long-lasting – Page 13 – Communicable Diseases Research

SARS-CoV-2 immunity and functional recovery of COVID-19 patients 1-year after infection

SARS-CoV-2 감염 1년 후 COVID-19 환자의 면역 및 기능 회복

Clinical Trial

Published on 2021-10-132022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 변종, 임상, 진단, 치료기술, 치료제,

Extracellular pH, osmolarity, temperature and humidity could discourage SARS-CoV-2 cell docking and propagation via intercellular signaling pathways

Biochemistry

Published on 2021-10-112022-10-28
Journal: PeerJ [Category] COVID-19,

[키워드] addition approach biochemical evidence Cell clinical investigation clinical trials country COVID-19 pandemic COVID-19 vaccination COVID-19 vaccine Critical disease Diseases docking dose Economic medical device endpoints example Extracellular Factor Factors Frequency help high mutation rate highlight identify implication Infection intercellular Intervention long-lasting Malta osmolarity pandemic pathway Preventive therapy Proteases rapid increase Research SARS-CoV-2 SARS-CoV-2 cell sialic acid signaling pathway sodium Support temperature therapeutic intervention Treatment User-friendly therapy vaccination vaccination rate vascular permeability viral cell virus virus infection virus variant warm
[DOI] 10.7717/peerj.12227 PMC 바로가기 [Article Type] Biochemistry

Impaired function and delayed regeneration of dendritic cells in COVID-19

코로나19에서 손상된 수지상 세포의 기능 장애 및 재생 지연

Clinical Trial

Published on 2021-10-062022-09-10
Journal: PLoS Pathogens [Category] MERS, SARS, 바이오마커, 임상,

[키워드] accompanied activated acute illness acute phase adaptive Adaptive immune response adaptive immune responses alteration analyzed antibody antibody-secreting cells antiviral immunity Blood CD14 CD14+ cell CD14+ cells CD163 CD4 CD86 Cell cells circulating classical monocyte classical monocytes Clinical management consequence contribute correlated COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity DCs dendritic cell dendritic cells Depletion disease disease severity downregulation dysregulated dysregulated innate immune response expansion follicular Frequency functional healthy controls helper cells HLADR hospitalized COVID-19 patient Host immune response identify immune responses immunopathology Impaired impairment Increased Inflammatory response Inflammatory responses inhibitory innate immune response long-lasting manifestation Mild modulation monocyte monocyte subsets Monocytes naïve Patient PD-L1 persistent recognize reduced reduction regeneration SARS-COV-2 infection Secondary infection secondary infections severe disease stimulate subpopulation subset susceptibility systemic inflammation T cell T cells T follicular helper cells the disease therapy these cell These cells Trigger upregulation Viral viral infection viral infections
[DOI] 10.1371/journal.ppat.1009742 PMC 바로가기 [Article Type] Clinical Trial

Sustainability of a school-based health intervention for prevention of non-communicable diseases in marginalised communities: protocol for a mixed-methods cohort study

Public Health

Published on 2021-10-052022-10-28
Journal: BMJ Open [Category] Coronavirus, Fulltext, MERS, SARS,

[키워드] adoption Analysis approach association Bay benefit change children clinical assessments cohort study community child health condition conducted COVID-19 pandemic Data collection disease effective Effectiveness enrolled evaluate Evidence Frequency Health hypothesise include increased risk Intervention lack long-lasting maintenance Nelson Mandela Non-communicable disease non-communicable diseases outcome populations positive postintervention Prevalence Preventive medicine protocol public health Quantitative Questionnaires randomised controlled trial resource School South Africa Sports Medicine sustainability
[DOI] 10.1136/bmjopen-2020-047296 PMC 바로가기 [Article Type] Public Health

Mental health status and quality of life in close contacts of COVID-19 patients in the post-COVID-19 era: a comparative study

코로나19 이후 시대 코로나19 환자 밀접접촉자의 정신건강상태와 삶의 질: 비교연구

Article

Published on 2021-10-022022-09-10
Journal: Translational Psychiatry [Category] MERS, SARS, 치료기술,

[키워드] age Analysis Analysis of covariance checklist close contact Contact covariance COVID-19 COVID-19 patient cross-sectional cross-sectional study demographic demographic data Depression depressive Depressive symptoms determine distress Early detection Effect Effects examined fatigue group groups Health Organization Health status independent Intervention life long-lasting media mental health multiple logistic regression no significant differences Perception performed PHQ-9 Post-traumatic stress disorder post-traumatic stress symptom Post-traumatic stress symptoms provided Psychiatric disorders Quality Quality of life reported Scientific community severe depression significant difference significantly significantly more traumatic stress symptoms was used were assessed with COVID-19 World Health Organization
[DOI] 10.1038/s41398-021-01623-0 PMC 바로가기 [Article Type] Article

Current scenario of COVID-19 vaccinations and immune response along with antibody titer in vaccinated inhabitants of different countries

다른 국가의 예방 접종을받은 주민의 항체 역가와 함께 COVID-19 예방 접종 및 면역 반응의 현재 시나리오

Review

Published on 2021-10-012022-09-11
Journal: International immunopharmacology [Category] SARS, 변종,

[키워드] Adaptive immunity addition addressed Antibody titer approach cellular Cellular and humoral responses cellular immunity Clinical management clinical trial Combination country COVID-19 COVID-19 pandemic COVID-19 vaccination Critical current generate Humoral response immune immune response immune responses Immunity inactivated induce Infection long-lasting neutralization Neutralizing antibodies nucleic acid overcome pathogenicity peptide phase 4 Population proportion response rising Safe Safety assessment SARS-CoV-2 SARS-CoV-2 variants Spread Trial vaccination Vaccine vaccine candidates Vaccine development Vaccine-induced immunity Vaccines variant variants variants of SARS-CoV-2 virus virus-neutralizing antibodies virus-neutralizing antibody
[DOI] 10.1016/j.intimp.2021.108050 PMC 바로가기 [Article Type] Review

Exosome-mediated mRNA delivery in vivo is safe and can be used to induce SARS-CoV-2 immunity

Research Article

Published on 2021-10-012022-10-30
Journal: The Journal of Biological Chemistry [Category] COVID-19, SARS,

[키워드] ACE2, angiotensin-converting enzyme II adverse effect antibody approach BCA, bicinchoninic acid BLI, bioluminescent imaging can be used Cationic lipid CDM, chemically defined media Cell cellular characterized COVID19 CTCS, clarified tissue culture supernatant CVS, concentrated vesicle suspension DOPE, dioleoyl phosphatidylethanolamine dose DOTAP, dioleoyl-3-trimethylammonium propane DTZ, diphenylterazine elicited encapsulation ER, endoplasmic reticulum EV, extracellular vesicle Evidence Exosome Exosomes Extracellular vesicles form functional had no human cell Humoral response HUVEC, human umbilical vein endothelial cell immunogenic induce injection Lipid nanoparticle lipofection LNP LNP, Lipid Nanoparticle long-lasting luciferase expression mice mRNA NTA, nanoparticle tracking analysis nucleocapsid ORF, open reading frame pfPBS, particle-free PBS previous study Protein repeated responses Safe SARS-CoV-2 immunity SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SEC, size-exclusion chromatography Skeletal muscle spike sustained T-cell tested the SARS-CoV-2 tissue Toxicity vitreous fluid
[DOI] 10.1016/j.jbc.2021.101266 PMC 바로가기 [Article Type] Research Article

Leveraging publicly available coronavirus data to identify new therapeutic targets for COVID-19

COVID-19에 대한 새로운 치료 목표를 식별하기 위해 공개적으로 사용 가능한 코로나 바이러스 데이터를 활용

Research Article

Published on 2021-09-292022-09-10
Journal: PLoS ONE [Category] MERS, SARS, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Analysis Antiviral Asymptomatic Bioinformatic bioinformatic analysis Brain coronavirus Coronavirus-2 COVID-19 dataset disease disease susceptibility dysfunction Effects Evidence evidence of facilitate Factor Gut heart Host identify immune immune surveillance include individuals Innate immunity interferon liver long-lasting Loss of Smell lung mechanism MERS-CoV outbreak promotion question representing respiratory responsible SARS-CoV-1 SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus subversion Surveillance susceptibility therapeutic target Variability Vascular Viral viral pathogen viral replication
[DOI] 10.1371/journal.pone.0257965 PMC 바로가기 [Article Type] Research Article

Retinal vessels modifications in acute and post-COVID-19

Article

Published on 2021-09-292022-10-29
Journal: Scientific Reports [Category] COVID-19, SARS,

Molecular Insights into SARS-CoV2-Induced Alterations of the Gut/Brain Axis

장/뇌 축의 SARS-CoV2 유발 변형에 대한 분자적 통찰력

Article

Published on 2021-09-282022-09-12
Journal: International Journal of Molecular Sciences [Category] SARS, 진단,

[키워드] Absorption ACE2 alteration alterations Amino acid amino acids Analysis angiotensin axis Brain cells chronic infection co-expression coding cognitive COVID COVID-19 DDC develop disorder disorders dopa Dopamine Enterocyte enterocytes enzyme Express expression expression level extreme fatigue highest host receptor Inflammation insight Intestinal Organoids involved L-DOPA Long COVID long-lasting metabolic pathway metabolism monoamine oxidase Neuropsychiatric Neurotransmitters Neutral pathway Patient performed precursor precursors reported responsible RNA-seq data SARS-CoV2 small intestine Symptom tissue tissues trace amines
[DOI] 10.3390/ijms221910440 PMC 바로가기 [Article Type] Article