Seroprevalence and asymptomatic carrier status of SARS-CoV-2 in Wuhan City and other places of China우한시 및 중국 기타 지역에서 SARS-CoV-2의 혈청형 및 무증상 보균자 현황Research Article Published on 2021-01-072022-08-13 Journal: PLoS Neglected Tropical Diseases [Category] Biochemistry, 진단, 치료기술, [키워드] age analyzed antibody approach Asymptomatic Asymptomatic carrier Asymptomatic carriers carrier carriers China city colloidal gold correlated correlation COVID-19 Elimination except for female healthy individual healthy individuals IgG and IgM IgM IgM antibody in healthy individual incidence individual investigated logistic regression model male males nation Older Older age outbreak positive rate Probability Region SARS-CoV-2 SARS-CoV-2 IgG seropositive Seroprevalence Sex significantly significantly higher the SARS-CoV-2 were infected Wuhan [DOI] 10.1371/journal.pntd.0008975 PMC 바로가기 [Article Type] Research Article
Accurately Differentiating Between Patients With COVID-19, Patients With Other Viral Infections, and Healthy Individuals: Multimodal Late Fusion Learning ApproachCOVID-19 환자, 다른 바이러스 감염 환자 및 건강한 개인을 정확하게 구분: 다중 모드 후기 융합 학습 접근Original Paper Published on 2021-01-062022-09-10 Journal: Journal of Medical Internet Research [Category] MERS, 치료기술, [키워드] Accuracy Admission approach assist binary classification biomedical imaging Chain Reaction clinical decision clinical information clinical outcomes Computed tomography COVID-19 Critical CT scan CT scans deep learning Diagnosis diagnosis support diagnostic Diagnostic method diagnostic methods differentiation Early detection early stage effective feature feature fusion Features fusion healthy healthy individuals imaging Infection lab lack large sample learning machine learning machine learning model multimodal objective Other Participants Patient patients with COVID-19 Pneumonia provided random Random forest recruited Result severe COVID-19 Support Testing Viral Viral pneumonia [DOI] 10.2196/25535 PMC 바로가기 [Article Type] Original Paper
SARS-CoV-2-specific antibody rearrangements in prepandemic immune repertoires of risk cohorts and patients with COVID-19코로나19 위험 집단과 환자의 전염병 전 면역 레퍼토리에서 SARS-CoV-2 특이 항체 재배열Clinical Trial Published on 2021-01-042022-09-12 Journal: The Journal of Clinical Investigation [Category] MERS, 임상, 진단, [키워드] acute respiratory syndrome Adaptive immunity age antibodies antibody antibody sequence B cell B cell receptor B cell response biochemical Blood Cancer Clinical course Cohort coronavirus coronavirus disease courses COVID-19 detrimental effect disease severity element explain fraction Future groups healthy individual healthy individuals immune immunoglobulins immunology individual less memory Neutralizing neutralizing antibody occurred pandemic Patient patients with COVID-19 receptor recognize reflect resulting retrieved risk SARS-CoV-2 SARS-CoV-2 antibody sequence serological data solid cancer validation cohorts while [DOI] 10.1172/JCI142966 PMC 바로가기 [Article Type] Clinical Trial
SARS-CoV-2 B cell receptor signatures in at-risk populations위험에 처한 인구에서 SARS-CoV-2 B 세포 수용체 서명Article Published on 2021-01-042022-09-12 Journal: The Journal of Clinical Investigation [Category] 진단, [키워드] acute respiratory syndrome age antibody B cell Cancer Clinical course coronavirus coronavirus disease epitope Frequency healthy individuals healthy subject individual Infection less Patients with cancer Population populations receptor recognizing SARS-CoV-2 SARS-CoV-2-specific B cell sequence spike glycoprotein subject [DOI] 10.1172/JCI144685 PMC 바로가기 [Article Type] Article
Frontline Science: COVID-19 infection induces readily detectable morphologic and inflammation-related phenotypic changes in peripheral blood monocytes최전선 과학: COVID-19 감염은 말초 혈액 단핵구에서 쉽게 감지할 수 있는 형태학적 및 염증 관련 표현형 변화를 유도합니다Multicenter Study Published on 2021-01-012022-09-11 Journal: Journal of leukocyte biology [Category] SARS, 바이오마커, 치료기술, [키워드] Activation acute lung injury acute respiratory distress acute respiratory distress syndrome Admission Analysis ARDS CD14 CD16 CD80 changes in clinical utility controls COVID-19 COVID-19 infection COVID-19 patient cytokine Cytokine storm detect detectable expression Factor feature Flow cytometric analysis flow cytometry forward scatter FSC FSC-high functional healthy individuals help Hospitalization ICU identify IL-10 IL-6 induce infection with COVID-19 inflammatory monocyte inflammatory monocytes intensive care intensive care unit intervene Lung injury M1/M2 macrophage Macrophage macrophage polarization monocyte Monocytes morphology outcome Patient patients with COVID-19 performed Peripheral blood peripheral blood samples phenotypic predict recognize respiratory distress Respiratory distress syndrome risk secretion Severity of disease side scatter significant difference significant differences subsequent subset syndrome TNF-α Treatment with COVID-19 [DOI] 10.1002/JLB.4HI0720-470R PMC 바로가기 [Article Type] Multicenter Study
Damaged lung gas exchange function of discharged COVID-19 patients detected by hyperpolarized 129 Xe MRI과분극 129 Xe MRI로 검출된 퇴원한 코로나19 환자의 폐가스 교환 기능 손상Research Article Published on 2021-01-012022-09-12 Journal: Science Advances [Category] MERS, 진단, [키워드] Abnormalities alveolar Computed tomography COVID-19 COVID-19 patient COVID-19 patients detect dimension diminished discharge discharged disease feasibility Gas exchange healthy individuals lung Lung function Lungs magnetic resonance imaging Microstructure MRI recovered patient reported Shortness of breath technique Vasculopathy Ventilation while [DOI] 10.1126/sciadv.abc8180 PMC 바로가기 [Article Type] Research Article
A distinct innate immune signature marks progression from mild to severe COVID-19뚜렷한 타고난 면역 신호는 경증에서 중증 COVID-19로의 진행을 나타냅니다.Article Published on 2020-12-262022-09-11 Journal: Cell Reports Medicine [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] appearance CCL3 CCL4 CD16 CD169 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Cytometry emergency granulopoiesis healthy individuals identify IFN-γ immune responses immune signature Inflammation inflammatory phenotype Inflammatory response Inflammatory responses innate immune innate immune response innate response mass cytometry mechanism Mild mild COVID-19 patient mild COVID-19 patients mild or severe Covid-19 MIP1α monocyte Monocytes observé Patient progression proteomics sampling SARS-CoV-2 severe COVID-19 severe disease severe patients sialoadhesin sialoadhesin. signature Stage stages sustained symptom onset targeted intervention targeted interventions trajectory [DOI] 10.1016/j.xcrm.2020.100166 PMC 바로가기 [Article Type] Article
HCoV- and SARS-CoV-2 Cross-Reactive T Cells in CVID PatientsImmunology Published on 2020-12-232022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] Anti-viral Antibody Response CD4+ cell CD4+ T cell CD4+ T cells CD8+ cell Cell characterized common variable immunodeficiency disorder (CVID) Coronavirus disease 2019 (COVID-19) correlation COVID-19 cross-reactive cross-reactivity CVID detectable Endemic evaluate evaluated Evidence Frequency had no HCoV-229E healthy control healthy individuals human endemic coronavirus 229E (HCoV-229E) human endemic coronavirus OC-43 (HCoV-OC43) IFNγ IL-2 Immunity less marker multifunctional nucleocapsid pathogen Patient patients patients with CVID peptide pools primary immunodeficiency (PID) profiles Protective Proteins provide raised reactive reactivity reported risk SARS-CoV-2 SARS-COV-2 infection Seven severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) severity T cell T cell response T cell responses TNFα virus [DOI] 10.3389/fimmu.2020.607918 PMC 바로가기 [Article Type] Immunology
Altitude and COVID‐19: Friend or foe? A narrative reviewOriginal Research Published on 2020-12-192022-10-28 Journal: Physiological Reports [Category] COVID-19, MERS, [키워드] aggravate altitude antioxidant ARDS Characteristics Clinical practice condition conditions coronavirus Corticosteroid COVID‐19 detrimental Dexamethasone dose Effect effective Effects elevated Epidemiology evaluated Evidence Friend healthy individuals heart failure Hypoxemia hypoxia hypoxic illness immune system Immunity incidence individual instance knowledge mechanisms Mitochondria mitochondrial Mortality MOST novel coronavirus disease overlap oxygen supply pandemic pathology pathophysiological pathophysiology Patient physiological response Prevent prophylactic measure recent reported Research responses risk SARS‐CoV‐2 infection similarity Symptom Symptoms treat Treatment treatment strategy while [DOI] 10.14814/phy2.14615 PMC 바로가기 [Article Type] Original Research
A blood transcriptome-based analysis of disease progression, immune regulation, and symptoms in coronavirus-infected patientsArticle Published on 2020-12-082022-10-04 Journal: Cell Death Discovery [Category] 바이오마커, [키워드] adaptive Analysis Anti-viral applied approach available data B cell Blood cell types Comorbidity complex condition coronavirus COVID-19 patient cytokine Cytokines cytolytic diabetes disease Disease progression dysregulated Gene Expression Genes healthy individual healthy individuals help heterogeneity HLA-DQA1 HLA-F Hospitalization IFN-γ IL6 immune regulation Immune status Immunity immunology increases in Infection Innate immunity Lung disease management mimicking Molecular biology mononuclear cell Neutrophils observation outcome overlapping pandemic parameter Pathways Patient patients PBMC PBMCs Peripheral blood platform Pneumonia profile reduced response RNA SARS-CoV SARS-CoV-2 patient significantly stages subset Symptom Systems biology the disease Thromboembolism TNF [DOI] 10.1038/s41420-020-00376-x PMC 바로가기 [Article Type] Article