Is SARS-CoV-2 Neutralized More Effectively by IgM and IgA than IgG Having the Same Fab Region?Hypothesis Published on 2021-06-132022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] anti-SARS-CoV-2 Anti-spike antibody approved Cell coated with concentrations COVID-19 domain effective evaluated explained Fab FDA host cell Ig isotype IgA IgG IgM kidney lentivirus lentiviruses mAb mAbs monoclonal antibody neutralization neutralization ability neutralize neutralized Neutralizing neutralizing antibody Protein SARS-CoV-2 Spike protein the SARS-CoV-2 therapy viral particle virions while [DOI] 10.3390/pathogens10060751 PMC 바로가기 [Article Type] Hypothesis
Capivasertib restricts SARS-CoV-2 cellular entry: a potential clinical application for COVID-19Research Paper Published on 2021-06-112022-10-29 Journal: International Journal of Biological Sciences [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome AKT inhibitor anti-SARS-CoV-2 Antiviral antiviral activity cancer patient capivasertib caused Cell cellular cellular entry concentrations coronavirus Coronavirus disease 2019 COVID-19 death drug entry of SARS-CoV-2 Infection inhibitor Interaction pandemic era pathway restrict SARS-CoV-2 screened targets virus with COVID-19 [DOI] 10.7150/ijbs.57810 PMC 바로가기 [Article Type] Research Paper
Green Tea Polyphenol Catechins Inhibit Coronavirus Replication and Potentiate the Adaptive Immunity and Autophagy-Dependent Protective Mechanism to Improve Acute Lung Injury in MiceArticle Published on 2021-06-072022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] activities acute lung injury acute respiratory syndrome adaptive Adaptive immunity against SARS-CoV Anti-inflammatory Antioxidative Antiviral antiviral therapeutics autophagy catechin catechins caused CD69 CD8 concentrations cytokine Cytokine storm gallate green Immunity indicated ingestion inhibited inhibiting inhibiting effect inhibitor mechanism mice oxidative stress polyphenol Prevent protective effect reduced Replication required reversed SARS Coronavirus SARS-CoV SARS-CoV infection SARS-CoV replication Signaling significantly T cell tea therapeutic effect treat type I cytokine upregulated VERO E6 cells [DOI] 10.3390/antiox10060928 PMC 바로가기 [Article Type] Article
Toxicity of hydroxychloroquine, a potential treatment for COVID-19, on free-living marine nematodesResearch article Published on 2021-06-012022-10-05 Journal: Marine pollution bulletin [Category] SARS, 치료법, [키워드] anticipated Concentration concentrations COVID-19 COVID-19 crisis Diversity Ecotoxicity Free-living marine nematodes HCQ high risk highest Hydroxychloroquine index microcosm nematode patients Potential treatment response risk Seafood treatment for COVID-19 Trophic widespread [DOI] 10.1016/j.marpolbul.2021.112361 [Article Type] Research article
Vitamin D Levels in COVID-19 Outpatients from Western Mexico: Clinical Correlation and Effect of Its SupplementationArticle Published on 2021-05-282022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Asymptomatic baseline benefit Biochemical parameters cholecalciferol clinical Concentration concentrations control group coronavirus COVID-19 Critical D-dimer deficiency determine dose Effect ergocalciferol ferritin Follow-up immunomodulatory effect in both groups in viral Latin America Level Outpatient outpatients Patient positive Prognosis raise SARS-CoV-2 Serum level Supplementation supplemented group Symptom symptomatic the disease Transferrin Vitamin D vitamin D insufficiency vitamin D level vitamin D serum were measured [DOI] 10.3390/jcm10112378 PMC 바로가기 [Article Type] Article
SARS-CoV-2 can recruit a heme metabolite to evade antibody immunitySARS-CoV-2는 항체 면역을 피하기 위해 헴 대사 산물을 모집할 수 있습니다Research Article Published on 2021-05-282022-09-12 Journal: Science Advances [Category] SARS, 진단, [키워드] access Antibody binding antibody immunity Bilirubin Biliverdin bind binding cleft concentrations conformational change Coronaviral distal dominant dominant epitope epitope evade flexible heme heme metabolism immune inhibited Interaction linear mapped mechanism metabolism metabolite Microscopy modulated N-terminal domain nanomolar affinity Neutralizing antibodies NTD physiological reactivity recruit recruitment regulated Relocation SARS-CoV-2 SARS-CoV-2 spike sera significantly subset target tetrapyrrole Viral antigen X-ray crystallography [DOI] 10.1126/sciadv.abg7607 PMC 바로가기 [Article Type] Research Article
Association of Circulating Sex Hormones With Inflammation and Disease Severity in Patients With COVID-19Research Published on 2021-05-252022-10-29 Journal: JAMA Network Open [Category] COVID-19, SARS, [키워드] 95% CI Admission age association C-reactive protein CD14 CD16 cellular signaling pathways circulating classical clinical trial cohort study collected Concentration concentrations conducted consecutive patient contribute COVID-19 COVID-19 illness diagnosed disease disease severity enrichment analysis estradiol exposure finding growth factor hepatocyte growth factor hormone hormone concentration Hospitalization Hospitalized Hypothesis IGF-1 Importance Inflammation Inflammatory cytokine intensive care interferon male measure median men monocyte mononuclear cell nasopharyngeal swabs objective outcome participant pathophysiologic Patient patients with COVID-19 Point predisposition prospective cohort study Protein receptor regulated Relevance remained required Result risk factor RNA sequencing serum serum sample setting severe COVID-19 severe COVID-19 illness severity Sex sex hormone Signaling signaling pathway single-center Testosterone the patient Treatment upregulated upregulation was performed were measured with COVID-19 women [DOI] 10.1001/jamanetworkopen.2021.11398 PMC 바로가기 [Article Type] Research
High plasma concentration of non-esterified polyunsaturated fatty acids is a specific feature of severe COVID-19 pneumoniaArticle Published on 2021-05-242022-10-04 Journal: Scientific Reports [Category] SARS, 바이오마커, 임상, [키워드] acute phase response Analysis association body mass index C-reactive protein Comorbidity Concentration concentrations correlated COVID-19 COVID-19 pathogenesis COVID-19 patient COVID-19 patients Cytokines dysregulated immune response enrolled Fatty acid feature form HDL High-density lipoprotein cholesterol hospitalized patient Immunopathogenesis Infection initial intensive care lipoprotein metabolism metabolic disorder MOST NEFA Non-COVID-19 obese patients Organ failure outcome Pathogenesis patients hospitalized plasma plasma concentration Pneumonia Polyunsaturated PUFA required respiratory severity Sepsis Severe COVID-19 pneumonia severe pneumonia SOFA therapeutic targets to define unique Ventilator-free days were assessed with COVID-19 [DOI] 10.1038/s41598-021-90362-9 PMC 바로가기 [Article Type] Article
Strong Inhibitory Activity and Action Modes of Synthetic Maslinic Acid Derivative on Highly Pathogenic Coronaviruses: COVID-19 Drug CandidateArticle Published on 2021-05-192022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] acid Action activity acute respiratory syndrome analogue anti-SARS-CoV-2 antiviral activity candidate Candidates carried chlorinated Compound concentrations coronavirus coronavirus disease COVID-19 derivative drug escaped examined global pandemic impair in vitro in vivo inhibitory concentration maslinic acid MERS-CoV mode molecular docking non-toxic Novel coronavirus oleanolic acid SAR SARS-CoV-2 SARS-CoV-2 main protease screened Strong synthetic tested Treatment viral replication [DOI] 10.3390/pathogens10050623 PMC 바로가기 [Article Type] Article
Optofluidic multiplex detection of single SARS-CoV-2 and influenza A antigens using a novel bright fluorescent probe assay403 Published on 2021-05-182022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS, [키워드] acute respiratory syndrome antibody Antigen antigens Biomarker biosensing clinically Concentration concentrations coronavirus COVID-19 pandemic diagnostic diagnostics fluorescent influenza A antigen Integrated optics molecular multiplex nasal swab nasopharyngeal swab sample optofluidics PCR-negative platform point of care point-of-care probe Protein protocol reported reporter SARS-CoV-2 sensitivity Significance single antigen detection target ultraviolet light urgency [DOI] 10.1073/pnas.2103480118 PMC 바로가기 [Article Type] 403