Glycaemic variability is associated with all-cause mortality in COVID-19 patients with ARDS, a retrospective subcohort study Research Published on 2022-06-142022-10-05 Journal: Scientific Reports [Category] 바이오마커, 임상, 치료법, [키워드] Aachen acute respiratory distress adjusted all-cause mortality ARDS caused clinically cohort study confounders Continuous coronavirus disease COVID-19 COVID-19 mortality COVID-19 patient death diabete diabetes elevated Factor Germany Glucose high mortality ICU ICU admission increase in intensive care Kaplan–Meier estimator likelihood mechanical ventilation median Metrics moderate Mortality mortality risk P/F ratio Patient patients with COVID-19 plasma procalcitonin retrospective severe ARDS significant increase statistically significant difference survival syndrome university Variability with COVID-19 [DOI] 10.1038/s41598-022-13816-8 [Article Type] Research
Early outcomes in adults hospitalized with severe SARS-CoV-2 infection receiving tocilizumab중증 SARS-CoV-2 감염으로 입원하여 토실리주맙을 투여받은 성인의 조기 결과Article Published on 2022-06-102022-09-12 Journal: Medicina clínica [Category] COVID19(2023년), SARS, 진단, [키워드] 95% CI Administered administration Admission adults hospitalized age ARDS Barcelona baseline Charlson index cohort study consecutive patient COVID-19 COVID19 Critical disease dose Endpoint English hazard hazard ratio Hebron IL6 Immonomodulation immune system Infection Inmunomodulación intensive care IQR Lung injury male media Mortality Neumonía viral New coronavirus outcome oxygen supplementation Patient patients patients with COVID-19 Pneumonia Preliminary data Prevent primary endpoint receiving respiratory SARS-CoV-2 SARS-COV-2 infection secondary severe SARS-CoV-2 Spain Spanish symptom onset the median Tocilizumab tocilizumab administration treated treatment with tocilizumab university Viral pneumonia [DOI] 10.1016/j.medcli.2021.06.012 PMC 바로가기 [Article Type] Article
SARS-CoV-2 triggering autoimmune diseases자가 면역 질환을 유발하는 SARS-CoV-2Review Published on 2022-06-012022-09-11 Journal: Cytokine [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] acquired immunity Activation acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ARDS autoantibody autoimmune antibodies Autoimmune disease Autoimmunity autoreactivity bystander caused CD4 CD8 chronic inflammation contribute coronavirus COVID-19 COVID-19 pandemic cytokine cytokine secretion Cytokine storm element elicit Evidence high mortality Hyperactivation Hyperstimulation immune response immune system Immunity immunological Immunosuppression Inflammation mechanism molecular molecular interaction molecular mimicry pandemic Patient respiratory respiratory distress Respiratory distress syndrome respiratory epithelium SARS-CoV-2 scarcity self-tolerance severe acute respiratory syndrome Coronavirus syndrome T cells the disease thought Trigger triggering triggers variety virus viruses [DOI] 10.1016/j.cyto.2022.155873 PMC 바로가기 [Article Type] Review
Lung targeted liposomes for treating ARDSARDS 치료를 위한 폐 표적 리포솜Article Published on 2022-06-012022-09-11 Journal: Journal of controlled release : official journal o [Category] 치료제, [키워드] accumulate accumulation acute respiratory distress acute respiratory distress syndrome Administered administration alveolar approach ARDS BAL Bronchoalveolar lavage C57BL/6 characterized combined treatment COPD COVID-19 COVID-19 infections cysteine cytokine secretion distal DPPC drug Efficiency encapsulation endotracheal exhibited Gas exchange Hypoxemia IL-1β IL-6 impair infections Inflammation Inflammatory marker inflammatory markers intravenous intravenously lipid composition Lipid nanoparticles lipopolysaccharide Liposome lung lung damage Lung diseases lung disorders lung endothelial lung epithelial Lung inflammation Lungs Macrophage macrophages marker medication Methylprednisolone mice mortality rate mortality rates MPS mucolytic agent Mucus N-acetyl cysteine NAC nanoparticle Nanotechnology nitric oxide outcome Patient penetration provided pulmonary reached reduce reducing Region respiratory respiratory distress Respiratory distress syndrome secretion steroid syndrome therapeutic therapeutic effect therapeutic efficacy TNFα Treatment Treatment outcome were assessed [DOI] 10.1016/j.jconrel.2022.03.028 PMC 바로가기 [Article Type] Article
Macklin effect on baseline chest CT scan accurately predicts barotrauma in COVID-19 patients베이스라인 흉부 CT 스캔에 대한 Macklin 효과는 COVID-19 환자의 압력 외상을 정확하게 예측합니다Observational Study Published on 2022-06-012022-09-12 Journal: Respiratory medicine [Category] MERS, 임상, 진단, 치료기술, [키워드] Accuracy acute respiratory distress syndrome ARDS barotrauma baseline case-control study Chest CT chest CT scan Computed tomography COVID-19 COVID-19 patient COVID-19 patients develop disease severity distress False positive high accuracy hospital Hospital admission Hospital stay ICU admission intensive care interstitial pneumonia Invasive mechanical ventilation material Mechanical mechanical ventilation Negative predictive value NPV Occurrence Patient Pneumomediastinum Pneumothorax positive PPV predict radiological sensitivity specificity subsequent suffered was measured was recorded [DOI] 10.1016/j.rmed.2022.106853 PMC 바로가기 [Article Type] Observational Study
COVID-19 patients with documented alcohol use disorder or alcohol-related complications are more likely to be hospitalized and have higher all-cause mortalityArticle Published on 2022-06-012023-07-08 Journal: Alcoholism, clinical and experimental research [Category] COVID19(2023년), [키워드] Alcoholic ARDS EtOH SARS-CoV-2 smoking Viral pneumonia [DOI] 10.1111/acer.14838 PMC 바로가기
Association between early cumulative fluid balance and successful liberation from invasive ventilation in COVID-19 ARDS patients – insights from the PRoVENT-COVID study: a national, multicenter, observational cohort analysisObservational Study Published on 2022-06-012022-10-04 Journal: Critical Care [Category] 임상, [키워드] 95% CI acute respiratory distress adjusted adjusted hazard ratio Affect Analysis analyzed ARDS association Cohort cohort analysis COVID-19 COVID-19 ARDS patient COVID-19 patient COVID-19 patients Cox proportional hazard Critical care critically ill patients cumulative Cumulative fluid balance Date Evidence Fluid management group hospital Increasing indicate International invasive ventilation invasively ventilated patient lack Liberation of ventilation. median multicenter National Netherland outbreak Patient patients performed potential benefit Primary outcome Probability required severity significantly syndrome three group Ventilated Ventilation with COVID-19 [DOI] 10.1186/s13054-022-04023-y PMC 바로가기 [Article Type] Observational Study
The role of hyaluronan synthesis and degradation in the critical respiratory illness COVID-19Review Published on 2022-06-012023-06-15 Journal: American journal of physiology. Cell physiology [Category] COVID19(2023년), MERS, SARS, [키워드] ARDS coronavirus COVID-19 Hyaluronan Inflammation [DOI] 10.1152/ajpcell.00071.2022 PMC 바로가기 [Article Type] Review
Silent hypoxia is not an identifiable characteristic in patients with COVID-19 infectionObservational Study Published on 2022-06-012022-10-05 Journal: Respiratory medicine [Category] COVID19(2023년), SARS, 임상, [키워드] acute respiratory distress adjusted age ARDS Asymptomatic cause characteristic clinical Clinical deterioration Cohort COVID-19 COVID-19 cohort died East Effect hospital hypoxaemia hypoxaemic respiratory failure hypoxia ICU ICU admission Infection linear Mortality Observational cohort study Patient patients patients with COVID-19 performed phenotype physiological positive required responses ROX index SARS-CoV-2 SARS-COV-2 infection symptomatic syndrome tested Trust Variability with COVID-19 [DOI] 10.1016/j.rmed.2022.106858 PMC 바로가기 [Article Type] Observational Study
Herbal inhibitors of SARS-CoV-2 M pro effectively ameliorate acute lung injury in miceSARS-CoV-2 M pro의 허브 억제제는 쥐의 급성 폐 손상을 효과적으로 개선합니다Article Published on 2022-06-012022-09-11 Journal: Iubmb Life [Category] COVID19(2023년), SARS, 치료제, [키워드] acute lung injury acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ALI/ARDS Anti-inflammatory ARDS bacterial lipopolysaccharide cell death China Chinese Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 patients distress effective effective drug effective drugs enzymatic activity functions Herbal identify in vitro in vivo Infectious disease Inhibition assays inhibitors of SARS-CoV-2 lipopolysaccharides Lung injury M pro mice MPro pan-anti-inflammatory protease respiratory distress Respiratory distress syndrome SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spread surface plasmon surface plasmon resonance syndrome the disease Traditional Chinese medicine treating COVID-19 patient Virtual screening virus [DOI] 10.1002/iub.2616 PMC 바로가기 [Article Type] Article