SARS-CoV-2 proteins – Page 15 – Communicable Diseases Research

Alignment of virus-host protein-protein interaction networks by integer linear programming: SARS-CoV-2

Research Article

Published on 2020-12-072022-10-28
Journal: PLoS ONE [Category] COVID-19, MERS, SARS,

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

비교 호스트 코로나 바이러스 단백질 상호 작용 네트워크는 범 바이러스 질병 메커니즘을 나타냅니다

Comparative Study

Published on 2020-12-042022-09-10
Journal: Science (New York, N.y.) [Category] MERS, SARS, 유전자 메커니즘, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis analyzed Antisera approach approaches asked Atypical carried caused Celecoxib cellular chaperone Characteristics characterized clinical outcomes clinical study clinically Cohort Comparative Comparative analysis complex conducted conserved coronavirus COVID-19 COVID-19 hospitalization COVID-19 pandemic COVID-19 patient curated dataset determine develop disease drug drug target drug treatment Effectiveness effort Endoplasmic reticulum engage ENhance Evidence Factor functional Genetic genetic data genetic screening genetic screens Genome-wide association study Genotype genotypes Hospitalization Host Host immune response host protein hosts human cells human coronaviruses human protein Hypothesis Hypothesis testing identify IL17RA independent individual indomethacin Infection infectious agent infectious agents inhibit inhibit SARS-CoV-2 inhibitor interact Interaction investigated left less life cycle Localization mapped mechanism MERS MERS-CoV Microscopy Middle East Middle East respiratory syndrome Coronavirus mitochondrial modulate molecular molecular mechanism molecular mechanisms NSP open Open reading frame ORF Orf9b Outbreaks pathogenic coronavirus pathogenic human coronavirus pathogenic human coronaviruses pathway patient data patients treated plasma proliferation Protein protein-protein interaction provide public health raised receptor receptors respiratory respiratory syndrome coronavirus right risk risk of COVID-19 SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 ORF9b SARS-CoV-2 patient SARS-CoV-2 patients SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 replication Science selected severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shedding SIGMAR1 significant changes in strain Strains Structure subset target targets tested Therapeutic strategies Therapeutics therapy urgency utility Viral viral infection Viral protein Viral proteins virus Virus life cycle virus strain viruses
[DOI] 10.1126/science.abe9403 PMC 바로가기 [Article Type] Comparative Study

Protein-Driven Mechanism of Multiorgan Damage in COVID-19

Research article

Published on 2020-12-012022-10-05
Journal: Medicine in Drug Discovery [Category] 신약개발,

Antagonism of Type I Interferon by Severe Acute Respiratory Syndrome Coronavirus 2

중증급성호흡기증후군 코로나바이러스 2에 의한 I형 인터페론의 길항작용

Review

Published on 2020-12-012022-09-11
Journal: Journal of interferon & cytokine research : the of [Category] SARS, 변종, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antagonism Antiviral caused coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 early stage eliminating evade facilitate Host Host immune response IFN-I immune immune evasion Infection innate immune response innate immune system interferon knowledge molecular mechanism molecular mechanisms pandemic Pathogenesis Prevent provided respiratory responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins severe acute respiratory syndrome Coronavirus Signaling Transmission Type type I interferon Vaccine Viral viral replication virus
[DOI] 10.1089/jir.2020.0214 PMC 바로가기 [Article Type] Review

Dynamic changes in anti-SARS-CoV-2 antibodies during SARS-CoV-2 infection and recovery from COVID-19

SARS-CoV-2 감염 및 COVID-19 회복 중 항 SARS-CoV-2 항체의 동적 변화

Article

Published on 2020-11-272022-09-10
Journal: Nature Communications [Category] SARS, 진단, 치료기술, 치료법,

[키워드] addition anti-SARS-CoV-2 antibody antibody Antibody Response Antibody responses change changes in clinical parameter Clinical parameters COVID-19 COVID-19 diagnosis COVID-19 patients discharge disease domain dynamic Hospitalization IgG IgG antibodies IgG level IgM IgM and IgG immune response Immunoglobulin immunoglobulin M immunological immunology information Laboratory laboratory findings large cohort Lower lymphocyte Moderate COVID-19 moderate COVID-19 patients neutrophil nucleoprotein occur older patient older patients Patient patients positive Protein provide RBD RBD-specific IgG Receptor-binding domain recovered patient recovered patients RNA S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 proteins SARS-CoV-2 RNA Spike protein tested Treatment understanding Vaccine development variables Viral viral infection viral shedding younger patient younger patients
[DOI] 10.1038/s41467-020-19943-y PMC 바로가기 [Article Type] Article

SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses

SARS-CoV-2는 호스트 방어를 억제하기 위해 스플라이싱, 번역 및 단백질 트래피킹을 방해합니다.

Article

Published on 2020-11-252022-09-11
Journal: Cell [Category] MERS, SARS, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus bind cause cell membrane cellular cellular processe coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disrupt Disruption domain engage function Host host defenses Infection Interaction interfere interferon interferon response leads molecular basis mRNA mRNA splicing mRNA translation nsp1 nsp16 NSP8 Nsp9 Protein protein trafficking protein translation respiratory Respiratory disease ribosomal RNA ribosome RNA RNA-protein interactions RNAs SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2 protein SARS-CoV-2 proteins severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 snRNA splicing suppress the cell the interferon translation Viral viral infection
[DOI] 10.1016/j.cell.2020.10.004 PMC 바로가기 [Article Type] Article

Data, Reagents, Assays and Merits of Proteomics for SARS-CoV-2 Research and Testing

Research

Published on 2020-11-252022-10-30
Journal: Molecular & Cellular Proteomics : MCP [Category] COVID-19, SARS,

[키워드] A549 ACE2 African green monkey Analysis approach BRCA1 Breast cancer Caco-2 Calu-3 can be used cause cell line change changed Chlorocebus clinical proteomics Cohort COVID-19 COVID-19 pandemic COVID-19 research diagnostic diagnostics evaluate Evidence expression expression data facilitate Factor feasibility genomes globe Innate immunity involved kDa label-free quantification manuscript mass spectrometry monitoring parallel reaction monitoring peer-reviewed peptides positive profile protease inhibitors Protein protein expression Proteins proteome proteomic proteomics Region representing Research SARS-CoV-2 SARS-CoV-2 cell SARS-COV-2 infection SARS-CoV-2 proteins SARS-CoV-2 research Spread SRP9 stable-isotope labeling supernatant synthetic synthetic peptide targeted mass spectrometry Testing TMPRSS2 transcriptional regulators Vero Cell Vero E6 Vero E6 cell viral entry viral infection virus widespread
[DOI] 10.1074/mcp.RA120.002164 PMC 바로가기 [Article Type] Research

CovMulNet19, Integrating Proteins, Diseases, Drugs, and Symptoms: A Network Medicine Approach to COVID-19

Original Research: COVID-19 Research in Network and Systems Medicine

Published on 2020-11-172022-10-30
Journal: Network and Systems Medicine [Category] COVID-19,

[키워드] Analysis approach bootstrap Comorbidities Comorbidity Complex networks Compound condition conditions COVID-19 COVID-19 patients disease Disease network drug Extensive Factors human proteins Inclusion Interaction interactome intestinal material Medicine molecular molecular interaction multidimensional network network analysis Neurological disease pathology patients Proteins randomization Randomized reported representing risk factor SARS-CoV-2 proteins similarity Symptom Symptoms the disease treat
[DOI] 10.1089/nsm.2020.0011 PMC 바로가기 [Article Type] Original Research: COVID-19 Research in Network and Systems Medicine

Lung transcriptome of a COVID-19 patient and systems biology predictions suggest impaired surfactant production which may be druggable by surfactant therapy

Article

Published on 2020-11-102022-10-04
Journal: Scientific Reports [Category] 유전자 메커니즘, 치료제,

[키워드] acute lung injury affecting Analysis analyzed biopsy Cell cholesterol Clinical management complicate Computational biology and bioinformatics COVID-19 COVID-19 patient Cytokine storm downregulated drug dysregulated EGR1 enrichment analysis Gene Expression gene expression pattern HIF-1 hypoxia impairment lung lung damage lung tissue mapped mechanism Microbiology mitochondrial molecular mechanism molecular networks NDUFA10 NDUFAF5 network nsp5 ORF8 oseltamivir Patient PLAT Protein responses SAMM50 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 proteins Signaling symptomatic Systems biology Therapies therapy thrombosis Transcriptome TTF1 virus
[DOI] 10.1038/s41598-020-76404-8 PMC 바로가기 [Article Type] Article

Perversely expressed long noncoding RNAs can alter host response and viral proliferation in SARS-CoV-2 infection

Research Article

Published on 2020-10-272022-10-31
Journal: Future Virology [Category] COVID-19,