I mmunosenescence and Inflammaging: Risk Factors of Severe COVID-19 in Older PeopleI 면역노화와 염증: 고령자의 중증 COVID-19 위험 요인Review Published on 2020-10-272022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, [키워드] Adaptive immune response addition advanced age aging aging process change condition coronavirus correlation COVID-19 Cytokines decrease decreases disease disease pathogenesis dysfunction exacerbated Factor immune responses immunological immunological change immunological changes immunosenescence include individual Infection inflammaging Inflammatory cytokines Influenza involved main mechanism main mechanisms mechanism occur Older SARS-CoV-2 SARS-COV-2 infection susceptibility susceptible the disease [DOI] 10.3389/fimmu.2020.579220 PMC 바로가기 [Article Type] Review
Clinical Outcomes of COVID-19 Patients with Pre-existing, Compromised Immune Systems: A Review of Case ReportsReview Published on 2020-10-182022-10-29 Journal: International Journal of Medical Sciences [Category] COVID-19, MERS, SARS, [키워드] advanced age appear causes clinical Clinical characteristics Clinical outcome Comorbidities Complication Compromised conducted COVID-19 COVID-19 mortality COVID-19 pandemic COVID-19 patient deficiency ENhance Human Immune suppression immune system immune systems immunosuppressants increased risk indicate individual individuals Infection naïve Organ transplant outcome Patient primary antibody recipient recipients report required review risk SARS-CoV-2 severe symptom the patient the SARS-CoV-2 virus viruses [DOI] 10.7150/ijms.50537 PMC 바로가기 [Article Type] Review
Immunesenescence: A Predisposing Risk Factor for the Development of COVID-19?Immunology Published on 2020-10-062022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] accelerated activated acute respiratory syndrome advanced age aging Bearing characterized co-morbidity coronavirus Coronavirus disease 2019 COVID-19 COVID-19 treatment demographic group described development dysregulated effective exacerbate Factor feature females functional Gender group high risk highlight immune dysfunction Immune profile immune response immune system Immunesenescence inflammaging Inflammatory less Lymphocytes male Monocytes obese obesity occur Older pathogen patients phenotypic Premature question response risk factor SARS-Cov_2 SARS-CoV-2 senescent severe COVID-19 subject susceptibility T cells T2D therapeutic options Treatment type 2 diabete [DOI] 10.3389/fimmu.2020.573662 PMC 바로가기 [Article Type] Immunology
First results of the “Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS)”“SARS-CoV-2 감염 환자(LEOSS)에 대한 린 유럽 공개 설문조사” 첫 결과Multicenter Study Published on 2020-10-012022-09-10 Journal: Infection [Category] MERS, SARS, 치료기술, [키워드] 95% CI ACE acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjusted odds ratio advanced age age Analysis analyzed association baseline characteristics body mass body mass index cardiovascular cardiovascular disease Clinical characteristics clinical condition Clinical stage Clinical stages Cohort cohort study coronavirus Course COVID-19 COVID-19 diagnosis diabete diabetes Diagnosis disease stage ENhance enrolled European increased risk individual inhibitor International kidney Kidney diseases LEOSS logistic regression models Male sex multicenter multivariable analysis neurological open outcome patients required respiratory Result risk factor Risk factors SARS-CoV-2 SARS-CoV-2-infected patients severe acute respiratory syndrome Coronavirus smoking Stage statin supplementary material survey Treatment were assessed [DOI] 10.1007/s15010-020-01499-0 PMC 바로가기 [Article Type] Multicenter Study
SARS-CoV-2: From Structure to Pathology, Host Immune Response and Therapeutic ManagementReview Published on 2020-09-242022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] advanced age aerosol approach Autoimmune disease bats coronavirus COVID-19 COVID-19 pandemic COVID-19 pathology current diabetes diagnostics different disease Diseases Factors form genetic variability homology Host immune response Human immune response infecting Infection Inflammation Inflammatory inflammatory condition inflammatory process Last molecular mechanism obesity other coronavirus Pathogens physical pro-inflammatory prolonged exposure response Risk factors risk of COVID-19 RNA genome SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection sensitivity sequence homology shown single-stranded Spread Structure syndrome the SARS-CoV-2 the SARS-CoV-2 virus Vaccine development viral respiratory virus [DOI] 10.3390/microorganisms8101468 PMC 바로가기 [Article Type] Review
Clinical and imaging features predict mortality in COVID-19 infection in IranResearch Article Published on 2020-09-242022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] Accuracy advanced age age assessment Attention Care Chest Chest CT Chest radiograph Chinese clinical clinical feature Clinical features co-morbidities Community conducted COVID-19 COVID-19 infection COVID-19 infections COVID-19 positive patient CT chest Deceased demographics disease distribution Factor feature Follow-up fraction generate Health Healthcare system help increased mortality Infection initial Iran Laboratory Leukocytosis Logistic lung lymphocyte management men Mortality multiple logistic regression New coronavirus oxygen saturation Oxygenation pandemic Patient Platelet positive COVID-19 predict presenting symptoms radiologic retrospective cohort study ROC Curve RT-PCR scoring system severity Specific surviving patients Tehran vital signs was used were assessed while women worsening [DOI] 10.1371/journal.pone.0239519 PMC 바로가기 [Article Type] Research Article
Cellular senescence as a potential mediator of COVID‐19 severity in the elderlyReview Published on 2020-09-212022-10-28 Journal: Aging Cell [Category] COVID-19, MERS, SARS, [키워드] accumulate advanced age alleviate association Biomarker cellular cellular senescence characterized complex Consequences contribute coronavirus disease COVID‐19 COVID‐19 patient Cytokine storm detrimental disease disease severity distress early phase Efficacy evaluate Factor functional growth Health identifying IMPROVE individual infect inflammatory reaction limit Lower respiratory tract lung failure mechanism novel Betacoronavirus Older Pathogenesis Prevent promote rising mortality risk SARS‐CoV‐2 SARS‐CoV‐2 infection second senescence senescent cell severe complication severity syndrome the disease therapy tissue damage Vaccinations Vaccine vaccine response [DOI] 10.1111/acel.13237 PMC 바로가기 [Article Type] Review
PRO: The COVID-19 pandemic will result in increased antimicrobial resistance ratesOpinion Published on 2020-09-172022-10-29 Journal: JAC-Antimicrobial Resistance [Category] COVID-19, [키워드] advanced age broad-spectrum antibiotic Cardiopulmonary Care COVID-19 COVID-19 pandemic COVID-19 patients diabete Factor first-wave hospital Hospitalization hospitalized COVID-19 patient indirect effect infection rates infections likelihood outcome public health Region reported Selection Spread systemic diseases Worry [DOI] 10.1093/jacamr/dlaa049 PMC 바로가기 [Article Type] Opinion
Male gender and kidney illness are associated with an increased risk of severe laboratory-confirmed coronavirus diseaseResearch Article Published on 2020-09-162022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, SARS, [키워드] 95% CI 95% confidence interval advanced age Analysis analyzed association benefit Care Chronic kidney disease CIs coronavirus disease COVID-19 COVID-19 severity Dyspnea evaluated Factor Gender Health Hospital admission humans identify increased risk Infection kidney Kidney diseases knowledge laboratory-confirmed male management Older Pain Participants Patient polymerase chain predictor protocol Quantitative Result retrospective cohort study risk risk ratio RRs severe acute respiratory syndrome coronavirus 2 severe coronavirus disease severe COVID-19 severe disease subjects subset Thoracic took place Treatment [DOI] 10.1186/s12879-020-05408-6 PMC 바로가기 [Article Type] Research Article
Exercise for Older Adults Improves the Quality of Life in Parkinson’s Disease and Potentially Enhances the Immune Response to COVID-19Review Published on 2020-09-062022-10-28 Journal: Brain Sciences [Category] COVID-19, [키워드] acting addition advanced age anti-inflammatory response Antiviral autonomic Cell COVID-19 COVID-19 pandemic disorder dysfunction Evidence exercise Health immune immune response immune system IMPROVE increased risk individuals Infection infection risk life literature review Medical conditions neurodegenerative disorder neuronal novel SARS-CoV-2 virus offer Older Older adults outcome outcomes Parkinson’s disease Parkinson’s disease patients performed pro-immune response Probability problem PROTECT Protective pulmonary dysfunction Quality recent response responsible SARS-CoV-2 shown substantia [DOI] 10.3390/brainsci10090612 PMC 바로가기 [Article Type] Review