression flow cytometry FOXP3 healthy control HLA‐DR immune responses immune system immunological immunological change immunological changes immunosorbent Infection infections innate immune system investigated leukocyte population Lymphocytes Mild Mild disease multiparametric flow cytometry neutrophil Neutrophils nucleocapsid pandemic parameters Patient patients Peripheral blood qPCR Quantitative quantitative PCR RBD receptor receptor‐binding domain Recombination reduction reflected regression analysis respiratory responses Result SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‑CoV2 SARS‐CoV‐2 sense sense of taste severe acute respiratory syndrome Coronavirus significantly Spike protein subject T cell T cells T regulatory cell T regulatory cells T‐cell Taste thymic emigrant thymic emigrants transitional B cell transitional B cells triggered Viral
[DOI] 10.1111/all.14647 PMC 바로가기 [Article Type] Original Article

Exposome and Immunity Training: How Pathogen Exposure Order Influences Innate Immune Cell Lineage Commitment and Function

Review

Published on 2020-11-112022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS,

[키워드] Activation adaptive Alter antigen exposure caused Cell change characteristic commitment COVID-19 Critical cumulative deleterious effect dendritic cells disease DNA methylation dose Effect environmental exposure Epigenetic epigenetics exposome exposure function genetics Health Histone modification Host identify immune immune responses Immunity immunomodulatory IMPROVE increasingly individual Infection inflammatory disease influence Innate innate immune innate immune system Innate immunity key factor Lineage macrophages mechanism memory Monocytes morbidity Mortality NK cells non-specific phenotype Prevent Prophylactic Protective provide Research response SARS-CoV-2 shown subsequent Tolerance trained immunity vaccination
[DOI] 10.3390/ijms21228462 PMC 바로가기 [Article Type] Review

SARS-CoV-2 and interferon blockade

Review

Published on 2020-11-092022-10-30
Journal: Molecular Medicine [Category] COVID-19, SARS,

[키워드] activate Activation Adaptive immune response block blockade Cytotoxic T cell effective Implications include innate immune system interferon Neutralizing antibodies Pathways reduce SARS-CoV-2 therapeutic viral infection
[DOI] 10.1186/s10020-020-00231-w PMC 바로가기 [Article Type] Review

1 H, 13 C, and 15 N backbone chemical shift assignments of coronavirus-2 non-structural protein Nsp10

Article

Published on 2020-11-072022-10-27
Journal: Biomolecular Nmr Assignments [Category] Coronavirus, COVID-19, SARS,