Expansion of CD56 dim CD16 neg NK Cell Subset and Increased Inhibitory KIRs in Hospitalized COVID-19 PatientsCD56 DIM CD16 Neg NK 세포 서브 세트의 확장 및 입원 COVID-19 환자에서 증가 된 억제 KIR.Article Published on 2021-12-282022-09-10 Journal: Viruses [Category] SARS, 바이오마커, [키워드] acute respiratory syndrome coronavirus alteration CD16 CD56 coronavirus COVID-19 COVID-19 infection COVID-19 patients Cytokines cytotoxicity Defense deficiency Depletion distribution elevated ENhance expansion Frequency hospitalized COVID-19 patient hospitalized COVID-19 patients IFN-γ impairment Increased induce Infection Inflammatory cytokines inhibitory innate response KIR KIR receptor KIR receptors NK cell NK cell subsets NK cells no difference no differences phenotype produced respiratory SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus subset virus [DOI] 10.3390/v14010046 PMC 바로가기 [Article Type] Article
Final Results of a Randomized, Placebo-Controlled, Two-Arm, Parallel Clinical Trial of Proxalutamide for Hospitalized COVID-19 Patients: A Multiregional, Joint Analysis of the Proxa-Rescue AndroCoV TrialEndocrinology/Diabetes/Metabolism Published on 2021-12-252022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 1:1 95% CI 95% confidence interval ACE2 addition all-cause mortality androgen Androgen receptor angiotensin-converting enzyme 2 antiandrogens Arm ARMS baseline Brazil clinical clinical trial COVID COVID-19 Day demonstrated discharge Drug efficacy effective Efficacy evaluate expression female Final highest hospital Hospital stay Hospitalization hospitalized COVID-19 patient hospitalized COVID-19 patients improvement Inflammatory response interquartile range IQR joint material median mortality rate mortality rates North outcome outcomes oxygen pandemic performed Placebo placebo group preliminary report Prevent proxalutamide randomization randomized clinical trial RCT RCTs reduced reduction in Region Regulation Result risk ratio SARS-CoV-2 score Sepsis South statistical analysis statistically statistically significant stratified by sex study population subject the placebo group TMPRSS2 transmembrane protease serine 2 Trial usual care was performed WHO [DOI] 10.7759/cureus.20691 PMC 바로가기 [Article Type] Endocrinology/Diabetes/Metabolism
Development of a prediction score for in-hospital mortality in COVID-19 patients with acute kidney injury: a machine learning approachArticle Published on 2021-12-242022-10-04 Journal: Scientific Reports [Category] SARS, 치료법, [키워드] 95% CI Accuracy acute kidney AKI approach assist build can be used category cause characteristic Characteristics coefficient Comorbidity condition COVID-19 COVID-19 patient cross-sectional defined develop development Diagnosis disease severity Elastic evaluated healthcare worker hospitalized COVID-19 patient in-hospital mortality Intensive KDIGO Kidney diseases Kidney injury Laboratory Latin America multicentre Predictive predictor variable prognostic prospective cohort study registry resource Risk factors validation cohort were used with COVID-19 [DOI] 10.1038/s41598-021-03894-5 PMC 바로가기 [Article Type] Article
The outcomes of patients with diabetes mellitus in The Philippine CORONA StudyArticle Published on 2021-12-242022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] 95% CI acute respiratory syndrome Admission build calculated Cohort cohort study Confirmed COVID-19 infection coronavirus coronavirus disease COVID-19 COVID-19 patient Diabetes complications Diabetes Mellitus diagnosed distribution female hazard ratio hospital Hospital admission Hospital stay hospitalized COVID-19 patient ICU ICU admission ICU admissions increased mortality increased risk independent intensive care Kaplan–Meier male median age Mortality multivariate logistic regression NEUROLOGY Odds ratio outcome Patient patients with diabete patients with diabetes performed Respiratory failure retrospective risk severe COVID-19 severe infections shown significantly significantly higher significantly increased subgroup analysis subgroups t tests ventilator were used [DOI] 10.1038/s41598-021-03898-1 PMC 바로가기 [Article Type] Article
Epidemiological Characteristics of Hospitalized Patients with Moderate versus Severe COVID-19 Infection: A Retrospective Cohort Single Centre StudyArticle Published on 2021-12-232022-11-01 Journal: Diseases [Category] COVID-19, [키워드] age Analysis ARDS average C-reactive protein CDC Clinical characteristics clinical factor Clinical outcome clinical outcomes Comorbidity conducted COVID-19 COVID-19 severity CRP D-dimer Demographic factors elevated epidemiological Epidemiological factors Factor Factors fatality FIVE Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients identify intensive care Intervention Laboratory Laboratory parameters LDH majority male management marker mechanical ventilation moderate Mortality NIV non-invasive ventilation non-severe patient noticeable difference Older Oman Patient prevalent progression reduce resource Respiratory disease retrospective cohort study SARS-CoV-2 selected Sepsis severe COVID-19 illness Severe patient severity single-center steroid syndrome therapeutic therapeutic intervention WBC were assessed white cell with COVID-19 [DOI] 10.3390/diseases10010001 PMC 바로가기 [Article Type] Article
Integrated miRNA/cytokine/chemokine profiling reveals severity-associated step changes and principal correlates of fatality in COVID-19Article Published on 2021-12-202022-10-04 Journal: iScience [Category] 바이오마커, 유전자 메커니즘, [키워드] Abstract Accuracy association Blood blood sample CCL20 change chemokine circulating clinical clinical feature Clinical finding Cohort complex system Complex system biology COVID-19 COVID-19 pathology COVID-19 patients cytokine demonstrated disease severity fatal COVID-19 fatality feasibility greater hallmark Health Sciences highlight hospital hospitalized COVID-19 patient IL10 IL6 IMPROVE independent microRNA miRNA miRNA profiles miRNA signature Patient profile reveal separated Severe case severe COVID-19 severe disease [DOI] 10.1016/j.isci.2021.103672 PMC 바로가기 [Article Type] Article
Cardiac Arrhythmias and COVID-19: Correlation With Disease SeverityCardiology Published on 2021-12-182022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 95% CI ACE-I African American age Analysis angiotensin-converting enzyme inhibitor arrhythmia Arrhythmias association Atrial fibrillation baseline characteristics blocker cardiac Cardiac arrhythmia cardiac arrhythmias cardiovascular complication CCI Comorbidity coronavirus disease correlation COVID-19 death demographic characteristics diagnoses disease severity electrical evaluate had more HFNC hospitalized COVID-19 patient incidence Invasive mechanical ventilation Laboratory life-threatening male nasal New Older Oxygen requirement Patient patients hospitalized patients who survived patients with arrhythmia Poisson regression positive airway pressure positively correlated receptor recruited reported Result retrospective risk significantly higher the patient therapy USA Ventilation was used with COVID-19 [DOI] 10.7759/cureus.20507 PMC 바로가기 [Article Type] Cardiology
Overweight and Obesity Are Associated With Acute Kidney Injury and Acute Respiratory Distress Syndrome, but Not With Increased Mortality in Hospitalized COVID-19 Patients: A Retrospective Cohort StudyEndocrinology Published on 2021-12-142022-10-31 Journal: Frontiers in Endocrinology [Category] COVID-19, [키워드] acute kidney failure Acute kidney injury acute respiratory distress Analysis association Clinical course complications condition COVID-19 during admission evaluate groups Hospital stay hospitalized COVID-19 patient hospitalized COVID-19 patients in-hospital mortality in-hospital mortality rate Increased increased mortality Length malignancy Mortality multicenter multivariate logistic regression obese obesity objective Observational cohort study organ outcome outcomes overweight Patient patients patients hospitalized performed Probability recipients respiratory Result retrospective syndrome with COVID-19 women [DOI] 10.3389/fendo.2021.747732 PMC 바로가기 [Article Type] Endocrinology
Characteristics of peripheral white blood cells in COVID-19 patients revealed by a retrospective cohort studyResearch Published on 2021-12-092022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, SARS, [키워드] analyzed association basophil branch changes in China city COVID-19 COVID-19 patient COVID-19 patients death died discharged eosinophil eosinophils glucocorticoid hematological Hematological change hospitalized COVID-19 patient immune response investigated Level lymphocyte Lymphocytes New non-survivor outcome Patient patients peripheral poor prognosis positive correlation predictor Prognosis proportion recruited Result retrospective cohort study SARS-COV-2 infection severe COVID-19 patient significantly lower subgroup analysis supplementary material survivor Survivors Tongji Hospital Treatment was performed White blood cell with COVID-19 Wuhan [DOI] 10.1186/s12879-021-06899-7 PMC 바로가기 [Article Type] Research
Frequency of Cardiovascular Complications and Its Association with Prognosis of COVID-19 PatientsResearch Article Published on 2021-12-082022-10-27 Journal: BioMed Research International [Category] COVID-19, MERS, [키워드] Admission age arrhythmia Arrhythmias association Cardiac complications cardiac troponin cardiovascular cardiovascular complication Cardiovascular disorders changes chest pain CK-MB Coagulation Complication Coronary artery disease Coronavirus disease 2019 COVID-19 COVID-19 cases COVID-19 patients Creatine kinase-MB death determine Diabetes Mellitus ECG enrolled evaluate expired Frequency had no Hospitalization hospitalized COVID-19 patient hyperlipidemia lab Laboratory test myocarditis outcome Patient patients Prognosis repeated significant difference three group Treatment underlying diseases was performed [DOI] 10.1155/2021/7073348 PMC 바로가기 [Article Type] Research Article