interleukin-6 – Page 14 – Communicable Diseases Research

Impact of cytokine storm on severity of COVID-19 disease in a private hospital in West Jakarta prior to vaccination

백신 접종 전 서부 자카르타의 사립 병원에서 사이토카인 폭풍이 COVID-19 질병의 중증도에 미치는 영향

Research Article

Published on 2022-01-252022-09-12
Journal: PLoS ONE [Category] 진단,

Matrix metalloproteinases (MMP) 3 and 9 as biomarkers of severity in COVID-19 patients

COVID-19 환자의 중증도 바이오마커로서의 기질 금속단백분해효소(MMP) 3 및 9

Clinical Trial

Published on 2022-01-242022-09-10
Journal: Scientific Reports [Category] 바이오마커, 임상, 진단, 치료법,

[키워드] benefit Biomarker Biomarkers circulating neutrophil circulating neutrophils clinical heterogeneity contribute controls coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 severity disease severity Diseases Health Organization help Hospital admission Hospitalization hospitalized patient immunology inflammatory process interleukin-6 lung damage Lung inflammation matrix matrix metalloproteinases Medical research metalloproteinase MMP3 MMP9 molecular basis monocyte Monocytes myeloperoxidase Neutrophils no correlation occur pathogenic positively correlated Potential biomarker potential biomarkers predict progression Protein Proteins regeneration serum Serum level serum levels severe COVID-19 patient severe COVID-19 patients severe patients severity severity of COVID-19 significantly increased targeted therapy the WHO to define was increased was reduced WHO World Health Organization
[DOI] 10.1038/s41598-021-04677-8 PMC 바로가기 [Article Type] Clinical Trial

Lung Ultrasound Signs and Their Correlation With Clinical Symptoms in COVID-19 Pregnant Women: The “PINK-CO” Observational Study

Medicine

Published on 2022-01-212022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] acute respiratory syndrome Admission approach Biomarker C-reactive protein Characteristics clinical coronavirus correlated COVID-19 Department diagnosed diagnostic exposure help Infection initial interleukin-6 Italy lung Lung ultrasound lung ultrasound score (LUS) median objective Obstetric oxygen saturation pandemic participant Patient patients patients with COVID-19 pregnant women Registration Reporting Result Retrospective study reverse transcription-PCR RT-PCR SARS-CoV-2 SARS-COV-2 infection setting SIGN significantly single-center Swab test Symptom symptomatic and asymptomatic Ultrasound with COVID-19 women
[DOI] 10.3389/fmed.2021.768261 PMC 바로가기 [Article Type] Medicine

Cerebrospinal fluid findings in COVID-19: a multicenter study of 150 lumbar punctures in 127 patients

COVID-19의 뇌척수액 발견: 127명의 환자에서 150번의 요추 천자에 대한 다기관 연구

Multicenter Study

Published on 2022-01-202022-09-10
Journal: Journal of Neuroinflammation [Category] 바이오마커, 진단,

[키워드] absence ACD Analysis Antibody index autoantibodies autoantibody Blood-CSF barrier Central nervous system cerebrospinal cerebrospinal fluid Cerebrospinal fluid (CSF) characterized CNS CNS disorder complications of COVID-19 Comprehensive contribute Coronavirus disease 2019 (COVID-19) correlated COVID-19 CSF cytokine cytokine level cytokine levels Cytokines diagnostic Direct direct infection disease dysfunction elevated Encephalitis Encephalopathy endotheliopathy European Guillain–Barré syndrome IL-6 immune Infection Inflammation Inflammatory interleukin-6 Lactate Lumbar puncture lumbar punctures lymphoma median Meningitis multicenter multiple sclerosis neurological Neurological disorder Neurological disorders Neurological involvement Neurological symptom Neurological symptoms objective Oligoclonal bands Patient patients with COVID-19 persistent Polymerase chain reaction (PCR) positive Protein remained Result Retrospective analysis routine SARS-CoV-2 SARS-CoV-2 antibodies serum Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) subarachnoid hemorrhage supplementary material Symptom syndrome systemic inflammation tested total protein treatable was increased WCC white cell
[DOI] 10.1186/s12974-021-02339-0 PMC 바로가기 [Article Type] Multicenter Study

Arrhythmogenic mechanisms of interleukin-6 combination with hydroxychloroquine and azithromycin in inflammatory diseases

염증성 질환에서 하이드 록시 클로로 퀴인 및 아지트로 마이신과의 인터루킨 -6 조합의 부정맥 메커니즘

Article

Published on 2022-01-202022-09-01
Journal: Scientific Reports [Category] 진단, 치료제,

[키워드] Abnormalities abnormality action potential addition Administered analyzed arrhythmia Arrhythmias asystole Azithromycin bradycardia cardiac injury Cardiology caused characterized Combination COVID-19 Critical cytokine Cytokine storm disease drug drug combination Drug discovery Electrocardiograms electrocardiographic elevated examined greater HCQ heart rate Hydroxychloroquine IL-6 IL-6 receptor immunology In-vitro Inflammation inflammatory disease Inflammatory diseases Injury interleukin-6 management mechanism Medical research Mild mild to moderate moderate monoclonal antibody pharmacotherapy Physiology PIGS prolongation QTc QTC prolongation reducing reduction in risk selective selective inhibition TCZ therapy Tocilizumab
[DOI] 10.1038/s41598-022-04852-5 PMC 바로가기 [Article Type] Article

Understanding the Link Between Obesity and Severe COVID-19 Outcomes: Causal Mediation by Systemic Inflammatory Response

Observational Study

Published on 2022-01-182022-10-05
Journal: The Journal of Clinical Endocrinology and Metaboli [Category] 임상,

[키워드] 95% CI association Biomarker Biomarkers BMI C-reactive protein Care Causal causal pathway clinical trial Cohort Columbia University COVID-19 CRP D-dimer death erythrocyte sedimentation rate ESR evaluate evidence of ferritin finding greater Hospitalized Inflammation Inflammatory marker interleukin-6 Intervention likelihood Massachusetts General Hospital mechanical ventilation mediation Mediation analysis moderate MONITOR obese patients obesity outcomes pathway Patient patients peak inflammatory proportion replicated response Result risk factor SARS-CoV-2 SARS-CoV-2-infected patient severe COVID-19 severe COVID-19 disease severe disease subgroup Support supported systemic systemic inflammation systemic inflammatory therapeutic understanding Ventilation White blood cell York
[DOI] 10.1210/clinem/dgab629 PMC 바로가기 [Article Type] Observational Study

In Silico Studies on Psilocybin Drug Derivatives Against SARS-CoV-2 and Cytokine Storm of Human Interleukin-6 Receptor

SARS-CoV-2 및 인간 인터루킨-6 수용체의 사이토카인 폭풍에 대한 실로시빈 약물 유도체에 대한 실리코 연구

Immunology

Published on 2022-01-142022-09-11
Journal: Frontiers in Immunology [Category] SARS, 치료제,

An updated overview of recent advances, challenges, and clinical considerations of IL-6 signaling blockade in severe coronavirus disease 2019 (COVID-19)

Article

Published on 2022-01-112022-10-04
Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 임상,

[키워드] Abstract administration Anti-inflammatory approach ARDS blockade challenge chemokine Clinical data clinical trial combination therapy Concentration coronavirus disease-2019 COVID-19 Cytokine storm Cytokines dosage downstream drugs dysregulated immune response Efficacy explained Future Health hepatic injury highest Hyperinflammatory IL-6 IL-6 inhibitor IL-6 pathway IL-6 signaling IMPROVE interleukin-6 Jak-STAT Janus-kinase inhibitor lung damage membrane monotherapy non-specific Pathways pleiotropic pro-inflammatory progression pulmonary damage recent receptor reduce risk sarilumab severe coronavirus disease severe COVID-19 Side effect Signaling therapeutic approaches Tocilizumab Treatment
[DOI] 10.1016/j.intimp.2022.108536 PMC 바로가기 [Article Type] Article

Cytokine Hemoadsorption as Rescue Therapy for Critically Ill Patients With SARS-CoV-2 Pneumonia With Severe Respiratory Failure and Hypercytokinemia

Medicine

Published on 2022-01-102022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] “cytokine storm” acute respiratory distress syndrome (ARDS) All the patient analyzed benefit Berlin C-reactive protein Case series clinical response clinically coronavirus 2019 disease COVID-19 Critically ill patient cytokine cytokine removal D-dimer death dysregulated Europe evaluate failure ferritin Germany hemoadsorption high risk hypercytokinemia ICU identifying IL-6 Ill improvement in-hospital mortality inflammatory biomarkers Inflammatory response intensive care interleukin-6 Invasive mechanical ventilation organ dysfunction Oxygenation PaO pathophysiology Patient plasma Prone position prone positioning reduction in rescue respiratory Respiratory failure Retrospective study SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pneumonia severe respiratory failure significant difference single center SOFA score Therapies therapy Treatment with COVID-19
[DOI] 10.3389/fmed.2021.779038 PMC 바로가기 [Article Type] Medicine

Association between plasma glycocalyx component levels and poor prognosis in severe influenza type A (H1N1)

Article

Published on 2022-01-072022-10-04
Journal: Scientific Reports [Category] 바이오마커, 신종인플루엔자,

[키워드] 28-day mortality acute lung injury Admission albumin levels Analysis APACHE II association blood sample cause Clinical data collected component contribute correlated Cutoff demonstrated determine disease severity Diseases Disruption endothelial Factor H1N1 H1N1 influenza healthy control hospital indicated Influenza influenza A influenza type A interleukin-6 Lactate mild cases organ dysfunction Patient patients with influenza plasma poor prognosis positively correlated Predictive Predictive markers prospective observational study sensitivity Sepsis severity significantly higher SOFA score specificity survival Syndecan-1 tumor necrosis factor-α viral infection virus infection were measured
[DOI] 10.1038/s41598-021-04146-2 PMC 바로가기 [Article Type] Article