Turning the Tide: Natural Products and Natural-Product-Inspired Chemicals as Potential Counters to SARS-CoV-2 InfectionPharmacology Published on 2020-07-022022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acute respiratory syndrome anti-SARS-CoV-2 antiviral activities Antiviral agents cause Chemical coronavirus coronavirus disease counter COVID-19 drug Ebselen effective EIDD-2801 GS-5734 highly pathogenic homoharringtonine Ivermectin natural natural products natural-product-inspired Potential potential anti-SARSCoV-2 agents product public health Research Safe SARS-CoV-2 SARS-COV-2 infection small molecule Turning [DOI] 10.3389/fphar.2020.01013 PMC 바로가기 [Article Type] Pharmacology
Ethical issues in the COVID-19 pandemic control preparedness in a developing economy개발 도상국에서 COVID-19 전염병 통제 준비의 윤리적 문제Commentary Published on 2020-06-292022-09-01 Journal: The Pan African Medical Journal [Category] MERS, 진단, [키워드] access to treatment Adequate Antidote arising Autonomy best Compliance Contact tracing COVID-19 pandemic criteria curative disease disease control distance effective Epidemic Ethics facilitate Guidance highly pathogenic implementation incidence Infectious disease management measure open outbreak Outbreaks pandemic pandemic preparedness positive Prevalence preventive measures reduce screened social distancing Space Spread tested the disease the WHO Treatment while WHO definition [DOI] 10.11604/pamj.supp.2020.35.23121 PMC 바로가기 [Article Type] Commentary
Betacoronavirus Genomes: How Genomic Information has been Used to Deal with Past Outbreaks and the COVID-19 PandemicReview Published on 2020-06-262022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Betacoronavirus betacoronaviruses bioinformatic analysis caused coronavirus coronavirus disease COVID-19 diagnostic systems drug fatality feature Genome sequencing genomic genomic information Genomics highly pathogenic information MERS MERS-CoV Middle East Molecular epidemiology morbidity outbreak Outbreaks pandemic Pathogenesis Phylogenetic analysis SARS-CoV SARS-CoV-2 Strains syndrome Transmission vaccine candidates [DOI] 10.3390/ijms21124546 PMC 바로가기 [Article Type] Review
The ORF6, ORF8 and nucleocapsid proteins of SARS-CoV-2 inhibit type I interferon signaling pathwayArticle Published on 2020-06-232022-11-01 Journal: Virus research [Category] COVID-19, SARS, 신종인플루엔자, [키워드] accessory proteins activated Activation acute respiratory syndrome aggravate antiviral response conducted contributing to coronavirus coronavirus protein COVID-19 Critical Defense dysregulation highly pathogenic Host IFN-β immune response Infection inhibit inhibited inhibiting inhibitor Innate innate immune innate immune response Innate immunity interferon interferon beta interferon-stimulated gene ISGs ISRE modulating molecular morbidity NF-κB pathway nucleocapsid protein Nucleocapsid proteins on type ORF6 ORF8 ORF8 protein pandemic promoter Protein public health reported SARS-CoV-2 SARS-COV-2 infection screened Sendai virus severe pneumonia signaling pathway structural proteins Transcription Treatment type I interferon viral infection Viral protein [DOI] 10.1016/j.virusres.2020.198074 PMC 바로가기 [Article Type] Article
Coronaviruses and Central Nervous System ManifestationsNeurology Published on 2020-06-232022-11-01 Journal: Frontiers in Neurology [Category] COVID-19, [키워드] accumulating Altered mental status animal model Anosmia brain disorders caused Central nervous system CNS Corona virus coronaviral infections coronavirus Coronavirus infection COVID-19 disease etiologies Evidence explained headache highlight highly pathogenic include manifestation morbidity and mortality nervous neurological & psychiatric symptoms neurological infection and inflammation previous study SARS-CoV-2 SARS-COV-2 infection Spread stroke Symptom syndrome System virus worldwide pandemic Wuhan, China [DOI] 10.3389/fneur.2020.00715 PMC 바로가기 [Article Type] Neurology
COVID-19 and Heart: From Clinical Features to Pharmacological ImplicationsReview Published on 2020-06-222022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] acute respiratory syndrome Admission angiotensin-converting enzyme inhibitor Arrhythmias association Cardiac biomarkers cardiological cardiovascular disease cardiovascular diseases China clinical clinical feature Clinical outcome coronavirus coronavirus disease Coronavirus disease 2019 (COVID-19) country COVID-19 COVID-19 patient CVD disease disease severity epidemiological data feature highly pathogenic Hospital admission implication management morbidity and mortality myocardial injury outbreak pandemic Patient pharmacological Prognosis SARS-CoV-2 SARS-COV-2 infection Spread Wuhan, China [DOI] 10.3390/jcm9061944 PMC 바로가기 [Article Type] Review
Potential for elimination of SAR‐CoV‐2 through vaccination as inspired by elimination of multiple influenza viruses through natural pandemics or mass vaccinationReview Published on 2020-06-112022-11-01 Journal: Journal of medical virology [Category] COVID-19, [키워드] caused China clade claimed coronavirus disease costly COVID‐19 COVID‐19 Efficacy eliminated Elimination H7N9 herd immunity highly pathogenic Human humans Immunity Influenza Influenza virus Intensive International National pandemic Pandemics Potential SARS‐CoV‐2 SARS‐CoV‐2 suggested vaccination Vaccine virus [DOI] 10.1002/jmv.26162 PMC 바로가기 [Article Type] Review
How Are We Facing It? Dispatches From Pathology Residents in a COVID-19 Lombardy Hospital우리는 어떻게 직면하고 있습니까? COVID-19 롬바르디아 병원 병리과 레지던트의 파견Public Health Published on 2020-06-042022-08-31 Journal: Frontiers in Public Health [Category] MERS, SARS, 진단, 치료기술, [키워드] accompanied adopted Autopsy clinical information common sense coronavirus coronavirus disease COVID-19 Department disease healthcare healthcare worker Healthcare workers highly pathogenic hot spot infectious information involved Italian learning lombardy management mandatory National National Health Service outbreak pathologist Pathologists pathology Patient Policy Post-mortem receive reduce reported resident Safety smart work specimen status surgical tissue samples Viral viral infection Viral load WHO guidelines [DOI] 10.3389/fpubh.2020.00259 PMC 바로가기 [Article Type] Public Health
A Review on SARS-CoV-2 Virology, Pathophysiology, Animal Models, and Anti-Viral InterventionsReview Published on 2020-05-292022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] acute respiratory syndrome animal animal model animal models Antiviral antiviral therapy antivirals Clinical features coronavirus CoV COVID-19 disease effective group highly pathogenic in vitro in vivo model include knowledge MERS-CoV pathophysiology randomized clinical trials review SARS-CoV-1 SARS-CoV-2 supportive care tested therapy Treatment Vaccine Virology [DOI] 10.3390/pathogens9060426 PMC 바로가기 [Article Type] Review
Evaluation of the efficacy and safety of intravenous remdesivir in adult patients with severe COVID-19: study protocol for a phase 3 randomized, double-blind, placebo-controlled, multicentre trial중증 COVID-19 성인 환자에 대한 정맥 주사 렘데시비르의 효능 및 안전성 평가: 무작위 배정, 이중 맹검, 위약 대조, 다기관 임상 3상 연구 프로토콜Study Protocol Published on 2020-05-242022-09-10 Journal: Trials [Category] MERS, SARS, 비임상, [키워드] Administered Administrative information Adult patients Antiviral assigned asymptomatic infection breath category caused China Clinical efficacy Clinical improvement clinical manifestation clinical manifestations clinical status clinical trial concern conducted coronavirus disease Coronavirus disease 2019 Coronavirus infections Coronaviruses COVID-19 COVID-19 virus death defined discharge double-blind Efficacy Efficacy and safety Emergency enrolment event futility GS-5734 Health Organization highly pathogenic hospital in vitro in vivo experiments include Infection inhibitory inhibitory effect Inhibitory effects interim analysis Intravenous remdesivir intravenously laboratory-confirmed MERS-CoV Mild multicentre nucleoside Ordinal Scale Patient Phase 3 Placebo placebo-controlled placebo-controlled trial Pneumonia primary endpoint protocol Public public health emergency randomization Randomized Randomly Remdesivir reported required Respiratory failure SARS-CoV SARS-CoV-2 virus severe COVID-19 severe pneumonia severe viral pneumonia Spread Standard Study protocol Symptoms Treatment Trial Trial registration upper respiratory symptoms Viral Viral pneumonia virus infection World Health Organization Wuhan [DOI] 10.1186/s13063-020-04352-9 PMC 바로가기 [Article Type] Study Protocol