Unleashing immuno-mass spectrometry superpowers to detect SARS-CoV-2SARS-CoV-2를 탐지하기 위한 면역 질량 분석기의 초능력 발휘Comment Published on 2021-07-102022-09-11 Journal: EBioMedicine [Category] SARS, 치료기술, 치료법, 치료제, [키워드] capture COVID-19 pandemic detect diagnose Immuno-capture IMPROVE large cohort Mass spec mass spectrometry Nasopharyngeal swab Nasopharyngeal swab samples Nucleocapsid proteins Previous studies previous study Protein Rapid respiratory respiratory infections responses robust SARS-CoV-2 SARS-CoV-2 nucleocapsid show subjects therapeutic [DOI] 10.1016/j.ebiom.2021.103480 PMC 바로가기 [Article Type] Comment
Targeting liquid–liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity Research Published on 2021-07-082022-10-05 Journal: Nature cell biology [Category] SARS, 변종, 치료제, [키워드] aggregation antiviral immune response antiviral response contributing to Coronavirus disease 2019 demonstrated disrupt domain exhibited Host in vitro in vivo inhibit inhibit SARS-CoV-2 innate antiviral immunity innate immune Innate immunity interferon-stimulated genes low expression MAVS mechanism morbidity Mutation nucleocapsid protein pandemic peptide promote Protein reduced Replication reported required RNA RNA virus SARS-CoV-2 nucleocapsid screened suppresse targeting the SARS-CoV-2 undergo Viral load [DOI] 10.1038/s41556-021-00710-0 [Article Type] Research
Mass Spectrometric Analysis of Urine from COVID-19 Patients for Detection of SARS-CoV-2 Viral Antigen and to Study Host ResponseSARS-CoV-2 바이러스 항원 검출 및 숙주 반응 연구를 위한 COVID-19 환자의 소변 질량 분광 분석Article Published on 2021-07-022022-09-11 Journal: Journal of Proteome Research [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] acute phase response Affect alteration Amino acid amino acid transporter Analysis approach body fluid body fluids Brain capture Chain Reaction complement complement system coronavirus COVID-19 COVID-19 negative COVID-19 patient COVID-19 patients Culture detect detection diagnosed Glucose immune response in urine Infection involved Kidney function kidneys liver Lungs mass mass spectrometry microbial Nasopharyngeal swab nasopharyngeal swabs NPHS2 nucleocapsid protein organ Pathogenesis pathogenesis of COVID-19 peptide peptides polymerase chain polymerase chain reaction positive Protein proteome proteomic proteomics public health Quantitative quantitative proteomic analysis Regulation renal response reverse transcriptase Reverse transcriptase polymerase chain reaction RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid SARS-CoV-2 positive individual SARS-CoV-2 positive individuals SLC36A2 SLC5A10 sodium subset transcriptase Urine Viral Viral antigen viral antigens Viral RNA virus were used [DOI] 10.1021/acs.jproteome.1c00391 PMC 바로가기 [Article Type] Article
Fetal and placental infection with SARS-CoV-2 in early pregnancy임신 초기 SARS-CoV-2에 의한 태아 및 태반 감염Case Reports Published on 2021-07-012022-09-11 Journal: Journal of medical virology [Category] SARS, 치료법, [키워드] accompanied acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Chain Reaction clinician consequence coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection double-stranded RNA dsRNA early pregnancy fetal fetus first trimester histological histological examination Hyperinflammatory immunofluorescence immunohistochemistry in some Infection Inflammation kidney lung management Microscopy miscarriage nucleocapsid protein organ organs outcomes pandemic Particle Particles Placenta placental Placental infection polymerase chain polymerase chain reaction positive Pregnancy pregnant women produced Prominent Protein provided Quantitative Replication responsible reverse transcription RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid SARS-CoV-2 protein severe acute respiratory syndrome Coronavirus target targets tissues Transmission Viral RNA [DOI] 10.1002/jmv.26965 PMC 바로가기 [Article Type] Case Reports
Parallel detection of SARS-CoV-2 RNA and nucleocapsid antigen in nasopharyngeal specimens from a COVID-19 patient screening cohortCOVID-19 환자 스크리닝 코호트의 비인두 표본에서 SARS-CoV-2 RNA 및 뉴클레오캡시드 항원의 병렬 검출Article Published on 2021-07-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis Antigen Cohort Concentration Concordance coronavirus correlated COVID-19 patient Ct values cycle threshold demonstrated diagnostic ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay examined interquartile range IQR median nasopharyngeal specimen nucleocapsid antigen patients PCR Quantitative resource RNA RT-PCR SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 RNA SARS-CoV-2 RNA detection SARS-CoV-2 RT-PCR sensitivity Spearman specificity specimen specimens time-consuming viral loads was performed [DOI] 10.1016/j.ijid.2021.05.082 PMC 바로가기 [Article Type] Article
COVID-19 (SARS-CoV-2) lymphocyte responses are associated with inflammatory biomarkers in total joint replacement surgery candidates pre-operativelyCOVID-19(SARS-CoV-2) 림프구 반응은 수술 전 총 관절 교체 수술 후보의 염증성 바이오마커와 관련이 있습니다Research Article Published on 2021-06-302022-09-10 Journal: Journal of Orthopaedic Surgery and Research [Category] MERS, SARS, 바이오마커, 치료법, [키워드] addition analyzed antibodies antibody antibody production Blood candidate Cohort coronavirus COVID-19 cross-reactivity elective surgeries Elective surgery exhibited exposure to General population IgG antibodies IgG antibody IL-1ra IL-1β IL-6 Immunity Inflammatory biomarker inflammatory biomarkers joint LTT lymphocyte lymphocyte response lymphocyte responses Lymphocytes median age memory nucleocapsid nucleocapsid protein Nucleocapsid proteins parameter Patient peripheral Peripheral blood positive pre-vaccination pro-inflammatory biomarkers profiles protective immunity Protein reactive reactivity recent Registered response Result Retrospective study risk SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 nucleocapsid SARS-CoV-2 virus serum spike and nucleocapsid proteins Spike protein Spike proteins T cell T cell memory the SARS-CoV-2 the SARS-CoV-2 virus the Spike the spike protein TNFα Total Total joint arthroplasty Trial registration vaccination vaccination Methods [DOI] 10.1186/s13018-021-02563-7 PMC 바로가기 [Article Type] Research Article
Cross-Reactivity of Two SARS-CoV-2 Serological Assays in a Setting Where Malaria Is Endemic말라리아가 풍토병인 환경에서 두 SARS-CoV-2 혈청학적 분석의 교차 반응성Article Published on 2021-06-182022-09-11 Journal: Journal of Clinical Microbiology [Category] MERS, SARS, 말라리아, 진단, 치료법, [키워드] Abbott alleviate antibody Antibody binding Architect assays association avidity Concentration COVID-19 Critical cross-reactivity Endemic Euroimmun False positive False positives IgG IgG level indicated malaria moderate Nigeria PCR PCR-positive plasma Plasmodium Plasmodium falciparum Plasmodium falciparum infection positive Previous studies previous study Protein reduced SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 patient SARS-CoV-2 patients Serological assay serological assays serology setting significantly higher tested urea urea concentration urea concentrations was performed WASH [DOI] 10.1128/JCM.00514-21 PMC 바로가기 [Article Type] Article
Multiple Roles of SARS-CoV-2 N Protein Facilitated by Proteoform-Specific Interactions with RNA, Host Proteins, and Convalescent AntibodiesArticle Published on 2021-06-152022-10-30 Journal: JACS Au [Category] COVID-19, [키워드] antibodies antigenic approved bind C-terminal C-terminus convalescent convalescent plasma coronavirus COVID-19 cyclosporin A epitope exhibited functional highlight identify IgA antibody IgG IgM immunogenic Interaction mass spectrometry motif motifs Multiple N protein N-terminal nucleocapsid Protein Proteolytic processing Replication ribonucleoprotein RNA role SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 nucleocapsid significantly therapeutic intervention Therapies Viral protein virion assembly virus [DOI] 10.1021/jacsau.1c00139 PMC 바로가기 [Article Type] Article
Seroprevalence of SARS-CoV-2 (COVID-19) exposure in pet cats and dogs in Minnesota, USA미국 미네소타의 애완 동물 고양이와 개에서 SARS-COV-2 (COVID-19) 노출의 혈청 유병률Research Article Published on 2021-06-142022-09-01 Journal: Virulence [Category] SARS, 진단, 치료기술, 치료법, [키워드] antibody Antigen antigens assays average canine cat cats caused coronavirus coronavirus SARS-CoV-2 Coronaviruses COVID-19 COVID-19 pandemic cross cutoff value detect dog early phase ELISA ELISAs enzyme enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays Evidence evidence of exhibited experiment feline coronaviruses Households identify IgG antibodies IgG antibody neutralization antibodies Neutralization assay neutralizing activities Neutralizing activity pandemic Protein RBD RBD-specific antibodies RBD-specific antibody RBD-specific IgG reported SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 N protein SARS-CoV-2 nucleocapsid sensitivity sera seropositive seropositive sample seropositive samples Seroprevalence serum sample serum samples Seven specific antibodies specific IgG antibodies specificity Spike protein Spread stomatitis the SARS-CoV-2 the spike protein USA vesicular stomatitis vesicular stomatitis virus was used zoonoses [DOI] 10.1080/21505594.2021.1936433 PMC 바로가기 [Article Type] Research Article
Serological profiles of pan-coronavirus-specific responses in COVID-19 patients using a multiplexed electro-chemiluminescence-based testing platform다중 전기 화학 발광 기반 테스트 플랫폼을 사용한 COVID-19 환자에서 Pan-Coronavirus 특이 적 반응의 혈청 학적 프로파일Research Article Published on 2021-06-032022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 치료법, [키워드] antibody Antibody Response antibody response against Antibody responses carried collected Contact tracing COVID-19 COVID-19 patient COVID-19 sample COVID-19 samples CoVs cross-reactive cross-reactivity diagnosed with COVID-19 Diagnosis diagnostic domain epitope epitope specificity full-length spike protein group healthcare HKU1 hospital human coronavirus human CoV human CoVs IgG response IgG responses IgM and IgG IgM response IgM responses MERS MERS-CoV Multiplex assay N-terminal domain Non-COVID-19 nucleocapsid protein OC43 occur plasma sample plasma samples platform Prevalence profile Protein reactivity Receptor-binding domain reported response responses robust SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 nucleocapsid SARS-CoV-2 spike protein seasonal coronavirus serological assessment South South Korea specificity Spike protein Spike proteins subject Symptom the SARS-CoV-2 the spike protein unique [DOI] 10.1371/journal.pone.0252628 PMC 바로가기 [Article Type] Research Article