Critical ACE2 Determinants of SARS-CoV-2 and Group 2B Coronavirus Infection and ReplicationObservation Published on 2021-03-162022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] ACE2 ACE2 receptor acute respiratory syndrome Amino acid angiotensin-converting enzyme 2 animal model caused chimeric Contact coronavirus COVID-19 COVID-19 pathogenesis determinant Epidemics events Evidence examined group Host host range Host receptors human ACE2 humanized identify in vitro infect Infection Interaction Intervention mice molecular murine predicted public health threat rapid response receptor Receptor binding domain receptors residue SARS-CoV-2 SARS-COV-2 infection Virus-host interactions [DOI] 10.1128/mBio.03149-20 PMC 바로가기 [Article Type] Observation
SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interfaceSARS-CoV-2 중화 인간 재조합 항체는 RBD-ACE2 인터페이스에서 결합하는 팬데믹 전 건강한 기증자로부터 선택됩니다Article Published on 2021-03-112022-09-10 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료제, [키워드] ACE2 ACE2 receptor ACE2-RBD acute respiratory disease anti-SARS-CoV-2 antibody Antibody therapy binding Biotechnology candidate caused Cell cell entry coronavirus COVID-19 enzyme expressing Expression systems healthy healthy donor human ACE2 human donor IgG independent Infection Infectious diseases inhibit Interaction material naïve neutralization neutralize Neutralizing offer pandemic phage RBD RBD-ACE2 receptor Receptor binding domain recognizing recovering patient Respiratory disease S1 subunit sarbecovirus SARS-CoV-2 SARS-CoV-2 virus SARS-CoV-2 virus infection scFv selected Spike protein subsequent the S1 subunit the spike protein therapeutic unique VeroE6 cells Viral viral infection viral spike protein virus virus infection [DOI] 10.1038/s41467-021-21609-2 PMC 바로가기 [Article Type] Article
A potent neutralizing nanobody against SARS‐CoV‐2 with inhaled delivery potentialOriginal Article Published on 2021-03-042022-10-30 Journal: MedComm [Category] COVID-19, [키워드] ACE2 antiviral activity blocked Candidates coronavirus disease COVID‐19 dose Efficacy enzyme exhibited global public health highest human ACE2 immunized Inhaled Interaction large‐scale production mutants nanobody nebulization Neutralizing Neutralizing activity pandemic Pichia pastoris produced Prophylactic RBD reached receptor‐binding domain recognize reported SARS‐CoV‐2 SARS‐CoV‐2 Seven shown stability stability profile therapeutic therapeutic drug treat variant [DOI] 10.1002/mco2.60 PMC 바로가기 [Article Type] Original Article
Cutting Edge: Mouse SARS-CoV-2 Epitope Reveals Infection and Vaccine-Elicited CD8 T Cell Responses최첨단: 마우스 SARS-CoV-2 에피토프, 감염 및 백신 유발 CD8 T 세포 반응 밝혀내Article Published on 2021-03-012022-09-11 Journal: Journal of immunology (Baltimore, Md. : 1950) [Category] SARS, 변종, 치료법, [키워드] Adenovirus CD8 CD8 T cell COVID-19 COVID-19 vaccine cross-reactivity Culture Cutting dominant elicited epitope Heterologous HLA-A HLA-A*02 hospitalized patient hospitalized patients human ACE2 human disease Humoral immunity Immunity immunization intranasal magnitude memory mice mouse mucosa PBMC peptide recombinant adenovirus respiratory mucosa response responses robust SARS-CoV-2 SARS-CoV-2 nucleoprotein severity Spike protein systemically T cell T cell response T cell responses transgenic mice vaccination vaccine-elicited T cell vector viral spike protein Viral variants [DOI] 10.4049/jimmunol.2001400 PMC 바로가기 [Article Type] Article
Neuroinvasion of SARS-CoV-2 in human and mouse brain인간과 쥐의 뇌에서 SARS-CoV-2의 신경 침범Article Published on 2021-03-012022-09-11 Journal: The Journal of Experimental Medicine [Category] SARS, 비임상, 진단, 치료기술, [키워드] ACE2 Affect antibody approach Autopsies Autopsy Brain brain organoids breath Central nervous system cerebrospinal fluid changes in CNS Consensus consequence cortical COVID-19 COVID-19 patient detect died direct infection Evidence evidence of feature human ACE2 Human brain Immune cell in vivo independent infect Infection infections interferon mice Neuroinvasive Neuron neuronal infection neurons organ system organ systems overexpressing Patient prevented probe respiratory Respiratory disease response SARS-CoV-2 SARS-CoV-2 neuroinvasion second type I interferon with infection [DOI] 10.1084/jem.20202135 PMC 바로가기 [Article Type] Article
SARS-CoV-2 spike D614G change enhances replication and transmission Research Published on 2021-02-262022-10-05 Journal: Nature [Category] SARS, 변종, 유전자 메커니즘, [키워드] ACE2 airway angiotensin-converting enzyme 2 binding circulating COVID-19 Culture D614G D614G substitution ENhance epithelial Evolution of SARS-CoV-2 founder effect Human human ACE2 humans IMPROVE in vitro increases in nasal predominant Prevalence provide receptor reflect Replication SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 variant spike glycoprotein the SARS-CoV-2 Transmissibility Transmission variant virus [DOI] 10.1038/s41586-021-03361-1 [Article Type] Research
SARS CoV-2 Spike Protein in silico Interaction With ACE2 Receptors From Wild and Domestic SpeciesGenetics Published on 2021-02-152022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] ACE2 ACE2 receptor acute respiratory syndrome Analysis angiotensin-converting enzyme 2 bat coronaviruses cellular receptor coronavirus COVID-19 described evaluated Felidae homology modeling Host human ACE2 in silico Interaction molecular docking molecular docking analysis natural pandemic performed predicted Protein public health RBD receptor RT-qPCR SARS CoV-2 SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S protein SARS-CoV-2 spike protein Specy spike Spike protein suggested susceptibility susceptible the SARS-CoV-2 WHO World Health Organization [DOI] 10.3389/fgene.2021.571707 PMC 바로가기 [Article Type] Genetics
Generation of enzymatically competent SARS‐CoV‐2 decoy receptor ACE2‐Fc in glycoengineered Nicotiana benthamiana글리코엔지니어링된 Nicotiana benthamiana에서 효소적으로 유능한 SARS-CoV-2 미끼 수용체 ACE2-Fc의 생성Research Article Published on 2021-02-122022-09-10 Journal: Biotechnology Journal [Category] 변종, [키워드] ACE2 ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affinity angiotensin binding cell entry cellular competent complex Concentration coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 decoy dimeric domain enzyme enzyme activity functional fusion protein Generation glycan glycosylated glycosylation host cell host cell receptor Human human ACE2 Interaction Nicotiana benthamiana posttranslational modification Prevent primary host produced receptor receptor‐binding domain recombinant ACE2 recombinant protein expression respiratory SARS‐CoV‐2 SARS‐CoV‐2 severe acute respiratory syndrome Coronavirus soluble ACE2 Spike protein therapeutic potential treat Treatment variant virus virus infectivity Virus neutralization [DOI] 10.1002/biot.202000566 PMC 바로가기 [Article Type] Research Article
Dynamics of binding ability prediction between spike protein and human ACE2 reveals the adaptive strategy of SARS-CoV-2 in humans스파이크 단백질과 인간 ACE2 간의 결합 능력 예측의 역학은 인간에서 SARS-CoV-2의 적응 전략을 보여줍니다Article Published on 2021-02-042022-09-10 Journal: Scientific Reports [Category] MERS, 바이오마커, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Amino acid Analysis analyzed binding ability binding affinity collected Computational biology and bioinformatics conserved coronavirus country COVID-19 pandemic Dynamics Ethnic groups genome sequence hACE2 Host hosts Human human ACE2 Interaction Mutation natural reservoir Novel coronavirus Phylogenetic analysis Phylogeny plasticity RBD Receptor-binding domain recombination event reconstructed Region respiratory reveal S gene SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spike protein spike protein RBD stability the receptor-binding domain the spike protein Transmission variant variants viral infection [DOI] 10.1038/s41598-021-82938-2 PMC 바로가기 [Article Type] Article
BNT162b vaccines protect rhesus macaques from SARS-CoV-2 Research Published on 2021-02-012022-10-05 Journal: Nature [Category] SARS, 비임상, 유전자 메커니즘, [키워드] Antibody Response BNT162b BNT162b1 BNT162b2 candidate candidate vaccine CD4+ COVID-19 disease domain dose dose-dependent effective elicit ENCODE evaluated Evidence full-length geometric mean titre Germany human ACE2 human sera immunize immunogen intramuscular Lipid nanoparticles Lower respiratory tract macaque Messenger RNA mice Phase I populations prefusion conformation proline PROTECT RBD residue rhesus macaque S glycoprotein Safe SARS-CoV-2 secreted spike glycoprotein T cell responses titre transmembrane Trial trimer vaccination Vaccine vaccine candidate Viral RNA [DOI] 10.1038/s41586-021-03275-y [Article Type] Research