Analysis of Chest CT Results of Coronavirus Disease 2019 (COVID-19) Patients at First Follow-Up2019년 코로나바이러스감염증-19(COVID-19) 환자의 1차 추시 시 흉부 CT 결과 분석Research Article Published on 2020-11-012022-09-12 Journal: Canadian Respiratory Journal [Category] MERS, SARS, 진단, [키워드] Admission analyzed Chest CT consolidation COVID-19 cured discharge exclusion criteria faster Follow-up ground-glass opacity hospital Inclusion lesion lesions Manifestations moderate objective outcome Patient patients with COVID-19 proportion pulmonary lesion pulmonary lesions radiologist remained required Result Severe case severe cases Severe patient severe patients statistically [DOI] 10.1155/2020/5328267 PMC 바로가기 [Article Type] Research Article
IP-10 and MCP-1 as biomarkers associated with disease severity of COVID-19Research Article Published on 2020-10-292022-10-30 Journal: Molecular Medicine [Category] COVID-19, MERS, SARS, [키워드] Activation Analysis analyzed Biomarker caused change Clinical symptoms COVID-19 COVID-19 patient COVID-19 patients Critically ill Critically ill patient critically ill patients cytokine death disease disease severity ELISA Endothelial dysfunction enzyme-linked immunosorbent Factor ICU in both group Inflammation inflammatory protein involved IP-10 Laboratory Macrophage MCP-1 monocyte chemoattractant protein-1 no significant difference no statistical difference outcome Patient platelet activation poor prognosis recruited Result retrospective risk of death SARS-CoV-2 selected serum Severe patient severity of COVID-19 significantly higher single-center study survival thrombosis Tongji Hospital two group venous viral respiratory Wuhan, China [DOI] 10.1186/s10020-020-00230-x PMC 바로가기 [Article Type] Research Article
Convalescent plasma transfusion therapy in severe COVID-19 patients- a safety, efficacy and dose response study: A structured summary of a study protocol of a phase II randomized controlled trial중증 COVID-19 환자의 회복기 혈장 수혈 요법- 안전성, 효능 및 용량 반응 연구: 2상 무작위 대조 시험 연구 프로토콜의 구조화된 요약Letter Published on 2020-10-262022-08-13 Journal: Trials [Category] MERS, SARS, 임상, [키워드] (neutrophil 24 hour 24 hours allergic allergic reaction Antibody titre Arm ARMS automated blinded Blinding body temperature BSMMU Care checked Clinical improvement collaboration collected comparator computer Controlled Controlled trial convalescent plasma COVID-19 creatinine criteria CRP CT scan deaths defined diastolic discharge dissemination Donor donors dose dose response effective effective dose Efficacy Efficacy and safety element ELISA end point enrolled Evidence evidence of excluded expected FiO2 generate Health Organization hospital Hospital stay ICU identify in-hospital mortality inclusion criteria initial intervention arms Laboratory laboratory parameter Laboratory parameters Laboratory tests lactating women lung lymphocyte multi-arm multicentre neutralizing antibody neutrophil normality number objective open outcome Oxford oxygen oxygen saturations PaO2 paO2/fiO2 participant Participants Patient PCR assay performed plasma Plasma transfusion positive pregnant Primary outcome proportion protocol random number table randomised Randomized controlled trial RCT receive recorded recording recruit recruited recruitment reduction in required respiratory respiratory distress respiratory rate respiratory symptoms room air RT-PCR RT-PCR assay Sample size sample size calculation SARS-CoV-2 secondary outcome serum creatinine Serum ferritin Seven Severe case severe cases severe COVID-19 severe COVID-19 patient severe COVID-19 patients Severe patient severe patients Severe respiratory distress Sex SGOT SGPT SpO2 sputum standard care status Study protocol Support systolic the patient therapy These data titre transfusion Treatment Trial university University of Oxford ventilator website World Health Organization X-ray [DOI] 10.1186/s13063-020-04734-z PMC 바로가기 [Article Type] Letter
Clinical characteristics of 116 hospitalized patients with COVID-19 in Wuhan, China: a single-centered, retrospective, observational studyResearch Article Published on 2020-10-222022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, MERS, SARS, [키워드] 2019 novel coronavirus Acute cardiac injury Acute heart failure acute respiratory illness age Analysis anorexia ARDS cardiovascular cardiovascular comorbidities cardiovascular disease caused Characteristics Chest Chest computed tomography clinical clinical symptom Cluster collected common Comorbidities Comorbidity complications conditions Corona Coronary heart disease COVID-19 COVID-19 patient demographic data develop diabete dry cough Dyspnea electronic medical records elevated elevated lactate dehydrogenase enrolled fatigue female Fever global pandemic Heart injury Hospitalization hospitalized patient hypertension implication infected with SARS-CoV-2 Infection IQR Laboratory laboratory-confirmed Lymphocyte count Measures non-severe cases occur occurred Older outcome patchy Patient patients Prevalence radiological finding Result retrospective SARS-CoV-2 Severe case severe cases Severe patient significantly higher Symptom the disease the median Treatment with COVID-19 Wuhan Wuhan, China [DOI] 10.1186/s12879-020-05452-2 PMC 바로가기 [Article Type] Research Article
Neurological manifestations in coronavirus disease 2019 (COVID-19) patients: a systematic review of literatureReview Published on 2020-10-212022-10-31 Journal: CNS Spectrums [Category] COVID-19, MERS, [키워드] Affect Analysis ARDS article available data cause CNS controlled trials Corona virus coronavirus disease COVID-19 COVID-19 patients COVID-19 severity database diagnosed with COVID-19 Dizziness eligibility excluded glial cell headache highest incidence induce Infection limitations manifestation neurological Neurological complication neurological manifestation neurological manifestations Neurological symptom Neuron nonrandomized objective observational study occur Participants Pathologies Patient patients Pediatric patient reported representing Result SARS-CoV2 Severe patient Symptom systematic literature search systematic review the disease virus was performed [DOI] 10.1017/S1092852920001935 PMC 바로가기 [Article Type] Review
COVID-19 as an Immune Complex Hypersensitivity in Antigen Excess Conditions: Theoretical Pathogenetic Process and Suggestions for Potential Therapeutic Interventions항원 과잉 조건에서 면역 복합 과민증으로서의 COVID-19: 이론적 병인 과정 및 잠재적 치료 개입에 대한 제안Immunology Published on 2020-10-212022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] ACE-2 receptor activated Activation anti-spike antibodies Antigen antigen excess antigenic nature Asymptomatic carried Coagulation complement Complement activation complement system complex component conditions COVID-19 Critical determine develop excess Factor FIBRIN homeostasis Human immune system hypersensitivity Hypothesis hypothetical IgM and IgG immune complex immune response immune response mechanisms induce Infection inflammatory factors innate immune interfere Kawasaki-like disease lung macrophages membrane neutrophil Neutrophils occur pathology Potential Process Severe patient Spike antigen subject suggestion supported symptomatic systemic disorders therapeutic intervention thrombi tissue tissue damage vascular inflammation Viral viral infection Viral proteins virus [DOI] 10.3389/fimmu.2020.566000 PMC 바로가기 [Article Type] Immunology
Safety and efficacy of antiviral combination therapy in symptomatic patients of Covid-19 infection – a randomised controlled trial (SEV-COVID Trial): A structured summary of a study protocol for a randomized controlled trialLetter Published on 2020-10-202022-10-29 Journal: Trials [Category] COVID-19, MERS, SARS, [키워드] 1:1 2019-nCoV allergic Antipyretic Antiretroviral therapy Antiviral Arm as required assigned Breastfeeding Care categories cause clinical combination therapy compassionate use cough country COVID-19 COVID-19 infection criteria death defined described discharged disease dissemination drug Efficacy element eligibility criteria enrolled enrolment Etiquette exclusion criteria exploratory female Fever Frequency H1N1 hand hygiene Hydration Hydroxychloroquine ICU Patients inclusion criteria India Infection infection with SARS-CoV-2 investigator Laboratory Loading dose Lopinavir/ritonavir Lopinavir/Ritonavir combination mechanical ventilation medication Mortality non-ICU non-invasive ventilation Non-severe case Normalisation number nutrition objective off-label organ oxygen saturation paO2/fiO2 participant Participants Patient pharmacotherapy Placebo positive Precaution progression protocol QT prolongation randomisation randomised randomised controlled trial randomization Randomized controlled trial Randomly receipt recruitment regimen Registration registry replaced required Research respiratory rate ribavirin RT-PCR Safety Sample size SARS-CoV-2 RT-PCR screened secondary secure Serious Adverse Event Severe COVID-19 Infection Severe patient severity specimen Standard standard treatment status stratified study period Study protocol supplemental oxygen Support Suppressant surgical sustained symptomatic patient Tablet tested the patient therapeutic intervention therapy time time to defervescence treated Treatment treatment arm treatment group Trial upper respiratory tract Vasopressor Ventilation ventilator wear website [DOI] 10.1186/s13063-020-04774-5 PMC 바로가기 [Article Type] Letter
The therapeutic efficacy of Huashi Baidu Formula combined with antiviral drugs in the treatment of COVID-19 A protocol for systematic review and meta-analysis3800 Published on 2020-10-162022-10-30 Journal: Medicine [Category] Coronavirus, MERS, SARS, [키워드] analyzed antiviral drug antiviral drugs article Baidu CBM China Chinese citation Clinical diagnosis Clinical treatment CNKI Cochrane Library Combination Corona coronary pneumonia COVID-19 Efficacy and safety evaluate Formula global public health Guidance Huashi Baidu Formula Infrastructure lack Meta-analysis protocol recorded Research respiratory infectious disease Science screened Severe patient Stata systematic review therapeutic efficacy Treatment VIP [DOI] 10.1097/MD.0000000000022715 PMC 바로가기 [Article Type] 3800
Sex differences in clinical characteristics and risk factors for mortality among severe patients with COVID-19: a retrospective studyResearch Paper Published on 2020-10-152022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, [키워드] 95% CI Acute cardiac injury Acute kidney injury acute respiratory distress Admission age arrhythmia Clinical characteristics Clinical outcome clinician Coagulopathy Comorbidities complications coronavirus disease COVID-19 cumulative death develop early stage Evidence Factor female females Fever global pandemic greater help hypersensitive identify In-hospital death Infection male males Mortality much higher Multivariable regression not differ Odds ratio outcome Patient patients potential risk procalcitonin Renmin Hospital retrospective cohort study Retrospective study risk factor Risk factors serious complication severe COVID-19 patient severe COVID-19 patients Severe patient severe patients Sex difference survival rate susceptible syndrome troponin I university Wuhan Wuhan, China [DOI] 10.18632/aging.103793 PMC 바로가기 [Article Type] Research Paper
Clinical characteristics and laboratory indicator analysis of 67 COVID-19 pneumonia patients in Suzhou, ChinaResearch Article Published on 2020-10-122022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, MERS, SARS, [키워드] Analysis analyzed cause Characteristics China clinical collected conducted correlated COVID-19 COVID-19 pneumonia patient Critical cumulative death epidemiological FIB fibrinogen helping hormone indicated Laboratory laboratory data lesion lung lobe Lymphocyte count Myoglobin no significant effect OVID-19 Patient patients patients with COVID-19 Pneumonia positively correlated reached Respiratory failure Result Retrospective analysis SARS-CoV-2 sensitivity severe cases severe coronavirus disease severe COVID-19 Severe patient severe patients significantly significantly higher sudden suggested therapy Treatment was increased [DOI] 10.1186/s12879-020-05468-8 PMC 바로가기 [Article Type] Research Article