IgV somatic mutation of human anti–SARS-CoV-2 monoclonal antibodies governs neutralization and breadth of reactivity인간 항-SARS-CoV-2 단일 클론 항체의 IgV 체세포 돌연변이가 중화 및 반응성의 폭을 지배합니다Research Article Published on 2021-05-102022-09-10 Journal: JCI Insight [Category] SARS, 변종, 진단, [키워드] approach B cell B cell responses B cells Blood breadth C-terminal coding sequence coding sequences convalescent coronavirus Course COVID-19 D614G domain effective exhibited expressed germline half-maximal inhibitory concentration half-maximal inhibitory concentrations identify Immunity immunoglobulins immunology Infection infection with SARS-CoV-2 mAb mAbs memory B cell memory B cells Molecular biology monoclonal antibody mutant mutant spike protein Mutation neutralization neutralize neutralized Neutralizing potency pseudotyped Pseudotyped virus reactivity SARS-CoV-2 SARS-CoV-2 spike sequenced Spike proteins subject thought Treatment Vaccine variant variants virus viruses Wuhan [DOI] 10.1172/jci.insight.147386 PMC 바로가기 [Article Type] Research Article
Patterns and persistence of SARS-CoV-2 IgG antibodies in Chicago to monitor COVID-19 exposureCOVID-19 노출을 모니터링하기 위한 시카고의 SARS-CoV-2 IgG 항체 패턴 및 지속성Clinical Medicine Published on 2021-05-102022-09-10 Journal: JCI Insight [Category] SARS, 진단, 치료기술, [키워드] Advancing antibodies antibody assessment Asymptomatic center Chicago Community community survey Concentration Contact coronavirus COVID-19 COVID-19 cases decay detectable diagnosis of COVID-19 Dixon estimate exposure to family foundation funding greater hospitalized COVID-19 IgG IgG level IgG levels IgG response immunoglobulins indicated mail MONITOR network NIH no significant difference overlapped participant participated pattern persistence positive PCR test produced Receptor-binding domain recruited reported retained SARS-CoV-2 SARS-CoV-2 IgG antibody Science serology seropositive individual seropositive individuals seropositive participant seropositive participants Seroprevalence subsequent subset the receptor-binding domain university vaccination Vaccine Viral virus detection was measured widespread with COVID-19 [DOI] 10.1172/jci.insight.146148 PMC 바로가기 [Article Type] Clinical Medicine
Guillain-Barre syndrome in 220 patients with COVID-19Review Published on 2021-05-042022-10-31 Journal: The Egyptian Journal of Neurology, Psychiatry and Neurosurgery [Category] COVID-19, [키워드] age concerning COVID-19 CSF Diagnosis Guillain-barrè syndrome immune reaction immunoglobulins IMPROVE Infection Nerve conduction not differ occur outbreak outcome pandemic pathophysiology Patient patients patients with COVID-19 recent finding reported SARS-CoV-2 Treatment virus [DOI] 10.1186/s41983-021-00310-7 PMC 바로가기 [Article Type] Review
A complementary critical appraisal on systematic reviews regarding the most efficient therapeutic strategies for the current COVID-19 (SARS-CoV-2) pandemic현재 COVID-19(SARS-CoV-2) 전염병에 대한 가장 효율적인 치료 전략에 관한 체계적인 검토에 대한 보완적인 비판적 평가Meta-Analysis Published on 2021-05-012022-09-11 Journal: Journal of medical virology [Category] SARS, 치료제, [키워드] Administered article Chloroquine clinical symptom Clinical symptoms clinical trial clinical trials complementary concept coronavirus COVID-19 COVID-19 drug treatment COVID-19 pandemic COVID-19 treatment criteria critical appraisal database death Deleterious drug drug treatment Effect Efficacy Evidence Favipiravir Hydroxychloroquine Hypotension Immunoglobulin immunoglobulins Increasing initial initial screening Liver function test Lopinavir Lopinavir/ritonavir maintain mechanical ventilation Medicine mesh terms meta-analyses mortality rate pandemic Patient plasma reduced Remdesivir Research resources Ritonavir SARS-CoV-2 Science Direct searched severe symptoms severely ill patients Side effect Side effects steroid Steroids subsequent suggested systematic review systematic reviews the cytokine storm therapeutic strategy Tocilizumab Treatment viral clearance were assessed [DOI] 10.1002/jmv.26811 PMC 바로가기 [Article Type] Meta-Analysis
Transient plasma cell dyscrasia in COVID-19 patients linked to IL-6 triggeringIL-6 유발과 관련된 COVID-19 환자의 일시적 형질 세포 이상Article Published on 2021-05-012022-09-11 Journal: Microbes and infection [Category] 진단, 치료법, [키워드] accompanied Anomaly Cell Cohort COVID-19 COVID-19 patient cytokine Cytokine storm dyscrasia elevated gammopathy humoral Humoral response IL-6 immune response immunoglobulins investigated plasma Plasma cell Plasma cell dyscrasia positive Protein reported SARS-CoV-2 selected serological severe COVID-19 patients spike Spike protein Swab the disease Transient Trigger triggering triggers Viral Viral antigen viral spike protein [DOI] 10.1016/j.micinf.2021.104808 PMC 바로가기 [Article Type] Article
Analysis of IgM, IgA, and IgG isotype antibodies Directed against SARS-CoV-2 spike glycoprotein and ORF8 in the course of COVID-19COVID-19 과정에서 SARS-CoV-2 스파이크 당단백질 및 ORF8에 대한 IgM, IgA 및 IgG 이소타입 항체 분석Article Published on 2021-04-262022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis analyzed anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgM antibodies antibody cross-reactivity Antigen best clinical parameter Clinical parameters Combination coronavirus Course COVID-19 cross-reaction cross-reactions CRP diagnostic ELISA Evidence evidence of Frame identify IgA IgG IgG isotype antibodies IgG isotype antibody IgM IgM antibodies IL-6 immune response Immunity immunoassay immunoassays immunoblot Immunoblot analysis immunoglobulins infected patients Infection Inflammation information kidney LDH Liver injury no correlation Open reading frame ORF8 parameter positive patients presence of antibody Protein question Reactions reliability respiratory SARS-CoV-2 SARS-CoV-2 patient SARS-CoV-2 patients SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 spike glycoprotein sensitivity serological serum immunoglobulin serum immunoglobulins serum sample serum samples specificity spike glycoprotein tested the disease viral infection [DOI] 10.1038/s41598-021-88356-8 PMC 바로가기 [Article Type] Article
Assessment of S1-, S2-, and NCP-Specific IgM, IgA, and IgG Antibody Kinetics in Acute SARS-CoV-2 Infection by a Microarray and Twelve Other Immunoassays마이크로어레이 및 12개의 기타 면역분석을 통한 급성 SARS-CoV-2 감염에서 S1, S2 및 NCP 특이적 IgM, IgA 및 IgG 항체 동역학 평가Comparative Study Published on 2021-04-202022-09-11 Journal: Journal of Clinical Microbiology [Category] MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] acute COVID-19 acute respiratory syndrome acute respiratory syndrome coronavirus acute SARS-CoV-2 infection analyzed antibodies antibody antibody kinetics Antigen assessment blood sample Blood samples commercial immunoassay coronavirus coronavirus disease Coronavirus disease 2019 declined detection rate ELISA ELISAs enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays hospitalized patient hospitalized patients IgA IgA levels IgG IgG antibodies IgG antibody IgG response IgG responses IgM immunoassay immunoassays Immunoglobulin immunoglobulins Infection Kinetics Lower respiratory tract Microarray nucleocapsid protein occur Other Patient patients Pneumonia post-symptom onset progressed quantified Rapid test reached respiratory SARS SARS-CoV-2 sensitivities sensitivity Seven severely ill patients specific IgM Specificities specificity the microarray total Ig tracheal Viral Viral concentration viral concentrations [DOI] 10.1128/JCM.02890-20 PMC 바로가기 [Article Type] Comparative Study
SARS-CoV-2 Antibody Screening in Healthcare Workers in Non-Infectious Hospitals in Two Different Regions of Southern Poland (Upper Silesia and Opole Voivodeships): A Prospective Cohort Study폴란드 남부의 서로 다른 두 지역(Upper Silesia 및 Opole Voivodeships)의 비감염성 병원 의료 종사자를 대상으로 한 SARS-CoV-2 항체 검사: 전향적 코호트 연구Article Published on 2021-04-202022-09-10 Journal: International Journal of Environmental Research an [Category] MERS, SARS, 치료기술, [키워드] antibody screening Asymptomatic benefit blood collection coronavirus coronavirus SARS-CoV-2 COVID-19 detection determine different time point ELISA test emergency wards evaluated had no HCW HCWs health-care professionals healthcare healthcare worker Healthcare workers hospital Hospital environment Host human coronavirus IgA IgG IgM IgM/IgG immunoglobulins individual Infection Local negative RT-PCR New coronavirus non-infectious patients PCR test PCR testing performed Poland Population positive Prevalence Prospective reduce Region risk RT-PCR RT-PCR test RT-PCR testing sampling SARS-CoV-2 SARS-COV-2 infection Screening semi-quantitative ELISA sera serologic responses serological surveillance Seropositivity socio-demographic Spread Symptoms symptoms of infection test results university university hospital upper Volunteer worker [DOI] 10.3390/ijerph18084376 PMC 바로가기 [Article Type] Article
Screening of severe acute respiratory syndrome coronavirus-2 infection during labor and delivery using polymerase chain reaction and immunoglobulin testing중합효소연쇄반응과 면역글로불린 검사를 이용한 분만 중 중증급성호흡기증후군 코로나바이러스-2 감염 검사Article Published on 2021-04-152022-09-11 Journal: Life sciences [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Admission Asymptomatic Chain Reaction coronavirus Coronavirus 2019 coronavirus disease Coronavirus-2 COVID-19 Evidence evidence of groups hospital Hospital admission Immunoglobulin Immunoglobulin G immunoglobulins Infection intensive care intensive care unit labor Labor and delivery Laboratory Maternal mild clinical symptom mild clinical symptoms mother Newborn no significant difference no significant differences on admission outcome outcomes PCR PCR test polymerase chain polymerase chain reaction positive PCR pregnant women Prevalence required respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 PCR screened Screening serological test serum immunoglobulin serum immunoglobulins Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Spanish women [DOI] 10.1016/j.lfs.2021.119200 PMC 바로가기 [Article Type] Article
A randomized, double-blind, placebo-controlled phase III clinical trial to evaluate the efficacy and safety of SARS-CoV-2 vaccine (inactivated, Vero cell): a structured summary of a study protocol for a randomised controlled trialSARS-CoV-2 백신(비활성화, Vero 세포)의 효능과 안전성을 평가하기 위한 무작위 이중 맹검 위약 대조 임상 3상 시험: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-04-132022-09-10 Journal: Trials [Category] MERS, SARS, 비임상, 임상, 치료기술, [키워드] 1:1 24 hour 24 hours 95% confidence interval Activation Active surveillance administration Administrative Personnel Adverse adverse event adverse events Adverse reaction Adverse reactions African green monkey age Algorithm Aluminium aluminium hydroxide anaphylaxis Antibody test Antibody titer Antigen Arm asplenia assigned assumed assumption Autoimmune baseline bleeding disorders Blinding blood product blood products blood sample Blood samples breastfeeding women breath carried Cell culture China chloride Clinical efficacy clinical trial code Cohort cohorts comparator consent form cooperation Corticosteroid Corticosteroids COVID-19 COVID-19 cases COVID-19 disease COVID-19 symptoms COVID-19 test criteria Critical CRO Data and Safety Monitoring Board Day development diary dihydrogen DIHYDROGEN PHOSPHATE disease disodium disodium hydrogen phosphate dissemination dose dose of vaccination double blind double-blind double-blind study Efficacy Efficacy and safety element eligible Endpoint enrolled enrolment ethics committee evaluate event excluded exclusion criteria expected Follow-up follow-up period Frequency Gender genders green monkey group groups healthcare Healthcare professional healthcare professionals higher risk HIV infection hospital Hospitalization hydrogen Hydrogen phosphate hydroxide hypersensitivity identity IgG level IgG levels IgG test immunogenicity Immunoglobulin immunoglobulins immunosuppressive immunosuppressive therapy inactivated Inactivated Vaccines incidence incidence rate include Inclusion individual information informed consent form initiated Interactive Web Response System intramuscular dose investigator IWRS IWRS system kidney knowledge Local local reactions management medical doctors medical emergency Ministry of Health mortality rates neutralizing antibody Neutralizing antibody titer Novel coronavirus number Nurses objective Omega Other participant PCR PCR positivity performed Phase III Clinical Trial phosphate Placebo placebo group placebo-controlled positive pregnancy test pregnant preparation primary efficacy endpoint professional proportion protocol randomised randomised controlled trial randomised placebo controlled trial randomization Randomized Randomly Reactions receive recorded regimens Registration reported response risk risk of infection RT-PCR RT-PCR test RT-PCR tests Safety Monitoring Board Sample size SARS-CoV-2 vaccine SARS-CoV-2 virus screened second dose secondary Secondary objectives Serious Adverse Event Serious Adverse Events seroconversion rate Seropositivity severity severity of COVID-19 shown Sinovac sodium Sodium chloride sodium dihydrogen phosphate Sponsor status study group Study protocol subject subject’ supplementary material Symptom symptomatic symptomatic case symptomatic cases System systemic adverse reaction the ethics committee the timing the vaccine therapy Treatment treatment arm Trial Turkey two-sided vaccinated groups vaccination Vaccine Vero Vero Cell Web website width with COVID-19 within 6 months [DOI] 10.1186/s13063-021-05180-1 PMC 바로가기 [Article Type] Letter