endothelial – Page 14 – Communicable Diseases Research

Endothelial Dysfunction through Oxidatively Generated Epigenetic Mark in Respiratory Viral Infections

Review

Published on 2021-11-072022-10-31
Journal: Cells [Category] COVID-19, SARS, 신종인플루엔자,

The Pathogenesis of COVID-19 Myocardial Injury: An Immunohistochemical Study of Postmortem Biopsies

Immunology

Published on 2021-11-052022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] acute phase Analysis Apoptosis apoptotic cell arrythmia Autopsy biopsy caspase-1 caspase-9 CD163 collagen control group controls COVID-19 COVID-19 patients COVID-19 sample died edema endothelial Endothelium expression fibrosis heart hearts histological ICAM-1 IHC IL-1β IL-4 IL-6 immunohistochemistry increased expression Injury interstitial invasive involved less local inflammation marker mast cell mechanism monoclonal antibody Mortality Myocardial Myocardial dysfunction myocardial injury Myocardium not differ objective Pathogenesis pathogenesis of COVID-19 pathology pathway Patient performed positive Postmortem rationale Result SARS-CoV-2 significantly staining Surveillance TGF-β TNF-α was performed
[DOI] 10.3389/fimmu.2021.748417 PMC 바로가기 [Article Type] Immunology

SARS-CoV-2 Spike Protein S1-Mediated Endothelial Injury and Pro-Inflammatory State Is Amplified by Dihydrotestosterone and Prevented by Mineralocorticoid Antagonism

Article

Published on 2021-11-032022-10-28
Journal: Viruses [Category] COVID-19, MERS, SARS,

[키워드] abrogated Activation acute respiratory syndrome Adhesion Molecule affected androgen androgen signaling angiotensin receptor blocker antagonism Cell circulating condition coronavirus Coronavirus-2 COVID-19 death defined diagnosed with COVID-19 Dihydrotestosterone E-selectin Effect endothelial Endothelial cell endothelial injury exacerbated exposure FDA-approved drug higher odd ICAM-1 in vitro Inflammatory cytokine marker men men and women Mineralocorticoid monocyte Necrosis patients hospitalized receptor reduced SARS-CoV-2 SARS-CoV-2 spike spike Spike protein spironolactone state tested therapeutic effect THP-1 TNF-α transcript Treatment vascular effect VCAM-1 were measured with COVID-19 women
[DOI] 10.3390/v13112209 PMC 바로가기 [Article Type] Article

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Encephalitis Is a Cytokine Release Syndrome: Evidences From Cerebrospinal Fluid Analyses

중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 뇌염은 사이토카인 방출 증후군입니다: 뇌척수액 분석의 증거

Article

Published on 2021-11-022022-09-12
Journal: Clinical Infectious Diseases: An Official Publicat [Category] MERS, SARS, 진단,

[키워드] Acidic Activation acute respiratory syndrome alteration Blood brain barrier cerebrospinal fluid coronavirus coronavirus 2 COVID-19 CSF CXCL13 Cytokine release syndrome Cytokine storm Cytokine storm syndrome cytokine-release syndrome dysfunction Encephalitis endothelial exhibited expressed GFAp healthy control ICANS IL-6 IL-8 Immune-mediated indicated Inflammatory Inflammatory biomarker investigated marker mechanism mechanisms myeloid cell Necrosis neurological manifestation neuronal Patient polymerase chain Protein Real-time PCR recent Release respiratory SARS-CoV-2 SARS-COV-2 infection Severe case severe cases soluble Triggering Receptor suggested TNF- α YKL-40
[DOI] 10.1093/cid/ciaa1933 PMC 바로가기 [Article Type] Article

Endothelial Dysfunction as a Component of Severe Acute Respiratory Syndrome Coronavirus 2-Related Multisystem Inflammatory Syndrome in Children With Shock

쇼크가 있는 어린이의 중증 급성 호흡기 증후군 코로나바이러스 2 관련 다기관 염증 증후군의 구성 요소로서의 내피 기능 장애

Observational Study

Published on 2021-11-012022-09-11
Journal: Critical Care Medicine [Category] SARS, 바이오마커, 임상,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus age angiopoietin Antigen cardiogenic Cardiogenic shock center children component Control coronavirus correlated correlations criteria disease control dysfunction Ejection fraction elevated endothelial Endothelial dysfunction hospital Inflammatory inotrope Inotropes interquartile range Lactate marker measurement mechanisms median observational study Plasma level Plasma levels prevention respiratory score selectin Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity Shock significantly Spearman coefficient syndrome the median troponin Vasoactive vasopressors ventricular ventricular ejection von Willebrand factor were assessed
[DOI] 10.1097/CCM.0000000000005093 PMC 바로가기 [Article Type] Observational Study

Hypoxia alters the expression of ACE2 and TMPRSS2 SARS-CoV-2 cell entry mediators in hCMEC/D3 brain endothelial cells

저산소증은 hCMEC/D3 뇌 내피 세포에서 ACE2 및 TMPRSS2 SARS-CoV-2 세포 진입 매개체의 발현을 변경합니다

Article

Published on 2021-11-012022-09-11
Journal: Microvascular research [Category] SARS, 유전자 메커니즘,

[키워드] accompanied ACE2 ACE2 mRNA acute respiratory syndrome coronavirus Alter angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 (ACE2) blood-brain barrier Blood-brain barrier (BBB) Blot Brain Cell cell entry changes in Control control group coronavirus 2 COVID19 decrease Effect endothelial Endothelial cell endothelial cell damage endothelial cells enzyme expression expression of SARS-CoV-2 Factor followed by groups Human Human brain Human cerebral microvascular endothelial cells (hCMEC/D3) hypoxia hypoxic hypoxic condition identify IL-6 in vitro induce interleukin interleukin 6 marker mechanism mRNA Neurological complication Neurological complications oxygen pro-inflammatory cytokine protease Protein protein expression qPCR receptor reduced regulate replicated respiratory SARS-CoV-2 SARS-CoV-2 cell SARS-COV-2 infection Serine serine 2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 subsequent susceptibility TMPRSS2 TMPRSS2 expression TMPRSS2 protein transmembrane transmembrane protease serine 2 transmembrane protease serine 2 (TMPRSS2) von Willebrand factor western blot
[DOI] 10.1016/j.mvr.2021.104232 PMC 바로가기 [Article Type] Article

The potential role of neopterin in Covid-19: a new perspective

Covid-19에서 네오프테린의 잠재적 역할: 새로운 관점

Review

Published on 2021-11-012022-09-11
Journal: Molecular and cellular biochemistry [Category] MERS, 바이오마커,

[키워드] Activation Adhesion Molecule adhesion molecules Anti-inflammatory antibody antioxidant effect antioxidant effects attenuate cellular Clinical symptoms compensatory mechanism complications COVID-19 patients COVID-19 severity Dyspnea endothelial feature foam cells Hospitalization hyper-inflammation immune activation immune response Incubation period independent INF-γ inflammasomes Inflammation interferon gamma Macrophage macrophage foam cell Macrophage stimulation macrophages macrophages activation marker mechanism member Migration monocyte Monocytes monocytes/macrophage Neopterin NF-κB NF-κB signaling NLRP3 organ damage oxidative stress Patient Perspective Prognostic factor Protective raise reflect SARS-COV-2 infection severity stimulated T helper Th1
[DOI] 10.1007/s11010-021-04232-z PMC 바로가기 [Article Type] Review

GDF15: an emerging modulator of immunity and a strategy in COVID-19 in association with iron metabolism

GDF15: 철 대사와 관련된 COVID-19의 면역 조절제 및 전략

Review

Published on 2021-11-012022-09-11
Journal: Trends in endocrinology and metabolism: TEM [Category] Coronavirus, SARS, 바이오마커, 신약개발, 치료법,

[키워드] ACE2 acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus alteration angiotensin appear association attachment cardiovascular diseases caused contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critically ill Cytokine storm death domain drug therapy ENCODE endothelial envelope enzyme expressed GDF15 growth host cell host cells Immunity increases in iron iron homeostasis Iron metabolism life cycle mediator membrane metabolism multiorgan failure nucleocapsid outcome pandemic Patient patients with COVID-19 progression of disease Proteins provide Receptor-binding domain respiratory distress Respiratory distress syndrome responsible SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 structural protein structural proteins subunit syndrome target TGF-β therapeutic therapy tissue tissue damage Tolerance transforming growth factor vascular dysfunction virus Virus life cycle with COVID-19
[DOI] 10.1016/j.tem.2021.08.011 PMC 바로가기 [Article Type] Review

Drug delivery systems as immunomodulators for therapy of infectious disease: Relevance to COVID-19

감염성 질환 치료를 위한 면역조절제로서의 약물 전달 시스템: COVID-19와 관련성

Review

Published on 2021-11-012022-09-11
Journal: Advanced drug delivery reviews [Category] MERS, 신약개발, 진단, 치료제,

[키워드] Activation adaptive approach approaches blocking agents cellular Coagulation complement complex complex interplay COVID-19 damage drug delivery system drug delivery systems endothelial Endothelium global pandemic identify immune Immune cell immune cells Immune suppression immunomodulator immunomodulatory IMPROVE improvement Inflammasome inflammasomes Inflammation Interaction involved limit moderate to severe molecular nanomedicine not limited outcome pathogen clearance pathology pathophysiology Patient patients with moderate Prognosis Relevance SARS-CoV-2 severe COVID-19 survival rates Therapeutic approach therapeutic approaches therapeutic option therapy tissue damage
[DOI] 10.1016/j.addr.2021.113848 PMC 바로가기 [Article Type] Review

Could Soluble Endothelial Protein C Receptor Levels Recognize SARS-CoV2-Positive Patients Requiring Hospitalization?

가용성 내피 단백질 C 수용체 수준이 입원이 필요한 SARS-CoV2-양성 환자를 인식할 수 있습니까?

Observational Study

Published on 2021-11-012022-09-11
Journal: Shock (Augusta, Ga.) [Category] MERS, SARS, 바이오마커, 임상,

[키워드] 95% CI activated activities activity Admission age an area Analysis Anti-inflammatory Anticoagulant APC BMI characteristic clinical impact Cohort contribute COVID-19 COVID-19 patient COVID-19 patients D-dimers elevated endothelial EPCR Factor Hospital admission Hospitalization hospitalized patient hospitalized patients identify inhibit investigated lead Level multiple logistic regression Multiple logistic regression analysis Outpatient outpatients Pathways Patient patients phenotype plasma point-of-care potential risk Predictive Predictive value prognostic Protein protein C receiver receiver operating characteristic receptor regulate reported ROC ROC Curve Symptoms was performed were measured
[DOI] 10.1097/SHK.0000000000001780 PMC 바로가기 [Article Type] Observational Study