High‐resolution HLA genotyping identifies alleles associated with severe COVID‐19: A preliminary study from IndiaShort Report Published on 2021-07-212022-10-30 Journal: Immunity, Inflammation and Disease [Category] COVID-19, SARS, [키워드] allele analyzed Asymptomatic Cohort COVID‐19 COVID‐19 demonstrated disease genotyped genotyping group HLA HLA genotyping human leukocyte antigen identify India individual loci MiSeq Patient polymerase chain recruited Result risk SARS‐CoV‐2 severe Covid‐19 severe disease significant difference Stratification vaccination Variability was performed [DOI] 10.1002/iid3.481 PMC 바로가기 [Article Type] Short Report
Diagnostic Potential of the Plasma Lipidome in Infectious Disease: Application to Acute SARS-CoV-2 InfectionArticle Published on 2021-07-202022-10-30 Journal: Metabolites [Category] COVID-19, [키워드] Analysis application applied AUC Clinical management Cohort cohorts COVID-19 COVID-19 symptom develop Diagnosis effect size effective evaluate facilitate feature healthy control healthy controls healthy controls; Improved individual Infectious disease Kruskal–Wallis test Lipid Lipidomics lipids liquid chromatography-mass spectrometry (LC-MS) Logistic regression metabolic effect metabolic phenotyping Patient Potential Precision predictive power produced profile reported required respiratory infections returned ROC AUC SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-positive individual sensitivity specificity Stratification Symptom Treatment validation cohort was performed [DOI] 10.3390/metabo11070467 PMC 바로가기 [Article Type] Article
COVIDomic: A multi-modal cloud-based platform for identification of risk factors associated with COVID-19 severityResearch Article Published on 2021-07-142022-10-28 Journal: PLoS Computational Biology [Category] COVID-19, SARS, [키워드] accelerate acute infection Analysis Antibiotic resistance bioinformatics collected Community coronavirus Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 research Data analysis determine Epidemiology expected facilitate feature Genetic geographical location Health implication IMPROVE include Infection Interpretation management metatranscriptomic microbial Organisms Outbreaks pathogen Patient patients with COVID-19 platform provide respiratory tract respond risk factor SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 strain sequenced severity strain Stratification Symptom Symptoms the disease variety with COVID-19 Wuhan, China [DOI] 10.1371/journal.pcbi.1009183 PMC 바로가기 [Article Type] Research Article
Mechanisms of troponin release into serum in cardiac injury associated with COVID-19 patientsArticle Published on 2021-07-112022-10-29 Journal: International journal of cardiology and cardiovascular diseases [Category] COVID-19, [키워드] Affect antibodies antibody cardiac troponin clinical decision co-morbidity COVID-19 COVID-19 patient COVID-19 patients Critical cTnT diabetes Elevation Evidence heart failure hypertension hypertrophic cardiomyopathy infected with SARS-CoV-2 Inflammation Injury mechanism membrane molecular mechanism myocardial injury necrotic cell death Patient Prognosis Proteins provoke SARS-CoV-2 sensitivity serum serum troponin Signaling Stratification Therapies Treatment troponin with COVID-19 [DOI] 10.46439/cardiology.1.006 PMC 바로가기 [Article Type] Article
Effect of curcumin-pipeine supplementation on clinical status, mortality rate, oxidative stress, and inflammatory markers in critically ill ICU patients with COVID-19: a structured summary of a study protocol for a randomized controlled trialCOVID-19가 있는 중환자 중환자실 환자의 임상 상태, 사망률, 산화 스트레스 및 염증 지표에 대한 커큐민-피페인 보충제의 효과: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-07-062022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] 1:1 addition Administered All participants allocation sequence ALT anticipated Anticoagulant assigned AST baseline Blinding Blood oxygen saturation C-reactive protein Capsule clinical clinical status Clinical symptoms clinical trial clinical trials CLOCK collected color conducted congenital disorders control group coronavirus COVID-19 creatinine Critically ill CRP Curcumin definitive diagnosis Diseases disorders dissemination double-blind drug Effect Efficacy element eligible patient enteral feeding erythrocyte sedimentation erythrocyte sedimentation rate ESR exclusion criteria Factors female Fever File Hepatic insufficiency hospital ICU ICU patient ICU Patients immune include inclusion criteria independent Inflammatory marker intensive care intensive care unit Intervention intervention group investigators Iran kidney function marker kidney function markers labeling LDH liver male maltodextrin marker matching placebo Medical Sciences Mortality mortality rate normalization number Nurses objective odor outcome oxidative stress oxygen Pancreatitis parameter parenteral nutrition participant Participants Patient PCR test performed physician Physicians piperine Placebo placebo group placebo-controlled Primary outcome protocol provided random randomised randomised controlled trial Randomized Randomized controlled trial Randomly receive recruited Registered registration date registration number registry renal respiratory rate Sample size sealed secondary outcome Secondary outcomes sedimentation rate sensitivity sequence Seven Sex shape status Stratification stratified block randomization study participant Study participants Study protocol supplementary material Support Tablet Taste temperature the placebo group title Trial Trial registration turmeric underlying disease underlying diseases university ventilator Version Warfarin website weight [DOI] 10.1186/s13063-021-05372-9 PMC 바로가기 [Article Type] Letter
The multidimensional prognostic index (MPI) for the prognostic stratification of older inpatients with COVID-19: A multicenter prospective observational cohort studyObservational Study Published on 2021-07-012022-10-05 Journal: Archives of gerontology and geriatrics [Category] SARS, 임상, [키워드] 95% confidence interval Accuracy Admission affected Area association AUC calculated Care CIs clinical decision Comprehensive Comprehensive geriatric assessment COVID-19 COVID-19 infection COVID-19 research Curve domain eight enrolled evaluate females frailty hazard ratio higher risk hospital Hospitalized HRs ICU ICU admission in-hospital mortality Inpatient Inpatients intensive care intensive care unit Italian less LOS Mortality MPI multicenter multidimensional Multidimensional prognostic index multivariable multivariable analysis NIV non-invasive ventilation not significant Older older patient Participants predict Prognosis prognostic prospective observational cohort regression analysis SARS-COV-2 infection Stratification three group Topic was used with COVID-19 [DOI] 10.1016/j.archger.2021.104415 PMC 바로가기 [Article Type] Observational Study
Risk stratification of cardiac sequelae detected using cardiac magnetic resonance in late convalescence at the six-month follow-up of recovered COVID-19 patients회복된 COVID-19 환자의 6개월 추적 관찰에서 후기 요양기에서 심장 자기 공명을 사용하여 감지된 심장 후유증의 위험 계층화Article Published on 2021-07-012022-09-11 Journal: The Journal of Infection [Category] SARS, 치료기술, [키워드] Follow-up recovered COVID-19 patient Stratification [DOI] 10.1016/j.jinf.2021.04.016 PMC 바로가기 [Article Type] Article
Risk estimation of SUDEP during COVID-19 pandemic era in a tertiary referral centerObservational Study Published on 2021-07-012022-10-05 Journal: Epilepsy research [Category] 임상, [키워드] Active epilepsy age Cairo carried checklist Comorbidities COVID-19 COVID-19 pandemic cross-sectional death detect drug Drug resistant epilepsy epilepsy Factor Frequency individual IQR knowledge lockdown Logistic regression analysis median medication medications mitigate Patient patients Psychiatric reported risk risk factor Safety second wave Seizure Stratification the median The SUDEP and seizure safety checklist. university virus was done worsening [DOI] 10.1016/j.eplepsyres.2021.106625 PMC 바로가기 [Article Type] Observational Study
COVID-19 and male reproduction: Current research and unknown factorsCOVID-19 및 남성 생식: 현재 연구 및 알려지지 않은 요인Review Published on 2021-07-012022-09-11 Journal: Andrology [Category] 치료기술, 치료제, [키워드] Analysis article carrier COVID-19 COVID-19 patients current disease onset early stage Effect English evaluated Factor fatal COVID-19 fatal disease FIBRIN genetic material impair Infection Inflammation Injury male male reproduction microthrombi occurred orchiepididymitis organ OVID parameter participant pathological pathological change Patient patient groups positive recovered patients reported Research SARS-CoV-2 Semen seminiferous seminiferous tubule spermatic Spermatic cord Stratification substandard survivor Survivors systematic review testes Testis tissue Viral RNA virus was performed [DOI] 10.1111/andr.12970 PMC 바로가기 [Article Type] Review
Higher vs lower doses of dexamethasone in patients with COVID-19 and severe hypoxia (COVID STEROID 2) trial: Protocol and statistical analysis planCOVID-19 및 중증 저산소증(COVID STEROID 2) 환자에 대한 덱사메타손의 고용량 및 저용량 시험: 프로토콜 및 통계 분석 계획Comparative Study Published on 2021-07-012022-09-11 Journal: Acta Anaesthesiologica Scandinavica [Category] SARS, 임상, [키워드] adjusted all-cause mortality analysed benefit blinded clinical benefit clinical trial coronavirus disease Coronavirus disease 2019 Corticosteroid Corticosteroids COVID COVID-19 COVID-19 patient days alive death Denmark Dexamethasone dose doses of corticosteroid Evidence Healthcare system Healthcare systems hospital hypoxia implication include India inflammatory lung disease International Invasive mechanical ventilation investigator-initiated life low-dose low-dose corticosteroid lower dose Lung diseases mean difference median offer outcome outlined pandemic Patient patients patients with COVID-19 present Primary outcome protocol Quality of life randomised renal replacement therapy replacement therapy reported secondary Secondary outcomes serious adverse reaction Serious adverse reactions severe COVID-19 severe hypoxia Society Statistical analysis plan steroid Stratification stratified Support Switzerland systemic systemic corticosteroid systemic corticosteroids Trial variable with COVID-19 [DOI] 10.1111/aas.13795 PMC 바로가기 [Article Type] Comparative Study