Characterization of a Lineage C.36 SARS-CoV-2 Isolate with Reduced Susceptibility to Neutralization Circulating in Lombardy, Italy계통의 특성화 C.36 SARS-COV-2 분리 물의 중화에 대한 감수성 감소가 이탈리아 롬바르디아에서 순환Brief Report Published on 2021-07-312022-09-01 Journal: Viruses [Category] SARS, 변종, 진단, [키워드] characterization concerning COVID-19 deletions evade genomic sequencing humoral Humoral response isolate Isolation Italy L452R Lineage lombardy molecular neutralization Phenotypes R346K recurrence SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 isolates SARS-CoV-2 spike SARS-CoV-2 strain sera single-point mutation single-point mutations spike susceptibility traits Transmissibility Vaccine variant of concern [DOI] 10.3390/v13081514 PMC 바로가기 [Article Type] Brief Report
Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains부모 SARS-CoV-2 균주보다 B.1.1.7 감염 후 항체 교차 반응성 감소Research Article Published on 2021-07-292022-09-10 Journal: eLife [Category] SARS, 변종, 진단, [키워드] (alpha (Beta acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody antibody cross-reactivity asymmetric B.1.1.7 B.1.351 Beta binding antibodies coronavirus COVID-19 cross-reactivity drop Dynamics elicited examined exhibited Francis Crick funding Human Immunity immunogenicity infecting Infection Magdeburg Max Planck neutralisation Neutralising Antibodies parental reduced respiratory SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus significantly significantly more South Africa spike glycoprotein Spread strain Strains supported titre titres United Kingdom vaccination variant viral variant virus virus neutralising antibody [DOI] 10.7554/eLife.69317 PMC 바로가기 [Article Type] Research Article
D614G Substitution of SARS-CoV-2 Spike Protein Increases Syncytium Formation and Virus Titer via Enhanced Furin-Mediated Spike CleavageSARS-CoV-2 스파이크 단백질의 D614G 대체는 강화된 푸린 매개 스파이크 절단을 통해 융합체 형성 및 바이러스 역가를 증가시킵니다Research Article Published on 2021-07-272022-09-10 Journal: mBio [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed Cell cleavage coronavirus D614G D614G substitution enhanced enhancement expressing S protein Formation furin furin cleavage site furin inhibitor increase isolates mechanism Mutation Plaque assay promote Protein rapid expansion respiratory S protein S proteins SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains severe acute respiratory syndrome Coronavirus significantly higher spike Substitution syncytium syncytium formation the S protein titer Transmissibility Treatment variant Viral viral isolate virus titer [DOI] 10.1128/mBio.00587-21 PMC 바로가기 [Article Type] Research Article
A Possible Role of Remdesivir and Plasma Therapy in the Selective Sweep and Emergence of New SARS-CoV-2 VariantsReview Published on 2021-07-242022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Administered anti-spike antibodies Brazil changes characterized clinical trial convalescent plasma coronavirus COVID-19 COVID-19 pandemic elicited emergence Europe favor Genetic Hypothesis Immune escape Immunocompromised patient include Infection Lineage MONITOR monoclonal antibody multiple mutation mutants Mutation neutralizing antibody New new SARS-CoV-2 Occurrence Patient physician plasma therapy promoter recent Remdesivir replaced role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 variants South Africa Spread Support the patient therapy treat Vaccine immunization variant variants viral mutation viral spike protein whole-genome sequencing [DOI] 10.3390/jcm10153276 PMC 바로가기 [Article Type] Review
Whole genome sequencing and phylogenetic analysis of six SARS-CoV-2 strains isolated during COVID-19 pandemic in Tunisia, North Africa북아프리카 튀니지에서 Covid-19 Pandemic 동안 분리 된 6 개의 SARS-Cov-2 균주의 전체 게놈 시퀀싱 및 계통 발생 학적 분석Research Article Published on 2021-07-142022-09-10 Journal: BMC Genomics [Category] SARS, 치료기술, [키워드] approach circulating clade COVID-19 outbreak COVID-19 pandemic Critical Diagnosis distribution early phase favor genetic variability Genome genomic data Genotype genotypes International Local Molecular epidemiology NGS North nucleotide outbreak Phylogenetic analysis positive sample reported Result SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 virus SARS-CoV-2 viruses sequence sequences SNP SNP mutation SNPs Strains Transmission Tunisia Vaccine development virus viruses was performed Whole genome sequencing [DOI] 10.1186/s12864-021-07870-1 PMC 바로가기 [Article Type] Research Article
COVIDomic: A multi-modal cloud-based platform for identification of risk factors associated with COVID-19 severityResearch Article Published on 2021-07-142022-10-28 Journal: PLoS Computational Biology [Category] COVID-19, SARS, [키워드] accelerate acute infection Analysis Antibiotic resistance bioinformatics collected Community coronavirus Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 research Data analysis determine Epidemiology expected facilitate feature Genetic geographical location Health implication IMPROVE include Infection Interpretation management metatranscriptomic microbial Organisms Outbreaks pathogen Patient patients with COVID-19 platform provide respiratory tract respond risk factor SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 strain sequenced severity strain Stratification Symptom Symptoms the disease variety with COVID-19 Wuhan, China [DOI] 10.1371/journal.pcbi.1009183 PMC 바로가기 [Article Type] Research Article
Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch toleranceArticle Published on 2021-07-132022-10-04 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료제, [키워드] antiviral drug antiviral therapeutics approach B.1.1.7 cellular circumvent CRISPR CRISPR-Cas systems D614G degrade demonstrated described dominant variant effector Efficiency genomic highlight host immunity impair Interaction mammalian cell mammalian cells molecular Mutagenesis mutant mutated pathogenic viruses Prevent Region replication-competent SARS-CoV-2 Resilience RNA RNA transcript RNAi RNAi therapy SARS-CoV-2 SARS-CoV-2 mutants SARS-CoV-2 replication SARS-CoV-2 strain SARSCoV-2 single-nucleotide specificity spike subgenomic RNAs suppress suppresse Synthetic biology the Spike Tolerance transcript variant variants of concern viral escape viral replication [DOI] 10.1038/s41467-021-24577-9 PMC 바로가기 [Article Type] Article
An intranasal vaccine durably protects against SARS-CoV-2 variants in miceArticle Published on 2021-07-102022-11-01 Journal: Cell Reports [Category] COVID-19, SARS, [키워드] Abstract Administered antibody Antibody neutralization Antibody Response attenuate B.1.1.28 B.1.351 B.1.617.1 Bone marrow chimpanzee adenovirus-vectored vaccine Complete COVID-19 cross-protection cross-protective dose dose response dose-dependent manner Durability Efficacy function IgA IgG Immunity immunization immunogenic induce inhibitory intranasal intranasally long-lived plasma cell Lower respiratory tract mice mucosal immunity neutralized Neutralizing Pathogenesis PROTECT protection Protective provide reported robust SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains SARS-CoV-2 variant secreting serum serum antibody Spike protein trials vaccination Vaccine vaccine dose variant variants of concern viruses [DOI] 10.1016/j.celrep.2021.109452 PMC 바로가기 [Article Type] Article
Potent RBD-specific neutralizing rabbit monoclonal antibodies recognize emerging SARS-CoV-2 variants elicited by DNA prime-protein boost vaccinationResearch Article Published on 2021-07-082022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, SARS, [키워드] Analysis B.1.1.7 B.1.351 B.1.351 variants B.1.429 B.1.526 boost COVID-19 D614G diagnostic DNA DNA vaccine domain effective elicited epitope Epitopes heterologous prime-boost immunization host immunity induce Measures monoclonal antibody neutralization neutralization potency neutralize Neutralizing overlapping P.1 point-of-care potent priming Protein pseudovirus rabbit mAb RBD RBD protein recognize S1 protein SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 WT Sequence analysis Spike protein tested the SARS-CoV-2 vaccination Vaccine variant Variant of concerns variants virus wild type [DOI] 10.1080/22221751.2021.1942227 PMC 바로가기 [Article Type] Research Article
Characterization of a new SARS-CoV-2 variant that emerged in Brazil브라질에서 출현한 새로운 SARS-CoV-2 변종 특성 규명Comparative Study Published on 2021-07-062022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition animal model Antigen aspartic acid BNT162b2 Brazil characterization characterized circulating comparable convalescent human plasma convalescent patient Convalescent patients convalescent sera coronavirus COVID-19 deaths glycine hamster hamsters Host host range in viral Infection Japan less Lower respiratory tract Messenger RNA mice multiple mutation multiple mutations neutralization titer Neutralizing antibodies neutralizing antibody new SARS-CoV-2 number of deaths P.1 P.1 variant P.1 variants passive transfer pathogenicity Patient plasma position prevented protective immune response Protein reduced Reinfection Replication replicative respiratory S protein SARS-CoV-2 SARS-CoV-2 disease SARS-COV-2 infection SARS-CoV-2 strain sera serum severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown Significance strain Strains Syrian hamsters the S protein transfer Vaccine vaccinee variant variant of SARS-CoV-2 variants Viral viral infectivity virus replication [DOI] 10.1073/pnas.2106535118 PMC 바로가기 [Article Type] Comparative Study