Polycations and polyanions in SARS-CoV-2 infectionSARS-CoV-2 감염의 다중양이온 및 다중음이온Review Published on 2021-01-012022-09-11 Journal: Medical Hypotheses [Category] 치료제, [키워드] Adding administration aggravate Cell cell membrane conjunction COVID-19 cytokine Cytokines cytotoxicity Effect electrostatic repulsion heparin heparins Histones Innate immunity neutrophil Neutrophils nuclear opsonin oxidants polyanions Polycations pro-inflammatory released SARS-CoV-2 SARS-COV-2 infection secreted the cell therapy virus particle virus particles [DOI] 10.1016/j.mehy.2020.110470 PMC 바로가기 [Article Type] Review
An Update on the Pathogenesis of COVID-19 and the Reportedly Rare Thrombotic Events Following VaccinationCOVID-19의 병인 및 백신 접종 후 보고된 희귀 혈전 사건에 대한 업데이트Review Published on 2021-01-012022-09-11 Journal: Clinical and applied thrombosis/hemostasis : offic [Category] 변종, 신약개발, 임상, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 approved caused coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines Efficacy feature Health health problem heparin heparin induced thrombocytopenia immunological influx information knowledge manuscript pandemic Pathogenesis pathogenesis of COVID-19 pathophysiological progressed respiratory Safe safety and efficacy SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus thrombocytopenia thromboembolic Thromboembolic event Thromboembolic events thrombosis thrombotic Vaccines variant Virological [DOI] 10.1177/10760296211021498 PMC 바로가기 [Article Type] Review
Cardiovascular Comorbidities and Pharmacological Treatments of COVID-19 Patients Not Requiring HospitalizationObservational Study Published on 2020-12-252022-10-04 Journal: International Journal of Environmental Research an [Category] MERS, 임상, [키워드] 95% CI acute respiratory syndrome administration age anticoagulation Azithromycin cardiovascular cardiovascular comorbidity cardiovascular diseases Clinical characteristics clinical feature Combination Comorbidities Comorbidity coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patient database described diabete distribution Drug administration earth evaluated Experimental drugs health emergency heparin highly pathogenic Hospitalization hypertension infected patient inhibitors Italy laboratory-confirmed low molecular weight heparin majority males management material Naples outbreak outpatient’s setting Patient performed pharmacological physician Prevalence prevalent primary care Regression model responsible Retrospective analysis risk Risk factors SARS-CoV-2 significantly study population therapy treated Venous Thromboembolism weight [DOI] 10.3390/ijerph18010102 PMC 바로가기 [Article Type] Observational Study
Pharmacotherapy in COVID 19: Potential Impact of Targeting the Complement SystemReview Published on 2020-12-242022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] Activation acute respiratory syndrome C3 C5 caused claimed Coagulopathy complement Complication compstatin coronavirus Coronavirus disease 2019 COVID COVID-19 Effect heparin immune defense Impact increases in Infection Inflammation invading pathogens life-threatening patients with COVID-19 pharmacotherapy Potential Respiratory illness SARS-CoV-2 System targeting tissue damage Treatment [DOI] 10.3390/biomedicines9010011 PMC 바로가기 [Article Type] Review
Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with HeparinArticle Published on 2020-12-232023-07-02 Journal: Thrombosis and haemostasis [Category] SARS, [키워드] Circular dichroism coronavirus COVID-19 heparin Molecular modelling RBD S1 SARS-CoV-2 spike surface plasmon resonance [DOI] 10.1055/s-0040-1721319 PMC 바로가기
Incidence of symptomatic, image-confirmed venous thromboembolism following hospitalization for COVID-19 with 90-day follow-up90일 추적 관찰과 함께 COVID-19로 입원한 후 증상이 있는 영상 확인 정맥 혈전 색전증의 발생률Article Published on 2020-12-222022-09-11 Journal: Blood advances [Category] SARS, 바이오마커, [키워드] 24 hour 24 hours Admission anticoagulation bleeding Care caution collected COVID-19 death discharge discharged event Follow-up heparin highlighting hospital Hospitalization indication invasive ventilation level of care low molecular weight low molecular weight heparin Lung imaging major bleeding majority medical record medical records National Noninvasive ventilation Observational data occurred on admission Patient patients presenting Prevention strategy Randomized controlled trial receive receiving reported retrospective risk standard thromboprophylaxis subsegmental symptomatic therapeutic anticoagulation Thromboprophylaxis thrombosis Treatment Venous Thromboembolism VTE ward were excluded [DOI] 10.1182/bloodadvances.2020003349 PMC 바로가기 [Article Type] Article
Coronavirus-induced coagulopathy during the course of disease질병 경과 중 코로나바이러스 유발 응고병증Research Article Published on 2020-12-172022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, SARS, 바이오마커, 진단, [키워드] Activation Administered adult COVID-19 patient adverse outcome age alteration Analysis analyzed anticoagulation Antithrombotic argatroban change Coagulation Coagulopathy comparable coronavirus coronavirus disease Course COVID-19 COVID-19 patient COVID-19 patients D-dimer D-dimer level D-dimer levels D-dimers decrease diagnosed disease elevated event fibrinogen fibrinogen level heparin heparin-induced thrombocytopenia Hospitalized hypercoagulability ICU incidence increased risk intensive care intensive care unit treatment investigated Laboratory low-molecular-weight-heparin male marker mean value observation period outpatients Patient patients died patients treated peak levels Platelet count Prophylaxis proportion prothrombin Prothrombin time receiving required Result retrospective Sensitivity analyses sensitivity analysis significant decrease single-center subsequent Switzerland the disease thrombin thrombin time thrombocytopenia thromboembolic Thromboembolic event Thromboembolic events Thromboembolism Treatment two patients unfractionated heparin university venous ward [DOI] 10.1371/journal.pone.0243409 PMC 바로가기 [Article Type] Research Article
Equipoise, Trust, and the Need for Cardiologists to Randomly Assign Patients Into Anticoagulation Trials in the Time of COVID코로나 시대에 심장 전문의가 환자를 항응고 시험에 무작위로 배정해야 하는 균형, 신뢰, 필요성Article Published on 2020-12-152022-09-11 Journal: Circulation [Category] Fulltext, MERS, 임상, [키워드] Abstract cardiologist clinical trial clinical trial protocols Controlled trial COVID COVID-19 heparin Post-exposure prophylaxis Randomized controlled trial time Trust [DOI] 10.1161/CIRCULATIONAHA.120.052069 PMC 바로가기 [Article Type] Article
The transcriptomic profiling of SARS-CoV-2 compared to SARS, MERS, EBOV, and H1N1SARS, MERS, EBOV 및 H1N1과 비교한 SARS-CoV-2의 전사체 프로파일링Comparative Study Published on 2020-12-102022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 신종인플루엔자, 유전자 메커니즘, [키워드] Analysis anti-SARS-CoV-2 Arthritis association cellular claimed Comparative analysis COVID-19 Cytokines demonstrated determine FGF1 FIVE FOXO1 gene signature Genes Genetic global mortality GO term GO terms H1N1 heparin hepatitis B highly pathogenic host antiviral responses IL-6 IL-8 immune regulation Infection Inflammatory responses Influenza influenza A inhibitor Interaction involved life malaria MERS MERS-CoV miRNA modulation molecular NRCAM other respiratory virus Other respiratory viruses pandemic pathway potential therapy PPI protein-protein interaction provide RAGE respiratory respiratory viruses rheumatoid arthritis SAA2 SARS-CoV SARS-CoV-2 SARS-COV-2 infection SERPINB1 Signaling significantly target the SARS-CoV-2 therapeutic Transcriptome transcriptomic understanding unique Viral viral infection viral infections virus viruses [DOI] 10.1371/journal.pone.0243270 PMC 바로가기 [Article Type] Comparative Study
A randomized, open-label, adaptive, proof-of-concept clinical trial of modulation of host thromboinflammatory response in patients with COVID-19: the DAWn-Antico studyCOVID-19 환자의 숙주 혈전 염증 반응 조절에 대한 무작위, 공개, 적응, 개념 증명 임상 시험: DAWn-Antico 연구Randomized Controlled Trial Published on 2020-12-092022-08-13 Journal: Trials [Category] MERS, SARS, 임상, [키워드] Activation adaptive added Anakinra Aprotinin bradykinin cellular entry Clinical improvement clinical status clinical trial Coagulation Combination complications Contact country COVID-19 COVID-19 disease COVID-19 pandemic D-dimer defined develop Disease progression dose drug effective EU Clinical Trial EU Clinical Trials fibrinolysis heparin heparins high mortality hospitalized COVID-19 patients Host hyperinflammation ICU in vitro incidence Infection inflammatory parameters Inflammatory response information inhibitor inhibitory effect initial intensive care Intervention investigated Kallikrein local inflammatory response low molecular weight Low molecular weight heparins marker modulate modulation multicenter Open-label Ordinal Scale outcome pathophysiological pathway Patient Primary outcome Prognostic factor proof-of-concept clinical trial Randomized randomized clinical trial reached receptor receptor antagonist reduce regimen SARS-CoV-2 second wave severe COVID-19 severe COVID-19 disease shown standard thromboprophylaxis supplementary material the WHO Thromboinflammatory response thrombotic Thrombotic complications Thrombotic events Trial Trial registration vaccination Viral viral replication WHO ordinal scale [DOI] 10.1186/s13063-020-04878-y PMC 바로가기 [Article Type] Randomized Controlled Trial