Time-to-Death Longitudinal Characterization of Clinical Variables and Longitudinal Prediction of Mortality in COVID-19 Patients: A Two-Center StudyMedicine Published on 2021-04-292022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute respiratory syndrome analyzed AUC biochemical build C-reactive protein Cell Characteristics characterization clinical clinical marker clinical variable clinical variables cohort study Coronavirus-2 COVID-19 D-dimer death demonstrated Deterioration discharge evaluated fluctuation Hospital admission Intervention lactate dehydrogenase longitudinal Lymphocytes measurement Mortality New York non-survivor Non-survivors outcome Patient performance physiological polymerase chain positive predicted prediction Predictive predictor Prevent procalcitonin progression provide receiver operating characteristics respiratory rate SARS-CoV-2 survivor Survivors Temporal Tongji Hospital trend university variable were used with COVID-19 Wuhan, China [DOI] 10.3389/fmed.2021.661940 PMC 바로가기 [Article Type] Medicine
SARS-CoV-2 Receptor ACE2 Gene Is Associated with Hypertension and Severity of COVID 19: Interaction with Sex, Obesity, and SmokingSARS-CoV-2 수용체 ACE2 유전자는 고혈압 및 COVID 19의 심각성과 관련이 있습니다: 성, 비만 및 흡연과의 상호 작용Article Published on 2021-04-202022-09-11 Journal: American journal of hypertension [Category] SARS, 변종, [키워드] 95% confidence interval ACE2 ACE2 gene ACE2 variant ACE2 variants acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 association Blood blood pressure both sexes cause Comorbidity condition conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID COVID-19 COVID-19 severity entry receptor enzyme females genetic analysis Genotype human cells hypertension individual individuals Interaction male males non-survivor nucleotide obese obesity outcome polymorphism populations risk allele risk factor rs233575 SARS-CoV-2 SARS–CoV-2 several variants severe acute respiratory syndrome Coronavirus severity Sex Significant significant interaction significantly single nucleotide Single nucleotide polymorphism smoking T allele tested UK biobank variant with COVID-19 [DOI] 10.1093/ajh/hpaa223 PMC 바로가기 [Article Type] Article
Characteristics and Risk Factors Associated With Mortality in Critically Ill Patients With COVID-19Anesthesiology Published on 2021-04-122022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 28-day mortality 95% CI assessment chronic Clinical characteristics Cohort Comorbidity COVID-19 cTnT demonstrated Factor failure hazard ratio ICU ICU patient Ill independent IQR Laboratory medical record morbidity and mortality multivariate Cox regression myocarditis Netherland non-survivor Non-survivors Older Organ failure outcome Patient patients with COVID-19 Physiology Pneumonia pulmonology and critical care Result sars-cov-2 (severe acute respiratory syndrome coronavirus -2) secondary outcome severity significantly significantly higher SOFA survivor Symptoms with COVID-19 [DOI] 10.7759/cureus.14442 PMC 바로가기 [Article Type] Anesthesiology
Longitudinal assessment of IFN-I activity and immune profile in critically ill COVID-19 patients with acute respiratory distress syndrome급성 호흡 곤란 증후군이 있는 중환자 COVID-19 환자의 IFN-I 활성 및 면역 프로파일에 대한 종단 평가Clinical Trial Published on 2021-04-122022-08-13 Journal: Critical Care [Category] MERS, 바이오마커, 임상, [키워드] acute respiratory distress acute respiratory distress syndrome alteration appear ARDS ARDS patient ARDS patients Bacterial sepsis cellular COVID-19 COVID-19 patient COVID-19 patients Critically ill critically ill COVID-19 patients Critically ill patient critically ill patients cytokine cytokine levels Cytokines decrease described Elevation expression followed by Hospital stay ICU admission IFN response IFN-I IFN-stimulated gene IFN-stimulated genes IFNα2 immune immune parameter Immune profile immune response immune responses immuno-inflammatory Immunosuppression intensity ISG longitudinal longitudinal immune monitoring lymphocyte Lymphocyte count marker mHLA-DR non-survivor normal values Occurrence outcome pandemic plasma question respiratory distress Result SARS-CoV2 infection Secondary infection secondary infections Sepsis similarities similarity supplementary material Survivors syndrome TNF-α Type-I IFN [DOI] 10.1186/s13054-021-03558-w PMC 바로가기 [Article Type] Clinical Trial
Nutritional risk and therapy for severe and critical COVID-19 patients: A multicenter retrospective observational studyObservational Study Published on 2021-04-012022-10-05 Journal: Clinical nutrition (Edinburgh, Scotland) [Category] SARS, 임상, [키워드] adjusted adverse events age and sex albumin BMI Characteristics clinical COVID-19 Critical Critically ill death electronic medical records enrolled evaluate greater high risk higher risk hospital ICU In-hospital In-hospital death Inclusion increase in Laboratory Malnutrition median multicenter non-survivor NRS score NUTRIC score nutrition nutritional risk outcome Patient patients patients with COVID-19 plasma protein predict protein level retrospective risk risk of death Screening significantly Standard deviation survival Survivors therapy transfer was reduced Wuhan, China [DOI] 10.1016/j.clnu.2020.09.040 PMC 바로가기 [Article Type] Observational Study
ICU outcomes and survival in patients with severe COVID-19 in the largest health care system in central FloridaResearch Article Published on 2021-03-252022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] admitted to ICU AdventHealth analyzed baseline Care characterized Clinical characteristics Clinical outcome cohort study common Comorbidities Comorbidity COVID-19 criteria demographics described diabete ECMO exclusion expiratory female Health health system hospital hospitalized patients hypertension ICU ICU admission ICU Patients IQR Laboratory LOS Lower Major management marker measure mechanical ventilation median Mortality mortality rate non-survivor Non-survivors observational study outcome Patient patients with COVID-19 PEEP positive required Result severe coronavirus disease severe COVID-19 severity Standard of care study period survival survivor Therapies United States ventilator parameters [DOI] 10.1371/journal.pone.0249038 PMC 바로가기 [Article Type] Research Article
Is the heart rate variability monitoring using the analgesia nociception index a predictor of illness severity and mortality in critically ill patients with COVID-19? A pilot study진통 통각 지수를 사용한 심박수 변동성 모니터링이 COVID-19 중증 환자의 질병 중증도 및 사망률의 예측인자입니까? 파일럿 연구Observational Study Published on 2021-03-242022-09-12 Journal: PLoS ONE [Category] MERS, SARS, 임상, 진단, [키워드] Analysis ANIm anti-inflammatory response autonomic Autonomic nervous system autonomous conducted correlated COVID-19 patient COVID-19 patients Critically ill Critically ill patient critically ill patients date of death death Depletion discharge domain energy Frequency heart rate HRV Hypothesis IL-6 IL-6 level IL-6 levels Illness severity intensive care unit interval limit management material mechanical ventilation MONITOR mortalities Mortality nervous system non-survivor normalized on mechanical ventilation parameter parasympathetic parasympathetic system Patient pilot study predicted Predictive Result sensitivity severity single-center SOFA SOFA score specificity Standard deviation surgical survival Time domain Variability were recorded worse prognosis [DOI] 10.1371/journal.pone.0249128 PMC 바로가기 [Article Type] Observational Study
Blood neurofilament light concentration at admittance: a potential prognostic marker in COVID-19입원 시 혈액 신경섬유 광 농도: COVID-19의 잠재적인 예후 마커Original Communication Published on 2021-03-202022-09-10 Journal: Journal of Neurology [Category] MERS, SARS, 바이오마커, 치료기술, [키워드] Acidic adjusted analyses Adjusted analysis Admission Analysis analyzed Biomarker Biomarkers Blood blood sample Blood samples clinical outcomes Clinical signs CNS Concentration COVID-19 COVID-19 patient COVID-19 patients detect discharged disease severity Effects GFAp Glial fibrillary acidic protein hypothese hypotheses Increased increased mortality Inflammatory biomarker inflammatory biomarkers Injury Inpatient intensive care intensive care unit light chain Linear model linear models measurement MONITOR Mortality nervous system Neurofilament light non-survivor Non-survivors objective on admission overall mortality Patient Prognostic marker Protein repeated Result risk SARS-CoV-2 serum serum biomarker serum biomarkers serum concentrations significantly higher Simoa subgroups survivor Symptoms the patient [DOI] 10.1007/s00415-021-10517-6 PMC 바로가기 [Article Type] Original Communication
Red Cell Distribution Width Upon Hospital Admission Predicts Short-Term Mortality in Hospitalized Patients With COVID-19: A Single-Center ExperienceMedicine Published on 2021-03-182022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] 28-day mortality 95% CI 95% confidence interval adjusted Admission Analysis association Cell China collected Comorbidity conducted confounders consecutive patient COVID-19 described died disease distribution eligible patient experience Final globe Increased independent IQR medical condition Mortality Non-COVID-19 non-survivor Odds ratio patients with COVID-19 pre-COVID-19 Predictive Prognosis Prognostic marker Prognostic value recorded Red Red cell distribution width remained retrospective short-term mortality significantly higher Spread suggested survivor tested Vienna width with COVID-19 [DOI] 10.3389/fmed.2021.652707 PMC 바로가기 [Article Type] Medicine
Immunological Characteristics in Type 2 Diabetes Mellitus Among COVID-19 Patients코로나19 환자 중 제2형 당뇨병의 면역학적 특성Observational Study Published on 2021-03-112022-09-11 Journal: Frontiers in Endocrinology [Category] SARS, 유전자 메커니즘, 임상, [키워드] Admission analyzed CD4 CD8 clinical Concentration Context contribute COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients COVID-19 pneumonia cytokine Cytokines D-dimer declined diabetes Diabetes Mellitus Diabetic diabetic patients dimer disease elevated evaluated feature ferritin flow cytometry groups high mortality Hospitalized hyperglycemia Identifier IL-10 IL-6 IL-8 IL‐6 IL‐8 Imbalance Immune cell immune cells immune system immunological immunological characteristics indicated laboratory parameter Laboratory parameters Lymphocytes lymphopenia Mortality Myoglobin nitrogen NK cell NK cells non-survivor Non-survivors objective participant pathogenic mechanism pathogenic mechanisms patients Pneumonia reduced reduction reductions Registration remained Result Retrospective study Sample serum serum concentrations severity significantly subset survival survivor Survivors T cell T cells T lymphocytes Th1/Th2 ratio TNF‐α Type type 2 diabete type 2 diabetes Type 2 diabetes mellitus urea urea nitrogen were measured [DOI] 10.3389/fendo.2021.596518 PMC 바로가기 [Article Type] Observational Study