mononuclear cell – Page 16 – Communicable Diseases Research

The Current Status and Challenges in the Development of Vaccines and Drugs against Severe Acute Respiratory Syndrome-Corona Virus-2 (SARS-CoV-2)

Review

Published on 2021-06-012022-10-27
Journal: BioMed Research International [Category] Coronavirus, COVID-19, MERS, SARS,

The Current Status and Challenges in the Development of Vaccines and Drugs against Severe Acute Respiratory Syndrome-Corona Virus-2 (SARS-CoV-2)

중증 급성 호흡기 증후군-코로나 바이러스 -2 (SARS-COV-2)에 대한 백신 및 약물의 발달의 현재 상태와 도전.

Review

Published on 2021-06-012022-09-10
Journal: BioMed Research International [Category] 변종, 신약개발, 진단, 치료기술,

[키워드] acute respiratory distress addition addressed angiotensin Angiotensin-converting enzyme Antibody Response Antibody-dependent enhancement bind cause challenge change characterized Clinical management clinical manifestation clinical manifestations clinically Complete complications of COVID-19 coronavirus coronavirus disease Coronavirus disease-19 COVID-19 COVID-19 patient COVID-19 patients current Cytokine storm described develop development drug effective eosinophil greater Hypothesis Immunity immunopathological include individual Infection infiltration lack lung Lungs lymphopenia management mechanism mechanisms membrane molecular molecular and serological tests mononuclear cell mutant pathogenesis of SARS-CoV-2 pathophysiology patients Pneumonia Prevent protease PROTECT provide reduce Replication Research respiratory respiratory distress S glycoprotein SARS-CoV-2 serological test Serological tests Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 Spread status T cell tested the antibody response therapeutic therapeutic intervention Treatment treatment of COVID-19 patients understanding Vaccine variant variants of SARS-CoV-2 variations Viral Viral load virulence virus virus transmission
[DOI] 10.1155/2021/8160860 PMC 바로가기 [Article Type] Review

Single-cell epigenomic landscape of peripheral immune cells reveals establishment of trained immunity in individuals convalescing from COVID-19

말초 면역 세포의 단일 세포 후성유전체 환경은 COVID-19에서 회복 중인 개인의 훈련된 면역 확립을 보여줍니다

Article

Published on 2021-06-012022-09-11
Journal: Nature cell biology [Category] SARS, 유전자 메커니즘, 임상, 치료기술, 치료법,

[키워드] accelerated activated acute respiratory syndrome acute respiratory syndrome coronavirus adaptive Analysis antibody asymptomatic infection B cell B-cell cause CD14 CD16 CD8 chromatin collected coronavirus coronavirus 2 COVID-19 death developmental differentiation epigenomic exhibited expansion healthy donors highlighting immature Immune cell immune cells immune response immune responses Immunity Immunological memory individual individuals Infection IRF1 Lineage Memory cells monocyte Monocytes mononuclear cell performed Peripheral blood Peripheral blood mononuclear cells Plasma cells profile promote reported reveal SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe complication severe complications single-cell T cell T cells
[DOI] 10.1038/s41556-021-00690-1 PMC 바로가기 [Article Type] Article

SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of the immune cells

Research Article

Published on 2021-05-282022-10-31
Journal: Heliyon [Category] COVID-19,

[키워드] ¹H-NMR Acetate acute respiratory distress ARDS autologous CD8 CD8⁺ T cells change characterized convalescent COVID-19 patients convalescent patient Convalescent patients COVID-19 Cytometry cytotoxic function elevated expression Flow flow cytometry Glutamate granzyme Granzyme A Immune cell immune cells immune response infectious disease outbreak interfere investigated Lactate metabolic function metabolites Mild moderate Moderate COVID-19 mononuclear cell Patient patients PBMCs perforin Peripheral blood SARS-COV-2 infection SARS-CoV-2 virus significantly suggested syndrome T cell T cells Taurine virus
[DOI] 10.1016/j.heliyon.2021.e07147 PMC 바로가기 [Article Type] Research Article

COVID-19 Severity Potentially Modulated by Cardiovascular-Disease-Associated Immune Dysregulation

Article

Published on 2021-05-282022-10-28
Journal: Viruses [Category] COVID-19,

Association of Circulating Sex Hormones With Inflammation and Disease Severity in Patients With COVID-19

Research

Published on 2021-05-252022-10-29
Journal: JAMA Network Open [Category] COVID-19, SARS,

[키워드] 95% CI Admission age association C-reactive protein CD14 CD16 cellular signaling pathways circulating classical clinical trial cohort study collected Concentration concentrations conducted consecutive patient contribute COVID-19 COVID-19 illness diagnosed disease disease severity enrichment analysis estradiol exposure finding growth factor hepatocyte growth factor hormone hormone concentration Hospitalization Hospitalized Hypothesis IGF-1 Importance Inflammation Inflammatory cytokine intensive care interferon male measure median men monocyte mononuclear cell nasopharyngeal swabs objective outcome participant pathophysiologic Patient patients with COVID-19 Point predisposition prospective cohort study Protein receptor regulated Relevance remained required Result risk factor RNA sequencing serum serum sample setting severe COVID-19 severe COVID-19 illness severity Sex sex hormone Signaling signaling pathway single-center Testosterone the patient Treatment upregulated upregulation was performed were measured with COVID-19 women
[DOI] 10.1001/jamanetworkopen.2021.11398 PMC 바로가기 [Article Type] Research

SARS-CoV-2 variants of concern partially escape humoral but not T-cell responses in COVID-19 convalescent donors and vaccinees

우려되는 SARS-CoV-2 변이체는 COVID-19 회복기 기증자와 백신에서 체액성 반응을 부분적으로 탈출하지만 T 세포 반응은 회피하지 않습니다

Article

Published on 2021-05-252022-09-11
Journal: Science Immunology [Category] Fulltext, SARS, 변종, 진단, 치료기술,

[키워드] addition antibody antigens B.1.1.7 B.1.351 B.1.351 variant B.1.351 variants BNT162b2 CD4 Cellular immune response cellular immune responses Cohort COVID-19 convalescent donor COVID-19 disease cross-reactivity detect elicited exhibited functional HCW Health care Health care worker homologous humoral Humoral and cellular immune responses Humoral immunity Immune escape immune response immune responses individuals Mild Mild COVID-19 disease mononuclear cell mononuclear cells mutated Mutation neutralizing capacity no difference no differences not affected peptide peptide pool peptide pools Peripheral blood Peripheral blood mononuclear cells Protein raised recall Region required S protein S proteins SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells second dose seronegative single vaccination Specific stimulated T cells T-cell activation T-cell Response T-cell-mediated immunity vaccination vaccinee variant variants virus virus-specific T cell wild type
[DOI] 10.1126/sciimmunol.abj1750 PMC 바로가기 [Article Type] Article

Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines

비활성화 및 RBD-서브유닛 백신에 의해 유발된 순환 SARS-CoV-2 변이체에 대한 체액 면역 반응

Article

Published on 2021-05-212022-09-11
Journal: Cell Research [Category] Fulltext, SARS, 변종, 진단,

[키워드] (inactivated vaccine) 501Y.V2 administration anti-RBD antibody antigenic B.1.351 boost caused circulating SARS-CoV-2 variant circulating SARS-CoV-2 variants combating Combination comparable conformation Contact convalescent CoronaVac Cryoelectron microscopy disrupt dominant E484K Effect elicited humoral immune response Immune escape immune response immunology inactivated Inactivated vaccine induce K417N leads less majority mononuclear cell mononuclear cells Mutation mutations N-terminal domain NAb NAbs natural infection neutralization neutralization activity Neutralizing activity Neutralizing antibodies neutralizing antibody NTD Peripheral blood Peripheral blood mononuclear cells plasma polar RBD RBD variants receptor Receptor-binding domain reduced reduction regions respond SARS-CoV-2 variant SARS-CoV-2 variants second dose Sequencing single-cell the receptor-binding domain Tolerance Vaccine vaccinee vaccinees variants VDJ X-ray crystallography ZF2001
[DOI] 10.1038/s41422-021-00514-9 PMC 바로가기 [Article Type] Article

The Biobanque québécoise de la COVID-19 (BQC19)—A cohort to prospectively study the clinical and biological determinants of COVID-19 clinical trajectories

Biobanque québécoise de la COVID-19(BQC19) - COVID-19 임상 궤적의 임상 및 생물학적 결정 요인을 전향적으로 연구하기 위한 코호트

Research Article

Published on 2021-05-192022-09-12
Journal: PLoS ONE [Category] MERS, SARS, 진단,

[키워드] addition analyses anti-SARS-CoV-2 antibody approved Canada circulating Clinical data clinical variables Cohort Community coordination coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 crisis death determinant disease DNA and RNA effort global pandemic health authorities Health Organization Hospitalized immediate action include individuals Infection International limit Local magnitude management Manifestations marker metabolome mononuclear cell multiplex National Novel coronavirus novel coronavirus disease organized outbreak pandemic patients Peripheral blood Peripheral blood mononuclear cells plasma positive proteome Research researcher responses responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR serum Spectrum storage trajectory Transcriptome transcriptome sequencing uninfected urgency Whole blood whole genome World Health Organization
[DOI] 10.1371/journal.pone.0245031 PMC 바로가기 [Article Type] Research Article

Interplay between SARS‐CoV‐2 and human long non‐coding RNAs

Short Communication

Published on 2021-05-092022-10-29
Journal: Journal of Cellular and Molecular Medicine [Category] COVID-19, MERS, SARS,