1 H, 13 C, and 15 N backbone chemical shift assignments of coronavirus-2 non-structural protein Nsp10Article Published on 2020-11-072022-10-27 Journal: Biomolecular Nmr Assignments [Category] COVID-19, [키워드] backbone Coronavirus-2 COVID19-NMR drugs element ENCODE function genomic in viral innate immune system Interaction International involved Ligand methyltransferase molecular component NMR non-structural protein nsp14 Nsps PROTECT Protein Proteins Replication replication-transcription complex RNA RNA genome RNA-dependent RNA polymerase RTC SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 RNA Solution NMR-spectroscopy structural proteins Structure subgenomic RNAs transcriptional variety Via viral envelope viral life cycle Viral RNA virus [DOI] 10.1007/s12104-020-09984-1 PMC 바로가기 [Article Type] Article
A Novel Coronavirus Disease (COVID-19): a Review of Host Cell Signaling PathwaysReview Article Published on 2020-11-012022-10-28 Journal: Tanaffos [Category] COVID-19, [키워드] acute respiratory syndrome caused changes in coronavirus coronavirus disease CoV COVID-19 CoVs develop evaluate genetic variants Health Healthcare system Host host cell host cell factor host-pathogen interaction host-pathogen interactions Inflammation innate immune system Interaction lung Lung inflammation molecular novel pandemic persistence physician positive-sense progression proliferation promote recognize reduce review risk RNA viruses SARS-CoV-2 signaling pathway signaling pathways targeted therapy PMC 바로가기 [Article Type] Review Article
Can hyperbaric oxygen safely serve as an anti-inflammatory treatment for COVID-19?고압산소가 COVID-19의 항염증 치료제로 안전하게 사용될 수 있습니까?Article Published on 2020-11-012022-09-11 Journal: Medical Hypotheses [Category] 비임상, [키워드] activate acute respiratory distress acute respiratory distress syndrome Affect Anecdote anti-inflammatory treatment ARDS attenuation breath Can Case report change chemokines Clinical practice compassionate use consequence COVID-19 CT-scan cytokine Cytokines evaluated HBO Hypothesis hypoxia Inflammatory inflammatory cascade inflammatory condition inflammatory conditions Inflammatory response innate immune response innate immune system lung Mild symptom mild symptoms Organ failure oxygen Patient Pneumonitis Prevent Prospective clinical trial pulmonary CT randomized clinical trial reduce reduce mortality respiratory distress safe and reduce SARS-CoV-2 syndrome Tolerance treat Viral [DOI] 10.1016/j.mehy.2020.110224 PMC 바로가기 [Article Type] Article
Phosphatidylglycerol and surfactant: A potential treatment for COVID-19?Research article Published on 2020-11-012022-10-05 Journal: Medical Hypotheses [Category] 치료법, [키워드] Activation acute respiratory distress syndrome addition administration approved ARDSacute respiratory distress syndrome benefit cellular component concerning Critically ill patient damaged damaged cells DAMPdanger- or damage-associated molecular pattern danger- or damage-associated molecular pattern death decrease distress drug food Hypothesis ILInterleukin IMPROVE individual Infants Inflammation innate immune system interleukin limit lung Lung function Lung infection Lung pathology microbial mitigate Neonatal NFκBnuclear factor kappa-light-chain-enhancer of activated B cells non-infected cell nuclear factor kappa-light-chain-enhancer of activated B cells PAMPpathogen-associated molecular pattern pathogen-associated molecular pattern PGphosphatidylglycerol phosphatidylglycerol Potential treatment Protein Pulmonary edema reducing released secretory phospholipase A2 sPLA2secretory phospholipase A2 Spread suggested syndrome tension tested thought TLRToll-like receptor TNFαtumor necrosis factor-alpha Toll-like receptor treat Treatment tumor necrosis factor-alpha Type II pneumocyte utility viral infection with COVID-19 Work of breathing [DOI] 10.1016/j.mehy.2020.110277 [Article Type] Research article
Proteins associated with neutrophil degranulation are upregulated in nasopharyngeal swabs from SARS-CoV-2 patientsResearch Article Published on 2020-10-202022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome affected Analysis analyzed antimicrobial AZU1 cathepsin caused coronavirus coronavirus disease COVID-19 CTSG death degranulation differentially expressed disease pathology ELANE Elastase highlight Hospitalization identify Infection information Innate innate immune system Interaction molecular MPO Myeloblastin naso-oropharyngeal sample Nasopharyngeal swab NETosis neutrophil degranulation Non-invasive pathway patients PCR PCR positive PCR testing Protein Proteins proteomics provide PRTN3 Sample SARS-CoV-2 SARS-CoV-2 patient SARS-CoV-2 patients significantly statistically significant swab sample System TCN1 upregulated [DOI] 10.1371/journal.pone.0240012 PMC 바로가기 [Article Type] Research Article
Positive selection within the genomes of SARS-CoV-2 and other Coronaviruses independent of impact on protein functionBioinformatics Published on 2020-10-162022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] acute respiratory disease addition Affect changed changes in Characteristics COVID-19 Critical detect effort Evolution gene encoding genes encoding Genetic genetic code Genome genomes highlight highlighting Host humans identify in viral independent indicate innate immune system molecular Mutation nonsynonymous Novel coronavirus Perspective positive Positive selection Protein Region Result RNA molecules RNA stability SARS-CoV-2 spike synonymous target Test the SARS-CoV-2 genome Transcription translation unique viral life cycle [DOI] 10.7717/peerj.10234 PMC 바로가기 [Article Type] Bioinformatics
Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple FieldsMicrobiology Published on 2020-10-162022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] affecting AMP AMPs antimicrobial antimicrobial peptide antimicrobial peptides application Bacteria classification coronavirus COVID-19 COVID-19 pandemic design environmental factor field fungi inhibitory effect innate immune system introduced mechanism of action microorganism mode of action motifs Multiple Organisms parasite peptide peptides problem Progress Research use of antibiotics viruses [DOI] 10.3389/fmicb.2020.582779 PMC 바로가기 [Article Type] Microbiology
The bacillus Calmette–Guérin vaccination allows the innate immune system to provide protection from severe COVID-19 infection42 Published on 2020-10-132022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] Coronavirus, MERS, SARS, [키워드] innate immune system Severe COVID-19 Infection vaccination [DOI] 10.1073/pnas.2015234117 PMC 바로가기 [Article Type] 42
A “Window of Therapeutic Opportunity” for Anti-Cytokine Therapy in Patients With Coronavirus Disease 2019Immunology Published on 2020-10-062022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] adaptive administration affected anti-cytokine therapy benefit Case report coronavirus COVID-19 criteria cytokine Cytokine storm Effect effective Hyperactivation immune immune activation immune dysfunction Immunosuppressant immunosuppressive drug Infectious disease information innate and adaptive immune response innate immune system observational study offer Patient severe coronavirus disease T cell therapeutic tocilizumab (IL-6 inhibitor) viral burden viral damage [DOI] 10.3389/fimmu.2020.572635 PMC 바로가기 [Article Type] Immunology
Increased Complement Receptor-3 levels in monocytes and granulocytes distinguish COVID-19 patients with pneumonia from those with mild symptomsResearch article Published on 2020-10-012022-10-05 Journal: International Journal of Infectious Diseases [Category] SARS, 바이오마커, [키워드] analysed antibody panel Antigen approach Biomarker CD11b Cell circulating leukocyte clinically Complement receptor 3 count COVID-19 COVID-19 patient COVID-19 patients cytokine release develop diagnostic eight examined explain feature febrile fibrinogen finding flow cytometry granulocyte healthy volunteers hypoxia hypoxic Immunological memory Immunology and inflammation Increased infected individual Infection Inflammatory innate immune cell innate immune response innate immune system leukocyte leukocyte activation Level memory Mild symptom mild symptoms monocyte natural NK cell over-expression Patient patients with COVID-19 Pneumonia potential therapeutic target Rapid receptor remained required Respiratory complications Respiratory failure specimen subsequent Therapeutics thrombotic understanding Ventilated ventilatory support with COVID-19 [DOI] 10.1016/j.ijid.2020.08.004 [Article Type] Research article