Anti-SARS-CoV-2 Antibodies Within IVIg Preparations: Cross-Reactivities With Seasonal Coronaviruses, Natural Autoimmunity, and Therapeutic ImplicationsIVIg 제제 내 항SARS-CoV-2 항체: 계절성 코로나바이러스와의 교차 반응성, 자연 자가면역 및 치료적 의미Immunology Published on 2021-02-172022-09-11 Journal: Frontiers in Immunology [Category] MERS, 진단, 치료기술, [키워드] antibodies antibodies to SARS-CoV-2 antibody Antigen antigenic epitopes antigenic peptide antigenic protein antigens autoantibody autoreactive antibodies autoreactive antibody autoreactivity Baxalta benefit calibrator common cold comparable condition conserved coronavirus Coronaviruses COVID-19 COVID-19 infection cross-react cross-reacting antibodies cross-reactive antibody cross-reactivity with COVID-19 cut-off defined Donor ELISA enzyme-linked immunosorbent enzyme-linked immunosorbent assay epitope Epitopes False positivity Flebogamma Germany healthy donors IgG antibody Immune-mediated immunodeficiency Immunoglobulin in-hospital mortality index individuals infected individual Innovation IVIG Lubeck natural Patient patients peptides positive Protective Protein receiving Recognition recognizing SARS-CoV-2 screened seasonal semi-quantitative serum significantly lower symptomatic T-cell T-cells tested therapy titers treated uninfected [DOI] 10.3389/fimmu.2021.627285 PMC 바로가기 [Article Type] Immunology
A case of multisystem inflammatory syndrome in an African adolescent male: case report아프리카 청소년 남성의 다기관 염증 증후군 1예: 증례 보고Case Reports Published on 2021-02-162022-09-01 Journal: The Pan African Medical Journal [Category] MERS, 진단, [키워드] African age association cardiac function Cardiogenic shock Case report children COVID-19 infection Definition Deterioration disease entity epidemiological Evidence evidence of Fever identify Immunoglobulin Infection Inflammation Inflammatory Inflammatory marker inflammatory markers intravenous Intravenous immunoglobulin Laboratory laboratory confirmation maculopapular rash male MIS-C morbidity and mortality Multisystem inflammatory syndrome organ dysfunction Patient persistent fever presenting Rash Recognition reported resulting SARS-CoV-2 SARS-COV-2 infection Shock Steroids sub-Saharan Africa sudden Support syndrome Treatment with COVID-19 [DOI] 10.11604/pamj.2021.38.174.27910 PMC 바로가기 [Article Type] Case Reports
[Emotional management of the health crisis by coronavirus: A narrative review][코로나바이러스에 의한 건강 위기의 감정 관리: 내러티브 리뷰]Review Published on 2021-02-012022-09-11 Journal: Enfermería clínica (English Edition) [Category] SARS, 임상, [키워드] accumulated Anxiety base Burnout Care CINAHL Community concerning coronavirus Coronavirus infections database Depression discrimination effective eligibility criteria emotional emotions English Epidemics Evidence group guilt Health Health crisis Human resources Initially Intention limit management measure MERS-CoV Nurse Nurses Nursing outbreak professionalism professionals Recognition recommendation reduce resources SARS-CoV-1 security social stigma Spanish Support support groups synthesis Web [DOI] 10.1016/j.enfcli.2020.05.010 PMC 바로가기 [Article Type] Review
[COVID-19 as an occupational disease or work-related accident: Considerations regarding insurance cover and reporting obligation in the statutory accident insurance][COVID-19 업무상 질병 또는 업무상 재해 : 법정상해보험의 보험적용 및 신고의무에 관한 고려사항]Article Published on 2021-02-012022-09-11 Journal: Deutsche medizinische Wochenschrift (1946) [Category] 치료기술, [키워드] activities activity comparable conjunction Contact contact with COVID-19 disease COVID-19 illness direct contact disease Diseases English General population Health Service increased risk Infection insured person Intensive Laboratory occupational disease occur Recognition SARS-CoV-2 virus social welfare subject [DOI] 10.1055/a-1341-7867 PMC 바로가기 [Article Type] Article
Evolutionary and structural analysis elucidates mutations on SARS-CoV2 spike protein with altered human ACE2 binding affinity인간 ACE2 결합 친화도가 변경된 SARS-CoV2 스파이크 단백질의 돌연변이를 설명하는 진화적 및 구조적 분석Article Published on 2021-01-292022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] 변종, [키워드] ACE2 ACE2 binding affinity Alter Analysis analyzed binding binding affinity binding energy binding free energy docking Efficacy ENhance evaluate facilitate FIVE free energy Free energy calculations G476S glycoprotein host cell human ACE2 hydrogen Hydrogen bond identify Mutation pandemic Population Population variants Positive selection Proteomic analysis RBD RBD variant RBD variants RBD-ACE2 Receptor-binding domain Recognition reduced residue reveal SARS-CoV2 SARS-CoV2 genome Selection Selection bias spike spike glycoprotein Spike protein spike variant Structural analysis the RBD the receptor-binding domain V367F V483A variant variations while Wuhan [DOI] 10.1016/j.bbrc.2021.01.035 PMC 바로가기 [Article Type] Article
Recognition of the SARS-CoV-2 receptor binding domain by neutralizing antibodiesArticle Published on 2021-01-292022-10-28 Journal: Biochemical and Biophysical Research Communication [Category] COVID-19, SARS, [키워드] accumulating ACE2 antibody Antibody avidity Antibody Response binding site COVID-19 pandemic COVID-19 research cross-neutralization cross-neutralize engage epitope Epitopes Germline-encoded motifs host receptor molecular feature monoclonal antibody MOST neutralization potency Neutralizing antibodies neutralizing antibody pandemic virus Protein RBD RBD natural mutations Receptor binding domain receptor binding domain (RBD) Recognition researcher SARS-CoV SARS-CoV-2 the SARS-CoV-2 therapeutic Vaccine viral entry [DOI] 10.1016/j.bbrc.2020.10.012 PMC 바로가기 [Article Type] Article
Can SARS-CoV-2 Virus Use Multiple Receptors to Enter Host Cells?Review Published on 2021-01-202022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 Anti-viral immunity c-lectin type receptor Can carbohydrate catastrophic Cell CLR CLRs contribute coronavirus disease Coronavirus-2 COVD-19 COVID-19 demonstrated Dipeptidyl peptidase-4 engage ezrin Glucose glucose-regulated protein 78 glycosylated glycosylation GRP78 Health host cell immune immunopathological independent Infection Inflammation innate immune system Interaction mannose receptor Multiple N-glycans non-immune NRP1 Occurrence Protein receptor Recognition regulated reported responsible S protein SARS-CoV-2 SARS-CoV-2 S protein Spike protein Spread susceptibility the S protein therapeutic target TLR TLRs Toll-like receptor viral clearance viral surface [DOI] 10.3390/ijms22030992 PMC 바로가기 [Article Type] Review
Key genetic elements, single and in clusters, underlying geographically dependent SARS-CoV-2 genetic adaptation and their impact on binding affinity for drugs and immune control지리적으로 의존적인 SARS-CoV-2 유전자 적응의 기초가 되는 단일 및 클러스터의 주요 유전 요소 및 약물 및 면역 조절에 대한 결합 친화도에 미치는 영향Article Published on 2021-01-192022-09-11 Journal: Journal of Antimicrobial Chemotherapy [Category] 변종, 치료제, [키워드] (RdRp acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 America amino acids analogues analysed antigenicity Asia B cell best binding affinity chymotrypsin Chymotrypsin-like protease circulation class close monitoring Cluster Clustering Clusters Compound Coronavirus-2 country drug drug susceptibility drugs Effectiveness element elements epitope Epitopes Europe evaluate FDA-approved drug FDA-approved drugs Genetic Hierarchical hierarchical clustering highlighting immune inhibitor modulate modulating Mutation Neutralizing antibodies neutralizing antibody occurred Oceania Penciclovir predicted protease purine purine analogue RdRP RdRp inhibitor Recognition reduced Remdesivir RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 proteins SARS-CoV-2 sequence SARS-CoV-2 sequences severe acute respiratory syndrome Coronavirus specific mutation specific mutations stability tenofovir the binding affinity Treatment Vaccine Viral Viral proteins Virtual screening was used were assessed [DOI] 10.1093/jac/dkaa444 PMC 바로가기 [Article Type] Article
Selecting Controls for Minimizing SARS-CoV-2 Aerosol Transmission in Workplaces and Conserving Respiratory Protective Equipment Supplies작업장에서 SARS-CoV-2 에어로졸 전파를 최소화하고 호흡기 보호 장비 공급을 보존하기 위한 제어 선택Article Published on 2021-01-142022-08-31 Journal: Annals of work exposures and health [Category] MERS, 치료제, [키워드] aerosol aerosol transmission assessment categories concentrations Contact Control control banding controls COVID-19 develop disease effective eliminating Evidence evidence of example focus hierarchy hierarchy of controls high risk Infection Infectious disease inhalation occupational safety and health offer organism pandemic Particle pathway Personal protective equipment prevention programs receptor Recognition reduce respiratory risk risk assessments SARS-CoV-2 supply Transmission Workplace workplace exposure. [DOI] 10.1093/annweh/wxaa083 PMC 바로가기 [Article Type] Article
High-risk chest radiographic features associated with COVID-19 disease severityResearch Article Published on 2021-01-142022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] 95% CI 95% confidence interval adjusted odds ratio analyses Analysis association baseline chest radiographic clinical feature COVID-19 COVID-19 patient criteria CXR defined disease severity Endpoint entire cohort feature Features healthcare hypoxia identify independent radiologist initial Logistic regression analysis middle zone objective Odds ratio outcome Patient patients primary endpoint Recognition recorded requiring supplemental oxygen resource Result screened severe COVID-19 significantly study period supplemental oxygen to define were assessed were excluded with COVID-19 zone [DOI] 10.1371/journal.pone.0245518 PMC 바로가기 [Article Type] Research Article