Central and peripheral nervous system involvement by COVID-19: a systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findingsResearch Article Published on 2021-06-022022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, MERS, [키워드] Affect Analysis articles Brain Central and peripheral nervous system cerebrospinal fluid Cerebrospinal fluid findings Characteristics clinical manifestations Collaborative effort condition conducted COVID-19 described Electrophysiology ENhance Evidence excluded feature Frequency generate knowledge measure Measures mechanism mortality rate nervous system Neuroimaging neurological neurological impairment Neurological involvement neurological manifestation Neuropathology pathophysiologic pathophysiological mechanism pathophysiology Patient patients patients with COVID-19 Prevalence provided Registered Registration reported Result SARS-CoV-2 SARS-COV-2 infection structures subjects systematic review therapeutic translational [DOI] 10.1186/s12879-021-06185-6 PMC 바로가기 [Article Type] Research Article
A scheme for inferring viral-host associations based on codon usage patterns identifies the most affected signaling pathways during COVID-19코돈 사용 패턴을 기반으로 바이러스 숙주 연관을 추론하는 체계는 COVID-19 동안 가장 영향을 받는 신호 경로를 식별합니다Article Published on 2021-06-012022-09-11 Journal: Journal of biomedical informatics [Category] 신약개발, 유전자 메커니즘, [키워드] affected Analysis arsenic Arsenic trioxide association Bipartite graph Cell signaling centrality clinical trial codon codon usage Codon usage bias Codons correlated COVID-19 COVID-19 pathogenesis Dexamethasone disease pathogenesis drugs expression help Host host protein host proteins Hydroxychloroquine identify Infection Interaction interferon beta MAPK mechanism molecular mechanism multiple pathway multiple pathways network non-structural proteins Nsp3 observé organized pair Pathogenesis pathway Pathways performed PPI PPI network Protein Protein interaction network protein-protein interaction recent relative Relative synonymous codon usage. reveal Ritonavir SARS-COV-2 infection SARS-CoV-2 proteins signaling pathway similarity spike structural protein synonymous target the SARS-CoV-2 therapeutic target translational trioxide understanding Viral protein Viral proteins while [DOI] 10.1016/j.jbi.2021.103801 PMC 바로가기 [Article Type] Article
Predictive Markers of Immunogenicity and Efficacy for Human VaccinesReview Published on 2021-06-012022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acute respiratory syndrome adopted animal model applied approach coronavirus Data analysis develop Efficacy effort help high-throughput technologies Human human populations humans identifying immune immune signature Immunity immunogenicity in silico in vivo imaging increasingly machine learning malaria marker methodology Pandemics Pathogens preclinical models preclinical study Predictive predictive biomarkers Predictive model probe protective responses Research responses SARS-CoV-2 Systems biology systems immunology translational Tuberculosis unsupervised analyses vaccination Vaccination strategies Vaccine vaccine candidate vaccine signatures Vaccines Zika virus [DOI] 10.3390/vaccines9060579 PMC 바로가기 [Article Type] Review
COVID-19 epidemic strongly affected cancer research in Italy: a survey of the Italian Cancer Society (SIC)COVID-19 전염병은 이탈리아의 암 연구에 큰 영향을 미쳤습니다: 이탈리아 암 학회(SIC)의 설문 조사Article Published on 2021-06-012022-09-12 Journal: ESMO open [Category] MERS, SARS, 진단, [키워드] activity acute respiratory syndrome adopted affected Cancer cancer patient cancer research. Care Complete conducted coronavirus country COVID-19 COVID-19 epidemic COVID-19 pandemic COVID-19 testing defined emergency situation European help Infection involved Italian Italian regions Italy knowledge Laboratory lockdown many case material measure offered overcome pandemic persistence Research researcher Safe SARS-CoV-2 Society Stage translational [DOI] 10.1016/j.esmoop.2021.100165 PMC 바로가기 [Article Type] Article
Association between Interferon-Lambda-3 rs12979860, TLL1 rs17047200 and DDR1 rs4618569 Variant Polymorphisms with the Course and Outcome of SARS-CoV-2 PatientsSARS-CoV-2 환자의 경과 및 결과에 따른 Interferon-Lambda-3 rs12979860, TLL1 rs17047200 및 DDR1 rs4618569 변이 다형성 간의 연관성Article Published on 2021-05-282022-09-10 Journal: Genes [Category] SARS, 바이오마커, 변종, 진단, [키워드] A allele acute respiratory syndrome acute respiratory syndrome coronavirus allele allelic approach Clinical practice Comorbidities control group coronavirus correlated COVID-19 COVID-19 positive patient COVID-19 severity Critical CRP cytokine D-dimer DDR DDR1 dimer disease severity domain ferritin Genotype genotypes genotyping healthy control highest host response IFN-λ immune response incidence of COVID-19 Infection Inflammatory responses Innate immunity interferon Lambda LDH Mortality outcome patients polymorphism Polymorphisms presence of comorbidities probe Prognosis provide receptor respiratory respiratory viral infection respiratory viral infections SARS-CoV-2 serum severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significant difference significant differences single nucleotide SNP SNPs statistically significant difference TaqMan TaqMan probe tested the disease therapy TLL1 translational variant Variation Viral viral infections were assessed [DOI] 10.3390/genes12060830 PMC 바로가기 [Article Type] Article
Effects of potent neutralizing antibodies from convalescent plasma in patients hospitalized for severe SARS-CoV-2 infection중증 SARS-CoV-2 감염으로 입원한 환자에서 회복기 혈장의 강력한 중화항체 효과Randomized Controlled Trial Published on 2021-05-272022-08-13 Journal: Nature Communications [Category] SARS, 바이오마커, 임상, 진단, 치료기술, 치료법, 치료제, [키워드] approach autologous humoral response benefit clinical benefit comparable convalescent plasma Course COVID-19 COVID-19 patient COVID-19 patients Cytokines decision disease course donors drug Effect ENhance focus Hospital admission hospitalized COVID-19 patient Immunological response IMPROVE Infection majority neutralizing antibody neutralizing SARS-CoV-2 antibodies neutralizing SARS-CoV-2 antibody no effect Patient patients hospitalized plasma proinflammatory cytokines randomized clinical trial respiratory respiratory tract Safe SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection selected serum proinflammatory cytokine serum proinflammatory cytokines severe SARS-CoV-2 standard care survival the disease translational Translational research treat treated Treatment treatment for COVID-19 Trial Viral viral clearance viral infection Virological virological and immunological responses [DOI] 10.1038/s41467-021-23469-2 PMC 바로가기 [Article Type] Randomized Controlled Trial
Lower Gene Expression of Angiotensin Converting Enzyme 2 Receptor in Lung Tissues of Smokers with COVID-19 PneumoniaCOVID-19 폐렴이 있는 흡연자의 폐 조직에서 안지오텐신 전환 효소 2 수용체의 낮은 유전자 발현Article Published on 2021-05-262022-09-01 Journal: Biomolecules [Category] SARS, 진단, [키워드] ACE-2 acute respiratory syndrome age angiotensin Angiotensin converting enzyme receptor Angiotensin-converting enzyme aspect Autopsies Bayesian biological interaction case sery cell entry receptor Chain Reaction complex concerning coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 pneumonia Critical enzyme evaluated expression expressor focus Gender Gene Expression hypertension Infection less Lower lung lung tissue lung tissue sample lung tissue samples mRNA expression observational study polymerase chain polymerase chain reaction prevalent real-time polymerase chain reaction respiratory retrospective risk factor SARS-CoV-2 SARS-CoV-2 genome Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 Severe COVID-19 pneumonia smoker Smokers smoking susceptibility susceptibility to infection translational Vascular injury Viral virus with COVID-19 [DOI] 10.3390/biom11060796 PMC 바로가기 [Article Type] Article
Uncertainty in the positioning of patients receiving treatment for brain metastases and wearing surgical mask underneath thermoplastic mask during COVID‐19 crisisCOVID-19 위기 동안 뇌전이 치료를 받고 열가소성 마스크 아래에 수술용 마스크를 착용하는 환자의 위치 불확실성87.55.%2212x Published on 2021-05-242022-09-10 Journal: Journal of Applied Clinical Medical Physics [Category] MERS, SARS, 치료기술, [키워드] absolute value absolute values beams Brain clinically couch COVID‐19 COVID‐19 database feasibility feasible image guidance immobilization investigated less longitudinal Masks MOST Patient patient positioning patient positioning error patients receiving treatment Radiotherapy reduce risk of infection roll Standard deviation stereotactic radiosurgery surgical surgical mask Thermoplastic Tolerance translational Uncertainty vertical [DOI] 10.1002/acm2.13279 PMC 바로가기 [Article Type] 87.55.%2212x
Noninvasive Measurement of Pulmonary Function in Experimental Mouse Models of Airway Disease기도 질환의 실험적 마우스 모델에서 폐 기능의 비침습적 측정Review Published on 2021-05-192022-09-12 Journal: Lung [Category] MERS, SARS, 진단, [키워드] airway Airway hyperresponsiveness allergic Allergic asthma animal models Asthma Compliance conscious disease function gold standard human airway in vivo include invasive Laboratory lung Lung function lung mechanics marker measurement mice Model mouse mouse model noninvasive parameter Pathogenesis performed provide provided pulmonary Pulmonary function Pulmonary function testing repeated required Research respiratory infection respiratory parameter SARS-CoV-2 sensitivity translational validation study [DOI] 10.1007/s00408-021-00443-9 PMC 바로가기 [Article Type] Review
Unconventional viral gene expression mechanisms as therapeutic targets Reviews Published on 2021-05-192022-10-05 Journal: Nature [Category] 치료제, [키워드] antiviral therapies coding Efficiency effort enzymatic activity enzyme Factor Genome Host Human genome mechanism Perspective protein expression provide regulatory sequences review targeting therapeutic target Transcription translation translational unique viral gene expression virus viruses [DOI] 10.1038/s41586-021-03511-5 [Article Type] Reviews