Anti-SARS-CoV-2 IgG responses are powerful predicting signatures for the outcome of COVID-19 patientsAnti-SARS-CoV-2 IgG 반응은 COVID-19 환자의 결과에 대한 강력한 예측 신호입니다Article Published on 2021-11-262022-09-12 Journal: Journal of advanced research [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, [키워드] accessory protein Admission antibody association assumed Biomarker clinical information Clinical management Clinical outcome Comorbidities correlated COVID-19 COVID-19 mortality COVID-19 patient COVID-19 patients Cox proportional hazard demographics Disease progression disease severity Evidence global pandemic hospitalized COVID-19 patient identify IgG IgG antibody IgG response IgG responses implication Laboratory laboratory biomarker magnitude Microarray non-structural protein Non-structural/accessory protein nsp1 nsp10 Nsp7 NSP8 ORF3b Orf9b outcome outcomes Patient patient death patients positive rate Predicting signature predictive power Protein RdRP SARS-CoV-2 SARS-CoV-2 proteome SARS-CoV-2 specific antibody serum severity Severity of disease survivor symptoms onset was used [DOI] 10.1016/j.jare.2021.11.014 PMC 바로가기 [Article Type] Article
Long-Lasting Immunity Against SARS-CoV-2: Dream or Reality?Medicine Published on 2021-11-252022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Administered Against antibody Antiviral antiviral T cells arise cellular cellular immunity Course COVID-19 COVID-19 patient death disease dose Dream functional hospitalized COVID-19 patient humoral Humoral immunity immune protection Immunotherapy individuals Infection initial majority Mild pandemic PROTECT protective immunity question Reinfection reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific T cell severe disease T cell These data transfer Vaccine variants [DOI] 10.3389/fmed.2021.770381 PMC 바로가기 [Article Type] Medicine
Functional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response기능적 회복기 혈장 항체 및 주입 전 역가는 초기 중증 COVID-19 면역 반응을 형성합니다Article Published on 2021-11-252022-09-10 Journal: Nature Communications [Category] MERS, SARS, 유전자 메커니즘, 임상, 진단, 치료기술, 치료법, [키워드] administration Anti-nucleocapsid antibodies anti-nucleocapsid antibody Anti-spike anti-Spike IgG antibodies antibody Antibody titer binding convalescent plasma Evolution function functional heterogeneous nature heterogenous hospitalized COVID-19 patient hospitalized COVID-19 patients humoral humoral immune responses Humoral immunity Humoral response humoral responses immune immune response immune responses modulation nucleocapsid-specific antibody outcomes pandemic Patient plasma profile Receptor binding recipient SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 pandemic severe COVID-19 Severe infection Symptoms the SARS-CoV-2 therapy transfer Translational immunology Trial viral infection [DOI] 10.1038/s41467-021-27201-y PMC 바로가기 [Article Type] Article
Intermediate-to-therapeutic versus prophylactic anticoagulation for coagulopathy in hospitalized COVID-19 patients: a systemic review and meta-analysisResearch Published on 2021-11-242022-10-29 Journal: Thrombosis Journal [Category] COVID-19, [키워드] Abstract Analysis Anticoagulant anticoagulation assessment association benefit bleeding bleeding event certainty of evidence Characteristics CIs Coagulopathy COVID-19 COVID-19 patient COVID-19 patients Critically ill database defined demonstrated development Efficacy and safety higher risk hospitalized COVID-19 hospitalized COVID-19 patient ICU In-hospital in-hospital mortality incidence increased the risk intensive care unit major bleeding major bleeding event Meta-analysis moderate Mortality patients Primary outcome Prophylactic protocol random effect randomized clinical trial ranged reducing Registered Result risk searched secondary outcome significantly supplementary material survival Systemic review Thromboprophylaxis thrombotic event weighed [DOI] 10.1186/s12959-021-00343-1 PMC 바로가기 [Article Type] Research
Low Brachial Artery Flow-Mediated Dilation Predicts Worse Prognosis in Hospitalized Patients with COVID-19Article Published on 2021-11-222022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 95% CI Admission Analysis Artery association bFMD brachial brachial artery clinical manifestations clinically composite endpoint coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Cox regression Cox regression analysis death Dilation distress eight Endothelial dysfunction endothelial function enrolled higher risk Hospital admission hospitalized COVID-19 patient ICU In-hospital In-hospital death increased risk Injury intensive care multivariable analyses Non-invasive non-invasive ventilation pathogenic Patient patients died Pneumonia predict Prognosis prognostic Radiographic SARS-CoV-2 Stratification the median univariable with COVID-19 [DOI] 10.3390/jcm10225456 PMC 바로가기 [Article Type] Article
Indications of Persistent Glycocalyx Damage in Convalescent COVID-19 Patients: A Prospective Multicenter Study and HypothesisObservational Study Published on 2021-11-212022-10-04 Journal: Viruses [Category] MERS, 임상, 치료기술, [키워드] analyzed caused controls convalescent COVID-19 patient convalescent COVID-19 patients convalescent patient Course COVID-19 COVID-19 infection COVID-19 pandemic Critical disease cross-sectional damage Degradation demonstrated disease disease course Disease progression elevated Endothelial cell endothelial damage Evidence glycocalyx healthy controls healthy individual Hospitalization hospitalized COVID-19 patient hospitalized patient hyperinflammation indication infected with SARS-CoV-2 Injury long-COVID-19 lung damage median Mild multicenter multicenter study no difference parameter persistent progression Prospective SARS CoV-2 SARS-CoV-2 significantly symptom onset Syndecan-1 virus with mild disease [DOI] 10.3390/v13112324 PMC 바로가기 [Article Type] Observational Study
Increasing Burden of Nursing Care on the Treatment of COVID-19 Patients in the Aging Society: Analyses During the First to the Third Wave of Pandemic in Kyoto City, JapanMedicine Published on 2021-11-182022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] 95% confidence interval activity Admission aging aging society Anxiety burden Care center Characteristics Chronic kidney disease city Cluster Complication coronavirus disease COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients daily living Diabetes Mellitus discharge disease disease severity duration of hospitalization Elderly patient elderly patients enrolled evaluate Health healthcare healthcare worker Healthcare workers hospital Hospitalization hospitalized COVID-19 patient hospitals Increasing Intervention Japan Kyoto Mental Mental Disorders Mortality Nursing nursing care Older organization outcome P -value pandemic Patient physical Poor poor prognosis prevalent proportion reduce required resource resources significantly significantly more study period the patient underlying disease unique Wave with COVID-19 [DOI] 10.3389/fmed.2021.767110 PMC 바로가기 [Article Type] Medicine
Immune-Mediated Glycocalyx Remodeling in Hospitalized COVID-19 PatientsShort Communication Published on 2021-11-182022-10-31 Journal: Cardiovascular Drugs and Therapy [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress acute respiratory syndrome addition ARDS association circulating Clinical deterioration component contribute coronavirus disease Coronavirus-2 COVID-19 COVID-19 patient Degradation disease elevated glycocalyx hallmark healthy control hospitalized COVID-19 patient IL-6 immune dysfunction immune mechanism immune responses Infection Inflammation Inflammatory cytokine IQR mammalian cells marker Mortality observational study occur offer organ dysfunction pathobiology of COVID-19 pathogenesis of COVID-19 phasic progression prospective cohort study remodeling Result risk stratification SARS-CoV-2 SARS-CoV-2 infections SDC1 Sepsis syndrome therapeutic approaches thrombosis TNFα Vascular vascular dysfunction Vascular injury vessel with COVID-19 [DOI] 10.1007/s10557-021-07288-7 PMC 바로가기 [Article Type] Short Communication
Low FXIII activity levels in intensive care unit hospitalized COVID-19 patientsResearch Published on 2021-11-042022-10-29 Journal: Thrombosis Journal [Category] COVID-19, [키워드] accompanied analyzed Antigen average Care clinical variable correlated COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients crosslinking D-dimer levels Fibrinogen levels function FVIII FXIII Hospitalization Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients hypercoagulable ICU inhibitor intensive care Level Lungs mechanism microthrombi Patient patients performed plasma Result resulting severe COVID-19 patients significant decrease significantly lower was measured were measured were recorded [DOI] 10.1186/s12959-021-00333-3 PMC 바로가기 [Article Type] Research
Special report of the RSNA COVID-19 task force: systematic review of outcomes associated with COVID-19 neuroimaging findings in hospitalized patientsSystematic Review Published on 2021-11-012022-10-27 Journal: The British Journal of Radiology [Category] Coronavirus, COVID-19, MERS, SARS, [키워드] adult COVID-19 patients advance age all-cause mortality Analysis articles COVID-19 COVID-19 patient demographics element feature hemorrhage high mortality rate highest hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient ICH Ischemic Stroke leptomeningeal leukoencephalopathy literature review Mortality Necrosis Neurological symptom outcome outcomes Patient performed Prognostic marker reported Specific stroke systematic review unique were recorded with COVID-19 [DOI] 10.1259/bjr.20210149 PMC 바로가기 [Article Type] Systematic Review