Integrating longitudinal clinical laboratory tests with targeted proteomic and transcriptomic analyses reveal the landscape of host responses in COVID-19Article Published on 2021-06-082022-10-04 Journal: Cell Discovery [Category] 바이오마커, 변종, 진단, 치료제, [키워드] addition alveolar epithelial cells Alveolar macrophages Analysis blood cell bronchoalveolar cause Cell signalling characterized conditions coronavirus disease Course COVID-19 cytokine diagnostics Disease progression elevated events Factor gene regulatory network host response host responses immunology indicate Integrative analysis Laboratory test Laboratory tests lung lymphocytopenia microenvironment monocyte organ pathophysiology Patient Peripheral blood proteomes proteomic proteomics provide Shanghai systemic immune response therapy Transcriptome transcriptomic [DOI] 10.1038/s41421-021-00274-1 PMC 바로가기 [Article Type] Article
Detection of differentially abundant cell subpopulations in scRNA-seq datascRNA-seq 데이터에서 차등적으로 풍부한 세포 하위 집단의 검출Article Published on 2021-06-012022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] Analysis approach brain tissue Cell cell subpopulation cell type Cluster Clustering Clusters comparison Comprehensive Computational approaches COVID-19 patients current described detect detection distribution embryonic embryonic development healthy highlight immune individuals initial Local local differential abundance Melanoma neighboring cell phenotype Phenotypes Responder responders reveal RNA-Seq scRNA-seq scRNA-seq data scRNA-seq dataset scRNA-seq datasets Single Cell Single-cell RNA sequencing subpopulation therapy transcriptomic [DOI] 10.1073/pnas.2100293118 PMC 바로가기 [Article Type] Article
Fluoxetine as an anti-inflammatory therapy in SARS-CoV-2 infectionSARS-CoV-2 감염에서 항염증제로서의 FluoxetineArticle Published on 2021-06-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] SARS, 유전자 메커니즘, [키워드] activated acute respiratory syndrome acute respiratory syndrome coronavirus Admission Anti-inflammatory effects Anti-inflammatory therapy antidepressants Asthma B cell caused cell line cell lines Clinical outcome complex coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 Critical Cytokine IL6 Cytokine storm disease downstream drug Fluoxetine gp130 Hyperinflammatory response hyperinflammatory state identify IL6 IL6R IL6ST increase Infection Inflammation inflammatory pathways intensive care intensive care unit admission interact interleukin 6 knockdown mechanism Mortality NF-κB NFkB1 nuclear Nuclear factor kappa B subunit 1 Organ failure Patient potential therapy Protein receptor regulate respiratory SARS-CoV-2 SARS-COV-2 infection Selective serotonin reuptake inhibitors Sepsis Serotonin severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Signal transduction SSRIs subunit suppressed target gene transcription factor Transcription factor NF-κB. transcriptomic variety [DOI] 10.1016/j.biopha.2021.111437 PMC 바로가기 [Article Type] Article
Transcriptomic Signature Differences Between SARS-CoV-2 and Influenza Virus Infected PatientsSARS-CoV-2와 인플루엔자 바이러스 감염 환자 간의 전사 서명 차이Observational Study Published on 2021-05-312022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 임상, [키워드] adverse outcome adverse outcomes B cell blood cell Blood cells Cell cell cycle Complete Complication COVID-19 COVID-19 pathogenesis COVID-19 severity degranulation develop difference distress dramatic increase dysregulated dysregulation dysregulation of T cells Evidence feature gene expression pattern group healthy host response IFN immune profiling immune signature Immunoglobulin Increasing individuals individuals with COVID-19 infected individuals infected with SARS-CoV-2 Influenza influenza viruses involved life-threatening metabolism Neutrophils NK cells over-expression Patient provided reason reduction respiratory distress responses RNA-sequencing SARS-CoV-2 SARS-COV-2 infection severity signature Symptom T cells Toxicity transcriptomic transcriptomic profile transcriptomic profiles website whole blood transcriptome [DOI] 10.3389/fimmu.2021.666163 PMC 바로가기 [Article Type] Observational Study
Comparative Transcriptomic and Molecular Pathway Analyses of HL-CZ Human Pro-Monocytic Cells Expressing SARS-CoV-2 Spike S1, S2, NP, NSP15 and NSP16 GenesArticle Published on 2021-05-312022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] antigen processing arising binding bioinformatics cell line Comparative complex complications of COVID-19 contribute COVID-19 pandemic Critical disease down-regulated down-regulated gene down-regulation Endoplasmic reticulum endoribonuclease (NSP15) enrichment analysis expression facilitate global public health heart development Heat shock Host host gene Human Immunity insulin signaling pathway Interaction methyltransferase Methyltransferase (NSP16) nervous system neurodegeneration neutrophil degranulation Nucleocapsid (NP) nucleocapsid protein offer oxidative phosphorylation pathway phosphatidylinositol 3-kinase positive Protein Regulation response RNA sequencing RNA-sequencing S1 subunit S2 subunit SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 proteins SARS-CoV-2 virus Signaling signaling pathway spike Spike S1 Spike S2 Stress target host cell transcriptomic transcriptomic alteration up-regulated viral gene viral spike virus receptor [DOI] 10.3390/microorganisms9061193 PMC 바로가기 [Article Type] Article
Viral fibrotic scoring and drug screen based on MAPK activity uncovers EGFR as a key regulator of COVID-19 fibrosisMAPK 활성을 기반으로 한 바이러스성 섬유증 스코어링 및 약물 스크리닝은 COVID-19 섬유증의 주요 조절자로서 EGFR을 밝혀냅니다Article Published on 2021-05-272022-09-10 Journal: Scientific Reports [Category] 신약개발, 치료제, [키워드] ACE2 activity Analysis Antiviral antiviral activity approach Cell cell line Cell signalling Cluster cluster of gene complication of COVID-19 correlation COVID-19 COVID-19 progression COVID-19 research COVID-19 treatment Data mining Data processing downregulate drug Drug discovery dual EGF EGFR entry receptor epidermal epidermal growth factor ErbB ERK fibrosis growth factor Host Idiopathic pulmonary fibrosis imaging in vitro infected cells inhibitor inhibitors involved lung cells machine learning MAPK molecular basis Patient phenotype predicted provide pulmonary fibrosis quantified responsible RNA-sequencing SARS-CoV-2 SARS-CoV-2-infected cell SARS-CoV-2-infected cells sequencing data Signaling the cells transcriptomic transcriptomic data Treatment understanding utility Virtual drug screening [DOI] 10.1038/s41598-021-90701-w PMC 바로가기 [Article Type] Article
Transcriptional Changes in CD16+ Monocytes May Contribute to the Pathogenesis of COVID-19CD16+ 단핵구의 전사 변화가 COVID-19의 발병에 기여할 수 있음Immunology Published on 2021-05-242022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] analyzed Antigen presentation apoptotic caused CD16 CD16+ CD16+ monocyte CD16+ monocytes Cell cell activation cell movement change changes in characterized contribute contributing to COVID-19 COVID-19 case COVID-19 cases COVID-19 pandemic death dysregulated dysregulated immune response elevated expressed expression function functions gene signatures Genes healthy individual healthy individuals host response immune cells infiltration Inflammation Inflammatory Inflammatory response Inflammatory responses innate immune cell Innate immune cells interferon interferon response involved MHC class mild case mild cases mitochondrial Monocytes Non-classical monocytes Pathogenesis PBMC people with COVID-19 phenotype RNA sequencing data SARS-CoV-2 Severe case severe cases severity severity of COVID-19 Single Cell Single-cell transcriptomics the disease These cells tissue repair tissues transcriptional change Transcriptional changes transcriptomic upregulated upregulation Viral viral infections [DOI] 10.3389/fimmu.2021.665773 PMC 바로가기 [Article Type] Immunology
Peripheral blood microRNAs and the COVID-19 patient: methodological considerations, technical challenges and practice points말초혈액 microRNA와 COVID-19 환자: 방법론적 고려사항, 기술적 과제 및 실천 포인트Review Published on 2021-05-012022-09-11 Journal: RNA Biology [Category] SARS, 바이오마커, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 addressed among others Analysis angiotensin Angiotensin-converting enzyme ARDS Biomarker biopsies Blood circulating circulating miRNA profile circulating miRNA profiles Clinical practice coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 emergency COVID-19 patients detection Early detection experimental design heparin infection with SARS-CoV-2 Interpretation liquid biopsy LMWH low molecular weight low molecular weight heparin management methodological Methods microRNA MicroRNAs miRNA miRNA signature miRNAs ncRNA noncoding RNA pandemic peripheral public health qPCR reproducibility respiratory respiratory distress resulting rigour robust RT-qPCR SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus transcriptomic translation variable [DOI] 10.1080/15476286.2021.1885188 PMC 바로가기 [Article Type] Review
Investigating Cellular Trajectories in the Severity of COVID-19 and Their Transcriptional Programs Using Machine Learning Approaches기계 학습 접근 방식을 사용하여 COVID-19의 심각도와 그 전사 프로그램의 세포 궤적 조사Article Published on 2021-04-242022-09-10 Journal: Genes [Category] MERS, 유전자 메커니즘, [키워드] Algorithm applied BALF Bronchoalveolar lavage fluid cellular change Complement pathway COVID-19 COVID-19 infection COVID-19 pathogenesis COVID-19 patient COVID-19 patients COVID-19 severity deep learning disease severity driver Drivers function functions GATA3 Gene Expression identify Infection machine learning machine learning algorithm Machine learning algorithms Macrophage macrophages marker mechanism MITF pathway Program RNA sequencing SARS-CoV-2 virus SARS-CoV-2 virus infection severity single cell RNA-seq single-cell Single-cell RNA sequencing T cells the disease the SARS-CoV-2 virus tissue Trajectories trajectory trajectory inference transcription factor transcription factors transcriptional transcriptomic virus infection [DOI] 10.3390/genes12050635 PMC 바로가기 [Article Type] Article
Evidence of a dysregulated vitamin D endocrine system in SARS-CoV-2 infected patient’s lung cellsSARS-CoV-2에 감염된 환자의 폐 세포에서 조절되지 않는 비타민 D 내분비계의 증거Article Published on 2021-04-212022-09-10 Journal: Scientific Reports [Category] MERS, 유전자 메커니즘, [키워드] affected Analysis applied BALF BALF cell BALF cells Bronchoalveolar lavage fluid Cell cell cycle cells computational approach Computational approaches conserved CYP27A1 cytokine signaling dataset differentially expressed differentially expressed gene Differentially expressed genes downregulated dysregulated eight elements Endocrine endocrine system Evidence evidence of Gene Expression Genes healthy individuals immune system indirect mechanism infected cells infected with SARS-CoV-2 Infection Interaction Level lung cell lung cells modulated motif NF-κB pathway Patient patients predicted provided receptor reduced Regulation retinoid SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cells Signaling status the cells transcriptomic transcriptomics Vitamin D vitamin D endocrine system Vitamin D receptor [DOI] 10.1038/s41598-021-87703-z PMC 바로가기 [Article Type] Article