Neck circumference as reliable predictor of mechanical ventilation support in adult inpatients with COVID-19: A multicentric prospective evaluationObservational Study Published on 2021-01-012022-10-05 Journal: Diabetes/metabolism research and reviews [Category] SARS, 임상, [키워드] adjusted Admission age analyses Anthropometric data association AUC biochemical BMI body mass index cardiometabolic collected Comorbidities COPD COVID-19 COVID-19 adult patient diabetes enrolled evaluated female hospital Hospital admission hypertension IMV Inpatient Inpatients invasive mechanical Invasive mechanical ventilation Italian log-rank males material mechanical ventilation support multivariable logistic regression Neck neck circumference obesity parameter Patient performed predict primary outcome measure Prospective Study Respiratory illness Respiratory Support risk Sex shown significantly strongly related study period subject [DOI] 10.1002/dmrr.3354 PMC 바로가기 [Article Type] Observational Study
Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrumCOVID-19 임상 스펙트럼 전반에 걸쳐 어린이와 성인에서 SARS-CoV-2에 대한 뚜렷한 항체 반응Article Published on 2021-01-012022-09-11 Journal: Nature Immunology [Category] Fulltext, SARS, 임상, 진단, 치료기술, 치료법, [키워드] acute respiratory distress acute respiratory distress syndrome age Anti-spike antibodies Antibody Response ARDS breadth caused children clinical clinical manifestations Clinical manifestations of COVID-19 cohorts coronavirus Course COVID-19 COVID-19 cohort develop IgA antibodies IgG IgG antibodies IgG antibody IgM immune response implication independent independent of Infection Inflammatory life-threatening manifestation MIS-C N protein Neutralizing activity New coronavirus new coronavirus SARS-CoV-2 Protective reduced respiratory respiratory distress Respiratory distress syndrome Respiratory illness respiratory symptoms S protein SARS-CoV-2 SARS-COV-2 infection serological response specific antibodies syndrome the N protein the S protein [DOI] 10.1038/s41590-020-00826-9 PMC 바로가기 [Article Type] Article
Inhaled route and anti-inflammatory action of ivermectin: Do they hold promise in fighting against COVID-19?이버멕틴의 흡입 경로 및 항염 작용: COVID-19와의 싸움에서 약속이 있습니까?Article Published on 2021-01-012022-08-31 Journal: Medical Hypotheses [Category] SARS, 신약개발, 치료법, 치료제, [키워드] Administered administration anti-inflammatory action antiviral activity approved broad spectrum Clinical studies clinically coronavirus COVID-19 demonstrated DNA and RNA dose doses drug Drug repurposing effective effort global pandemic hypothesise hypothesised IC50 In-vitro Inhaled interfere Ivermectin lung Lungs nucleus oral administration prevention of COVID-19 Protein repurposing respiratory Respiratory illness RNA viruses SARS-CoV-2 SARS-CoV-2 nucleocapsid Scientific community severe respiratory illness Transport Treatment treatment strategy virus viruses [DOI] 10.1016/j.mehy.2020.110364 PMC 바로가기 [Article Type] Article
Endothelium Infection and Dysregulation by SARS-CoV-2: Evidence and Caveats in COVID-19SARS-CoV-2에 의한 내피 감염 및 조절 장애: COVID-19의 증거 및 주의 사항Review Published on 2020-12-262022-09-10 Journal: Viruses [Category] MERS, SARS, 치료제, [키워드] ACE2 acute respiratory syndrome ADAM17 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 binding bradykinin–kallikrein pathway caused cellular receptor clinical development Complication contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Deleterious direct infection downregulation dysfunction Endothelial cell endothelial cells Endothelial dysfunction Endothelium event Evidence evidence of exacerbate global public health human lung immunothrombosis include infect Inflammatory lead manifestation Neurological diseases pandemic parameter pericyte Protein RAAS recent renal respiratory Respiratory illness SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe COVID-19 severe disease spike Spike protein therapeutic agent therapeutic agents Therapeutics thrombotic Viral viral spike protein [DOI] 10.3390/v13010029 PMC 바로가기 [Article Type] Review
Pharmacotherapy in COVID 19: Potential Impact of Targeting the Complement SystemReview Published on 2020-12-242022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] Activation acute respiratory syndrome C3 C5 caused claimed Coagulopathy complement Complication compstatin coronavirus Coronavirus disease 2019 COVID COVID-19 Effect heparin immune defense Impact increases in Infection Inflammation invading pathogens life-threatening patients with COVID-19 pharmacotherapy Potential Respiratory illness SARS-CoV-2 System targeting tissue damage Treatment [DOI] 10.3390/biomedicines9010011 PMC 바로가기 [Article Type] Review
Harnessing Cellular Immunity for Vaccination against Respiratory VirusesReview Published on 2020-12-212022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] activate acute respiratory disease acute respiratory syndrome approach Aside B cell response candidate CD4+ CD8+ T cell Cellular immune response cellular immunity Clinical sign Coronavirus-2 Coronaviruses Critical detrimental Efficacy and safety examined group Health humoral immune response illness immunocompromised individuals immunopathology Infants Infection Influenza long-lasting métapneumovirus Mild morbidity Mortality Nanoparticles neutralizing antibody Patient Pneumonia Protein Research respiratory Respiratory illness respiratory syncytial virus respiratory viral respiratory viral infections respiratory viruses response rhinovirus RNA RNA vaccines robust RSV SARS-CoV-2 severe disease subunits tested These viruses upper respiratory vaccination Vaccine vaccine candidate vaccine candidates viral infection virus Virus-like particle virus-like particles viruses VLPs [DOI] 10.3390/vaccines8040783 PMC 바로가기 [Article Type] Review
Where Virtual Care Was Already a Reality: Experiences of a Nationwide Telehealth Service Provider During the COVID-19 PandemicViewpoint Published on 2020-12-152022-10-30 Journal: Journal of Medical Internet Research [Category] Coronavirus, MERS, SARS, [키워드] baseline Care category changed Chronic illness COVID-19 COVID-19 pandemic declined Demand doctor experience growth Health Inc. increase increase in Infectious disease objective pandemic Patient provided public health emergency reported Respiratory illness Result service telehealth Telemedicine The United States United States virus Volume [DOI] 10.2196/22727 PMC 바로가기 [Article Type] Viewpoint
Comparative effectiveness of N95 respirators and surgical/face masks in preventing airborne infections in the era of SARS-CoV2 pandemic: A meta-analysis of randomized trialsSARS-CoV2 대유행 시대 공기 감염 예방에 N95 인공 호흡기와 수술/안면 마스크의 비교 효과: 무작위 시험의 메타 분석Research Article Published on 2020-12-152022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 임상, [키워드] Abstract abstracts acute respiratory infections Analysis article articles Comparative coronavirus COVID-19 incidence database determine did not reduce Effectiveness eligible evaluated identify inception inclusion criteria Inconclusive Infection Influenza item laboratory-confirmed less Mask Medical mask medical masks Meta-analysis meta-analytic method meta-analytic methods Methodological quality N95 respirator N95 respirators no statistically significant difference PRISMA PROTECT provided Randomized controlled trial randomized trial RCT RCTs recommendation reducing Reporting required respiratory Respiratory illness respiratory infections respiratory virus respiratory viruses Result retrieved review risk Risk of bias risk of infection Sample size SARS-CoV2 searched statistical analysis statistically significant difference systematic reviews viruses Web of Science [DOI] 10.1371/journal.pone.0242901 PMC 바로가기 [Article Type] Research Article
Community use of face masks and similar barriers to prevent respiratory illness such as COVID-19: a rapid scoping reviewReview Published on 2020-12-102022-10-31 Journal: Eurosurveillance [Category] COVID-19, MERS, SARS, [키워드] assessment attack rate Cohort Community Control coronavirus cross-sectional study described development Effect Effectiveness Effects Evidence Face mask Hajj improvement incidence influenza-like-illness lowest Mask Meta-analysis narrative observational study Odds ratio outcome performed poor compliance Prevent Primary infection PROTECT random-effect randomised RCT RCTs reduce reduced required Respiratory disease Respiratory illness respiratory infection Result risk searched secondary attack rate suggested Trial wearing wearing face mask wearing masks while [DOI] 10.2807/1560-7917.ES.2020.25.49.2000725 PMC 바로가기 [Article Type] Review
Seasonality and immunity to laboratory-confirmed seasonal coronaviruses (HCoV-NL63, HCoV-OC43, and HCoV-229E): results from the Flu Watch cohort studyResearch Article Published on 2020-12-102022-10-28 Journal: Wellcome Open Research [Category] COVID-19, [키워드] 95% CI 95%CI Analysis assumption caused Cohort cohort study collected coronavirus Coronavirus infection dependent on develop England Epidemiology Evidence First wave H1N1 influenza HCoV-229E HCoV-NL63 HCoV-OC43 highest homologous identify Immunity individual Infection infections intensity laboratory-confirmed novel coronavirus SARS-CoV-2 pandemic participant PCR-confirmed prospective cohort study public health Reinfection Respiratory illness SARS-CoV-2 seasonal coronavirus seasonality second wave Swab tested Transmission [DOI] 10.12688/wellcomeopenres.15812.2 PMC 바로가기 [Article Type] Research Article